In vitro effect of manganese chloride exposure on energy metabolism and oxidative damage of mitochondria isolated from rat brain

Environmental Toxicology and Pharmacology

Volumn 26, Issue 2, 2008, Pages 232-236

  Zhang, Fanglin ^a   Xu, Zhaofa ^a   Gao, Jian ^a   Xu, Bin ^a   Deng, Yu ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

Author keywords

Energy metabolism; Manganese; Mitochondria damage; N Acetyl cysteine; Oxidative damage

Indexed keywords

ACETYLCYSTEINE; ACONITATE HYDRATASE; GLUTATHIONE; MALONALDEHYDE; MANGANESE CHLORIDE; MITOCHONDRIAL ENZYME; REACTIVE OXYGEN METABOLITE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN MITOCHONDRION; CONTROLLED STUDY; ENERGY METABOLISM; ENVIRONMENTAL EXPOSURE; ENZYME ACTIVITY; ENZYME ASSAY; FEMALE; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; NONHUMAN; OCCUPATIONAL EXPOSURE; PRIORITY JOURNAL; RAT;

RATTUS;

EID: 47849111019     PISSN: 13826689     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.etap.2008.04.003     Document Type: Article

References (44)

1. Aschner M., Erikson K.M., and Dorman D.C. Manganese dosimetry: species differences and implications for neurotoxicity. J. Crit. Rev. Toxicol. 35 (2005) 1-32
2. Banaclocha M.M. Therapeutic potential of N-acetylcysteine in age-related mitochondrial neurodegenerative diseases. J. Med. Hypotheses 56 (2001) 472-477
3. Baracca A., Sgarbi G., Solaini G., et al. Rhodamine 123 as a probe of mitochondrial membrane potential: evaluation of proton flux through F0 during ATP synthesis. J. Biochim. Biophys. Acta 1606 (2003) 137-146
4. Beutler, E., Grune, Stratton, 1975. Glutathione in Red Blood Cell Metabolism, A Manual of Biochemical Methods, vol. 36, J. Blood. New York, pp. 112-114.
5. Buege J.A., and Aust S.D. Microsomal lipid peroxidation. J. Methods Enzym. 52 (1978) 302-311
6. Bulteau A.L., Ikeda-Saito M., and Szweda L.I. Redox-dependent modulation of aconitase activity in intact mitochondria. J. Biochem. 42 (2003) 14846-14855
7. Chen J.Y., George C., Zhao T.Q., et al. Differential cytotoxicity of Mn(II) and Mn(III): special reference to mitochondrial [Fe-S] containing enzymes. J. Toxicol. Appl. Pharmacol. 175 (2001) 160-168
8. Cocco T., Sgobbo P., Clemente M., et al. Tissue-specific changes of mitochondrial functions in aged rats: effect of a long-term dietary treatment with N-acetylcysteine. J. Free Radic. Biol. Med. 38 6 (2005) 796-805
9. Davey G.P., Peuchen S., and Clark J.B. Energy thresholds in brain mitochondria: potential involvement in neurodegeneration. J. Biol. Chem. 273 (1998) 12753-12757
10. Duchen M.R. Mitochondria in health and disease: perspectives on a new mitochondrial biology. J. Mol. Aspects Med. 25 (2004) 365-451
11. Erikson K.M., Dobson A.W., Dorman D.C., et al. Manganese exposure and induced oxidative stress in the rat brain. J. Sci. Total Environ. 334 (2004) 409-416
12. Esterbauer H., Schauer R.J., and Zollner H. Chemistry and biochemistry of 4-hydroxynonenal, malondialdehyde, and related aldehydes. J. Free Radic. Biol. Med. 11 (1991) 81-128
13. Foster K.A., Galeffi F., Gerich F.J., et al. Optical and pharmacological tools to investigate the role of mitochondria during oxidative stress and neurodegeneration. J. Prog. Neurobiol. 79 3 (2006) 136-171
14. Gardner P.R., Raineri I., Epstein L.B., et al. Superoxide radical and iron modulate aconitase activity in mammalian cells. J. Biol. Chem. 270 (1995) 13399-13405
15. Gegg M.E., Beltran B., Salas-Pino S., et al. Differential effect of nitric oxide on GSH metabolism and mitochondrial function in astrocytes and neurons: implications for neuroprotection/neurodegeneration. J. Neurochem. 86 (2003) 228-237
16. Genova M.L., Pich M.M., Bernacchia A., et al. The mitochondrial production of reactive oxygen species in relation to aging and pathology. J. Ann. NY Acad. Sci. 1011 (2004) 86-100
17. Grattagliano I., Portincasa P., Cocco T., et al. Effect of dietary restriction and N-acetylcysteine supplementation on intestinal mucosa and liver mitochondrial redox status and function in aged rats. J. Exp. Gerontol. 39 (2004) 1323-1332
18. Hatefi Y. Preparation and properties of NADH-ubiquinone oxidoreductase (complex I). J. Methods Enzymol. 53 (1978) 11-14
19. Heron P., Cousins K., Boyd C., et al. Paradoxical effects of copper and manganese on brain mitochondrial function. J. Life Sci. 68 (2001) 1575-1583
20. Honda K., Casadesus G., Petersen R.B., et al. Oxidative stress and redox-active iron in Alzheimer's disease. J. Ann. NY Acad. Sci. 1012 (2004) 179-182
21. Jayakumar A.R., Rama Rao K.V., Kalaiselvi P., et al. Combined effects of ammonia and manganese on astrocytes in culture. J. Neurochem. Res. 29 (2004) 2051-2056
22. Katalin S., Hermina R., József T., et al. Mitochondria, metabolic disturbances, oxidative stress and the kynurenine system, with focus on neurodegenerative disorders. J. Neurol. Sci. 257 (2007) 221-239
23. Lawrence H.L., and Dean P.J. Methods in Toxicology, vol. 2: Mitochondrial Dysfunction (1993), Academic Press
24. Lenaz G., Baracca A., Fato R., et al. New insights into structure and function of mitochondria and their role in ageing and disease. J. Antioxid. Redox. Signal. 8 (2006) 417-425
25. Li Q.Y., Pedersen C., Day B.J., et al. Dependence of excitotoxic neurodegeneration on mitocondrial aconitase inactivation. J. Neurochem. 78 (2001) 746-755
26. Lowry O.H., Rosebrough N.J., Farr A.L., et al. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193 (1951) 265-275
27. Mackensen G.B., Patel M., Sheng H., et al. Neuroprotection from delayed postischemic administration of a metalloporphyrin catalytic antioxidant. J. Neurosci. 21 (2001) 4582-4592
28. Malecki E.A. Manganese toxicity is associated with mitochondrial dysfunction and DNA fragmentation in rat primary striatal neurons. J. Brain. Res. Bull. 55 2 (2001) 225-228
29. Martinez B.M. N-Acetylcysteine elicited increase in complex I activity in synaptic mitochondria from aged mice: implications for treatment of Parkinson's disease. J. Brain. Res. 859 (2000) 173-175
30. Michael A., Tomas R., Guilarte J.S., et al. Manganese: recent advances in understanding its transport and neurotoxicity. J. Toxicol. Appl. Pharmacol. 221 (2007) 131-147
31. Muramatsu Y. Novel neuroprotective compound SCH-20148 rescues thymocytes and SH-SY5Y cells from thapsigargin-induced mitochondrial membrane potential reduction and cell death. J. Eur. J. Pharmacol. 1016 (2007) 167-173
32. Nicholls D.G., and Budd S.L. Mitochondrial and neuronal survival. J. Physiol. Rev. 80 (2000) 315-360
33. Nicholls D.G., and Ward M.W. Mitochondrial membrane potential and neuronal glutamate excitotoxicity: mortality and millivolts. J. Trends Neurosci. 23 (2000) 166-174
34. Niki E., Yoshida Y., Saito Y., et al. Lipid peroxidation: mechanism, inhibition, and biological effects. Biochem. Biophys. J. Res. Commun. 336 (2005) 1-9
35. Normandin L., and Hazell A.S. Manganese neurotoxicity: an update of mechanisms. J. Metabol. Brain Dis. 17 (2002) 375-387
36. Reed D.J. Mechanisms of chemically induced cell injury and cellular protection mechanisms. J. Biochem. Toxicol. 356 (2001) 221-253
37. Schultz B.E., and Chan S.I. Structures and proton-pumping strategies of mitochondrial respiratory enzymes. J. Annu. Rev. Biophys. Biomol. Struct. 30 (2001) 23-65
38. Sipos I., Tretter L., and Adam-Vizi V. Quantitative relationship between inhibition of respiratory complexes and formation of reactive oxygen species in isolated nerve terminals. J. Neurochem. 84 (2003) 112-118
39. Tomas R., Guilarte, and Chen M.K. Manganese inhibits NMDA receptor channel function: implications to psychiatric and cognitive effects. J. Neurotoxicol. 751 (2007) 6-10
40. Vasquez-Vivar J., Kalyanaraman B., and Kennedy M.C. Mitochondrial aconitase is a source of hydroxyl radical an electron spin resonance investigation. J. Biol. Chem. 275 (2000) 14064-14069
41. Zhang S., Fu J., and Zhou Z. In vitro effect of manganese chloride exposure on reactive oxygen species generation and respiratory chain complexes activities of mitochondria isolated from rat brain. J. Toxicol. In Vitro 18 1 (2004) 71-77
42. Zhao P., Kalhorn T.F., and Slattery J.T. Selective mitochondrial glutathione depletion by ethanol enhances acetaminophen toxicity in rat liver. J. Hepatol. 36 (2002) 326-335
43. Zheng W., Ren S., and Graziano J.H. Manganese inhibits mitochondrial aconitase: a mechanism of manganese neurotoxicity. J. Brain Res. 799 (1998) 334-342
44. Zwingmann C., Leibfritz D., and Hazell A.S. Brain energy metabolism in a sub-acute rat model of manganese neurotoxicity: an ex vivo nuclear magnetic resonance study using [1-13C]glucose. J. Neurotoxicol. 25 (2004) 573-587