Structure and catalysis of acylaminoacyl peptidase: Closed and open subunits of a dimer oligopeptidase

Journal of Biological Chemistry

Volumn 286, Issue 3, 2011, Pages 1987-1998

  Harmat, Veronika ^a   Domokos, Klarissza ^b   Menyhárd, Dóra K ^a   Palló, Anna ^c   Szeltner, Zoltán ^b   Szamosi, Ilona ^b   Beke Somfai, Tamás ^a,d   Náray Szabó, Gábor ^a   Polgár, László ^b  

^a EÖTVÖS LORÁND UNIVERSITY   (Hungary)

^b INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

^c CHEMICAL RESEARCH CENTER   (Hungary)

^d CHALMERS UNIVERSITY OF TECHNOLOGY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; AEROPYRUM PERNIX; ASPARTIC ACIDS; CATALYTIC SITES; CATALYTIC TRIAD; CLOSED FORM; CONFORMATIONAL SELECTION; CRYSTAL STRUCTURE DETERMINATION; DIFFERENT SUBSTRATES; HOMODIMERS; HYDROLASES; MUTANT ENZYMES; NATIVE ENZYMES; PH DEPENDENCE; RATE-LIMITING STEPS; SIDE CHAINS; SPECIFICITY RATES; STRUCTURAL BASIS;

AMINO ACIDS; CATALYSIS; DIMERS; ENZYMES; ORGANIC ACIDS; PROPELLERS; RATE CONSTANTS; SUBSTRATES;

CRYSTAL STRUCTURE;

ACYLAMINOACYL PEPTIDASE; ALANINE; ASPARAGINE; ASPARTIC ACID; PROLYL ENDOPEPTIDASE; UNCLASSIFIED DRUG;

ACYLATION; ARTICLE; BINDING AFFINITY; CATALYSIS; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME BINDING; ENZYME KINETICS; ENZYME STRUCTURE; LIGAND BINDING; MUTATION; PH; PRIORITY JOURNAL;

AEROPYRUM; AMINO ACID SUBSTITUTION; ARCHAEAL PROTEINS; CATALYSIS; CRYSTALLOGRAPHY, X-RAY; MUTATION, MISSENSE; PEPTIDE HYDROLASES; PROTEIN STRUCTURE, TERTIARY;

AEROPYRUM PERNIX;

EID: 78751533121     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.169862     Document Type: Article

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