Up-regulatation of CYP3A expression through pregnent X receptor by praeruptorin D isolated from Peucedanum praeruptorum Dunn

Journal of Ethnopharmacology

Volumn 148, Issue 2, 2013, Pages 596-602

  Huang, Ling ^a,b   Huang, Min ^a   Li, Yu Hua ^a   Li, Rui Ming ^a   Zeng, Yu ^b   Kuang, Shao Yi ^b   Zhang, Li ^b   Wang, Yi Tao ^c   Bi, Hui Chang ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b HAINAN MEDICAL UNIVERSITY   (China)

^c University of Macau   (Macao)

Author keywords

Praeruptorin D Pregnane X receptor (PXR) Cytochrome P450 3A Induction Herb drug interaction

Indexed keywords

CYTOCHROME P450 3A11; CYTOCHROME P450 3A4; MESSENGER RNA; PLANT EXTRACT; PRAERUPTORIN D; PREGNANE X RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CATALYSIS; CONTROLLED STUDY; DRUG EFFECT; DRUG ISOLATION; DRUG METABOLISM; ENZYME ACTIVATION; ENZYME ACTIVITY; HERB DRUG INTERACTION; LIVER CELL; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; UPREGULATION;

ANIMALS; APIACEAE; CELL LINE; COUMARINS; CYTOCHROME P-450 CYP3A; GENE EXPRESSION; HEPATOCYTES; HERB-DRUG INTERACTIONS; HUMANS; MALE; MEDICINE, CHINESE TRADITIONAL; MEMBRANE PROTEINS; MICE; MICE, INBRED BALB C; PLANT EXTRACTS; RECEPTORS, STEROID; RNA, MESSENGER; TRANSCRIPTIONAL ACTIVATION; UP-REGULATION;

APIACEAE; MUS; PEUCEDANUM PRAERUPTORUM;

EID: 84879412953     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2013.05.008     Document Type: Article

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