Intercalative pyrimido[4',5':4,5]thieno(2,3-b)quinolines induce apoptosis in leukemic cells: A comparative study of methoxy and morpholino substitution

Investigational New Drugs

Volumn 29, Issue 5, 2011, Pages 873-882

  Shahabuddin, M S ^a   Nambiar, Mridula ^a   Advirao, Gopal M ^b   Raghavan, Sathees C ^a  

^a INDIAN INSTITUTE OF SCIENCE   (India)

^b KUVEMPU UNIVERSITY   (India)

Author keywords

Anticancer drug; Chemotherapy; Cytotoxicity; DNA damage; Double strand breaks

Indexed keywords

4 MORPHOLINO PYRIMIDO[4',5':4,5]THIENO(2,3 B)QUINOLINE; 8 METHOXY PYRIMIDO[4',5':4,5]THIENO(2,3 B)QUINOLINE 4(3H) ONE; LIPOCORTIN 5; QUINOLONE DERIVATIVE; UNCLASSIFIED DRUG; 8 METHOXYPYRIMIDO(4(1),5(1) 4,5)THIENO(2,3 B)QUINOLINE 4(3H) ONE; 8-METHOXYPYRIMIDO(4(1),5(1)-4,5)THIENO(2,3-B)QUINOLINE-4(3H)-ONE; INTERCALATING AGENT; MORPHOLINO OLIGONUCLEOTIDE; PHOSPHATIDYLSERINE; QUINOLINE DERIVATIVE; THIOPHENE DERIVATIVE;

APOPTOSIS; ARTICLE; BINDING AFFINITY; BIOPHYSICS; CELL ACTIVATION; CELL CYCLE; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; COMPARATIVE EFFECTIVENESS; CONTROLLED STUDY; CYTOTOXICITY; DNA FRAGMENTATION; DRUG DETERMINATION; DRUG EFFICACY; DRUG MECHANISM; DRUG STRUCTURE; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; LEUKEMIA CELL; PRIORITY JOURNAL; TREATMENT RESPONSE; CELL DEATH; CELL MEMBRANE; CELL PROLIFERATION; CHEMISTRY; COMPARATIVE STUDY; CONFOCAL MICROSCOPY; DNA REPLICATION; DRUG EFFECT; DRUG SCREENING; LEUKEMIA; METABOLISM; PATHOLOGY; TUMOR CELL LINE;

ANNEXIN A5; APOPTOSIS; CELL DEATH; CELL LINE, TUMOR; CELL MEMBRANE; CELL PROLIFERATION; DNA FRAGMENTATION; DNA REPLICATION; DRUG SCREENING ASSAYS, ANTITUMOR; G1 PHASE; HUMANS; INTERCALATING AGENTS; LEUKEMIA; MICROSCOPY, CONFOCAL; MORPHOLINOS; PHOSPHATIDYLSERINES; QUINOLINES; THIOPHENES;

EID: 84856074414     PISSN: 01676997     EISSN: 15730646     Source Type: Journal    
DOI: 10.1007/s10637-010-9436-0     Document Type: Article

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