Upregulation of mRNA encoding the M5 muscarinic acetylcholine receptor in human T- and B-lymphocytes during immunological responses

Neurochemical Research

Volumn 28, Issue 3-4, 2003, Pages 423-429

  Fujii, Takeshi ^a   Watanabe, Yoshihiro ^a   Inoue, Tomoyuki ^a   Kawashima, Koichiro ^a  

^a KEIO UNIVERSITY   (Japan)

Author keywords

Acetylcholine; Lymphocytes; Muscarinic receptors; Phytohemagglutinin; Protein kinase C; Staphylococcus aureus Cowan I

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; CALCINEURIN INHIBITOR; CALCIUM IONOPHORE; CHOLINERGIC RECEPTOR; IONOMYCIN; MESSENGER RNA; MUSCARINIC RECEPTOR; PHORBOL 12 ACETATE 13 MYRISTATE; PROTEIN KINASE C ACTIVATOR; TACROLIMUS;

ARTICLE; B LYMPHOCYTE; CELL LINE; CHOLINERGIC SYSTEM; CONTROLLED STUDY; DAUDI CELL; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOLOGY; LEUKEMIA CELL; LYMPHOCYTE ACTIVATION; PRIORITY JOURNAL; REGULATORY MECHANISM; STAPHYLOCOCCUS AUREUS; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

ANTIBODY FORMATION; B-LYMPHOCYTES; BACTERIAL PROTEINS; CARRIER PROTEINS; DRUG COMBINATIONS; HUMANS; IONOMYCIN; IONOPHORES; PHYTOHEMAGGLUTININS; RECEPTOR, MUSCARINIC M5; RECEPTORS, MUSCARINIC; RNA, MESSENGER; T-LYMPHOCYTES; TETRADECANOYLPHORBOL ACETATE; TUMOR CELLS, CULTURED; UP-REGULATION;

STAPHYLOCOCCUS; STAPHYLOCOCCUS AUREUS;

EID: 0037375479     PISSN: 03643190     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1022840416292     Document Type: Article

References (39)

1. Fujii, T., Tajima, S., Yamada, S., Watanabe, Y., Sato, K. Z., Matsui, M., Misawa, H., Fujimoto, K., Kasahara, T., and Kawashima, K. 1999. Constitutive expression of mRNA for the same choline acetyltransferase as that in the nervous system, an acetylcholine-synthesizing enzyme, in human leukemic T-cell lines. Neurosci. Lett. 259:71-74.
2. Tuček, S. 1982. The synthesis of acetylcholine in skeletal muscles of the rat. J. Physiol. 322:53-69.
3. Tuček, S. 1988. Choline acetyltransferase and the synthesis of acetylcholine. Pages 125-165, in Whittaker, V. P. (ed), Handbook of Experimental Pharmacology, 86, The Cholinergic Synapse, Springer Verlag, Berlin.
4. Kawashima, K. and Fujii, T. 2000. Extraneuronal cholinergic system in lymphocytes. Pharmacol. Ther. 86:29-48.
5. Maslinski, W., Kullberg, M., Nordstrom, O., and Bartfai, T. 1988. Muscarinic receptors and receptor mediated actions on rat thymocytes. J. Neuroimmunol. 17:265-274.
6. Maslinski, W. 1989. Cholinergic receptors of lymphocytes. Brain Behav. Immunol. 3:1-14.
7. Fujii, T. and Kawashima, K. 2001. The non-neuronal cholinergic system: An independent, non-neuronal cholinergic system in lymphocytes. Jpn. J. Pharmacol. 85:11-15.
8. 2+ oscillation and c-fos gene expression induced via muscarinic acetylcholine receptor stimulation in human leukemic T- and B-cell lines. Naunyn Schmiedebergs Arch. Pharmacol. 362:14-21.
9. 3 muscarinic acetylcholine receptors in human T- and B-cells. Jpn. J. Pharmacol. 84:124-132.
10. Imboden, B. J., Shoback, M. D., Pattison, G., and Stobo, D. J. 1986. Cholera toxin inhibits the T-cell antigen receptor-mediated increases in inositol triphosphate and cytoplasmic free calcium. Proc. Natl. Acad. Sci. USA 83:5673-5677.
11. Fujii, T., Tsuchiya, T., Yamada, S., Fujimoto, K., Suzuki, T., Kasahara, T., and Kawashima, K. 1996. Localization and synthesis of acetylcholine in human leukemic T cell lines. J. Neurosci. Res. 44:66-72.
12. Fujii, T., Yamada, S., Watanabe, Y., Misawa, H., Tajima, S., Fujimoto, K., Kasahara, T., and Kawashima, K. 1998. Induction of choline acetyltransferase mRNA in human mononuclear leukocytes stimulated by phytohemagglutinin, a T-cell activator. J. Neuroimmunol. 82:101-107.
13. Das, T., Sa, G., and Ray, P. K. 1999. Mechanisms of protein A superantigen-induced signal transduction for proliferation of mouse B cell. Immunol. Lett. 70:43-51.
14. Karray, S., Juompan, L., Maroun, R. C., Isenberg, D., Silverman, G. J., and Zouali, M. 1998. Structural basis of the gp120 superantigen-binding site on human immunoglobulins. J. Immunol. 161:6681-6688.
15. Dong, G. O., Kameyama, K., Rinken, A., and Haga, T. 1995. Ligand binding properties of muscarinic acetylcholine receptor subtypes (m1-m5) expressed in Baculovirus-infected insect cells. J. Pharmacol. Exp. Ther. 274:378-384.
16. Dörje, F., Wess, J., Lambrecht, G., Tacke, R., Mutschiler, E., and Brann, M. R. 1991. Antagonist binding profiles of five cloned human muscarinic receptor subtypes. J. Pharmacol. Exp. Ther. 256:727-733.
17. Höglund, A. U. and Baghdoyan, H. A. 1997. M2, M3 and M4, but not M1 muscarinic receptor subtypes are present in rat spinal cord. J. Pharmacol. Exp. Ther. 281:470-477.
18. Waelbroeck, M., Tastenoy, M., Camus, J., and Christophe, J. 1990. Binding of selective antagonists to four muscarinic receptors (M1 to M4) in rat forebrain. Mol. Pharmacol. 38:267-273.
19. Bonner, T. I., Buckley, N. J., Young, A. C., and Brann, M. R. 1987. Identification of a family of muscarinic acetylcholine receptor genes. Science 237:527-532.
20. Bonner, T. I., Young, A. C., Brann, M. R., and Buckley, N. J. 1988. Cloning and expression of the human and rat m5 muscarinic receptor genes. Neuron 1:403-410.
21. Hulme, E. C., Birdsall, N. J. M., Buckley, N. J. 1990. Muscarinic receptor subtypes. Annu. Rev. Pharmacol. Toxicol. 30:633-673.
22. Bany, U., Ryzewski, J., and Maslinski, W. 1999. Relative amounts of mRNA encoding four subtypes of muscarinic receptors (m2-m5) in human peripheral blood mononuclear cells. J. Neuroimmunol. 97:191-195.
23. Costa, P., Auger, C. B., Traver, D. J., and Costa, L. G. 1995. Identification of m3, m4 and m5 subtypes of muscarinic receptor mRNA in human blood mononuclear cells. J. Neuroimmunol. 60:45-51.
24. Fujino, H., Kitamura, Y., Yada, T., Uehara, T., and Nomura, Y. 1997. Stimulatory roles of muscarinic acetylcholine receptors on T cell antigen receptor/CD3 complex-mediated interleukin-2 production in human peripheral blood lymphocytes. Mol. Pharmacol. 51:1007-1014.
25. Hellström-Lindahl, E. and Nordberg, A. 1996. Muscarinic receptor subtypes in subpopulations of human blood mononuclear cells as analyzed by RT-PCR technique. J. Neuroimmunol. 68:139-144.
26. Sato, K.Z., Fujii, T., Watanabe, Y., Yamada, S., Ando, T., Fujimoto, K., and Kawashima, K. 1999. Diversity of mRNA for muscarinic acetylcholine receptor subtypes and neuronal acetylcholine receptor subunits in human mononuclear leukocytes and leukemic cell lines. Neurosci. Lett. 266:17-20.
27. Fujino, H., Uehara, T., Murayama, T., Okuma, Y., Ariga, H., and Nomura, Y. 2000. Extracellular signal regulated protein kinase and c-Jun N-terminal kinase are involved in m1 muscarinic receptor-enhanced interleukin-2 production pathway in Jurkat cells. Biol. Pharm. Bull. 23:1198-1205.
28. 2+ in Jurkat, a human leukemic helper T lymphocyte line. Mol. Pharmacol. 43:356-364.
29. Szelenyi, J., Paldi-Haris, P., and Hollan, S. 1987. Changes in the cholinergic system of lymphocytes due to mitogenic stimulation. Immunol. Lett. 16:49-54.
30. Nishizuka, Y. 1984. The role of protein kinase C in cell surface signal transduction and tumor promotion. Nature 308:693-698.
31. 2+ signaling and c-fos gene expression mediated via muscarinic receptors in human T cells. Gen. Pharmacol. 35:71-75.
32. Fujii, T., Ushiyama, N., Hosonuma, K., Suenaga, A., and Kawashima, K. 2002. Effects of human antithymocyte globulin on acetylcholine synthesis, its release and choline acetyltransferase transcription in a human leukemic T-cell line. J. Neuroimmunol. 128:1-8.
33. Rinner, I., Kawashima, K., and Schauenstein, K., 1998. Rat lymphocytes produce and secrete acetylcholine in dependent of differentiation and activation. J. Neuroimmunol. 81:31-37.
34. Jain, J., McCaffrey, P. G., Valge-Archer, V. E., and Rao, A. 1992. Nuclear factor of activated T cells contains Fos and Jun. Nature 356:801-804.
35. + T cells of asthmatic patients is suppressed by glucocorticoids and the immunosuppressants FK506 and cyclosporin A. Int. Immunol. 7:449-457.
36. Bock, H. A., Gallati, H., Zurcher, R. M., Bachofen, M., Mihatsch, M, J., Landmann, J., and Thiel, G. 1995. A randomized prospective trial of prophylactic immunosuppression with ATG-fresenius versus OKT-3 after renal transplantation. Transplantation 59:830-840.
37. Fujii, T. and Kawashima, K. 2001. Activation of cholinergic system in T-lymphocytes by stimulation of CD11a molecule. Neurosci. Res. 25(Suppl.):S147.
38. Remberger, M., Svahn, B. M., Heutschke, P., Lofgren, C., and Ringden, O. 1999. Effect on cytokine release and graft-versushost disease of different anti-T cell antibodies during conditioning for unrelated haematopoietic stem cell transplantation. Bone Marrow Transplant 24:823-830.
39. Wang, S. Z., Zhu, S. Z., and el Fakahany, E. E. 1994. Efficient coupling of m5 muscarinic acetylcholine receptors to activation of nitric oxide synthase. J. Pharmacol. Exp. Ther. 268:552-557.