Iron transporters are differentially regulated by dietary iron, and modifications are associated with changes in manganese metabolism in young pigs

Journal of Nutrition

Volumn 139, Issue 8, 2009, Pages 1474-1479

  Hansen, Stephanie L ^a   Trakooljul, Nares ^a   Liu, Hsiao Ching ^a   Moeser, Adam J ^a   Spears, Jerry W ^a  

^a NORTH CAROLINA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COPPER; FERROPORTIN; HEMOGLOBIN; HEPCIDIN; IRON; MANGANESE; MINERAL; NATURAL RESISTANCE ASSOCIATED MACROPHAGE PROTEIN 2; ORGANIC CATION TRANSPORTER 1; PROTEIN ZIP14; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DIET SUPPLEMENTATION; DUODENUM; FOOD COMPOSITION; GENE EXPRESSION; IMMUNOBLOTTING; IRON DEFICIENCY; IRON INTAKE; LIVER; MALE; METABOLISM; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SWINE; WEANING;

ANIMALS; ANTIMICROBIAL CATIONIC PEPTIDES; CATION TRANSPORT PROTEINS; COPPER; DIETARY SUPPLEMENTS; DUODENUM; GENE EXPRESSION; HEMOGLOBINS; ION TRANSPORT; IRON; IRON, DIETARY; LIVER; MALE; MANGANESE; SWINE; TRACE ELEMENTS; WEIGHT GAIN;

SUIDAE;

EID: 67749108051     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.3945/jn.109.105866     Document Type: Article

References (29)

1. NRC. Nutrient requirements of swine. 10th ed. Washington, DC: National Academy Press; 1998.
2. Arredondo M, Munoz P, Mura CV, Nunez MT. DMT1, a physiologically relevant apical Cu1+ transporter of intestinal cells. Am J Physiol Cell Physiol. 2003;284:C1525-30.
3. Garrick MD, Singleton S, Vargas F, Kuo HC, Zhao L, Knopfel M, Davidson T, Costa M, Paradkar P, et al. Dmt1: which metals does it transport? Biol Res. 2006;39:79-85.
4. Ganz T, Nemeth E. Regulation of iron acquisition and iron distribution in mammals. Biochimica et Biophysica Acta. 2006;1763; 690-9.
5. Blachier F, Vaugelade P, Robert V, Kibangou B, Canonne-Hergaux F, Delpal S, Bureau F, Blottiere H, Bougle D. Comparative capacities of the pig colon and duodenum for luminal iron absorption. Can J Physiol Pharmacol. 2007;85:185-92.
6. Öhrvik H, Oskarsson A, Lundh T, Skerfving S, Tallkvist J. Impact of iron status on cadmium uptake in suckling piglets. Toxicology. 2007;240: 15-24.
7. Tako E, Glahn RP, Welch RM, Lei X, Yasuda K, Miller DD. Dietary inulin affects the expression of intestinal enterocyte iron transporters, receptors and storage protein and alters the microbiota in the pig intestine. Br J Nutr. 2008;99:472-80.
8. Hansen SL, Ashwell MS, Legleiter LR, Fry RS, Lloyd KE, Spears JW. The addition of high manganese to a copper-deficient diet further depresses copper status and growth of cattle. Br J Nutr. 2009;101:1068-78.
9. Sigma Chemical Co. The quantitative, colorimetric determination of total hemoglobin. Tech. Bull. no. 525 (revised ed.). St. Louis (MO): Sigma Chemical; 1990.
10. Hansen SL, Schlegel P, Legleiter LR, Lloyd KE, Spears JW. Bioavailability of copper from copper glycinate in steers fed high dietary sulfur and molybdenum. J Anim Sci. 2008a;86:173-9.
11. Gengelbach GP, Ward JD, Spears JW. Effect of dietary copper, iron and molybdenum on growth and copper status of beef cows and calves. J Anim Sci. 1994;72:2722-7.
12. Knutson MD, Oukka M, Koss LM, Aydemir F, Wessling-Resnick M. Iron release from macrophages after erythrophagocytosis is up-regulated by ferroportin 1 overexpression and down-regulated by hepcidin. Proc Natl Acad Sci USA. 2005;102:1324-8.
13. National Center of Biotechnology Information [homepage on the Internet]. Bethesda (MD); 2009 [cited 2009 April 8]. Primer BLAST. Available from: http://www.ncbi.nlm.nih.gov/tools/primer-blast.
14. T method. Methods. 2001;25:402-8.
15. Nygard AB, Jørgensen CB, Cirera S, Fredholm M. Selection of reference genes for gene expression studies in pig tissues using SYBR green qPCR. BMC Mol Biol. 2007;8:67-73.
16. Yeh KY, Yeh M, Mims L, Glass J. Iron feeding induces ferroportin 1 and hephaestin migration and interaction in rat duodenal epithelium. Am J Physiol Gastrointest Liver Physiol. 2009;296:G55-65.
17. Underwood EJ, Suttle NF. The mineral nutrition of livestock. 3rd ed. Wallingford (U.K.): CABI Publishing; 1999.
18. De Domenico I, Mcvey Ward D, Kaplan J. Regulation of iron aquisition and storage: consequences for iron-linked disorders. Nat Rev Mol Cell Biol. 2008;9:72-81.
19. Muckenthaler MU, Galy B, Hentze MW. Systemic iron homeostasis and the iron-responsive element/iron-regulatory protein (IRE/IRP) regulatory network. Annu Rev Nutr. 2008;28;197-213.
20. Rincker MJ, Clarke SL, Eisenstein RS, Link JE, Hill GM. Effects of iron supplementation on binding activity of iron regulatory proteins and the subsequent effect on growth performance and indices of hematological and mineral status of young pigs. J Anim Sci. 2005;83:2137-45.
21. Garrick MD, Dolan KG, Horbinski C, Ghio AJ, Higgins D, Porubcin M, Moore EG, Hainsworth LN, Umbreit JN, et al. Dmt1: a mammalian transporter for multiple minerals. Biometals. 2003;16:41-54.
22. Nemeth E, Tuttle MS, Powelson J, Vaughn MB, Donovan A, Mcvey Ward D, Ganz T, Kaplan J. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science. 2004;306:2090-3.
23. Liuzzi JP, Aydemir F, Nam H, Knutson MD, Cousins RJ. Zip14 (Slc39a14) mediates non-transferrin-bound iron uptake into cells. Proc Natl Acad Sci USA. 2006;103:13612-7.
24. Liuzzi JP, Lichten LA, Rivera S, Blanchard RK, Aydemir TB, Knutson MD, Ganz T, Cousins RJ. Interleukin-6 regulates the zinc transporter Zip14 in liver and contributes to the hypozincemia of the acute-phase response. Proc Natl Acad Sci USA. 2005;102:6843-8.
25. Gunshin H, Mackenzie B, Berger UV, Gunshin Y, Romero MF, Boron WF. Cloning and characterization of a mammalian proton-coupled metal-ion transporter. Nature. 1997;388:482-8.
26. Chua AC, Morgan EH. Manganese metabolism is impaired in the Belgrade laboratory rat. J Comp Physiol [B]. 1997;167:361-9.
27. Girijashanker K, He L, Soleimani M, Reed JM, Li H, Liu Z, Wang B, Dalton TP, Nebert DW. Slc39a14 gene encodes ZIP14, a metal/biocarbonate symporter: similarities to the ZIP8 transporter. Mol Pharmacol. 2008;73:1413-23.
28. Hahn PF, Fairmain E. The copper content of some human and animal tissues. J Biol Chem. 1936;113:161-5.
29. Yu S, West CE, Beynen AC. Increasing intakes of iron reduce status, absorption and biliary excretion of copper in rats. Br J Nutr. 1994;71: 887-95.