TCH-1030 targeting on topoisomerase i induces S-phase arrest, DNA fragmentation, and cell death of breast cancer cells

Breast Cancer Research and Treatment

Volumn 138, Issue 2, 2013, Pages 383-393

  Liu, Yu Peng ^a   Chen, Hui Ling ^a   Tzeng, Cherng Chyi ^b   Lu, Pei Jung ^a   Lo, Cheng Wei ^c   Lee, Yu Cheng ^a   Tseng, Chih Hua ^b   Chen, Yeh Long ^b   Yang, Chia Ning ^c  

^a NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^b KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^c NATIONAL UNIVERSITY OF KAOHSIUNG   (Taiwan)

Author keywords

Cell cycle; DNA intercalation; Indenoquinoline; Topoisomerase I

Indexed keywords

9 METHOXY 6 (PIPERAZIN 1 YL) 11H INDENO[1,2 C]QUINOLIN 11 ONE O 3 (DIMETHYLAMINO)PROPYL OXIME; 9 METHOXY 6 11H INDENO[1,2 C]QUINOLIN 11 ONE DERIVATIVE; ANTINEOPLASTIC AGENT; CAMPTOTHECIN; CASPASE 3; DNA TOPOISOMERASE; DNA TOPOISOMERASE INHIBITOR; DOXORUBICIN; HISTONE H2AX; INDENOISOQUINOLINE; ISOMERASE INHIBITOR; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; TCH 1030; TOPOTECAN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL; CELL CYCLE PROGRESSION; CONTROLLED STUDY; DNA FRAGMENTATION; DRUG DNA INTERACTION; DRUG MECHANISM; DRUG STRUCTURE; ENZYME ACTIVATION; FLOW CYTOMETRY; HISTONE PHOSPHORYLATION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; S PHASE CELL CYCLE CHECKPOINT;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BREAST NEOPLASMS; CAMPTOTHECIN; CATALYTIC DOMAIN; CELL LINE, TUMOR; DNA FRAGMENTATION; DNA TOPOISOMERASES, TYPE I; FEMALE; HUMANS; INHIBITORY CONCENTRATION 50; MICE; MODELS, MOLECULAR; MOLECULAR TARGETED THERAPY; OXIMES; QUINOLINES; S PHASE CELL CYCLE CHECKPOINTS; TOPOISOMERASE I INHIBITORS; TUMOR BURDEN; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84879413417     PISSN: 01676806     EISSN: 15737217     Source Type: Journal    
DOI: 10.1007/s10549-013-2441-1     Document Type: Article

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