The mitochondrial disease associated protein Ndufaf2 is dispensable for Complex-1 assembly but critical for the regulation of oxidative stress

Neurobiology of Disease

Volumn 58, Issue , 2013, Pages 57-67

  Schlehe, Julia S ^a   Journel, Marion S M ^a   Taylor, Kelsey P ^a   Amodeo, Katherine D ^a   LaVoie, Matthew J ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Complex 1 assembly; Complex 1 disease; Mitochondria; Mitochondrial DNA mutations; Oxidative stress

Indexed keywords

PROTEIN NDUFAF2; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL GROWTH; CELL RESPIRATION; CELL STRAIN; CELLULAR DISTRIBUTION; CELLULAR STRESS RESPONSE; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DNA DETERMINATION; ENZYME KINETICS; FIBROBLAST CULTURE; GENE DELETION; HUMAN; HUMAN CELL; KNOCKOUT MOUSE; MOUSE; MUTATIONAL ANALYSIS; NONHUMAN; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN DEFICIENCY; PROTEIN DEPLETION; PROTEIN DETERMINATION; PROTEIN FUNCTION; PROTEIN LOCALIZATION;

COMPLEX-1 ASSEMBLY; COMPLEX-1 DISEASE; KNOCKOUT; KO; MITOCHONDRIA; MITOCHONDRIAL DNA; MITOCHONDRIAL DNA MUTATIONS; MTDNA; NOT SIGNIFICANT; NS; OCR; OXIDATIVE STRESS; OXYGEN CONSUMPTION RATE; PBS; PHOSPHATE BUFFERED SALINE; POLYVINYLIDENE FLUORIDE; PVDF; REACTIVE OXYGEN SPECIES; ROS; WILDTYPE; WT;

ANIMALS; CASPASE 3; CELL CYCLE; CELL DEATH; CELL LINE, TUMOR; CITRATE (SI)-SYNTHASE; ELECTRON TRANSPORT COMPLEX I; ELECTRON TRANSPORT COMPLEX II; GENE EXPRESSION REGULATION; HUMANS; MEMBRANE POTENTIALS; MICE; MICE, KNOCKOUT; MITOCHONDRIAL PROTEINS; MOLECULAR CHAPERONES; NADH DEHYDROGENASE; NEUROBLASTOMA; OXIDATIVE STRESS; OXYGEN CONSUMPTION; TIME FACTORS;

EID: 84879336524     PISSN: 09699961     EISSN: 1095953X     Source Type: Journal    
DOI: 10.1016/j.nbd.2013.05.007     Document Type: Article

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