Association of prohepcidin and hepcidin-25 with erythropoietin response and ferritin in hemodialysis patients

American Journal of Nephrology

Volumn 28, Issue 1, 2007, Pages 115-121

  Kato, Akihiko ^a   Tsuji, Takayuki ^a   Luo, Jinghui ^a   Sakao, Yukitoshi ^a   Yasuda, Hideo ^a   Hishida, Akira ^a  

^a HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Erythropoietin hyporesponsiveness; Hemodialysis, chronic; Hepcidin 25; Iron deficiency, functional; Prohepcidin

Indexed keywords

C REACTIVE PROTEIN; FERRITIN; HEMOGLOBIN; HEPCIDIN; HEPCIDIN 25; HORMONE PRECURSOR; PROHEPCIDIN; RECOMBINANT ERYTHROPOIETIN; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; FEMALE; HEMODIALYSIS PATIENT; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTIPLE REGRESSION; PRIORITY JOURNAL; SURFACE ENHANCED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY;

AGED; ANEMIA, IRON-DEFICIENCY; ANTIMICROBIAL CATIONIC PEPTIDES; BIOLOGICAL MARKERS; CROSS-SECTIONAL STUDIES; DRUG MONITORING; ERYTHROPOIETIN, RECOMBINANT; FEMALE; FERRITINS; HUMANS; KIDNEY FAILURE, CHRONIC; MALE; PROTEIN PRECURSORS; RENAL DIALYSIS; REPRODUCIBILITY OF RESULTS;

EID: 36249027662     PISSN: 02508095     EISSN: None     Source Type: Journal    
DOI: 10.1159/000109968     Document Type: Article

References (27)

1. Park CH, Valore EV, Waring AJ, Ganz T: Hepcidin, a urinary antimicrobial peptide synthesized in the liver. J Biol Chem 2001;276:7806-7810.
2. Nicolas G, Bennoun M, Devaux I, et al: Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice. Proc Natl Acad Sci USA 2001;98:8780-8785.
3. Nemeth E, Tuttle MS, Powelson J, et al: Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science 2004;306:2090-2093.
4. Knutson MD, Oukka M, Koss LM, et al: Iron release from macrophages after erythrophagocytosis is up-regulated by ferroportin 1 overexpression and down-regulated by hepcidin. Proc Natl Acad Sci USA 2005;102:1324-1328.
5. Nicolas G, Bennoun M, Porteu A, et al: Severe iron deficiency anemia in transgenic mice expressing liver hepcidin. Proc Natl Acad Sci USA 2002;99:4596-4601.
6. Roetto A, Papanikolaou G, Politou M, et al: Mutant antimicrobial peptide hepcidin is associated with severe juvenile hemochromatosis. Nat Genet 2003;33:21-22.
7. Weinstein DA, Roy NC, Fleming MD, et al: Inappropriate expression of hepcidin is associated with iron refractory anemia: implications for the anemia of chronic disease. Blood 2002;100:3776-3781.
8. Nemeth E, Valore EV, Territo M, et al: Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein. Blood 2003;101:2461-2463.
9. Kulalsiz H, Gehrke SG, Janetzko A, et al: Pro-hepcidin: expression and cell specific localization in the liver and its regulation in hereditary haemochromatosis, chronic renal insufficiency, and renal anemia. Gut 2004;53:735-743.
10. Tomosugi N, Kawabata H, Wakatabe R, et al: Detection of serum hepcidin in renal failure and inflammation by using ProteinChip system. Blood 2006;108:1381-1387.
11. Gunnell J, Yuen JY, Depner TA, Kaysen A: Acute-phase response predicts erythropoietin resistance in hemodialysis and peritoneal patients. Am J Kidney Dis 1999;33:63-72.
12. Kalantar-Zadeh K, McAllister C, Lehn S, et al: Effect of malnutrition-inflammation complex syndrome on EPO hyporesponsiveness in maintenance hemodialysis patients. Am J Kidney Dis 2003;42:761-773.
13. Kemna E, Tjalsma H, Laarakkers C, et al: Novel urine hepcidin assay by mass spectrometry. Blood 2005;106:3268-3270.
14. Dallalio G, Fleury T, Means RT: Serum hepcidin in clinical specimens. Br J Haematol 2003;122:996-1000.
15. Taes YEC, Wuyts B, Boelaert JR, et al: Prohepcidin accumulates in renal insufficiency. Clin Chem Lab Med 2004;42:387-389.
16. Malyszko J, Malyszko JS, Mysliwiec M: Hepcidin, an acute-phase protein and a marker of inflammation on kidney transplant recipients with and without coronary artery disease. Transplant Proc 2006;38:2895-2898.
17. Kulaksiz H, Theillig F, Bachmann S, et al: The iron-regulatory peptide hormone hepcidin: expression and cellular localization in the mammalian kidney. J Endocrinol 2005;184:361-370.
18. Hsu SP, Chiang CK, Chien CT, Hung KY: Plasma prohepcidin positively correlates with hematocrit in chronic hemodialysis patients. Blood Purif 2006;24:311-316.
19. Malyszko J, Malyszko JS, Hryszko T, et al: Is hepcidin a link between anemia, inflammation and liver function in hemodialyzed patients? Am J Nephrol 2005;25:586-590.
20. Eleftheriadis T, Kartsios C, Liakopoulos V, et al: Does hepcidin affect erythropoiesis in hemodialysis patients? Acta Haematol 2006;116:238-244.
21. Hadley KB, Johnson LK, Hunt J: Iron absorption by healthy women is not associated with either serum or urinary prohepcidin. Am J Clin Nutr 2006;84:150-155.
22. Roe MA, Spinks C, Heath AL, et al: Serum prohepcidin concentration: no association with iron absorption in healthy men; and no relationship with iron status in men carrying HFE mutations, hereditary haemochromatosis patients undergoing phlebotomy, or pregnant women. Br J Nutr 2007;97:544-549.
23. Lee P, Peng H, Gelbart T, et al: Regulation of hepcidin transcription by interleukin-1 and interleukin-6. Proc Natl Acad Sci USA 2005;102:1906-1920.
24. Kemna E, Pickkers P, Nemeth E, et al: Time-course analysis of hepcidin, serum iron, and plasma cytokine levels in humans injected with LPS. Blood 2005;106:1864-1866.
25. Kalantar-Zadeh K, Rodriguez A, Humphreys MH: Association between serum ferritin and measures of inflammation, nutrition and iron in haemodialysis patients. Nephrol Dial Transplant 2004;19:141-149.
26. Gejyo F, Saito A, Akizawa T, et al: 2004 Japanese Society for Dialysis Therapy guidelines for renal anemia in chronic hemodialysis patients. Ther Apher Dial 2004;8:443-459.
27. Murphy AT, Witcher DR, Luan P, Wroblewski VJ: Quantitation of hepcidin from human and mouse serum using liquid chromatography tandem mass spectrometry. Blood 2007;110:1048-1054.