Pyranocoumarin (±)-4′-O-acetyl-3′-O-angeloyl-cis- khellactone induces mitochondrial-dependent apoptosis in HL-60 cells

Planta Medica

Volumn 70, Issue 6, 2004, Pages 489-495

  Fong, Wang Fun ^a   Zhang, Jin Xia ^a   Wu, Jimmy Yiu Cheong ^a   Tse, Kai Wing ^a   Wang, Cheng ^a   Cheung, Hong Yeung ^a   Yang, Meng Su ^a  

^a CITY UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

4 O acetyl 3 O angeloyl khellactone; Apoptosis; Bax, Bcl 2; HL 60; Mitogen activated protein kinases; Peucedanum praeruptonim; Umbelliferae

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; CASPASE; CASPASE 8 INHIBITOR; CASPASE 9; CYTOCHROME C; DNA; ISOLEUCYLGLUTAMYLTHREONYLASPARTIC ACID FLUOROMETHYL KETONE; MITOGEN ACTIVATED PROTEIN KINASE; PROCASPASE 3; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL; PYRANOCOUMARIN 4' O ACETYL 3' O ANGELOYL KHELLACTONE; PYRANOCOUMARIN DERIVATIVE; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; 4' O ACETYL 3' O ANGELOYLKHELLACTONE; 4'-O-ACETYL-3'-O-ANGELOYLKHELLACTONE; ANTINEOPLASTIC AGENT; COUMARIN DERIVATIVE; PLANT EXTRACT; PYRONE DERIVATIVE;

APOPTOSIS; ARTICLE; CELL STRAIN HL 60; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; MEDICINAL PLANT; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; MITOCHONDRION; PLANT ROOT; PROTEIN DEGRADATION; PROTEIN SECRETION; RADIX PEUCEDANI; SIGNAL TRANSDUCTION; STIMULATION; APIALES; DOSE RESPONSE; DRUG EFFECT; PHYTOTHERAPY;

APIACEAE; PEUCEDANUM;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APIACEAE; APOPTOSIS; COUMARINS; DOSE-RESPONSE RELATIONSHIP, DRUG; HL-60 CELLS; HUMANS; MITOCHONDRIA; PHYTOTHERAPY; PLANT EXTRACTS; PLANT ROOTS; PYRANOCOUMARINS; PYRONES;

EID: 3042755222     PISSN: 00320943     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2004-827146     Document Type: Article

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