Bifunctional compounds eliciting both anti-inflammatory and cholinergic activity as potential drugs for neuroinflammatory impairments

Neuroscience Letters

Volumn 376, Issue 1, 2005, Pages 46-50

  Nizri, Eran ^a   Adani, Rellie ^b   Meshulam, Haim ^b   Amitai, Gabi ^b   Brenner, Talma ^a  

^a HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^b IIBR   (Israel)

Author keywords

AChE inhibitors; Bifunctional molecules; Central nervous system inflammation; Experimental autoimmune encephalomyelitis; Multiple sclerosis; Non steroidal anti inflammatory drugs

Indexed keywords

HYDROCARBON; IBUPROFEN DERIVATIVE; IBUPROFEN N DECYLPYRIDOSTIGMINE BROMIDE; IBUPROFEN N OCTYLPYRIDOSTIGMINE BROMIDE; MYELIN OLIGODENDROCYTE GLYCOPROTEIN; NITRIC OXIDE; PROSTAGLANDIN E2; PYRIDOSTIGMINE; UNCLASSIFIED DRUG;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASTROCYTE; CHOLINERGIC ACTIVITY; CONTROLLED STUDY; DOWN REGULATION; DRUG CONJUGATION; DRUG SCREENING; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE;

EID: 13444266300     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2004.11.030     Document Type: Article

References (19)

1. G. Amitai, R. Adani., I. Rabinovitz, E. Beit-Yanai, E. Shohami, G. Sod-Moriah, H. Meshulam, Bifunctional compounds eliciting both anti-inflammatory and cholinergic activity as potential drugs for CNS disorders, in: Cholinergic Mechanisms: Function and Dysfunction, Chapter 41, Newgen Imaging Systems Publishers, 2004, pp. 277-288.
2. C. Bolton, D. Gordon, and J.L. Turk A longitudinal study of the prostaglandin content of central nervous system tissues from guinea pigs with acute experimental allergic encephalomyelitis (EAE) Int. J. Immunopharmacol. 6 1984 155 161
3. L.V. Borovikova, S. Ivanova, M. Zhang, H. Yang, G.I. Botchkina, L.R. Watkins, H. Wang, N. Abumrad, J.W. Eaton, and K.J. Tracey Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin Nature 405 2000 458 462
4. T. Brenner, S. Brocke, F. Szafer, R.A. Sobel, J.F. Parkinson, D.H. Perez, and L. Steinman Inhibition of nitric oxide synthase for treatment of experimental autoimmune encephalomyelitis J. Immunol. 158 1997 2940 2946
5. T. Brenner, E. Poradosu, D. Soffer, C. Sicsic, A. Gazit, and A. Levitzki Suppression of experimental autoimmune encephalomyelitis by tyrphostin AG-556 Exp. Neurol. 154 1998 489 498
6. P. Dore-Duffy, S.Y. Ho, and C. Donovan Cerebrospinal fluid eicosanoid levels: endogenous PGD2 and LTC4 synthesis by antigen-presenting cells that migrate to the central nervous system Neurology 41 1991 322 324
7. D.A. Hafler Multiple sclerosis J. Clin. Invest. 113 2004 788 794
8. M. Irony-Tur-Sinai, I. Vlodavsky, S.A. Ben-Sasson, F. Pinto, C. Sicsic, and T. Brenner A synthetic heparin-mimicking polyanionic compound inhibits central nervous system inflammation J. Neurol. Sci. 206 2003 49 57
9. C.G. Jolivalt, R.B. Howard, L.S. Chen, A.P. Mizisin, and C.S. Lai A novel nitric oxide scavenger in combination with cyclosporine A ameliorates experimental autoimmune encephalomyelitis progression in mice J. Neuroimmunol. 138 2003 56 64
10. K. Kawashima, and T. Fujii The lymphocytic cholinergic system and its contribution to the regulation of immune activity Life Sci. 74 2003 675 696
11. C. Moon, M. Ahn, Y. Jee, S. Heo, S. Kim, H. Kim, K.B. Sim, C.S. Koh, Y.G. Shin, and T. Shin Sodium salicylate-induced amelioration of experimental autoimmune encephalomyelitis in Lewis rats is associated with the suppression of inducible nitric oxide synthase and cyclooxygenases Neurosci. Lett. 356 2004 123 126
12. F. Pinto, T. Brenner, P. Dan, M. Krimsky, and S. Yedgar Extracellular phospholipase A2 inhibitors suppress central nervous system inflammation Glia 44 2003 275 282
13. M. Prosiegel, I. Neu, G. Ruhenstroth-Bauer, G. Hoffmann, S. Vogl, L. Mehlber, and A. Wildfeuer Suppression of experimental autoimmune encephalitis by sulfasalazine N. Engl. J. Med. 321 1989 545 546
14. A.T. Reder, M. Thapar, A.M. Sapugay, and M.A. Jensen Prostaglandins and inhibitors of arachidonate metabolism suppress experimental allergic encephalomyelitis J. Neuroimmunol. 54 1994 117 127
15. R.D. Shytle, T. Mori, K. Townsend, M. Vendrame, N. Sun, J. Zeng, J. Ehrhart, A.A. Silver, P.R. Sanberg, and J. Tan Cholinergic modulation of microglial activation by alpha 7 nicotinic receptors J. Neurochem. 89 2004 337 343
16. L. Steinman Elaborate interactions between the immune and nervous systems Nat. Immunol. 5 2004 575 581
17. H. Wang, M. Yu, M. Ochani, C.A. Amella, M. Tanovic, S. Susarla, J.H. Li, H. Yang, L. Ulloa, Y. Al-Abed, C.J. Czura, and K.J. Tracey Nicotinic acetylcholine receptor alpha7 subunit is an essential regulator of inflammation Nature 421 2003 384 388
18. D.O. Willenborg, M.A. Staykova, and W.B. Cowden Our shifting understanding of the role of nitric oxide in autoimmune encephalomyelitis: a review J. Neuroimmunol. 100 1999 21 35
19. S.S. Zamvil, and L. Steinman The T lymphocyte in experimental allergic encephalomyelitis Annu. Rev. Immunol. 8 1990 579 621