-
1
-
-
23044491985
-
Keynote review: Is declining innovation in the pharmaceutical industry a myth?
-
Schmid EF, Smith DA: Keynote review: Is declining innovation in the pharmaceutical industry a myth? Drug Discov Today 2005;10:1031-1039.
-
(2005)
Drug Discov Today
, vol.10
, pp. 1031-1039
-
-
Schmid, E.F.1
Smith, D.A.2
-
2
-
-
31144438390
-
Innovation: Rescuing drug discovery: in vivo systems pathology and systems pharmacology
-
Van der Greef J, McBurney RN: Innovation: Rescuing drug discovery: in vivo systems pathology and systems pharmacology. Nat Rev Drug Discov 2005;4:961-967.
-
(2005)
Nat Rev Drug Discov
, vol.4
, pp. 961-967
-
-
Van der Greef, J.1
McBurney, R.N.2
-
3
-
-
8844232706
-
Functional genomics to new drug targets
-
Kramer R, Cohen D: Functional genomics to new drug targets. Nat Rev Drug Discov 2004;3:965-972.
-
(2004)
Nat Rev Drug Discov
, vol.3
, pp. 965-972
-
-
Kramer, R.1
Cohen, D.2
-
4
-
-
17844370543
-
Advances in knowledge management for pharmaceutical research and development
-
Torr-Brown S: Advances in knowledge management for pharmaceutical research and development. Curr Opin Drug Discov Devel 2005;8:316-322.
-
(2005)
Curr Opin Drug Discov Devel
, vol.8
, pp. 316-322
-
-
Torr-Brown, S.1
-
5
-
-
33745728404
-
How to successfully apply animal studies in experimental allergic encephalomyelitis to research on multiple sclerosis
-
Steinman L, Zamvil SS: How to successfully apply animal studies in experimental allergic encephalomyelitis to research on multiple sclerosis. Ann Neurol 2006;60:12-21.
-
(2006)
Ann Neurol
, vol.60
, pp. 12-21
-
-
Steinman, L.1
Zamvil, S.S.2
-
6
-
-
0036546066
-
New concepts in the immunopathogenesis of multiple sclerosis
-
Hemmer B, Archelos JJ, Hartung HP: New concepts in the immunopathogenesis of multiple sclerosis. Nat Rev Neurosci 2002;3:291-301.
-
(2002)
Nat Rev Neurosci
, vol.3
, pp. 291-301
-
-
Hemmer, B.1
Archelos, J.J.2
Hartung, H.P.3
-
7
-
-
0035554898
-
Multiple sclerosis: A two-stage disease
-
Steinman L: Multiple sclerosis: a two-stage disease. Nat Immunol 2001;2:762-764.
-
(2001)
Nat Immunol
, vol.2
, pp. 762-764
-
-
Steinman, L.1
-
8
-
-
0037441487
-
Axonal loss in the pathology of MS: Consequences for understanding the progressive phase of the disease
-
Bjartmar C, Wujek JR, Trapp BD: Axonal loss in the pathology of MS: consequences for understanding the progressive phase of the disease. J Neurol Sci 2003;206:165-171.
-
(2003)
J Neurol Sci
, vol.206
, pp. 165-171
-
-
Bjartmar, C.1
Wujek, J.R.2
Trapp, B.D.3
-
9
-
-
33845923772
-
Cholinergic Mechanisms: Function and Dysfunction
-
Chapt 41
-
Amitai G, Adani R, Rabinovitz I, Beit-Yanai E, Shohami E, Sod-Moriah G, Meshulam H: Cholinergic Mechanisms: Function and Dysfunction, Chapt 41. Newgen Imaging Systems, 2004.
-
(2004)
Newgen Imaging Systems
-
-
Amitai, G.1
Adani, R.2
Rabinovitz, I.3
Beit-Yanai, E.4
Shohami, E.5
Sod-Moriah, G.6
Meshulam, H.7
-
10
-
-
11844285723
-
The anti-inflammatory and cholinesterase inhibitor bifunctional compound IBU-PO protects from β-amyloid neurotoxicity by acting on Wnt signaling components
-
Farias GG, Godoy JA, Vazquez MC, Adani R, Meshulam H, Avila J, Amitai G, Inestrosa NC: The anti-inflammatory and cholinesterase inhibitor bifunctional compound IBU-PO protects from β-amyloid neurotoxicity by acting on Wnt signaling components. Neurobiol Dis 2005;18:176-183.
-
(2005)
Neurobiol Dis
, vol.18
, pp. 176-183
-
-
Farias, G.G.1
Godoy, J.A.2
Vazquez, M.C.3
Adani, R.4
Meshulam, H.5
Avila, J.6
Amitai, G.7
Inestrosa, N.C.8
-
11
-
-
33746628593
-
Case histories, magic bullets and the state of drug discovery
-
Drews J: Case histories, magic bullets and the state of drug discovery. Nat Rev Drug Discov 2006;5:635-640.
-
(2006)
Nat Rev Drug Discov
, vol.5
, pp. 635-640
-
-
Drews, J.1
-
12
-
-
2942620628
-
Simultaneous neuroprotection and blockade of inflammation reverses autoimmune encephalomyelitis
-
Kanwar JR, Kanwar RK, Krissansen GW: Simultaneous neuroprotection and blockade of inflammation reverses autoimmune encephalomyelitis. Brain 2004;127:1313-1331.
-
(2004)
Brain
, vol.127
, pp. 1313-1331
-
-
Kanwar, J.R.1
Kanwar, R.K.2
Krissansen, G.W.3
-
13
-
-
13444266300
-
Bifunctional compounds eliciting both anti-inflammatory and cholinergic activity as potential drugs for neuroinflammatory impairments
-
Nizri E, Adani R, Meshulam H, Amitai G, Brenner T: Bifunctional compounds eliciting both anti-inflammatory and cholinergic activity as potential drugs for neuroinflammatory impairments. Neurosci Lett 2005;376:46-50.
-
(2005)
Neurosci Lett
, vol.376
, pp. 46-50
-
-
Nizri, E.1
Adani, R.2
Meshulam, H.3
Amitai, G.4
Brenner, T.5
-
14
-
-
13844275122
-
Phenidone, a dual inhibitor of cyclooxygenases and lipoxygenases, ameliorates rat paralysis in experimental autoimmune encephalomyelitis by suppressing its target enzymes
-
Moon C, Ahn M, Wie MB, Kim HM, Koh CS, Hong SC, Kim MD, Tanuma N, Matsumoto Y, Shin T: Phenidone, a dual inhibitor of cyclooxygenases and lipoxygenases, ameliorates rat paralysis in experimental autoimmune encephalomyelitis by suppressing its target enzymes. Brain Res 2005;1035:206-210.
-
(2005)
Brain Res
, vol.1035
, pp. 206-210
-
-
Moon, C.1
Ahn, M.2
Wie, M.B.3
Kim, H.M.4
Koh, C.S.5
Hong, S.C.6
Kim, M.D.7
Tanuma, N.8
Matsumoto, Y.9
Shin, T.10
-
15
-
-
0035829592
-
A subset of NSAIDs lower amyloidogenic Aβ42 independently of cyclooxygenase activity
-
Weggen S, Eriksen JL, Das P, Sagi SA, Wang R, Pietrzik CU, Findlay KA, Smith TE, Murphy MP, Bulter T, Kang DE, Marquez-Sterling N, Golde TE, Koo EH: A subset of NSAIDs lower amyloidogenic Aβ42 independently of cyclooxygenase activity. Nature 2001;414:212-216.
-
(2001)
Nature
, vol.414
, pp. 212-216
-
-
Weggen, S.1
Eriksen, J.L.2
Das, P.3
Sagi, S.A.4
Wang, R.5
Pietrzik, C.U.6
Findlay, K.A.7
Smith, T.E.8
Murphy, M.P.9
Bulter, T.10
Kang, D.E.11
Marquez-Sterling, N.12
Golde, T.E.13
Koo, E.H.14
-
16
-
-
0031990814
-
Modulation of transcription factor NF-κB by enantiomers of the non-steroidal drug ibuprofen
-
Scheuren N, Bang H, Munster T, Brune K, Pahl A: Modulation of transcription factor NF-κB by enantiomers of the non-steroidal drug ibuprofen. Br J Pharmacol 1998;123:645-652.
-
(1998)
Br J Pharmacol
, vol.123
, pp. 645-652
-
-
Scheuren, N.1
Bang, H.2
Munster, T.3
Brune, K.4
Pahl, A.5
-
17
-
-
0030615201
-
Nuclear factor-κB: A pivotal transcription factor in chronic inflammatory diseases
-
Barnes PJ, Karin M: Nuclear factor-κB: a pivotal transcription factor in chronic inflammatory diseases. N Engl J Med 1997;336:1066-1071.
-
(1997)
N Engl J Med
, vol.336
, pp. 1066-1071
-
-
Barnes, P.J.1
Karin, M.2
-
18
-
-
0031722478
-
Nonsteroidal anti-inflammatory drugs increase tumor necrosis factor production in the periphery but not in the central nervous system in mice and rats
-
Sacco S, Agnello D, Sottocorno M, Lozza G, Monopoli A, Villa P, Ghezzi P: Nonsteroidal anti-inflammatory drugs increase tumor necrosis factor production in the periphery but not in the central nervous system in mice and rats. J Neurochem 1998;71:2063-2070.
-
(1998)
J Neurochem
, vol.71
, pp. 2063-2070
-
-
Sacco, S.1
Agnello, D.2
Sottocorno, M.3
Lozza, G.4
Monopoli, A.5
Villa, P.6
Ghezzi, P.7
-
19
-
-
0037461768
-
Nicotinic acetylcholine receptor α7 subunit is an essential regulator of inflammation
-
Wang H, Yu M, Ochani M, Amella CA, Tanovic M, Susarla S, Li JH, Yang H, Ulloa L, Al-Abed Y, Czura CJ, Tracey KJ: Nicotinic acetylcholine receptor α7 subunit is an essential regulator of inflammation. Nature 2003;421:384-388.
-
(2003)
Nature
, vol.421
, pp. 384-388
-
-
Wang, H.1
Yu, M.2
Ochani, M.3
Amella, C.A.4
Tanovic, M.5
Susarla, S.6
Li, J.H.7
Yang, H.8
Ulloa, L.9
Al-Abed, Y.10
Czura, C.J.11
Tracey, K.J.12
-
20
-
-
33645237919
-
Anti-inflammatory properties of cholinergic up-regulation: A new role for acetylcholinesterase inhibitors
-
Nizri E, Hamra-Amitay Y, Sicsic C, Lavon I, Brenner T: Anti-inflammatory properties of cholinergic up-regulation: a new role for acetylcholinesterase inhibitors. Neuropharmacology 2006;50:540-547.
-
(2006)
Neuropharmacology
, vol.50
, pp. 540-547
-
-
Nizri, E.1
Hamra-Amitay, Y.2
Sicsic, C.3
Lavon, I.4
Brenner, T.5
-
21
-
-
33745928735
-
A meta-analysis of the association between adherence to drug therapy and mortality
-
Simpson SH, Eurich DT, Majumdar SR, Padwal RS, Tsuyuki RT, Varney J, Johnson JA: A meta-analysis of the association between adherence to drug therapy and mortality. BMJ 2006;333:15.
-
(2006)
BMJ
, vol.333
, pp. 15
-
-
Simpson, S.H.1
Eurich, D.T.2
Majumdar, S.R.3
Padwal, R.S.4
Tsuyuki, R.T.5
Varney, J.6
Johnson, J.A.7
-
22
-
-
0031058999
-
The multilevel compliance challenge: Recommendations for a call to action. A statement for healthcare professionals
-
Miller NH, Hill M, Kottke T, Ockene IS: The multilevel compliance challenge: recommendations for a call to action. A statement for healthcare professionals. Circulation 1997;95:1085-1090.
-
(1997)
Circulation
, vol.95
, pp. 1085-1090
-
-
Miller, N.H.1
Hill, M.2
Kottke, T.3
Ockene, I.S.4
-
23
-
-
1642397582
-
Variations in patients' adherence to medical recommendations: A quantitative review of 50 years of research
-
DiMatteo MR: Variations in patients' adherence to medical recommendations: a quantitative review of 50 years of research. Med Care 2004;42:200-209.
-
(2004)
Med Care
, vol.42
, pp. 200-209
-
-
DiMatteo, M.R.1
-
24
-
-
33644668387
-
Finding new tricks for old drugs: An efficient route for public-sector drug discovery
-
O'Connor KA, Roth BL: Finding new tricks for old drugs: an efficient route for public-sector drug discovery. Nat Rev Drug Discov 2005;4:1005-1014.
-
(2005)
Nat Rev Drug Discov
, vol.4
, pp. 1005-1014
-
-
O'Connor, K.A.1
Roth, B.L.2
-
25
-
-
0034435563
-
New concepts in super-ovulation strategies for assisted conception treatments
-
Salha O, Balen AH: New concepts in super-ovulation strategies for assisted conception treatments. Curr Opin Obstet Gynecol 2000;12:201-206.
-
(2000)
Curr Opin Obstet Gynecol
, vol.12
, pp. 201-206
-
-
Salha, O.1
Balen, A.H.2
-
26
-
-
0034122651
-
Effects of growth hormone on body composition and bone metabolism
-
Carrel AL, Allen DB: Effects of growth hormone on body composition and bone metabolism. Endocrine 2000;12:163-172.
-
(2000)
Endocrine
, vol.12
, pp. 163-172
-
-
Carrel, A.L.1
Allen, D.B.2
-
27
-
-
10644259532
-
Neuroimmunoprotective effects of estrogen and derivatives in experimental autoimmune encephalomyelitis: Therapeutic implications for multiple sclerosis
-
Offner H: Neuroimmunoprotective effects of estrogen and derivatives in experimental autoimmune encephalomyelitis: therapeutic implications for multiple sclerosis. J Neurosci Res 2004;78:603-624.
-
(2004)
J Neurosci Res
, vol.78
, pp. 603-624
-
-
Offner, H.1
-
29
-
-
0026689421
-
The role of pregnancy in the course and etiology of rheumatoid arthritis
-
Da Silva J, Spector T: The role of pregnancy in the course and etiology of rheumatoid arthritis. Clin Rheumatol 1992;11:189-194.
-
(1992)
Clin Rheumatol
, vol.11
, pp. 189-194
-
-
Da Silva, J.1
Spector, T.2
-
30
-
-
0030904682
-
Suppressive cellular and molecular activities in maternofetal immune interactions; suppressor cell activity, prostaglandins, and α-fetoproteins
-
Olding LB, Papadogiannakis N, Barbieri B, Murgita RA: Suppressive cellular and molecular activities in maternofetal immune interactions; suppressor cell activity, prostaglandins, and α-fetoproteins. Curr Top Microbiol Immunol 1997;222:159-187.
-
(1997)
Curr Top Microbiol Immunol
, vol.222
, pp. 159-187
-
-
Olding, L.B.1
Papadogiannakis, N.2
Barbieri, B.3
Murgita, R.A.4
-
31
-
-
0032581445
-
Rate of pregnancy-related relapse in multiple sclerosis. Pregnancy in Multiple Sclerosis Group
-
Confavreux C, Hutchinson M, Hours MM, Cortinovis-Tourniaire P, Moreau T: Rate of pregnancy-related relapse in multiple sclerosis. Pregnancy in Multiple Sclerosis Group. N Engl J Med 1998;339:285-291.
-
(1998)
N Engl J Med
, vol.339
, pp. 285-291
-
-
Confavreux, C.1
Hutchinson, M.2
Hours, M.M.3
Cortinovis-Tourniaire, P.4
Moreau, T.5
-
32
-
-
4944260683
-
Myasthenia gravis and pregnancy
-
Ciafaloni E, Massey JM: Myasthenia gravis and pregnancy. Neurol Clin 2004;22:771-782.
-
(2004)
Neurol Clin
, vol.22
, pp. 771-782
-
-
Ciafaloni, E.1
Massey, J.M.2
-
33
-
-
0019732405
-
Influence of α-fetoprotein on the in vitro and in vivo immune response to acetylcholine receptor
-
Brenner T, Abramsky O, Lisak RP: Influence of α-fetoprotein on the in vitro and in vivo immune response to acetylcholine receptor. Ann NY Acad Sci 1981;377:208-221.
-
(1981)
Ann NY Acad Sci
, vol.377
, pp. 208-221
-
-
Brenner, T.1
Abramsky, O.2
Lisak, R.P.3
-
34
-
-
0021591654
-
Prevention of experimental autoimmune myasthenia gravis in rats by fetal α-fetoprotein-rich fractions
-
Brenner T, Zielinski A, Argov Z, Abramsky O: Prevention of experimental autoimmune myasthenia gravis in rats by fetal α-fetoprotein-rich fractions. Tumour Biol 1984;5:263-274.
-
(1984)
Tumour Biol
, vol.5
, pp. 263-274
-
-
Brenner, T.1
Zielinski, A.2
Argov, Z.3
Abramsky, O.4
-
35
-
-
73649177302
-
Experimental study of the behavior of adult human skin homografts during pregnancy. A preliminary report
-
Andresen RH, Monroe CW: Experimental study of the behavior of adult human skin homografts during pregnancy. A preliminary report. Am J Obstet Gynecol 1962;84:1096-1103.
-
(1962)
Am J Obstet Gynecol
, vol.84
, pp. 1096-1103
-
-
Andresen, R.H.1
Monroe, C.W.2
-
36
-
-
0018414280
-
Familial malignant melanoma of the female genitalia: A case report and review
-
Gleicher N, Cohen CJ, Deppe G, Gusberg SB: Familial malignant melanoma of the female genitalia: a case report and review. Obstet Gynecol Surv 1979;34:1-15.
-
(1979)
Obstet Gynecol Surv
, vol.34
, pp. 1-15
-
-
Gleicher, N.1
Cohen, C.J.2
Deppe, G.3
Gusberg, S.B.4
-
37
-
-
0021247968
-
Suppressive effect of pregnancy on the development of experimental allergic encephalomyelitis in rabbits
-
Evron S, Brenner T, Abramsky O: Suppressive effect of pregnancy on the development of experimental allergic encephalomyelitis in rabbits. Am J Reprod Immunol 1984;5:109-113.
-
(1984)
Am J Reprod Immunol
, vol.5
, pp. 109-113
-
-
Evron, S.1
Brenner, T.2
Abramsky, O.3
-
38
-
-
0029129436
-
Zeroing in on how hormones affect the immune system
-
Morell V: Zeroing in on how hormones affect the immune system. Science 1995;269:773-775.
-
(1995)
Science
, vol.269
, pp. 773-775
-
-
Morell, V.1
-
39
-
-
21044452340
-
Evidence that pregnancy specific glycoproteins regulate T-cell function and inflammatory autoimmune disease during pregnancy
-
Bebo BF Jr, Dveksler GS: Evidence that pregnancy specific glycoproteins regulate T-cell function and inflammatory autoimmune disease during pregnancy. Curr Drug Targets Inflamm Allergy 2005;4:231-237.
-
(2005)
Curr Drug Targets Inflamm Allergy
, vol.4
, pp. 231-237
-
-
Bebo Jr, B.F.1
Dveksler, G.S.2
-
40
-
-
0242523158
-
A protective effect of early pregnancy factor on experimental autoimmune encephalomyelitis induced in Lewis rats by inoculation with myelin basic protein
-
Harness J, Cavanagh A, Morton H, Mc-Combe P: A protective effect of early pregnancy factor on experimental autoimmune encephalomyelitis induced in Lewis rats by inoculation with myelin basic protein. J Neurol Sci 2003;216:33-41.
-
(2003)
J Neurol Sci
, vol.216
, pp. 33-41
-
-
Harness, J.1
Cavanagh, A.2
Morton, H.3
Mc-Combe, P.4
-
41
-
-
0037100274
-
Late pregnancy suppresses relapses in experimental autoimmune encephalomyelitis: Evidence for a suppressive pregnancy-related serum factor
-
Langer-Gould A, Garren H, Slansky A, Ruiz PJ, Steinman L: Late pregnancy suppresses relapses in experimental autoimmune encephalomyelitis: evidence for a suppressive pregnancy-related serum factor. J Immunol 2002;169:1084-1091.
-
(2002)
J Immunol
, vol.169
, pp. 1084-1091
-
-
Langer-Gould, A.1
Garren, H.2
Slansky, A.3
Ruiz, P.J.4
Steinman, L.5
-
42
-
-
6344274984
-
Differential regulation of Th1/Th2 cytokine responses by placental protein 14
-
Mishan-Eisenberg G, Borovsky Z, Weber MC, Gazit R, Tykocinski ML, Rachmilewitz J: Differential regulation of Th1/Th2 cytokine responses by placental protein 14. J Immunol 2004;173:5524-5530.
-
(2004)
J Immunol
, vol.173
, pp. 5524-5530
-
-
Mishan-Eisenberg, G.1
Borovsky, Z.2
Weber, M.C.3
Gazit, R.4
Tykocinski, M.L.5
Rachmilewitz, J.6
-
44
-
-
32644433044
-
Amelioration of autoimmune neuroinflammation by recombinant human α-fetoprotein
-
Irony-Tur-Sinai M, Grigoriadis N, Lourbopoulos A, Pinto-Maaravi F, Abramsky O, Brenner T: Amelioration of autoimmune neuroinflammation by recombinant human α-fetoprotein. Exp Neurol 2006;198:136-144.
-
(2006)
Exp Neurol
, vol.198
, pp. 136-144
-
-
Irony-Tur-Sinai, M.1
Grigoriadis, N.2
Lourbopoulos, A.3
Pinto-Maaravi, F.4
Abramsky, O.5
Brenner, T.6
-
45
-
-
0026440453
-
Isolation and partial characterization of a specific α-fetoprotein receptor on human monocytes
-
Suzuki Y, Zeng CQ, Alpert E: Isolation and partial characterization of a specific α-fetoprotein receptor on human monocytes. J Clin Invest 1992;90:1530-1536.
-
(1992)
J Clin Invest
, vol.90
, pp. 1530-1536
-
-
Suzuki, Y.1
Zeng, C.Q.2
Alpert, E.3
-
46
-
-
0024448716
-
Expression of α-fetoprotein receptors by human T lymphocytes during blastic transformation
-
Torres JM, Laborda J, Naval J, Darracq N, Calvo M, Mishal Z, Uriel J: Expression of α-fetoprotein receptors by human T lymphocytes during blastic transformation. Mol Immunol 1989;26:851-857.
-
(1989)
Mol Immunol
, vol.26
, pp. 851-857
-
-
Torres, J.M.1
Laborda, J.2
Naval, J.3
Darracq, N.4
Calvo, M.5
Mishal, Z.6
Uriel, J.7
|