A Novel Anticancer Agent, 8-Methoxypyrimido[4′,5′:4,5]thieno(2,3-b) Quinoline-4(3H)-One Induces Neuro 2a Neuroblastoma Cell Death through p53-Dependent, Caspase-Dependent and -Independent Apoptotic Pathways

PLoS ONE

Volumn 8, Issue 6, 2013, Pages

  Sahu, Upasana ^a   Sidhar, Himakshi ^a   Ghate, Pankaj S ^a   Advirao, Gopal M ^b   Raghavan, Sathees C ^c   Giri, Ranjit K ^a  

^a NATIONAL BRAIN RESEARCH CENTRE   (India)

^b KUVEMPU UNIVERSITY   (India)

^c INDIAN INSTITUTE OF SCIENCE   (India)

Author keywords

[No Author keywords available]

Indexed keywords

8 METHOXYPYRIMIDO[4',5':4,5]THIENO(2,3 B)QUINOLINE 4(3H) ONE; ANTINEOPLASTIC AGENT; APOPTOSIS INDUCING FACTOR; ATM PROTEIN; CASPASE; CASPASE 2; CASPASE 3; CASPASE 7; CASPASE 8; CASPASE 9; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BAX; PROTEIN P53; QUINOLINE DERIVATIVE; SERINE; UNCLASSIFIED DRUG; 8-METHOXYPYRIMIDO(4',5'-4,5)THIENO(2,3-B)QUINOLINE-4(3H)-ONE; FUSED HETEROCYCLIC RINGS;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL DEATH; CELL NUCLEUS; CELL STRAIN NEURO 2A; CELL STRAIN SH SY5Y; CONTROLLED STUDY; DNA FRAGMENTATION; DOSE TIME EFFECT RELATION; DRUG CYTOTOXICITY; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME DEGRADATION; ENZYME SPECIFICITY; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; MITOCHONDRION; MOUSE; NEUROBLASTOMA; NICK END LABELING; NONHUMAN; PROTEIN ANALYSIS; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; ANIMAL; DOSE RESPONSE; DRUG EFFECTS; ENZYMOLOGY; METABOLISM; PATHOLOGY; TUMOR CELL LINE;

ATAXIA TELANGIECTASIA;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CASPASES; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; HETEROCYCLIC COMPOUNDS, 4 OR MORE RINGS; HUMANS; MICE; NEUROBLASTOMA; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84879136856     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0066430     Document Type: Article

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