A self-compartmentalizing hexamer serine protease from Pyrococcus Horikoshii: Substrate selection achieved through multimerization

Journal of Biological Chemistry

Volumn 288, Issue 24, 2013, Pages 17884-17894

  Menyhárd, Dóra K ^a   Kiss Szemán, Anna ^a   Tichy Rács, Éva ^a,b   Hornung, Balázs ^a,c   Rádi, Krisztina ^a,d   Szeltner, Zoltán ^b   Domokos, Klarissza ^b   Szamosi, Ilona ^b   Náray Szabó, Gábor ^a   Polgár, László ^b   Harmat, Veronika ^a  

^a EÖTVÖS LORÁND UNIVERSITY   (Hungary)

^b INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d UNIVERSITY OF WARWICK   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; MONOMERS;

CATALYTIC APPARATUS; DIFFERENT SUBSTRATES; DOMAIN INTERFACES; MULTIMERIZATION; PYROCOCCUS HORIKOSHII; SCREENING STRATEGY; SERINE PROTEASE; SUBSTRATE SELECTION;

SUBSTRATES;

ACYLAMINOACYL PEPTIDASE; AMINOPEPTIDASE; AMYLOID BETA PROTEIN; DIMER; HEXAMER; HISTIDINE; MONOMER; POLYMER; TRIMER; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL COMPARTMENTALIZATION; CHANNEL GATING; CONTROLLED STUDY; COVALENT BOND; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME BINDING; ENZYME SPECIFICITY; ENZYME STABILITY; ENZYME SUBSTRATE; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN ASSEMBLY; PROTEIN MULTIMERIZATION; PYROCOCCUS HORIKOSHII; STRUCTURE ANALYSIS;

PYROCOCCUS HORIKOSHII;

EID: 84879062608     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.451534     Document Type: Article

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