New insights into intestinal iron absorption

Nephrology Dialysis Transplantation

Volumn 23, Issue 10, 2008, Pages 3063-3064

  Hörl, Walter H ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

Intestinal iron absorption

Indexed keywords

BONE MORPHOGENETIC PROTEIN 2; BONE MORPHOGENETIC PROTEIN 4; BONE MORPHOGENETIC PROTEIN 9; FERRITIN; HEPCIDIN; HFE PROTEIN; IRON; SMAD4 PROTEIN;

ANEMIA; CATALYSIS; DIETARY INTAKE; GENE MUTATION; HEMOCHROMATOSIS; HUMAN; INTESTINE ABSORPTION; IRON ABSORPTION; IRON DEFICIENCY; NOTE; PRIORITY JOURNAL;

ANIMALS; ANTIMICROBIAL CATIONIC PEPTIDES; HUMANS; INTESTINAL ABSORPTION; IRON; IRON, DIETARY; MEMBRANE PROTEINS; MICE; MODELS, BIOLOGICAL; MUTATION; SERINE ENDOPEPTIDASES;

EID: 52449117961     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfn458     Document Type: Note

References (12)

1. Du X, She E, Gelbart T et al. The serine protease TMPRSS6 is required to sense iron deficiency. Science 2008; 320: 1088-1092
2. Crichton RR, Danielson BG, Geisser P. Iron Therapy with Special Emphasis on Intravenous Administration. Bremen: Uni-Med Science, 2006
3. Deicher R, Hörl WH. New insights into the regulation of iron homeostasis. Eur J Clin Invest 2006; 36: 301-309
4. Nemeth E, Valore EV, Territo M et al. Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein. Blood 2003; 101: 2461-2463
5. Lee P, Peng H, Gelbart T et al. Regulation of hepcidin transcription by interleukin-1 and interleukin-6. Proc Natl Acad Sci USA 2005; 102: 1906-1910
6. Ahmad KA, Ahmann JR, Migas MC et al. Decreased liver hepcidin expression in the Hfe knockout mouse. Blood Cells Mol Dis 2002; 29: 361-366
7. Kawabata H, Fleming RE, Gui D et al. Expression of hepcidin is downregulated in TfR2 mutant mice manifesting a phenotype of hereditary hemochromatosis. Blood 2005; 105: 376-381
8. Papanikolaou G, Samuels ME, Ludwig EH et al. Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosis. Nat Genet 2004; 36: 77-82
9. Wang RH, Li C, Xu X et al. A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression. Cell Metab 2005; 2: 399-409
10. Truksa J, Peng H, Lee P et al. Bone morphogenetic proteins 2, 4, and 9 stimulate murine hepcidin 1 expression independently of Hfe, transferrin receptor 2 (Tfr2), and IL-6. Proc Natl Acad Sci USA 2006; 103: 10289-10293
11. Nicolas G, Chauvet C, Viatte L et al. The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation. J Clin Invest 2002; 110: 1037-1044
12. Roetto A, Papanikolaou G, Politou M et al. Mutant antimicrobial peptide hepcidin is associated with severe juvenile hemochromatosis. Nat Genet 2003; 33: 21-22