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Volumn 135, Issue 5, 2005, Pages 1331-1335

Stimulation of appetite by ghrelin is regulated by leptin restraint: Peripheral and central sites of action

Author keywords

Ghrelin; Leptin; Obesity; Restraint; Rhythms

Indexed keywords

APPETITE STIMULANT; GHRELIN; LEPTIN; NEUROPEPTIDE Y;

EID: 18344376775     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/135.5.1331     Document Type: Conference Paper
Times cited : (90)

References (39)
  • 1
    • 0033038418 scopus 로고    scopus 로고
    • Interacting appetite-regulating pathways in the hypothalamic regulation of body weight
    • Kalra, S. P., Dube, M. G., Pu, S., Xu, B., Horvath, T. L. & Kalra, P. S. (1999) Interacting appetite-regulating pathways in the hypothalamic regulation of body weight. Endocr. Rev. 20: 68-100.
    • (1999) Endocr. Rev. , vol.20 , pp. 68-100
    • Kalra, S.P.1    Dube, M.G.2    Pu, S.3    Xu, B.4    Horvath, T.L.5    Kalra, P.S.6
  • 2
    • 0037471351 scopus 로고    scopus 로고
    • Rhythmic, reciprocal ghrelin and leptin signaling: New insight in the development of obesity
    • Kalra, S. P., Bagnasco, M., Otukonyong, E. E., Dube, M. G. & Kalra, P. S. (2003) Rhythmic, reciprocal ghrelin and leptin signaling: new insight in the development of obesity. Regul. Pept. 111: 1-11.
    • (2003) Regul. Pept. , vol.111 , pp. 1-11
    • Kalra, S.P.1    Bagnasco, M.2    Otukonyong, E.E.3    Dube, M.G.4    Kalra, P.S.5
  • 3
    • 2342497831 scopus 로고    scopus 로고
    • NPY: A novel on/off switch for control of appetite and reproduction
    • Michel, M. C., ed., Springer-Verlag, Berlin
    • Kalra, S. P. & Kalra, P. S. (2004) NPY: a novel on/off switch for control of appetite and reproduction. In: Neuropeptide Y and Related Peptides (Michel, M. C., ed.), pp. 221-249. Springer-Verlag, Berlin.
    • (2004) Neuropeptide Y and Related Peptides , pp. 221-249
    • Kalra, S.P.1    Kalra, P.S.2
  • 4
    • 0242660829 scopus 로고    scopus 로고
    • Neuropeptide Y: A physiological orexigen modulated by the feedback action of ghrelin and leptin
    • Kalra, S. P. & Kalra, P. S. (2004) Neuropeptide Y: a physiological orexigen modulated by the feedback action of ghrelin and leptin. Endocrine 22: 49-56.
    • (2004) Endocrine , vol.22 , pp. 49-56
    • Kalra, S.P.1    Kalra, P.S.2
  • 5
    • 0036157858 scopus 로고    scopus 로고
    • Ghrelin and leptin pulse discharge in fed and fasted rats
    • Bagnasco, M., Kalra, P. S. & Kalra, S. P. (2002) Ghrelin and leptin pulse discharge in fed and fasted rats. Endocrinology 143: 726-729.
    • (2002) Endocrinology , vol.143 , pp. 726-729
    • Bagnasco, M.1    Kalra, P.S.2    Kalra, S.P.3
  • 6
    • 0036241839 scopus 로고    scopus 로고
    • Plasma leptin levels are pulsatile in adult rats: Effects of gonadectomy
    • Bagnasco, M., Kalra, P. S. & Kalra, S. P. (2002) Plasma leptin levels are pulsatile in adult rats: effects of gonadectomy. Neuroendocrinology 75: 257-263.
    • (2002) Neuroendocrinology , vol.75 , pp. 257-263
    • Bagnasco, M.1    Kalra, P.S.2    Kalra, S.P.3
  • 7
    • 0025721025 scopus 로고
    • Neuropeptide Y secretion increases in the paraventricular nucleus in association with increased appetite for food
    • Kalra, S. P., Dube, M. G., Sahu, A., Phelps, C. P. & Kalra, P. S. (1991) Neuropeptide Y secretion increases in the paraventricular nucleus in association with increased appetite for food. Proc. Natl. Acad. Sci. U.S.A. 88: 10931-10935.
    • (1991) Proc. Natl. Acad. Sci. U.S.A. , vol.88 , pp. 10931-10935
    • Kalra, S.P.1    Dube, M.G.2    Sahu, A.3    Phelps, C.P.4    Kalra, P.S.5
  • 8
    • 4344595580 scopus 로고    scopus 로고
    • NPY and cohorts in regulating appetite, obesity and metabolic syndrome: Beneficial effects of gene therapy
    • Kalra, S. P. & Kalra, P. S. (2004) NPY and cohorts in regulating appetite, obesity and metabolic syndrome: beneficial effects of gene therapy. Neuropeptides 38: 201-211.
    • (2004) Neuropeptides , vol.38 , pp. 201-211
    • Kalra, S.P.1    Kalra, P.S.2
  • 9
    • 0036461347 scopus 로고    scopus 로고
    • Obesity and metabolic syndrome: Long-term benefits of central leptin gene therapy
    • Prous, J. R., ed., Prous Science, Barcelona, Spain
    • Kalra, P. S. & Kalra, S. P. (2002) Obesity and metabolic syndrome: long-term benefits of central leptin gene therapy. In: Drugs of Today (Prous, J. R., ed.), pp. 745-757. Prous Science, Barcelona, Spain.
    • (2002) Drugs of Today , pp. 745-757
    • Kalra, P.S.1    Kalra, S.P.2
  • 10
    • 0041733148 scopus 로고    scopus 로고
    • Keeping obesity and metabolic syndrome at bay with central leptin and cytokine gene therapy
    • Hamilton, I., ed., Bentham Science Publications Ltd., San Francisco, CA
    • Kalra, S. P. & Kalra, P. S. (2003) Keeping obesity and metabolic syndrome at bay with central leptin and cytokine gene therapy. In: Current Medicinal Chemistry - Central Nervous System Agent (Hamilton, I., ed.), pp. 189-199. Bentham Science Publications Ltd., San Francisco, CA.
    • (2003) Current Medicinal Chemistry - Central Nervous System Agent , pp. 189-199
    • Kalra, S.P.1    Kalra, P.S.2
  • 11
    • 0034714042 scopus 로고    scopus 로고
    • Long-term differential modulation of genes encoding orexigenic and anorexigenic peptides by leptin delivered by rAAV vector in ob/ob mice. Relationship with body weight change
    • Dhillon, H., Ge, Y., Minter, R. M., Prima, V., Moldawer, L. L., Muzyczka, N., Zolotukhin, S., Kalra, P. S. & Kalra, S. P. (2000) Long-term differential modulation of genes encoding orexigenic and anorexigenic peptides by leptin delivered by rAAV vector in ob/ob mice. Relationship with body weight change. Regul. Pept. 92: 97-105.
    • (2000) Regul. Pept. , vol.92 , pp. 97-105
    • Dhillon, H.1    Ge, Y.2    Minter, R.M.3    Prima, V.4    Moldawer, L.L.5    Muzyczka, N.6    Zolotukhin, S.7    Kalra, P.S.8    Kalra, S.P.9
  • 12
    • 3843070617 scopus 로고    scopus 로고
    • Leptin inhibits ghrelin-induced obesity by two distinct central and peripheral mechanisms: Effects on adiponectin
    • Nov. 8-12, New Orleans, LA
    • Ueno, N., Dube, M. G., Katz, A., Kalra, P. S. & Kalra, S. P. (2003) Leptin inhibits ghrelin-induced obesity by two distinct central and peripheral mechanisms: effects on adiponectin. 33rd Annual Society for Neuroscience Meeting, Nov. 8-12, New Orleans, LA.
    • (2003) 33rd Annual Society for Neuroscience Meeting
    • Ueno, N.1    Dube, M.G.2    Katz, A.3    Kalra, P.S.4    Kalra, S.P.5
  • 13
    • 4344675633 scopus 로고    scopus 로고
    • Leptin modulates orexigenic effects of ghrelin and attenuates adiponectin and insulin levels and selectively the dark-phase feeding as revealed by central leptin gene therapy
    • Ueno, N., Dube, M. G., Inui, A., Kalra, P. S. & Kalra, S. P. (2004) Leptin modulates orexigenic effects of ghrelin and attenuates adiponectin and insulin levels and selectively the dark-phase feeding as revealed by central leptin gene therapy. Endocrinology 145: 4176-4184.
    • (2004) Endocrinology , vol.145 , pp. 4176-4184
    • Ueno, N.1    Dube, M.G.2    Inui, A.3    Kalra, P.S.4    Kalra, S.P.5
  • 15
    • 0034687376 scopus 로고    scopus 로고
    • Ghrelin induces adiposity in rodents
    • Tschop, M., Smiley, D. L. & Heiman, M. L. (2000) Ghrelin induces adiposity in rodents. Nature 407: 908-913.
    • (2000) Nature , vol.407 , pp. 908-913
    • Tschop, M.1    Smiley, D.L.2    Heiman, M.L.3
  • 17
    • 0035433977 scopus 로고    scopus 로고
    • A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans
    • Cummings, D. E., Purnell, J. Q., Frayo, R. S., Schmidova, K., Wisse, B. E. & Weigle, D. S. (2001) A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans. Diabetes 50: 1714-1719.
    • (2001) Diabetes , vol.50 , pp. 1714-1719
    • Cummings, D.E.1    Purnell, J.Q.2    Frayo, R.S.3    Schmidova, K.4    Wisse, B.E.5    Weigle, D.S.6
  • 19
    • 15044339140 scopus 로고    scopus 로고
    • Differential effects of methamphetannine on expression of neuropeptide Y mRNA in hypothalamus and on serum leptin and ghrelin concentrations in ad libitum fed and scheduled fed rats
    • Crowley, W. R., Ramoz, G., Keefe, D. A., Torto, R. & Kalra, S. P. (2005) Differential effects of methamphetannine on expression of neuropeptide Y mRNA in hypothalamus and on serum leptin and ghrelin concentrations in ad libitum fed and scheduled fed rats. Neuroscience 132: 167-173.
    • (2005) Neuroscience , vol.132 , pp. 167-173
    • Crowley, W.R.1    Ramoz, G.2    Keefe, D.A.3    Torto, R.4    Kalra, S.P.5
  • 21
    • 0038304457 scopus 로고    scopus 로고
    • Antagonism of ghrelin receptor reduces food intake and body weight gain in mice
    • Asakawa, A., Inui, A., Kaga, T., Katsuura, G., Fujimiya, M., Fujino, M. A. & Kasuga, M. (2003) Antagonism of ghrelin receptor reduces food intake and body weight gain in mice. Gut 52: 947-952.
    • (2003) Gut , vol.52 , pp. 947-952
    • Asakawa, A.1    Inui, A.2    Kaga, T.3    Katsuura, G.4    Fujimiya, M.5    Fujino, M.A.6    Kasuga, M.7
  • 23
    • 0033278997 scopus 로고    scopus 로고
    • Daily changes in hypothalamic gene expression of neuropeptide Y, galanin, proopiomelanocortin, and adipocyte leptin gene expression and secretion: Effects of food restriction
    • Xu, B., Kalra, P. S., Farmerie, W. G. & Kalra, S. P. (1999) Daily changes in hypothalamic gene expression of neuropeptide Y, galanin, proopiomelanocortin, and adipocyte leptin gene expression and secretion: effects of food restriction. Endocrinology 140: 2868-2875.
    • (1999) Endocrinology , vol.140 , pp. 2868-2875
    • Xu, B.1    Kalra, P.S.2    Farmerie, W.G.3    Kalra, S.P.4
  • 25
    • 2142687620 scopus 로고    scopus 로고
    • Leptin expression in hypothalamic PVN reverses dietary obesity and hyperinsulinemia but stimulates ghrelin
    • Bagnasco, M., Dube, M. G., Katz, A., Kalra, P. S. & Kalra, S. P. (2003) Leptin expression in hypothalamic PVN reverses dietary obesity and hyperinsulinemia but stimulates ghrelin. Obes. Res. 11: 1463-1470.
    • (2003) Obes. Res. , vol.11 , pp. 1463-1470
    • Bagnasco, M.1    Dube, M.G.2    Katz, A.3    Kalra, P.S.4    Kalra, S.P.5
  • 26
    • 0034882656 scopus 로고    scopus 로고
    • Dose-dependent effects of central leptin gene therapy on genes that regulate body weight and appetite in the hypothalamus
    • Dhillon, H., Kalra, S. P. & Kalra, P. S. (2001) Dose-dependent effects of central leptin gene therapy on genes that regulate body weight and appetite in the hypothalamus. Mol. Ther. 4: 139-145.
    • (2001) Mol. Ther. , vol.4 , pp. 139-145
    • Dhillon, H.1    Kalra, S.P.2    Kalra, P.S.3
  • 27
    • 85047681825 scopus 로고    scopus 로고
    • Long-term suppression of weight gain, adiposity, and serum insulin by central leptin gene therapy in prepubertal rats: Effects on serum ghrelin and appetite-regulating genes
    • Beretta, E., Dube, M. G., Kalra, P. S. & Kalra, S. P. (2002) Long-term suppression of weight gain, adiposity, and serum insulin by central leptin gene therapy in prepubertal rats: effects on serum ghrelin and appetite-regulating genes. Pediatr. Res. 52: 189-198.
    • (2002) Pediatr. Res. , vol.52 , pp. 189-198
    • Beretta, E.1    Dube, M.G.2    Kalra, P.S.3    Kalra, S.P.4
  • 28
    • 0036827697 scopus 로고    scopus 로고
    • Evidence for the existence of distinct central appetite and energy expenditure pathways and stimulation of ghrelin as revealed by hypothalamic site-specific leptin gene therapy
    • Bagnasco, M., Dube, M. G., Kalra, P. S. & Kalra, S. P. (2002) Evidence for the existence of distinct central appetite and energy expenditure pathways and stimulation of ghrelin as revealed by hypothalamic site-specific leptin gene therapy. Endocrinology 143: 4409-4421.
    • (2002) Endocrinology , vol.143 , pp. 4409-4421
    • Bagnasco, M.1    Dube, M.G.2    Kalra, P.S.3    Kalra, S.P.4
  • 29
    • 0036263327 scopus 로고    scopus 로고
    • Central leptin gene therapy blocks high fat diet-induced weight gain, hyperleptinemia and hyperinsulinemia: Effects on serum ghrelin levels
    • Dube, M. G., Beretta, E., Dhillon, H., Ueno, N., Kalra, P. S. & Kalra, S. P. (2002) Central leptin gene therapy blocks high fat diet-induced weight gain, hyperleptinemia and hyperinsulinemia: effects on serum ghrelin levels. Diabetes 51: 1729-1736.
    • (2002) Diabetes , vol.51 , pp. 1729-1736
    • Dube, M.G.1    Beretta, E.2    Dhillon, H.3    Ueno, N.4    Kalra, P.S.5    Kalra, S.P.6
  • 30
    • 1842634405 scopus 로고    scopus 로고
    • Effects of insulin, leptin, and glucagon on ghrelin secretion from isolated perfused rat stomach
    • Kamegai, J., Tamura, H., Shimizu, T., Ishii, S., Sugihara, H. & Oikawa, S. (2004) Effects of insulin, leptin, and glucagon on ghrelin secretion from isolated perfused rat stomach. Regul. Pept. 119: 77-81.
    • (2004) Regul. Pept. , vol.119 , pp. 77-81
    • Kamegai, J.1    Tamura, H.2    Shimizu, T.3    Ishii, S.4    Sugihara, H.5    Oikawa, S.6
  • 31
    • 0034802108 scopus 로고    scopus 로고
    • Minireview: Ghrelin and the regulation of energy balance - A hypothalamic perspective
    • Horvath, T. L., Diano, S., Sotonyi, P., Heiman, M. & Tschop, M. (2001) Minireview: ghrelin and the regulation of energy balance - a hypothalamic perspective. Endocrinology 142: 4163-4169.
    • (2001) Endocrinology , vol.142 , pp. 4163-4169
    • Horvath, T.L.1    Diano, S.2    Sotonyi, P.3    Heiman, M.4    Tschop, M.5
  • 32
    • 0026737862 scopus 로고
    • Hypothalamic neuropeptide Y gene expression in rats on scheduled feeding regimen
    • Sahu, A., White, J. D., Kalra, P. S. & Kalra, S. P. (1992) Hypothalamic neuropeptide Y gene expression in rats on scheduled feeding regimen. Brain Res. Mol. Brain Res. 15: 15-18.
    • (1992) Brain Res. Mol. Brain Res. , vol.15 , pp. 15-18
    • Sahu, A.1    White, J.D.2    Kalra, P.S.3    Kalra, S.P.4
  • 34
    • 0037471384 scopus 로고    scopus 로고
    • Endogenous ghrelin is an orexigenic peptide acting in the arcuate nucleus in response to fasting
    • Bagnasco, M., Tulipano, G., Melis, M. R., Argiolas, A., Cocchi, D. & Muller, E. E. (2003) Endogenous ghrelin is an orexigenic peptide acting in the arcuate nucleus in response to fasting. Regul. Pept. 111: 161-167.
    • (2003) Regul. Pept. , vol.111 , pp. 161-167
    • Bagnasco, M.1    Tulipano, G.2    Melis, M.R.3    Argiolas, A.4    Cocchi, D.5    Muller, E.E.6
  • 35
    • 0032096532 scopus 로고    scopus 로고
    • Neural substrates for leptin and neuropeptide Y (NPY) interaction: Hypothalamic sites associated with inhibition of NPY-induced food intake
    • Yokosuka, M., Xu, B., Pu, S., Kalra, P. S. & Kalra, S. P. (1998) Neural substrates for leptin and neuropeptide Y (NPY) interaction: hypothalamic sites associated with inhibition of NPY-induced food intake. Physiol. Behav. 64: 331-338.
    • (1998) Physiol. Behav. , vol.64 , pp. 331-338
    • Yokosuka, M.1    Xu, B.2    Pu, S.3    Kalra, P.S.4    Kalra, S.P.5
  • 36
    • 0033305207 scopus 로고    scopus 로고
    • Inhibition of neuropeptide Y (NPY)-induced feeding and c-Fos response in magnocellular paraventricular nucleus by a NPY receptor antagonist: A site of NPY action
    • Yokosuka, M., Kalra, P. S. & Kalra, S. P. (1999) Inhibition of neuropeptide Y (NPY)-induced feeding and c-Fos response in magnocellular paraventricular nucleus by a NPY receptor antagonist: a site of NPY action. Endocrinology 140: 4494-4500.
    • (1999) Endocrinology , vol.140 , pp. 4494-4500
    • Yokosuka, M.1    Kalra, P.S.2    Kalra, S.P.3
  • 37
    • 0035091692 scopus 로고    scopus 로고
    • The mPVN mediates blockade of NPY-induced feeding by a Y5 receptor antagonist: A c-FOS analysis
    • Yokosuka, M., Dube, M. G., Kalra, P. S. & Kalra, S. P. (2001) The mPVN mediates blockade of NPY-induced feeding by a Y5 receptor antagonist: a c-FOS analysis. Peptides 22: 507-514.
    • (2001) Peptides , vol.22 , pp. 507-514
    • Yokosuka, M.1    Dube, M.G.2    Kalra, P.S.3    Kalra, S.P.4
  • 39
    • 0034714041 scopus 로고    scopus 로고
    • Regulation of leptin secretion: Effects of aging on daily patterns of serum leptin and food consumption
    • Pu, S., Dube, M. G., Kalra, P. S. & Kalra, S. P. (2000) Regulation of leptin secretion: Effects of aging on daily patterns of serum leptin and food consumption. Regul. Pept. 92: 107-111.
    • (2000) Regul. Pept. , vol.92 , pp. 107-111
    • Pu, S.1    Dube, M.G.2    Kalra, P.S.3    Kalra, S.P.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.