Electrostatic effects and binding determinants in the catalysis of prolyl oligopeptidase: Site-specific mutagenesis at the oxyanion binding site

Journal of Biological Chemistry

Volumn 277, Issue 45, 2002, Pages 42613-42622

  Szeltner, Zoltán ^a   Rea, Dean ^a   Renner, Veronika ^b   Fülöp, Vilmos ^b   Polgár, László ^a  

^a INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

^b UNIVERSITY OF WARWICK   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; CHEMICAL ACTIVATION; ELECTROSTATICS; ENTROPY; HIGH TEMPERATURE EFFECTS; HYDROGEN BONDS; HYDROLYSIS; MUTAGENESIS; X RAY CRYSTALLOGRAPHY;

BINDING DETERMINANTS;

BIOCHEMISTRY;

AMINO ACID; ANILIDE; ANION; ARGININE; BENZYLOXYCARBONYLGLYCYLPROLINE 2 NAPHTHYLAMIDE; HYDROXYL GROUP; NAPHTHYL GROUP; OXYANION; OXYGEN; PROLYL ENDOPEPTIDASE; SUCCINYLGLYCYLPROLINE 4 NITROANILIDE; TYROSINE; UNCLASSIFIED DRUG;

ALKALINITY; AMINO ACID SEQUENCE; ARTICLE; BINDING SITE; CATALYSIS; COMPETITIVE INHIBITION; ELECTRICITY; ENTROPY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME BINDING; ENZYME SUBSTRATE COMPLEX; HIGH TEMPERATURE; HYDROGEN BOND; HYDROLYSIS; MEMORY DISORDER; PRIORITY JOURNAL; REACTION ANALYSIS; REACTION TIME; X RAY CRYSTALLOGRAPHY;

AMINO ACID SUBSTITUTION; ANIMALS; BASE SEQUENCE; BINDING SITES; BRAIN; CRYSTALLOGRAPHY, X-RAY; DNA PRIMERS; ELECTROSTATICS; GLYCINE; HYDROGEN BONDING; HYDROGEN-ION CONCENTRATION; KINETICS; MUTAGENESIS, SITE-DIRECTED; PROTEIN CONFORMATION; RECOMBINANT PROTEINS; SERINE ENDOPEPTIDASES; SWINE; THERMODYNAMICS; TYROSINE;

ARRHENIUS;

EID: 0037044875     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M208043200     Document Type: Article

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