DC-81-enediyne induces apoptosis of human melanoma A375 cells: Involvement of the ROS, p38 MAPK, and AP-1 signaling pathways

Cell Biology and Toxicology

Volumn 29, Issue 2, 2013, Pages 85-99

  Chen, Chung Yu ^a   Chen, Yin Kai ^a   Wang, Jeh Jeng ^a   Hsu, Chia Chen ^a   Tsai, Feng Yuan ^b   Sung, Ping Jyun ^c   Lin, Hsien Chang ^a   Chang, Long Sen ^d   Hu, Wan Ping ^a  

^a KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^b NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

^c NATIONAL MUSEUM OF MARINE BIOLOGY AND AQUARIUM   (Taiwan)

^d NATIONAL SUN YAT SEN UNIVERSITY   (Taiwan)

Author keywords

AP 1; Apoptosis; DC 81; Enediyne; p38; ROS

Indexed keywords

1,2,3,11A TETRAHYDRO 8 HYDROXY 7 METHOXY 5H PYRROLO[2,1 C][1,4]BENZODIAZEPIN 5 ONE ENEDIYNE; ACTIVATING TRANSCRIPTION FACTOR 2; ANTINEOPLASTIC AGENT; CALCIUM; CASPASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR AP 1; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; MELANOMA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ANTHRAQUINONES; APOPTOSIS; CASPASE 3; CELL LINE, TUMOR; CELL PROLIFERATION; DNA; DNA DAMAGE; ENEDIYNES; ENZYME INHIBITORS; HUMANS; IMIDAZOLES; MAP KINASE SIGNALING SYSTEM; MELANOMA; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; POLY(ADP-RIBOSE) POLYMERASES; PYRIDINES; PYRROLES; REACTIVE OXYGEN SPECIES; TRANSCRIPTION FACTOR AP-1;

STREPTOMYCES;

EID: 84879459598     PISSN: 07422091     EISSN: 15736822     Source Type: Journal    
DOI: 10.1007/s10565-012-9238-6     Document Type: Article

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