Variability of ferritin measurements in chronic kidney disease; implications for iron management

Kidney International

Volumn 75, Issue 1, 2009, Pages 104-110

  Ford, Bradley A ^a   Coyne, Daniel W ^a   Eby, Charles S ^a   Scott, Mitchell G ^a,b  

^a WASHINGTON UNIVERSITY   (United States)

^b Campus Box 8118 ^*  (United States)

Author keywords

Anemia; Ferritin; Hemodialysis; Iron

Indexed keywords

FERRITIN; IRON;

ADULT; AGED; ANEMIA; ARTICLE; CHRONIC KIDNEY DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HEMODIALYSIS; HUMAN; IMMUNOASSAY; INTERMETHOD COMPARISON; IRON STORAGE; MALE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL;

CHRONIC DISEASE; DECISION MAKING; FERRITINS; IRON; KIDNEY DISEASES; OBSERVER VARIATION; RENAL DIALYSIS; REPRODUCIBILITY OF RESULTS;

EID: 58049211920     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/ki.2008.526     Document Type: Article

References (33)

1. Sunder-Plassmann G, Horl WH. Laboratory diagnosis of anaemia in dialysis patients: use of common laboratory tests. Curr Opin Nephrol Hypertens 1997; 6: 566-569.
2. Fernandez-Rodriguez AM, Guindeo-Casasus MC, Molero-Labarta T et al. Diagnosis of iron deficiency in chronic renal failure. Am J Kidney Dis 1999; 34: 508-513.
3. Fishbane S, Shapiro W, Dutka P et al. A randomized trial of iron deficiency testing strategies in hemodialysis patients. Kidney Int 2001; 60: 2406-2411.
4. KDOQI. Clinical practice guidelines and clinical practice recommendations for anemia in chronic kidney disease. Am J Kidney Dis 2006; 47: S11-145.
5. Coyne D. Iron indices: what do they really mean? Kidney Int Suppl 2006; 69: S4-S8.
6. Fishbane S, Kalantar-Zadeh K, Nissenson AR. Serum ferritin in chronic kidney disease: reconsidering the upper limit for iron treatment. Semin Dial 2004; 17: 336-341.
7. Besarab A, Amin N, Ahsan M et al. Optimization of epoetin therapy with intravenous iron therapy in hemodialysis patients. J Am Soc Nephrol 2000; 11: 530-538.
8. Chang CH, Chang CC, Chiang SS. Reduction in erythropoietin doses by the use of chronic intravenous iron supplementation in iron-replete hemodialysis patients. Clin Nephrol 2002; 57: 136-141.
9. Singh AK, Coyne DW, Shapiro W et al. Predictors of the response to treatment in anemic hemodialysis patients with high serum ferritin and low transferrin saturation. Kidney Int 2007; 71: 1163-1171.
10. Coyne DW, Kapoian T, Suki W et al. Ferric gluconate is highly efficacious in anemichemodialysis patients with high serum ferritin and low transferrin saturation: results of the dialysis patients' response to IV iron with elevated ferritin (DRIVE) Study. J Am Soc Nephrol 2007; 18: 975-984.
11. Fishbane S, Frei GL, Maesaka J. Reduction in recombinant human erythropoietin doses by the use of chronic intravenous iron supplementation. Am J Kidney Dis 1995; 26: 41-46.
12. Lin JL, Chang MY, Tan DT et al. Short-term small-dose intravenous iron trial to detect functional iron deficiency in dialysis patients. Am J Nephrol 2001; 21: 91-97.
13. Cook JD, Skikne BS, Baynes RD. Serum transferrin receptor. Annu Rev Med 1993; 44: 63-74.
14. Kalantar-Zadeh K, Kalantar-Zadeh K, Lee GH. The fascinating but deceptive ferritin: to measure it or not to measure it in chronic kidney disease? Clin J Am Soc Nephrol 2006; 1(Suppl 1): S9-18.
15. Borel MJ, Smith SM, Derr J et al. Day-to-day variation in iron-status indices in healthy men and women. Am J Clin Nutr 1991; 54: 729-735.
16. College of American Pathologists##2007 k-A Survey, Ferritin, 2007.
17. Bock JL, Endres DB, Elin RJ et al. Comparison of fresh frozen serum to traditional proficiency testing material in a College of American Pathologists survey for ferritin, folate, and vitamin B12. Arch Pathol Lab Med 2005; 129: 323-327.
18. Kalantar-Zadeh K, Rodriguez RA, Humphreys MH. Association between serum ferritin and measures of inflammation, nutrition and iron in haemodialysis patients. Nephrol Dial Transplant 2004; 19: 141-149.
19. Bell H, Skinningsrud A, Raknerud N et al. Serum ferritin and transferrin saturation in patients with chronic alcoholic and non-alcoholic liver diseases. J Intern Med 1994; 236: 315-322.
20. Spinowitz BS, Schwenk MH, Jacobs PM et al. The safety and efficacy of ferumoxytol therapy in anemic chronic kidney disease patients. Kidney Int 2005; 68: 1801-1807.
21. Nissenson AR, Lindsay RM, Swan S et al. Sodium ferric gluconate complex in sucrose is safe and effective in hemodialysis patients: North American Clinical Trial. Am J Kidney Dis 1999; 33: 471-482.
22. Harris EK, Yaka T. On the calculation of a 'reference change' for comparing two consecutive measurements. Clin Chem 1983; 29: 25-30.
23. Souberbielle JC, Boutten A, Carlier MC et al. Inter-method variability in PTH measurement: implication for the care of CKD patients. Kidney Int 2006; 70: 345-350.
24. KDOQI guidelines for the management of renal osteodystrophy. Am J Kidney Dis 2003; 42(Suppl 3): S1-S201.
25. Canavese C, Bergamo D, Ciccone G et al. Validation of serum ferritin values by magnetic susceptometry in predicting iron overload in dialysis patients. Kidney Int 2004; 65: 1091-1098.
26. Fishbane S. Upper limit of serum ferritin: misinterpretation of the 2006 KDOQI anemia guidelines. Semin Dial. Published online: 1 February 2008. Doi:10.1111/j.1525-139X.2007.00420.X.
27. Kapoian T, O'Mara NB, Singh AK et al. Ferric gluconate reduces epoetin requirements in hemodialysis patients with elevated ferritin. J Am Soc Nephrol 2008; 19: 372-379.
28. Van Wyck DB, Roppolo M, Martinez CO et al. A randomized, controlled trial comparing IV iron sucrose to oral iron in anemic patients with nondialysis-dependent CKD. Kidney Int 2005; 68: 2846-2856.
29. Tessitore N, Solero GP, Lippi G et al. The role of iron status markers in predicting response to intravenous iron in haemodialysis patients on maintenance erythropoietin. Nephrol Dial Transplant 2001; 16(7): 1416-1423.
30. Fishbane S, Shapiro W, Dutka P et al. A randomized trial of iron deficiency testing strategies in hemodialysis patients (see comment). Kidney Int 2001; 60: 2406-2411.
31. Locatelli F, Aljama P, Barany P et al. Revised European best practice guidelines for the management of anaemia in patients with chronic renal failure. Nephrol Dial Transplant 2004; 19(Suppl 2): ii1-ii47.
32. Bland JM, Altman DG. Statistical methods for assessing agreement between two methods of clinical measurement. Lancet 1986; i: 307-310.
33. Linnet K. Performance of Deming regression analysis in case of misspecified analytical error ratio in method comparison studies. Clin Chem 1998; 44: 1024-1031.