Prohepcidin accumulates in renal insufficiency

Clinical Chemistry and Laboratory Medicine

Volumn 42, Issue 4, 2004, Pages 387-389

  Taes, Youri E C ^a   Wuyts, Birgitte ^a   Boelaert, Johan R ^b   De Vriese, An S ^b   Delanghe, Joris R ^a  

^a GHENT UNIVERSITY HOSPITAL   (Belgium)

^b General Hospital St Jan   (Belgium)

Author keywords

Hepcidin; Iron metabolism; Renal function

Indexed keywords

CHROMIUM 51; CREATININE; CYSTATIN C; EDETIC ACID; FERRITIN; HEMOGLOBIN; HEPCIDIN; HORMONE PRECURSOR; IRON; PROTEIN DERIVATIVE; TRANSFERRIN;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CORRELATION ANALYSIS; CREATININE BLOOD LEVEL; CREATININE CLEARANCE; ENZYME LINKED IMMUNOSORBENT ASSAY; ERYTHROCYTE COUNT; FEMALE; FERRITIN BLOOD LEVEL; HEMATOCRIT; HEMOGLOBIN DETERMINATION; HORMONE BLOOD LEVEL; HUMAN; IRON ABSORPTION; IRON BLOOD LEVEL; IRON METABOLISM; KIDNEY CLEARANCE; KIDNEY FAILURE; KIDNEY FUNCTION; MALE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; TRANSFERRIN BLOOD LEVEL;

AGED; ANTIMICROBIAL CATIONIC PEPTIDES; CREATININE; CYSTATINS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FERRITINS; HUMANS; INTRAMOLECULAR OXIDOREDUCTASES; IRON; KIDNEY FAILURE; MALE; METABOLIC CLEARANCE RATE; PROTEIN PRECURSORS; TRANSFERRIN;

EID: 2342569721     PISSN: 14346621     EISSN: None     Source Type: Journal    
DOI: 10.1515/CCLM.2004.069     Document Type: Article

References (17)

1. Brugnara C. Iron deficiency and erythropoiesis: new diagnostic approaches. Clin Chem 2003;49:1573-8.
2. Ganz T. Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation. Blood 2003;102:783-8.
3. Fleming RE, Sly WS. Hepcidin: a putative iron-regulatory hormone relevant to hereditary hemochromatosis and the anemia of chronic disease. Proc Natl Acad Sci USA 2001;98:8160-2.
4. Nicolas G, Viatte L, Bennoun M, Beaumont C, Kahn A, Vaulont S. Hepcidin, a new iron regulatory peptide. Blood Cells Mol Dis 2002;29:327-35.
5. Frazer DM, Wilkins SJ, Becker EM, Vulpe CD, McKie AT, Trinder D, et al. Hepcidin expression inversely correlates with the expression of duodenal iron transporters and iron absorption in rats. Gastroenterology 2002;123:835-44.
6. Nicolas G, Bennoun M, Porteu A, Mativet S, Beaumont C, Grandchamp B, et al. Severe iron deficiency anemia in transgenic mice expressing liver hepcidin. Proc Natl Acad Sci USA 2002;99:4596-601.
7. Roetto A, Papanikolaou G, Politou M, Alberti F, Girelli D, Christakis J, et al. Mutant antimicrobial peptide hepcidin is associated with severe juvenile hemochromatosis. Nat Genet 2003;33:21-2.
8. Weinstein DA, Roy CN, Fleming MD, Loda MF, Wolfsdorf JI, Andrews NC. Inappropriate expression of hepcidin is associated with iron refractory anemia: implications for the anemia of chronic disease. Blood 2002;100:3776-81.
9. Kulaksiz H, Gehrke S, Janetzko A, Rost D, Bruckner T, Kallinowski B, et al. Prohepcidin: expression and cell specific localisation in the liver and its regulation in hereditary haemochromatosis, chronic renal insufficiency, and renal anaemia. Gut 2003. In press.
10. Dallalio G, Fleury T, Means RT. Serum hepcidin in clinical specimens. Br J Haematol 2003;122:996-1000.
11. Park CH, Valore EV, Waring AJ, Ganz T. Hepcidin, a urinary antimicrobial peptide synthesized in the liver. J Biol Chem 2001;276:7806-10.
12. Chantler C, Garnett ES, Parsons V, Veall N. Glomerular filtration rate measurement in man by the single injection method using 51Cr-EDTA. Clin Sci 1969;37:169-80.
13. Chantler C, Barratt TM. Estimation of glomerular rate from plasma clearance of 51-chromium edetic acid. Arch Dis Child 1972;47:613-7.
14. Van de Wiele C, Van Den Eeckhaut A, Verweire W, Van Haelst JP, Versijpt J, Dierickx RA. Absolute 24 h quantification of 99mTc-DMSA uptake in patients with severely reduced kidney function: a comparison with 51Cr-EDTA clearance. Nucl Med Commun 1999;20:829-32.
15. Bartels H, Bohmer M, Heierli C. Serum creatinine determination without protein precipitation. Clin Chim Acta 1972;37:193-7.
16. Wuyts B, Bernard D, Van den Noortgate N, Van de Walle J, Van Vlem B, De Smet R, et al. Reevaluation of formulas for predicting creatinine clearance in adults and children, using compensated creatinine methods. Clin Chem 2003;49:1011-4.
17. Thomas L. Transferrin saturation. In: Thomas L, editor. Clinical laboratory diagnostics. Frankfurt/Main: TH-Books, 1998:275-7.