Leptin and tumor necrosis factor-α induce the tyrosine phosphorylation of signal transducer and activator of transcription proteins in the hypothalamus of normal rats in vivo

Endocrinology

Volumn 142, Issue 7, 2001, Pages 3027-3032

  Rizkt, Nasser M ^b   Stammsen, Daniela ^c   Preibisch, Gerald ^c   Eckel, Jürgen ^a  

^a LEIBNIZ CENTER FOR DIABETES RESEARCH AT HEINRICH HEINE UNIVERSITY DÜSSELDORF   (Germany)

^b MANSOURA UNIVERSITY   (Egypt)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

LEPTIN; PROTEIN ANTIBODY; STAT PROTEIN; STAT1 PROTEIN; STAT3 PROTEIN; STAT5 PROTEIN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENERGY BALANCE; FOOD INTAKE; HYPOTHALAMUS; IMMUNOBLOTTING; LIVER; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

ANIMALS; CYTOKINES; DNA-BINDING PROTEINS; HYPOTHALAMUS; INJECTIONS, INTRAVENOUS; LEPTIN; LIVER; MALE; PHOSPHORYLATION; RATS; RATS, WISTAR; RECOMBINANT PROTEINS; REFERENCE VALUES; STAT3 TRANSCRIPTION FACTOR; TRANS-ACTIVATORS; TUMOR NECROSIS FACTOR-ALPHA; TYROSINE;

EID: 0034984796     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/en.142.7.3027     Document Type: Article

References (36)

1. Adipose tissue as an endocrine and paracrine organ
2. Identification of targets of leptin action in rat hypothalamus
3. Leptin and its receptors: Regulators of whole-body homeostasis
4. STATs and gene regulation
5. Leptin signaling in the hypothalamus of normal rats in vivo
6. Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity
7. Adipose expression of tumor necrosis factor-α: Direct role in obesity-linked insulin resistance
8. Cachectic effects of recombinant human tumor necrosis factor in rats
9. Changes in body composition and dietary intake induced by tumor necrosis factor α and corticosterone-individually and in combination
10. Interleukins and tumor necrosis factor as inhibitors of food intake
11. Murine tumor necrosis factor α is transported from blood to brain in the mouse
12. Tumor necrosis factors in 1996
13. Induction of Jak/STAT signaling by activation of the type 1 TNF receptor
14. TNF receptor p55 plays a major role in centrally mediated increases of serum 1L-6 and corticosterone after intracerebroventricular injection of TNF
15. Effects of circulating tumor necrosis factor on the neuronal activity and expression of the genes encoding the tumor necrosis factor receptors (p55 and p75) in the rat brain: A view from the blood-brain barrier
16. Leptin impairs metabolic actions of insulin in isolated rat adipocytes
17. Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice
18. Physiological response to long-term peripheral and central leptin infusion in lean and obese mice
19. Hypothalamic expression of neuropeptide-Y in the New Zealand obese mouse
20. Insulin resistance in the heart: Studies on isolated cardiocytes of genetically obese Zucker rats
21. Evidence for the importance of a positive charge and an α-helical structure of the C-terminus for biological activity of human IL-6
22. The role of SOCS-3 in leptin signaling and leptin resistance
23. Synergestic effect of rhTNF-α and rhIL-1α in inducing anorexia in rats
24. Synergism between IL-1α and TNFα on the activity of the pitutary-adrenal axis and on food intake of rats
25. Tumor necrosis factor-α signals to the IFN-γ, receptor complex to increase Stat1α activation
26. Tumor necrosis factor-α contributes to obesity-related hyperleptinemia by regulating leptin release from adipocytes
27. Serum tumor necrosis factor levels in patients with infectious disease and septic shock
28. Cachectin activity in the serum of cachectic, tumor-bearing rats
29. Serum leptin levels in the acquired immunodeficiency syndrome
30. Requirment of STAT5b for sexual dimorphism of body growth rates and liver gene expression
31. Leptin induces tyrosine phosphorylation of cellular proteins including STAT-1 in human renal adenocarcinoma cells, ACHN
32. Regional induction of tumor necrosis factor α expression in the mouse brain after systemic lipopolysaccharide administration
33. Evidence for a direct central anorectic effect of tumor-necrosis-factor-α in the rat
34. Differential responsiveness of obese (fa/fa) and lean (Fa/Fa) Zucker rats to cytokine-induced anorexia
35. The role of neuropeptide Y in the antiobesity action of the obese gene product
36. Anorexigen (TNF-α, cholecystokinin) and orexigen (neuropeptide Y) plasma levels in peritoneal dialysis (PD) patients: Their relationship with nutritional parameters