Understanding and exploiting hepcidin as an indicator of anemia due to chronic kidney disease

Kidney Research and Clinical Practice

Volumn 32, Issue 1, 2013, Pages 11-15

  Larson, Derek S ^a   Coyne, Daniel W ^a  

^a WASHINGTON UNIVERSITY   (United States)

Author keywords

Anemia; Chronic kidney disease; Hepcidin; Iron

Indexed keywords

ANTIANEMIC AGENT; C REACTIVE PROTEIN; FERROPORTIN; HEPCIDIN; IRON; NATURAL RESISTANCE ASSOCIATED MACROPHAGE PROTEIN 2; RECOMBINANT ERYTHROPOIETIN; TRANSFERRIN;

ANEMIA; CHRONIC KIDNEY DISEASE; GLOMERULUS FILTRATION RATE; HEMATOLOGICAL PARAMETERS; HEMODIALYSIS; HEMODIALYSIS PATIENT; HUMAN; INFLAMMATION; IRON ABSORPTION; IRON BALANCE; IRON BLOOD LEVEL; IRON DEFICIENCY ANEMIA; IRON INTAKE; IRON OVERLOAD; IRON STORAGE; IRON THERAPY; IRON TRANSPORT; NONHUMAN; PRIORITY JOURNAL; REVIEW; TRANSFERRIN SATURATION;

EID: 84879192972     PISSN: 22119132     EISSN: 22119140     Source Type: Journal    
DOI: 10.1016/j.krcp.2013.01.001     Document Type: Article

References (51)

1. A. Krause, S. Neitz, H.J. Magert, A. Schulz, W.G. Forssmann, P. Schulz-Knappe, and K. Adermann LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity FEBS Lett 480 2000 147 150
2. C.H. Park, E.V. Valore, A.J. Waring, and T. Ganz Hepcidin, a urinary antimicrobial peptide synthesized in the liver J Biol Chem 276 2001 7806 7810
3. C. Pigeon, G. Ilyin, B. Courselaud, P. Leroyer, B. Turlin, P. Brissot, and O. Loreal A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload J Biol Chem 276 2001 7811 7819
4. M.W. Hentze, M.U. Muckenthaler, and N.C. Andrews Balancing acts: molecular control of mammalian iron metabolism Cell 117 2004 285 297
5. W.H. Horl New insights into intestinal iron absorption Nephrol Dial Transplant 23 2008 3063 3064
6. J.R. Hunt, C.A. Zito, and L.K. Johnson Body iron excretion by healthy men and women Am J Clin Nutr 89 2009 1792 1798
7. D.W. Coyne Hepcidin: clinical utility as a diagnostic tool and therapeutic target Kidney Int 80 2011 240 244
8. W.I. Leong, and B. Lonnerdal Hepcidin, the recently identified peptide that appears to regulate iron absorption J Nutr 134 2004 1 4
9. R.E. Fleming Advances in understanding the molecular basis for the regulation of dietary iron absorption Curr Opin Gastroenterol 21 2005 201 206
10. A. Uc, J.B. Stokes, and B.E. Britigan Heme transport exhibits polarity in Caco-2 cells: evidence for an active and membrane protein-mediated process Am J Physiol Gastrointest Liver Physiol 287 2004 G1150 G1157
11. A.T. McKie, D. Barrow, G.O. Latunde-Dada, A. Rolfs, G. Sager, E. Mudaly, M. Mudaly, C. Richardson, D. Barlow, A. Bomford, T.J. Peters, K.B. Raja, S. Shirali, M.A. Hediger, F. Farzaneh, and R.J. Simpson An iron-regulated ferric reductase associated with the absorption of dietary iron Science 291 2001 1755 1759
12. J. Petrak, and D. Vyoral Hephaestin - a ferroxidase of cellular iron export Int J Biochem Cell Biol 37 2005 1173 1178
13. S. Miret, R.J. Simpson, and A.T. McKie Physiology and molecular biology of dietary iron absorption Annu Rev Nutr 23 2003 283 301
14. T. Ganz Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation Blood 102 2003 783 788
15. T. Ganz Hepcidin and iron regulation, 10 years later Blood 117 2011 4425 4433
16. J.L. Babitt, and H.Y. Lin Molecular mechanisms of hepcidin regulation: implications for the anemia of CKD Am J Kidney Dis 55 2010 726 741
17. E. Nemeth, E.V. Valore, M. Territo, G. Schiller, A. Lichtenstein, and T. Ganz Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein Blood 101 2003 2461 2463
18. H. Kawabata, R.E. Fleming, D. Gui, S.Y. Moon, T. Saitoh, J. O'Kelly, Y. Umehara, Y. Wano, J.W. Said, and H.P. Koeffler Expression of hepcidin is down-regulated in TfR2 mutant mice manifesting a phenotype of hereditary hemochromatosis Blood 105 2005 376 381
19. G. Papanikolaou, M.E. Samuels, E.H. Ludwig, M.L. MacDonald, P.L. Franchini, M.P. Dube, L. Andres, J. MacFarlane, N. Sakellaropoulos, M. Politou, E. Nemeth, J. Thompson, J.K. Risler, C. Zaborowska, R. Babakaiff, C.C. Radomski, T.D. Pape, O. Davidas, J. Christakis, P. Brissot, G. Lockitch, T. Ganz, M.R. Hayden, and Y.P. Goldberg Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosis Nat Genet 36 2004 77 82
20. R.H. Wang, C. Li, X. Xu, Y. Zheng, C. Xiao, P. Zerfas, S. Cooperman, M. Eckhaus, T. Rouault, L. Mishra, and C.X. Deng A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression Cell Metab 2 2005 399 409
21. K.A. Ahmad, J.R. Ahmann, M.C. Migas, A. Waheed, R.S. Britton, B.R. Bacon, W.S. Sly, and R.E. Fleming Decreased liver hepcidin expression in the Hfe knockout mouse Blood cells Mol Dis 29 2002 361 366
22. J. Truksa, H. Peng, P. Lee, and E. Beutler Bone morphogenetic proteins 2, 4, and 9 stimulate murine hepcidin 1 expression independently of Hfe, transferrin receptor 2 (Tfr2), and IL-6 Proc Natl AcadV Sci USA 103 2006 10289 10293
23. E. Nemeth, M.S. Tuttle, J. Powelson, M.B. Vaughn, A. Donovan, D.M. Ward, T. Ganz, and J. Kaplan Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization Science 306 2004 2090 2093
24. E. Nemeth, and T. Ganz The role of hepcidin in iron metabolism Acta haematol 122 2009 78 86
25. J.F. Collins, M. Wessling-Resnick, and M.D. Knutson Hepcidin regulation of iron transport J Nutr 138 2008 2284 2288
26. G. Nicolas, M. Bennoun, A. Porteu, S. Mativet, C. Beaumont, B. Grandchamp, M. Sirito, M. Sawadogo, A. Kahn, and S. Vaulont Severe iron deficiency anemia in transgenic mice expressing liver hepcidin Proc Natl Acad Sci USA 99 2002 4596 4601
27. X. Du, E. She, T. Gelbart, J. Truksa, P. Lee, Y. Xia, K. Khovananth, S. Mudd, N. Mann, E.M. Moresco, E. Beutler, and B. Beutler The serine protease TMPRSS6 is required to sense iron deficiency Science 320 2008 1088 1092
28. D. Coyne Iron indices: what do they really mean? Kidney Int Suppl 101 2006 S4 S8
29. G. Nicolas, C. Chauvet, L. Viatte, J.L. Danan, X. Bigard, I. Devaux, C. Beaumont, A. Kahn, and S. Vaulont The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation J Clin Invest 110 2002 1037 1044
30. B. Young, and J. Zaritsky Hepcidin for clinicians Clin J Am Soc Nephrol 4 2009 1384 1387
31. B.A. Ford, C.S. Eby, M.G. Scott, and D.W. Coyne Intra-individual variability in serum hepcidin precludes its use as a marker of iron status in hemodialysis patients Kidney Int 78 2010 769 773
32. N. Tomosugi, H. Kawabata, R. Wakatabe, M. Higuchi, H. Yamaya, H. Umehara, and I. Ishikawa Detection of serum hepcidin in renal failure and inflammation by using ProteinChip System Blood 108 2006 1381 1387
33. B.A. Ford, D.W. Coyne, C.S. Eby, and M.G. Scott Variability of ferritin measurements in chronic kidney disease; implications for iron management Kidney Int 75 2009 104 110
34. H.P. Peters, C.M. Laarakkers, D.W. Swinkels, and J.F. Wetzels Serum hepcidin-25 levels in patients with chronic kidney disease are independent of glomerular filtration rate Nephrol Dial Transplant 25 2010 848 853
35. J. Zaritsky, B. Young, H.J. Wang, M. Westerman, G. Olbina, E. Nemeth, T. Ganz, S. Rivera, A.R. Nissenson, and I.B. Salusky Hepcidin - a potential novel biomarker for iron status in chronic kidney disease Clin J Am Soc Nephrol 4 2009 1051 1056
36. A. Kato, T. Tsuji, J. Luo, Y. Sakao, H. Yasuda, and A. Hishida Association of prohepcidin and hepcidin-25 with erythropoietin response and ferritin in hemodialysis patients Am J Nephrol 28 2008 115 121
37. D.R. Ashby, D.P. Gale, M. Busbridge, K.G. Murphy, N.D. Duncan, T.D. Cairns, D.H. Taube, S.R. Bloom, F.W. Tam, R.S. Chapman, P.H. Maxwell, and P. Choi Plasma hepcidin levels are elevated but responsive to erythropoietin therapy in renal disease Kidney Int 75 2009 976 981
38. G. Weiss, I. Theurl, S. Eder, C. Koppelstaetter, K. Kurz, T. Sonnweber, U. Kobold, and G. Mayer Serum hepcidin concentration in chronic haemodialysis patients: associations and effects of dialysis, iron and erythropoietin therapy Eur J Clin Invest 39 2009 883 890
39. B.J. Sasu, K.S. Cooke, T.L. Arvedson, C. Plewa, A.R. Ellison, J. Sheng, A. Winters, T. Juan, H. Li, C.G. Begley, and G. Molineux Antihepcidin antibody treatment modulates iron metabolism and is effective in a mouse model of inflammation-induced anemia Blood 115 2010 3616 3624
40. C. Brugnara, L.A. Chambers, E. Malynn, M.A. Goldberg, and M.S. Kruskall Red blood cell regeneration induced by subcutaneous recombinant erythropoietin: iron-deficient erythropoiesis in iron-replete subjects Blood 81 1993 956 964
41. N. Tessitore, D. Girelli, N. Campostrini, V. Bedogna, G. Pietro Solero, A. Castagna, E. Melilli, W. Mantovani, G. De Matteis, O. Olivieri, A. Poli, and A. Lupo Hepcidin is not useful as a biomarker for iron needs in haemodialysis patients on maintenance erythropoiesis-stimulating agents Nephrol Dial Transplant 25 2010 3996 4002
42. D.W. Coyne, T. Kapoian, W. Suki, A.K. Singh, J.E. Moran, N.V. Dahl, and A.R. Rizkala Ferric gluconate is highly efficacious in anemic hemodialysis patients with high serum ferritin and low transferrin saturation: results of the Dialysis Patients' Response to IV Iron with Elevated Ferritin (DRIVE) Study J Am Soc Nephrol 18 2007 975 984
43. M. Aapro, A. Osterborg, P. Gascon, H. Ludwig, and Y. Beguin Prevalence and management of cancer-related anaemia, iron deficiency and the specific role of i.v. iron Ann Oncol 23 2012 1954 1962
44. J.L. Babitt, F.W. Huang, Y. Xia, Y. Sidis, N.C. Andrews, and H.Y. Lin Modulation of bone morphogenetic protein signaling in vivo regulates systemic iron balance J Clin Invest 117 2007 1933 1939
45. N. Fatih, E. Camberlein, M.L. Island, A. Corlu, E. Abgueguen, L. Detivaud, P. Leroyer, P. Brissot, and O. Loreal Natural and synthetic STAT3 inhibitors reduce hepcidin expression in differentiated mouse hepatocytes expressing the active phosphorylated STAT3 form J Mol Med (Berlin, Germany) 88 2010 477 486
46. C. Peyssonnaux, A.S. Zinkernagel, R.A. Schuepbach, E. Rankin, S. Vaulont, V.H. Haase, V. Nizet, and R.S. Johnson Regulation of iron homeostasis by the hypoxia-inducible transcription factors (HIFs) J Clin Invest 117 2007 1926 1932
47. G. Rostoker, M. Griuncelli, C. Loridon, R. Couprie, A. Benmaadi, C. Bounhiol, M. Roy, G. Machado, P. Janklewicz, G. Drahi, H. Dahan, and Y. Cohen Hemodialysis-associated hemosiderosis in the era of erythropoiesis-stimulating agents: A MRI study Am J Med 125 2012 991 999 e991
48. Y.E. Taes, B. Wuyts, J.R. Boelaert, A.S. De Vriese, and J.R. Delanghe Prohepcidin accumulates in renal insufficiency Clin Chem Lab Med 42 2004 387 389
49. J. Malyszko, J.S. Malyszko, K. Pawlak, and M. Mysliwiec Hepcidin, iron status, and renal function in chronic renal failure, kidney transplantation, and hemodialysis Am J Hematol 81 2006 832 837
50. J.J. Kroot, E.H. Kemna, S.S. Bansal, M. Busbridge, N. Campostrini, D. Girelli, R.C. Hider, V. Koliaraki, A. Mamalaki, G. Olbina, N. Tomosugi, C. Tselepis, D.G. Ward, T. Ganz, J.C. Hendriks, and D.W. Swinkels Results of the first international round robin for the quantification of urinary and plasma hepcidin assays: need for standardization Haematologica 94 2009 1748 1752
51. G. Dallalio, T. Fleury, and R.T. Means Serum hepcidin in clinical specimens Br J Haematol 122 2003 996 1000