A novel DNA intercalator, 8-methoxy pyrimido[4′,5′:4,5]thieno (2,3-b)quinoline-4(3H)-one induces apoptosis in cancer cells, inhibits the tumor progression and enhances lifespan in mice with tumor

Molecular Carcinogenesis

Volumn 52, Issue 6, 2013, Pages 413-425

  Sharma, Sheetal ^a   Panjamurthy, Kuppusamy ^a   Choudhary, Bibha ^a,b   Srivastava, Mrinal ^a   Shahabuddin, Ms ^a   Giri, Ranjit ^c   Advirao, Gopal M ^d   Raghavan, Sathees C ^a  

^a INDIAN INSTITUTE OF SCIENCE   (India)

^b Institute of Bioinformatics and Applied Biotechnology   (India)

^c National Brain Research Center   (India)

^d KUVEMPU UNIVERSITY   (India)

Author keywords

Anticancer drug; Chemotherapy; DNA damage; DNA intercalator; Double strand breaks; Extrinsic pathway of apoptosis

Indexed keywords

8 METHOXY PYRIMIDO[4',5':4,5]THIENO(2,3 B)QUINOLINE 4(3H)ONE; ANTINEOPLASTIC AGENT; INTERCALATING AGENT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DRUG MECHANISM; LIFESPAN; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL CYCLE; CELL LINE, TUMOR; DNA; DNA BREAKS, DOUBLE-STRANDED; HUMANS; INTERCALATING AGENTS; LEUKEMIA; MICE; MICE, INBRED BALB C; NEOPLASMS; QUINOLINES; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; THIOPHENES;

ANIMALIA; MUS;

EID: 84871604829     PISSN: 08991987     EISSN: 10982744     Source Type: Journal    
DOI: 10.1002/mc.21867     Document Type: Article

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