Structural changes in the hydrophobic hinge region adversely affect the activity and fidelity of the I260Q mutator DNA polymerase β

Biochemistry

Volumn 52, Issue 25, 2013, Pages 4422-4432

  Gridley, Chelsea L ^a,b   Rangarajan, Sneha ^a,b   Firbank, Susan ^c   Dalal, Shibani ^d   Sweasy, Joann B ^d   Jaeger, Joachim ^a,b  

^a WADSWORTH CENTER   (United States)

^b STATE UNIVERSITY OF NEW YORK   (United States)

^c NEWCASTLE UNIVERSITY   (United Kingdom)

^d YALE CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA POLYMERASE; DOUBLE STRANDED DNA; MODELING STUDIES; ORDERED WATER; SIDE-CHAINS; STRUCTURAL CHANGE; STRUCTURAL VARIATIONS; TERNARY COMPLEX;

DNA; HYDROPHOBICITY;

POLYMERS;

APOENZYME; DNA DIRECTED DNA POLYMERASE BETA; DOUBLE STRANDED DNA; MUTANT PROTEIN; PARATHION;

ARTICLE; BINDING SITE; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME STRUCTURE; ENZYME SUBSTRATE; GENE MUTATION; HINGE REGION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; RAT; WILD TYPE;

AMINO ACID SUBSTITUTION; ANIMALS; APOENZYMES; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; DNA POLYMERASE BETA; GENETIC VARIATION; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MUTATION; RATS; SUBSTRATE SPECIFICITY;

RATTUS;

EID: 84879513246     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi301368f     Document Type: Article

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