Optimization of piperidyl-ureas as inhibitors of soluble epoxide hydrolase

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 2, 2010, Pages 571-575

  Eldrup, Anne B ^a   Soleymanzadeh, Fariba ^a   Farrow, Neil A ^a   Kukulka, Alison ^a   De Lombaert, Stéphane ^a  

^a BOEHRINGER INGELHEIM PHARMACEUTICALS INC   (United States)

Author keywords

EETs; Epoxide eicosatrienoic acids; sEH; Soluble epoxide hydrolase

Indexed keywords

1 4 (1H PYRROL 1 YL) N [4 (TRIFLUOROMETHOXY)PHENYL]PIPERIDINECARBOXAMIDE; EPOXIDE HYDROLASE; UNCLASSIFIED DRUG; UREA DERIVATIVE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IN VITRO STUDY; METABOLISM; NONHUMAN; PLASMA; RAT; SOLID STATE;

ADMINISTRATION, ORAL; ANIMALS; BINDING SITES; COMPUTER SIMULATION; ENZYME INHIBITORS; EPOXIDE HYDROLASES; HUMANS; MICROSOMES, LIVER; PIPERIDINES; RATS; UREA;

RATTUS;

EID: 72249121003     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.11.091     Document Type: Article

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