메뉴 건너뛰기




Volumn 45, Issue 1, 2013, Pages 73-85

Modulation of inflammatory pathways by the immune cholinergic system

Author keywords

7 nicotinic acetylcholine receptor; Acetylcholinesterase inhibitors; Multiple sclerosis; Myasthenia gravis; Neuroinflammation

Indexed keywords

ACETYLCHOLINESTERASE; ANTISENSE OLIGONUCLEOTIDE; AUTOANTIBODY; BUNGAROTOXIN RECEPTOR; CELECOXIB; CHOLINE ACETYLTRANSFERASE; CHOLINESTERASE INHIBITOR; CYCLOOXYGENASE 1 INHIBITOR; CYCLOOXYGENASE 2 INHIBITOR; EN 101; ESTERASE INHIBITOR; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; MESSENGER RNA; NAPROXEN; NICOTINE; NONSTEROID ANTIINFLAMMATORY AGENT; PREDNISONE; RIVASTIGMINE; TOLL LIKE RECEPTOR; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

EID: 84879198267     PISSN: 09394451     EISSN: 14382199     Source Type: Journal    
DOI: 10.1007/s00726-011-1192-8     Document Type: Review
Times cited : (55)

References (90)
  • 2
    • 0037638809 scopus 로고    scopus 로고
    • Effects of rofecoxib or naproxen vs placebo on Alzheimer disease progression: A randomized controlled trial
    • 10.1001/jama.289.21.2819 1:CAS:528:DC%2BD3sXktlKmsb0%3D 12783912
    • Aisen PS, Schafer KA, Grundman M, Pfeiffer E, Sano M, Davis KL, Farlow MR, Jin S, Thomas RG, Thal LJ (2003) Effects of rofecoxib or naproxen vs placebo on Alzheimer disease progression: a randomized controlled trial. JAMA 289:2819-2826
    • (2003) JAMA , vol.289 , pp. 2819-2826
    • Aisen, P.S.1    Schafer, K.A.2    Grundman, M.3    Pfeiffer, E.4    Sano, M.5    Davis, K.L.6    Farlow, M.R.7    Jin, S.8    Thomas, R.G.9    Thal, L.J.10
  • 5
    • 0030615201 scopus 로고    scopus 로고
    • Nuclear factor-kappaB: A pivotal transcription factor in chronic inflammatory diseases
    • 10.1056/NEJM199704103361506 1:CAS:528:DyaK2sXis1SrsLw%3D 9091804
    • Barnes PJ, Karin M (1997) Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases. N Engl J Med 336:1066-1071
    • (1997) N Engl J Med , vol.336 , pp. 1066-1071
    • Barnes, P.J.1    Karin, M.2
  • 6
    • 0036677420 scopus 로고    scopus 로고
    • Experimental autoimmune encephalitis and inflammation in the absence of interleukin-12
    • 1:CAS:528:DC%2BD38XmsVSiurc%3D 12189243
    • Becher B, Durell BG, Noelle RJ (2002) Experimental autoimmune encephalitis and inflammation in the absence of interleukin-12. J Clin Invest 110:493-497
    • (2002) J Clin Invest , vol.110 , pp. 493-497
    • Becher, B.1    Durell, B.G.2    Noelle, R.J.3
  • 7
    • 0019465142 scopus 로고
    • The rapid isolation of clonable antigen-specific T lymphocyte lines capable of mediating autoimmune encephalomyelitis
    • 10.1002/eji.1830110307 1:STN:280:DyaL3M3ht1alsw%3D%3D 6165588
    • Ben-Nun A, Wekerle H, Cohen IR (1981) The rapid isolation of clonable antigen-specific T lymphocyte lines capable of mediating autoimmune encephalomyelitis. Eur J Immunol 11:195-199
    • (1981) Eur J Immunol , vol.11 , pp. 195-199
    • Ben-Nun, A.1    Wekerle, H.2    Cohen, I.R.3
  • 8
    • 3142724732 scopus 로고    scopus 로고
    • Loss of T-bet, but not STAT1, prevents the development of experimental autoimmune encephalomyelitis
    • 10.1084/jem.20031819 1:CAS:528:DC%2BD2cXlslWmsro%3D 15238607
    • Bettelli E, Sullivan B, Szabo SJ, Sobel RA, Glimcher LH, Kuchroo VK (2004) Loss of T-bet, but not STAT1, prevents the development of experimental autoimmune encephalomyelitis. J Exp Med 200:79-87
    • (2004) J Exp Med , vol.200 , pp. 79-87
    • Bettelli, E.1    Sullivan, B.2    Szabo, S.J.3    Sobel, R.A.4    Glimcher, L.H.5    Kuchroo, V.K.6
  • 9
    • 0023879766 scopus 로고
    • Enhancement of experimental allergic encephalomyelitis in mice by antibodies against IFN-gamma
    • 1:CAS:528:DyaL1cXhs1Gqtr8%3D 3126227
    • Billiau A, Heremans H, Vandekerckhove F, Dijkmans R, Sobis H, Meulepas E, Carton H (1988) Enhancement of experimental allergic encephalomyelitis in mice by antibodies against IFN-gamma. J Immunol 140:1506-1510
    • (1988) J Immunol , vol.140 , pp. 1506-1510
    • Billiau, A.1    Heremans, H.2    Vandekerckhove, F.3    Dijkmans, R.4    Sobis, H.5    Meulepas, E.6    Carton, H.7
  • 11
    • 0037308205 scopus 로고    scopus 로고
    • The role of readthrough acetylcholinesterase in the pathophysiology of myasthenia gravis
    • 10.1096/fj.02-0609com 1:CAS:528:DC%2BD3sXhtVyqurg%3D 12554700
    • Brenner T, Hamra-Amitay Y, Evron T, Boneva N, Seidman S, Soreq H (2003) The role of readthrough acetylcholinesterase in the pathophysiology of myasthenia gravis. FASEB J 17:214-222
    • (2003) FASEB J , vol.17 , pp. 214-222
    • Brenner, T.1    Hamra-Amitay, Y.2    Evron, T.3    Boneva, N.4    Seidman, S.5    Soreq, H.6
  • 12
    • 33750575915 scopus 로고    scopus 로고
    • Myasthenia gravis: Past, present, and future
    • 10.1172/JCI29894 1:CAS:528:DC%2BD28XhtFyrsLnE 17080188
    • Conti-Fine BM, Milani M, Kaminski HJ (2006) Myasthenia gravis: past, present, and future. J Clin Invest 116:2843-2854
    • (2006) J Clin Invest , vol.116 , pp. 2843-2854
    • Conti-Fine, B.M.1    Milani, M.2    Kaminski, H.J.3
  • 14
    • 3042857903 scopus 로고    scopus 로고
    • Alzheimer's disease
    • 10.1056/NEJMra040223 1:CAS:528:DC%2BD2cXltlOjsb8%3D 15229308
    • Cummings JL (2004) Alzheimer's disease. N Engl J Med 351:56-67
    • (2004) N Engl J Med , vol.351 , pp. 56-67
    • Cummings, J.L.1
  • 15
    • 14544273721 scopus 로고    scopus 로고
    • Cognitive deficit associated with cholinergic and nerve growth factor down-regulation in experimental allergic encephalomyelitis in rats
    • 10.1073/pnas.0500073102 15710875
    • D'Intino G, Paradisi M, Fernandez M, Giuliani A, Aloe L, Giardino L, Calza L (2005) Cognitive deficit associated with cholinergic and nerve growth factor down-regulation in experimental allergic encephalomyelitis in rats. Proc Natl Acad Sci USA 102:3070-3075
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 3070-3075
    • D'Intino, G.1    Paradisi, M.2    Fernandez, M.3    Giuliani, A.4    Aloe, L.5    Giardino, L.6    Calza, L.7
  • 16
    • 34547558959 scopus 로고    scopus 로고
    • The alpha7 nicotinic acetylcholine receptor as a pharmacological target for inflammation
    • 10.1038/sj.bjp.0707264 17502850
    • de Jonge WJ, Ulloa L (2007) The alpha7 nicotinic acetylcholine receptor as a pharmacological target for inflammation. Br J Pharmacol 151:915-929
    • (2007) Br J Pharmacol , vol.151 , pp. 915-929
    • De Jonge, W.J.1    Ulloa, L.2
  • 17
    • 21044454884 scopus 로고    scopus 로고
    • Diagnosis and treatment of Alzheimer's disease
    • 10.1212/WNL.64.12-suppl-3.S34 1:CAS:528:DC%2BD2MXpvFKisLw%3D 15994222
    • Desai AK, Grossberg GT (2005) Diagnosis and treatment of Alzheimer's disease. Neurology 64:S34-S39
    • (2005) Neurology , vol.64
    • Desai, A.K.1    Grossberg, G.T.2
  • 18
    • 0028779203 scopus 로고
    • Myasthenia gravis
    • 10.1056/NEJM199406233302507 1:STN:280:DyaK2c3kslCrtQ%3D%3D 8190158
    • Drachman DB (1994) Myasthenia gravis. N Engl J Med 330:1797-1810
    • (1994) N Engl J Med , vol.330 , pp. 1797-1810
    • Drachman, D.B.1
  • 19
    • 0029671318 scopus 로고    scopus 로고
    • Mice with a disrupted IFN-gamma gene are susceptible to the induction of experimental autoimmune encephalomyelitis (EAE)
    • 1:CAS:528:DyaK28XlsVGj 8598493
    • Ferber IA, Brocke S, Taylor-Edwards C, Ridgway W, Dinisco C, Steinman L, Dalton D, Fathman CG (1996) Mice with a disrupted IFN-gamma gene are susceptible to the induction of experimental autoimmune encephalomyelitis (EAE). J Immunol 156:5-7
    • (1996) J Immunol , vol.156 , pp. 5-7
    • Ferber, I.A.1    Brocke, S.2    Taylor-Edwards, C.3    Ridgway, W.4    Dinisco, C.5    Steinman, L.6    Dalton, D.7    Fathman, C.G.8
  • 20
    • 0034519961 scopus 로고    scopus 로고
    • + signaling and c-fos gene expression mediated via muscarinic receptors in human T cells
    • 10.1016/S0306-3623(01)00093-3 1:CAS:528:DC%2BD3MXot1Oltrg%3D 11707312
    • + signaling and c-fos gene expression mediated via muscarinic receptors in human T cells. Gen Pharmacol 35:71-75
    • (2000) Gen Pharmacol , vol.35 , pp. 71-75
    • Fujii, T.1    Kawashima, K.2
  • 21
    • 0029985422 scopus 로고    scopus 로고
    • Localization and synthesis of acetylcholine in human leukemic T cell lines
    • 10.1002/(SICI)1097-4547(19960401)44:1<66: AID-JNR9>3.0.CO;2-G 1:CAS:528:DyaK28XitFGnu7s%3D 8926632
    • Fujii T, Tsuchiya T, Yamada S, Fujimoto K, Suzuki T, Kasahara T, Kawashima K (1996) Localization and synthesis of acetylcholine in human leukemic T cell lines. J Neurosci Res 44:66-72
    • (1996) J Neurosci Res , vol.44 , pp. 66-72
    • Fujii, T.1    Tsuchiya, T.2    Yamada, S.3    Fujimoto, K.4    Suzuki, T.5    Kasahara, T.6    Kawashima, K.7
  • 22
    • 0037375479 scopus 로고    scopus 로고
    • Upregulation of mRNA encoding the M5 muscarinic acetylcholine receptor in human T- and B-lymphocytes during immunological responses
    • 10.1023/A:1022840416292 1:CAS:528:DC%2BD3sXitFakurs%3D 12675126
    • Fujii T, Watanabe Y, Inoue T, Kawashima K (2003) Upregulation of mRNA encoding the M5 muscarinic acetylcholine receptor in human T- and B-lymphocytes during immunological responses. Neurochem Res 28:423-429
    • (2003) Neurochem Res , vol.28 , pp. 423-429
    • Fujii, T.1    Watanabe, Y.2    Inoue, T.3    Kawashima, K.4
  • 23
    • 34548493689 scopus 로고    scopus 로고
    • Enhanced serum antigen-specific IgG1 and proinflammatory cytokine production in nicotinic acetylcholine receptor alpha7 subunit gene knockout mice
    • 10.1016/j.jneuroim.2007.07.003 1:CAS:528:DC%2BD2sXhtVWitLzP 17675251
    • Fujii YX, Fujigaya H, Moriwaki Y, Misawa H, Kasahara T, Grando SA, Kawashima K (2007) Enhanced serum antigen-specific IgG1 and proinflammatory cytokine production in nicotinic acetylcholine receptor alpha7 subunit gene knockout mice. J Neuroimmunol 189:69-74
    • (2007) J Neuroimmunol , vol.189 , pp. 69-74
    • Fujii, Y.X.1    Fujigaya, H.2    Moriwaki, Y.3    Misawa, H.4    Kasahara, T.5    Grando, S.A.6    Kawashima, K.7
  • 24
    • 80052661771 scopus 로고    scopus 로고
    • Cytokine-induced alterations of alpha7 nicotinic receptor in colonic CD4 T cells mediate dichotomous response to nicotine in murine models of Th1/Th17- versus Th2-mediated colitis
    • 10.4049/jimmunol.1002711 1:CAS:528:DC%2BC3MXhtVGmsbzM 21784975
    • Galitovskiy V, Qian J, Chernyavsky AI, Marchenko S, Gindi V, Edwards RA, Grando SA (2011) Cytokine-induced alterations of alpha7 nicotinic receptor in colonic CD4 T cells mediate dichotomous response to nicotine in murine models of Th1/Th17- versus Th2-mediated colitis. J Immunol 187:2677-2687
    • (2011) J Immunol , vol.187 , pp. 2677-2687
    • Galitovskiy, V.1    Qian, J.2    Chernyavsky, A.I.3    Marchenko, S.4    Gindi, V.5    Edwards, R.A.6    Grando, S.A.7
  • 25
  • 26
    • 0037375876 scopus 로고    scopus 로고
    • Cholinesterases: New roles in brain function and in Alzheimer's disease
    • 10.1023/A:1022869222652 1:CAS:528:DC%2BD3sXitFarsr4%3D 12675140
    • Giacobini E (2003) Cholinesterases: new roles in brain function and in Alzheimer's disease. Neurochem Res 28:515-522
    • (2003) Neurochem Res , vol.28 , pp. 515-522
    • Giacobini, E.1
  • 27
    • 0028281395 scopus 로고
    • Depression, cognitive impairment and social stress in multiple sclerosis
    • 10.1016/0022-3999(94)90115-5 1:STN:280:DyaK2czgtVGnuw%3D%3D 8027959
    • Gilchrist AC, Creed FH (1994) Depression, cognitive impairment and social stress in multiple sclerosis. J Psychosom Res 38:193-201
    • (1994) J Psychosom Res , vol.38 , pp. 193-201
    • Gilchrist, A.C.1    Creed, F.H.2
  • 28
    • 0037114150 scopus 로고    scopus 로고
    • IL-12p35-deficient mice are susceptible to experimental autoimmune encephalomyelitis: Evidence for redundancy in the IL-12 system in the induction of central nervous system autoimmune demyelination
    • 1:CAS:528:DC%2BD38XpsFGjtr8%3D 12471147
    • Gran B, Zhang GX, Yu S, Li J, Chen XH, Ventura ES, Kamoun M, Rostami A (2002) IL-12p35-deficient mice are susceptible to experimental autoimmune encephalomyelitis: evidence for redundancy in the IL-12 system in the induction of central nervous system autoimmune demyelination. J Immunol 169:7104-7110
    • (2002) J Immunol , vol.169 , pp. 7104-7110
    • Gran, B.1    Zhang, G.X.2    Yu, S.3    Li, J.4    Chen, X.H.5    Ventura, E.S.6    Kamoun, M.7    Rostami, A.8
  • 29
    • 16244380177 scopus 로고    scopus 로고
    • Dendritic cells permit immune invasion of the CNS in an animal model of multiple sclerosis
    • 10.1038/nm1197 1:CAS:528:DC%2BD2MXhvVSqsr4%3D 15735653
    • Greter M, Heppner FL, Lemos MP, Odermatt BM, Goebels N, Laufer T, Noelle RJ, Becher B (2005) Dendritic cells permit immune invasion of the CNS in an animal model of multiple sclerosis. Nat Med 11:328-334
    • (2005) Nat Med , vol.11 , pp. 328-334
    • Greter, M.1    Heppner, F.L.2    Lemos, M.P.3    Odermatt, B.M.4    Goebels, N.5    Laufer, T.6    Noelle, R.J.7    Becher, B.8
  • 30
    • 0033568704 scopus 로고    scopus 로고
    • Structural roles of acetylcholinesterase variants in biology and pathology
    • 10.1046/j.1432-1327.1999.00693.x 1:CAS:528:DyaK1MXmt1Grt78%3D 10491113
    • Grisaru D, Sternfeld M, Eldor A, Glick D, Soreq H (1999) Structural roles of acetylcholinesterase variants in biology and pathology. Eur J Biochem 264:672-686
    • (1999) Eur J Biochem , vol.264 , pp. 672-686
    • Grisaru, D.1    Sternfeld, M.2    Eldor, A.3    Glick, D.4    Soreq, H.5
  • 31
    • 34248137873 scopus 로고    scopus 로고
    • APC-derived cytokines and T cell polarization in autoimmune inflammation
    • 10.1172/JCI31720 1:CAS:528:DC%2BD2sXlt1Omtr8%3D 17476341
    • Gutcher I, Becher B (2007) APC-derived cytokines and T cell polarization in autoimmune inflammation. J Clin Invest 117:1119-1127
    • (2007) J Clin Invest , vol.117 , pp. 1119-1127
    • Gutcher, I.1    Becher, B.2
  • 32
    • 0036546066 scopus 로고    scopus 로고
    • New concepts in the immunopathogenesis of multiple sclerosis
    • 10.1038/nrn784 1:CAS:528:DC%2BD38Xjsl2kurg%3D 11967559
    • Hemmer B, Archelos JJ, Hartung HP (2002) New concepts in the immunopathogenesis of multiple sclerosis. Nat Rev Neurosci 3:291-301
    • (2002) Nat Rev Neurosci , vol.3 , pp. 291-301
    • Hemmer, B.1    Archelos, J.J.2    Hartung, H.P.3
  • 33
    • 0032209673 scopus 로고    scopus 로고
    • B-cell-deficient mice develop experimental allergic encephalomyelitis with demyelination after myelin oligodendrocyte glycoprotein sensitization
    • 1:CAS:528:DyaK1cXntVWhu74%3D 9794370
    • Hjelmstrom P, Juedes AE, Fjell J, Ruddle NH (1998) B-cell-deficient mice develop experimental allergic encephalomyelitis with demyelination after myelin oligodendrocyte glycoprotein sensitization. J Immunol 161:4480-4483
    • (1998) J Immunol , vol.161 , pp. 4480-4483
    • Hjelmstrom, P.1    Juedes, A.E.2    Fjell, J.3    Ruddle, N.H.4
  • 36
    • 0037470612 scopus 로고    scopus 로고
    • The lymphocytic cholinergic system and its biological function
    • 10.1016/S0024-3205(03)00068-7 1:CAS:528:DC%2BD3sXhs1CltLo%3D 12628464
    • Kawashima K, Fujii T (2003) The lymphocytic cholinergic system and its biological function. Life Sci 72:2101-2109
    • (2003) Life Sci , vol.72 , pp. 2101-2109
    • Kawashima, K.1    Fujii, T.2
  • 37
    • 24944473104 scopus 로고    scopus 로고
    • Symptomatic therapy and neurorehabilitation in multiple sclerosis
    • 10.1016/S1474-4422(05)70193-9 16168933
    • Kesselring J, Beer S (2005) Symptomatic therapy and neurorehabilitation in multiple sclerosis. Lancet Neurol 4:643-652
    • (2005) Lancet Neurol , vol.4 , pp. 643-652
    • Kesselring, J.1    Beer, S.2
  • 38
    • 8644285059 scopus 로고    scopus 로고
    • Donepezil improved memory in multiple sclerosis in a randomized clinical trial
    • 10.1212/01.WNL.0000142989.09633.5A 1:CAS:528:DC%2BD2cXoslSlsrw%3D 15534239
    • Krupp LB, Christodoulou C, Melville P, Scherl WF, MacAllister WS, Elkins LE (2004) Donepezil improved memory in multiple sclerosis in a randomized clinical trial. Neurology 63:1579-1585
    • (2004) Neurology , vol.63 , pp. 1579-1585
    • Krupp, L.B.1    Christodoulou, C.2    Melville, P.3    Scherl, W.F.4    Macallister, W.S.5    Elkins, L.E.6
  • 39
    • 38349193123 scopus 로고    scopus 로고
    • Muscarinic acetylcholine receptors as CNS drug targets
    • 10.1016/j.pharmthera.2007.09.009 1:CAS:528:DC%2BD1cXhtV2itrc%3D 18082893
    • Langmead CJ, Watson J, Reavill C (2008) Muscarinic acetylcholine receptors as CNS drug targets. Pharmacol Ther 117:232-243
    • (2008) Pharmacol Ther , vol.117 , pp. 232-243
    • Langmead, C.J.1    Watson, J.2    Reavill, C.3
  • 41
    • 0028966091 scopus 로고
    • Prevention of experimental autoimmune encephalomyelitis by antibodies against interleukin 12
    • 10.1084/jem.181.1.381 1:CAS:528:DyaK2MXisl2rs7g%3D 7528773
    • Leonard JP, Waldburger KE, Goldman SJ (1995) Prevention of experimental autoimmune encephalomyelitis by antibodies against interleukin 12. J Exp Med 181:381-386
    • (1995) J Exp Med , vol.181 , pp. 381-386
    • Leonard, J.P.1    Waldburger, K.E.2    Goldman, S.J.3
  • 42
    • 33749318470 scopus 로고    scopus 로고
    • Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides
    • 10.1084/jem.20061308 1:CAS:528:DC%2BD28XhtVGls7fF 16982811
    • Liang SC, Tan XY, Luxenberg DP, Karim R, Dunussi-Joannopoulos K, Collins M, Fouser LA (2006) Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides. J Exp Med 203:2271-2279
    • (2006) J Exp Med , vol.203 , pp. 2271-2279
    • Liang, S.C.1    Tan, X.Y.2    Luxenberg, D.P.3    Karim, R.4    Dunussi-Joannopoulos, K.5    Collins, M.6    Fouser, L.A.7
  • 43
    • 17144376810 scopus 로고    scopus 로고
    • High-mobility group box 1 protein (HMGB1): Nuclear weapon in the immune arsenal
    • 10.1038/nri1594 1:CAS:528:DC%2BD2MXivVarsr8%3D 15803152
    • Lotze MT, Tracey KJ (2005) High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal. Nat Rev Immunol 5:331-342
    • (2005) Nat Rev Immunol , vol.5 , pp. 331-342
    • Lotze, M.T.1    Tracey, K.J.2
  • 44
    • 47549107705 scopus 로고    scopus 로고
    • Cognitive function over time in the Alzheimer's disease Anti-inflammatory Prevention Trial (ADAPT): Results of a randomized, controlled trial of naproxen and celecoxib
    • 10.1001/archneur.65.12.noc80051 18474729
    • Martin BK, Szekely C, Brandt J, Piantadosi S, Breitner JC, Craft S, Evans D, Green R, Mullan M (2008) Cognitive function over time in the Alzheimer's disease Anti-inflammatory Prevention Trial (ADAPT): results of a randomized, controlled trial of naproxen and celecoxib. Arch Neurol 65:896-905
    • (2008) Arch Neurol , vol.65 , pp. 896-905
    • Martin, B.K.1    Szekely, C.2    Brandt, J.3    Piantadosi, S.4    Breitner, J.C.5    Craft, S.6    Evans, D.7    Green, R.8    Mullan, M.9
  • 45
    • 70349148185 scopus 로고    scopus 로고
    • Roles of Ca(v) channels and AHNAK1 in T cells: The beauty and the beast
    • 10.1111/j.1600-065X.2009.00805.x 1:CAS:528:DC%2BD1MXhsFGlsL%2FJ 19754902
    • Matza D, Flavell RA (2009) Roles of Ca(v) channels and AHNAK1 in T cells: the beauty and the beast. Immunol Rev 231:257-264
    • (2009) Immunol Rev , vol.231 , pp. 257-264
    • Matza, D.1    Flavell, R.A.2
  • 46
    • 0242268945 scopus 로고    scopus 로고
    • Immunotherapeutic approaches to Alzheimer's disease
    • 10.1126/science.1088469 1:CAS:528:DC%2BD3sXos1Cmt7g%3D 14593170
    • Monsonego A, Weiner HL (2003) Immunotherapeutic approaches to Alzheimer's disease. Science 302:834-838
    • (2003) Science , vol.302 , pp. 834-838
    • Monsonego, A.1    Weiner, H.L.2
  • 48
    • 0022640843 scopus 로고
    • Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins
    • 1:CAS:528:DyaL28XhvVClsbk%3D 2419430
    • Mosmann TR, Cherwinski H, Bond MW, Giedlin MA, Coffman RL (1986) Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J Immunol 136:2348-2357
    • (1986) J Immunol , vol.136 , pp. 2348-2357
    • Mosmann, T.R.1    Cherwinski, H.2    Bond, M.W.3    Giedlin, M.A.4    Coffman, R.L.5
  • 49
    • 0036885067 scopus 로고    scopus 로고
    • The lineage decisions of helper T cells
    • 10.1038/nri954 1:CAS:528:DC%2BD38XptFKnu7g%3D 12461566
    • Murphy KM, Reiner SL (2002) The lineage decisions of helper T cells. Nat Rev Immunol 2:933-944
    • (2002) Nat Rev Immunol , vol.2 , pp. 933-944
    • Murphy, K.M.1    Reiner, S.L.2
  • 50
    • 34548629594 scopus 로고    scopus 로고
    • The emerging diversity of neuromuscular junction disorders
    • 1:CAS:528:DC%2BD2sXhtlKiu7jF 17915563
    • Newsom-Davis J (2007) The emerging diversity of neuromuscular junction disorders. Acta Myol 26:5-10
    • (2007) Acta Myol , vol.26 , pp. 5-10
    • Newsom-Davis, J.1
  • 51
    • 0030583840 scopus 로고    scopus 로고
    • The afferent discharges from sensors for interleukin 1 beta in the hepatoportal system in the anesthetized rat
    • 10.1016/S0165-1838(96)00098-7 1:CAS:528:DyaK28XntlWjurs%3D 8988487
    • Niijima A (1996) The afferent discharges from sensors for interleukin 1 beta in the hepatoportal system in the anesthetized rat. J Auton Nerv Syst 61:287-291
    • (1996) J Auton Nerv Syst , vol.61 , pp. 287-291
    • Niijima, A.1
  • 52
    • 13444266300 scopus 로고    scopus 로고
    • Bifunctional compounds eliciting both anti-inflammatory and cholinergic activity as potential drugs for neuroinflammatory impairments
    • 10.1016/j.neulet.2004.11.030 1:CAS:528:DC%2BD2MXptlGhsw%3D%3D 15694272
    • Nizri E, Adani R, Meshulam H, Amitai G, Brenner T (2005) Bifunctional compounds eliciting both anti-inflammatory and cholinergic activity as potential drugs for neuroinflammatory impairments. Neurosci Lett 376:46-50
    • (2005) Neurosci Lett , vol.376 , pp. 46-50
    • Nizri, E.1    Adani, R.2    Meshulam, H.3    Amitai, G.4    Brenner, T.5
  • 53
    • 33645237919 scopus 로고    scopus 로고
    • Anti-inflammatory properties of cholinergic up-regulation: A new role for acetylcholinesterase inhibitors
    • 10.1016/j.neuropharm.2005.10.013 1:CAS:528:DC%2BD28XivVOgtr4%3D 16336980
    • Nizri E, Hamra-Amitay Y, Sicsic C, Lavon I, Brenner T (2006) Anti-inflammatory properties of cholinergic up-regulation: a new role for acetylcholinesterase inhibitors. Neuropharmacology 50:540-547
    • (2006) Neuropharmacology , vol.50 , pp. 540-547
    • Nizri, E.1    Hamra-Amitay, Y.2    Sicsic, C.3    Lavon, I.4    Brenner, T.5
  • 54
    • 33845940740 scopus 로고    scopus 로고
    • Novel approaches to treatment of autoimmune neuroinflammation and lessons for drug development
    • 10.1159/000097628 1:CAS:528:DC%2BD28XhtlGnt7vE 17139193
    • Nizri E, Irony-Tur-Sinai M, Grigoriadis N, Abramsky O, Amitai G, Brenner T (2007a) Novel approaches to treatment of autoimmune neuroinflammation and lessons for drug development. Pharmacology 79:42-49
    • (2007) Pharmacology , vol.79 , pp. 42-49
    • Nizri, E.1    Irony-Tur-Sinai, M.2    Grigoriadis, N.3    Abramsky, O.4    Amitai, G.5    Brenner, T.6
  • 55
    • 36849093040 scopus 로고    scopus 로고
    • The role of cholinergic balance perturbation in neurological diseases
    • 10.1358/dnp.2007.20.7.1149629 1:CAS:528:DC%2BD1cXhvFGisw%3D%3D 17992264
    • Nizri E, Wirguin I, Brenner T (2007b) The role of cholinergic balance perturbation in neurological diseases. Drug News Perspect 20:421-429
    • (2007) Drug News Perspect , vol.20 , pp. 421-429
    • Nizri, E.1    Wirguin, I.2    Brenner, T.3
  • 56
    • 53149137393 scopus 로고    scopus 로고
    • Suppression of neuroinflammation and immunomodulation by the acetylcholinesterase inhibitor rivastigmine
    • 10.1016/j.jneuroim.2008.06.018 1:CAS:528:DC%2BD1cXhtFyls7fE 18692909
    • Nizri E, Irony-Tur-Sinai M, Faranesh N, Lavon I, Lavi E, Weinstock M, Brenner T (2008) Suppression of neuroinflammation and immunomodulation by the acetylcholinesterase inhibitor rivastigmine. J Neuroimmunol 203:12-22
    • (2008) J Neuroimmunol , vol.203 , pp. 12-22
    • Nizri, E.1    Irony-Tur-Sinai, M.2    Faranesh, N.3    Lavon, I.4    Lavi, E.5    Weinstock, M.6    Brenner, T.7
  • 57
    • 77649341442 scopus 로고    scopus 로고
    • Activation of the cholinergic anti-inflammatory system by nicotine attenuates neuroinflammation via suppression of Th1 and Th17 responses
    • 10.4049/jimmunol.0902212 1:CAS:528:DC%2BD1MXhtlKhtrzM 19846875
    • Nizri E, Irony-Tur-Sinai M, Lory O, Orr-Urtreger A, Lavi E, Brenner T (2009) Activation of the cholinergic anti-inflammatory system by nicotine attenuates neuroinflammation via suppression of Th1 and Th17 responses. J Immunol 183:6681-6688
    • (2009) J Immunol , vol.183 , pp. 6681-6688
    • Nizri, E.1    Irony-Tur-Sinai, M.2    Lory, O.3    Orr-Urtreger, A.4    Lavi, E.5    Brenner, T.6
  • 58
    • 0038127069 scopus 로고    scopus 로고
    • Evidence for the immunosuppressive role of nicotine on human dendritic cell functions
    • 10.1046/j.1365-2567.2003.01655.x 1:CAS:528:DC%2BD3sXltlCjtrw%3D 12807482
    • Nouri-Shirazi M, Guinet E (2003) Evidence for the immunosuppressive role of nicotine on human dendritic cell functions. Immunology 109:365-373
    • (2003) Immunology , vol.109 , pp. 365-373
    • Nouri-Shirazi, M.1    Guinet, E.2
  • 59
    • 33947393008 scopus 로고    scopus 로고
    • Nicotine alters the biological activities of developing mouse bone marrow-derived dendritic cells (DCs)
    • 10.1016/j.imlet.2007.02.005 1:CAS:528:DC%2BD2sXjsVems78%3D 17368810
    • Nouri-Shirazi M, Tinajero R, Guinet E (2007) Nicotine alters the biological activities of developing mouse bone marrow-derived dendritic cells (DCs). Immunol Lett 109:155-164
    • (2007) Immunol Lett , vol.109 , pp. 155-164
    • Nouri-Shirazi, M.1    Tinajero, R.2    Guinet, E.3
  • 60
    • 0037417254 scopus 로고    scopus 로고
    • Alzheimer's disease and Parkinson's disease
    • 10.1056/NEJM2003ra020003 1:CAS:528:DC%2BD3sXis1egt7c%3D 12672864
    • Nussbaum RL, Ellis CE (2003) Alzheimer's disease and Parkinson's disease. N Engl J Med 348:1356-1364
    • (2003) N Engl J Med , vol.348 , pp. 1356-1364
    • Nussbaum, R.L.1    Ellis, C.E.2
  • 61
    • 0242609242 scopus 로고    scopus 로고
    • Heart rate variability as early marker of multiple organ dysfunction syndrome in septic patients
    • 10.1016/j.jcrc.2003.08.005 14595568
    • Pontet J, Contreras P, Curbelo A, Medina J, Noveri S, Bentancourt S, Migliaro ER (2003) Heart rate variability as early marker of multiple organ dysfunction syndrome in septic patients. J Crit Care 18:156-163
    • (2003) J Crit Care , vol.18 , pp. 156-163
    • Pontet, J.1    Contreras, P.2    Curbelo, A.3    Medina, J.4    Noveri, S.5    Bentancourt, S.6    Migliaro, E.R.7
  • 62
    • 79955476932 scopus 로고    scopus 로고
    • Plasticity of the murine spleen T-cell cholinergic receptors and their role in in vitro differentiation of naive CD4 T cells toward the Th1, Th2 and Th17 lineages
    • 10.1038/gene.2010.72 1:CAS:528:DC%2BC3MXltVKnt74%3D 21270829
    • Qian J, Galitovskiy V, Chernyavsky AI, Marchenko S, Grando SA (2011) Plasticity of the murine spleen T-cell cholinergic receptors and their role in in vitro differentiation of naive CD4 T cells toward the Th1, Th2 and Th17 lineages. Genes Immun 12:222-230
    • (2011) Genes Immun , vol.12 , pp. 222-230
    • Qian, J.1    Galitovskiy, V.2    Chernyavsky, A.I.3    Marchenko, S.4    Grando, S.A.5
  • 64
    • 10744222732 scopus 로고    scopus 로고
    • Treatment with an acetylcholinesterase inhibitor in Alzheimer patients modulates the expression and production of the pro-inflammatory and anti-inflammatory cytokines
    • 10.1016/j.jneuroim.2003.11.003 1:CAS:528:DC%2BD2cXht1yksbg%3D 14975597
    • Reale M, Iarlori C, Gambi F, Feliciani C, Salone A, Toma L, DeLuca G, Salvatore M, Conti P, Gambi D (2004) Treatment with an acetylcholinesterase inhibitor in Alzheimer patients modulates the expression and production of the pro-inflammatory and anti-inflammatory cytokines. J Neuroimmunol 148:162-171
    • (2004) J Neuroimmunol , vol.148 , pp. 162-171
    • Reale, M.1    Iarlori, C.2    Gambi, F.3    Feliciani, C.4    Salone, A.5    Toma, L.6    Deluca, G.7    Salvatore, M.8    Conti, P.9    Gambi, D.10
  • 65
    • 33645227116 scopus 로고    scopus 로고
    • The acetylcholinesterase inhibitor, Donepezil, regulates a Th2 bias in Alzheimer's disease patients
    • 10.1016/j.neuropharm.2005.11.006 1:CAS:528:DC%2BD28XivVOgtrk%3D 16445950
    • Reale M, Iarlori C, Gambi F, Feliciani C, Isabella L, Gambi D (2006) The acetylcholinesterase inhibitor, Donepezil, regulates a Th2 bias in Alzheimer's disease patients. Neuropharmacology 50:606-613
    • (2006) Neuropharmacology , vol.50 , pp. 606-613
    • Reale, M.1    Iarlori, C.2    Gambi, F.3    Feliciani, C.4    Isabella, L.5    Gambi, D.6
  • 67
    • 67650391166 scopus 로고    scopus 로고
    • The selective alpha7 agonist GTS-21 attenuates cytokine production in human whole blood and human monocytes activated by ligands for TLR2, TLR3, TLR4, TLR9, and RAGE
    • 10.2119/molmed.2009.00039 1:CAS:528:DC%2BD1MXotlajtL8%3D 19593403
    • Rosas-Ballina M, Goldstein RS, Gallowitsch-Puerta M, Yang L, Valdes-Ferrer SI, Patel NB, Chavan S, Al-Abed Y, Yang H, Tracey KJ (2009) The selective alpha7 agonist GTS-21 attenuates cytokine production in human whole blood and human monocytes activated by ligands for TLR2, TLR3, TLR4, TLR9, and RAGE. Mol Med 15:195-202
    • (2009) Mol Med , vol.15 , pp. 195-202
    • Rosas-Ballina, M.1    Goldstein, R.S.2    Gallowitsch-Puerta, M.3    Yang, L.4    Valdes-Ferrer, S.I.5    Patel, N.B.6    Chavan, S.7    Al-Abed, Y.8    Yang, H.9    Tracey, K.J.10
  • 69
    • 33750047495 scopus 로고    scopus 로고
    • Management of sepsis
    • 10.1056/NEJMra043632 1:CAS:528:DC%2BD28XhtFWgu7vF 17050894
    • Russell JA (2006) Management of sepsis. N Engl J Med 355:1699-1713
    • (2006) N Engl J Med , vol.355 , pp. 1699-1713
    • Russell, J.A.1
  • 70
    • 0345086476 scopus 로고    scopus 로고
    • Diversity of mRNA expression for muscarinic acetylcholine receptor subtypes and neuronal nicotinic acetylcholine receptor subunits in human mononuclear leukocytes and leukemic cell lines
    • 10.1016/S0304-3940(99)00259-1 1:CAS:528:DyaK1MXjtF2qurY%3D 10336173
    • Sato KZ, Fujii T, Watanabe Y, Yamada S, Ando T, Kazuko F, Kawashima K (1999) Diversity of mRNA expression for muscarinic acetylcholine receptor subtypes and neuronal nicotinic acetylcholine receptor subunits in human mononuclear leukocytes and leukemic cell lines. Neurosci Lett 266:17-20
    • (1999) Neurosci Lett , vol.266 , pp. 17-20
    • Sato, K.Z.1    Fujii, T.2    Watanabe, Y.3    Yamada, S.4    Ando, T.5    Kazuko, F.6    Kawashima, K.7
  • 71
    • 0033551547 scopus 로고    scopus 로고
    • A double-blind, placebo-controlled trial of diclofenac/misoprostol in Alzheimer's disease
    • 10.1212/WNL.53.1.197 1:CAS:528:DyaK1MXkvFCkt7w%3D 10408559
    • Scharf S, Mander A, Ugoni A, Vajda F, Christophidis N (1999) A double-blind, placebo-controlled trial of diclofenac/misoprostol in Alzheimer's disease. Neurology 53:197-201
    • (1999) Neurology , vol.53 , pp. 197-201
    • Scharf, S.1    Mander, A.2    Ugoni, A.3    Vajda, F.4    Christophidis, N.5
  • 73
    • 0032536447 scopus 로고    scopus 로고
    • An interleukin (IL)-10/IL-12 immunoregulatory circuit controls susceptibility to autoimmune disease
    • 10.1084/jem.187.4.537 1:CAS:528:DyaK1cXhtFCqtLs%3D 9463404
    • Segal BM, Dwyer BK, Shevach EM (1998) An interleukin (IL)-10/IL-12 immunoregulatory circuit controls susceptibility to autoimmune disease. J Exp Med 187:537-546
    • (1998) J Exp Med , vol.187 , pp. 537-546
    • Segal, B.M.1    Dwyer, B.K.2    Shevach, E.M.3
  • 74
    • 0021331987 scopus 로고
    • The effects of smoking on ACTH and cortisol secretion
    • 10.1016/0024-3205(84)90330-8 1:CAS:528:DyaL2cXjtVyhtg%3D%3D 6319934
    • Seyler LE Jr, Fertig J, Pomerleau O, Hunt D, Parker K (1984) The effects of smoking on ACTH and cortisol secretion. Life Sci 34:57-65
    • (1984) Life Sci , vol.34 , pp. 57-65
    • Seyler, Jr.L.E.1    Fertig, J.2    Pomerleau, O.3    Hunt, D.4    Parker, K.5
  • 76
    • 34249337063 scopus 로고    scopus 로고
    • The role of nicotinic receptors in B-lymphocyte development and activation
    • 10.1016/j.lfs.2007.02.005 1:CAS:528:DC%2BD2sXmtVehtLs%3D 17363009
    • Skok MV, Grailhe R, Agenes F, Changeux JP (2007) The role of nicotinic receptors in B-lymphocyte development and activation. Life Sci 80:2334-2336
    • (2007) Life Sci , vol.80 , pp. 2334-2336
    • Skok, M.V.1    Grailhe, R.2    Agenes, F.3    Changeux, J.P.4
  • 77
    • 17644396349 scopus 로고    scopus 로고
    • Immunology of multiple sclerosis
    • 10.1146/annurev.immunol.23.021704.115707 1:CAS:528:DC%2BD2MXktFOju7w%3D 15771584
    • Sospedra M, Martin R (2005) Immunology of multiple sclerosis. Annu Rev Immunol 23:683-747
    • (2005) Annu Rev Immunol , vol.23 , pp. 683-747
    • Sospedra, M.1    Martin, R.2
  • 78
    • 33745728404 scopus 로고    scopus 로고
    • How to successfully apply animal studies in experimental allergic encephalomyelitis to research on multiple sclerosis
    • 10.1002/ana.20913 1:CAS:528:DC%2BD28XnsFSrsL0%3D 16802293
    • Steinman L, Zamvil SS (2006) How to successfully apply animal studies in experimental allergic encephalomyelitis to research on multiple sclerosis. Ann Neurol 60:12-21
    • (2006) Ann Neurol , vol.60 , pp. 12-21
    • Steinman, L.1    Zamvil, S.S.2
  • 80
    • 0037440372 scopus 로고    scopus 로고
    • Alzheimer's disease is associated with a selective increase in alpha7 nicotinic acetylcholine receptor immunoreactivity in astrocytes
    • 10.1002/glia.10132 12509811
    • Teaktong T, Graham A, Court J, Perry R, Jaros E, Johnson M, Hall R, Perry E (2003) Alzheimer's disease is associated with a selective increase in alpha7 nicotinic acetylcholine receptor immunoreactivity in astrocytes. Glia 41:207-211
    • (2003) Glia , vol.41 , pp. 207-211
    • Teaktong, T.1    Graham, A.2    Court, J.3    Perry, R.4    Jaros, E.5    Johnson, M.6    Hall, R.7    Perry, E.8
  • 81
    • 66449111088 scopus 로고    scopus 로고
    • Reflex control of immunity
    • 10.1038/nri2566 1:CAS:528:DC%2BD1MXmt1SktLk%3D 19461672
    • Tracey KJ (2009) Reflex control of immunity. Nat Rev Immunol 9:418-428
    • (2009) Nat Rev Immunol , vol.9 , pp. 418-428
    • Tracey, K.J.1
  • 82
    • 0023677710 scopus 로고
    • Multiple sclerosis: Involvement of interferons in lesion pathogenesis
    • 10.1002/ana.410240211 1:STN:280:DyaL1M%2FisVGhtQ%3D%3D 2460022
    • Traugott U, Lebon P (1988) Multiple sclerosis: involvement of interferons in lesion pathogenesis. Ann Neurol 24:243-251
    • (1988) Ann Neurol , vol.24 , pp. 243-251
    • Traugott, U.1    Lebon, P.2
  • 85
    • 0025293228 scopus 로고
    • Suppression of experimental allergic encephalomyelitis by intraventricular administration of interferon-gamma in Lewis rats
    • 10.1111/j.1365-2249.1990.tb03315.x 1:CAS:528:DyaK3cXlsFSntrc%3D 2117508
    • Voorthuis JA, Uitdehaag BM, De Groot CJ, Goede PH, van der Meide PH, Dijkstra CD (1990) Suppression of experimental allergic encephalomyelitis by intraventricular administration of interferon-gamma in Lewis rats. Clin Exp Immunol 81:183-188
    • (1990) Clin Exp Immunol , vol.81 , pp. 183-188
    • Voorthuis, J.A.1    Uitdehaag, B.M.2    De Groot, C.J.3    Goede, P.H.4    Van Der Meide, P.H.5    Dijkstra, C.D.6
  • 87
    • 0030587910 scopus 로고    scopus 로고
    • IFN-gamma plays a critical down-regulatory role in the induction and effector phase of myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis
    • 1:CAS:528:DyaK28Xmtlahtbw%3D 8871615
    • Willenborg DO, Fordham S, Bernard CC, Cowden WB, Ramshaw IA (1996) IFN-gamma plays a critical down-regulatory role in the induction and effector phase of myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis. J Immunol 157:3223-3227
    • (1996) J Immunol , vol.157 , pp. 3223-3227
    • Willenborg, D.O.1    Fordham, S.2    Bernard, C.C.3    Cowden, W.B.4    Ramshaw, I.A.5
  • 88
    • 0030456897 scopus 로고    scopus 로고
    • Experimental autoimmune encephalomyelitis induction in genetically B cell-deficient mice
    • 10.1084/jem.184.6.2271 1:STN:280:DyaK2s7jtVCiuw%3D%3D 8976182
    • Wolf SD, Dittel BN, Hardardottir F, Janeway CA Jr (1996) Experimental autoimmune encephalomyelitis induction in genetically B cell-deficient mice. J Exp Med 184:2271-2278
    • (1996) J Exp Med , vol.184 , pp. 2271-2278
    • Wolf, S.D.1    Dittel, B.N.2    Hardardottir, F.3    Janeway, Jr.C.A.4
  • 89
    • 0036685522 scopus 로고    scopus 로고
    • Inflammation in neurodegenerative disease - A double-edged sword
    • 10.1016/S0896-6273(02)00794-8 1:CAS:528:DC%2BD38Xmt12isrs%3D 12165466
    • Wyss-Coray T, Mucke L (2002) Inflammation in neurodegenerative disease - a double-edged sword. Neuron 35:419-432
    • (2002) Neuron , vol.35 , pp. 419-432
    • Wyss-Coray, T.1    Mucke, L.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.