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Volumn 14, Issue 6, 2013, Pages 11692-11712

Wharton's jelly-derived mesenchymal stem cells: Phenotypic characterization and Optimizing their therapeutic potential for clinical applications

Author keywords

Experimental protocol; Mesenchymal stem cells; Phenotypic characteristics; Therapeutic applications; Umbilical cord; Wharton's jelly

Indexed keywords

CARDIOVASCULAR DISEASE; CELL DIFFERENTIATION; CELL STRUCTURE; HUMAN; IMMUNE EVASION; IMMUNOMODULATION; IMMUNOREGULATION; IN VITRO STUDY; LIVER DISEASE; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STROMA CELL; MOLECULARLY TARGETED THERAPY; NERVE REGENERATION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PHENOTYPE; PROCESS OPTIMIZATION; REVIEW; STEM CELL EXPANSION; TISSUE ENGINEERING; TISSUE REGENERATION; TREATMENT INDICATION; UMBILICAL CORD; ANIMAL; CLINICAL TRIAL (TOPIC); CYTOLOGY; MEDICAL RESEARCH; WHARTON JELLY;

EID: 84879008073     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms140611692     Document Type: Review
Times cited : (255)

References (104)
  • 1
    • 84855813775 scopus 로고    scopus 로고
    • Connecting the dots: The promises of wharton's jelly stem cells for tissue repair and regeneration
    • La Rocca, G. Connecting the dots: The promises of wharton's jelly stem cells for tissue repair and regeneration. Open Tissue Eng. Regen. Med. J. 2011, 4, 3-5.
    • (2011) Open Tissue Eng. Regen. Med. J , vol.4 , pp. 3-5
    • la Rocca, G.1
  • 2
    • 0025981591 scopus 로고
    • Isolation, culture and characterisation of fibroblast-like cells derived from the wharton's jelly portion of human umbilical cord
    • McElreavey, K.D.; Irvine, A.I.; Ennis, K.T.; McLean, W.H. Isolation, culture and characterisation of fibroblast-like cells derived from the wharton's jelly portion of human umbilical cord. Biochem. Soc. Trans. 1991, 19, 29S.
    • (1991) Biochem. Soc. Trans , vol.29 S , pp. 19
    • McElreavey, K.D.1    Irvine, A.I.2    Ennis, K.T.3    McLean, W.H.4
  • 3
    • 13744258789 scopus 로고    scopus 로고
    • Translated by s. Freer. Oxford, UK: Oxford University Press
    • Wharton, T. Adenographia. Translated by s. Freer. Oxford, UK: Oxford University Press: 1996.
    • (1996) Adenographia
    • Wharton, T.1
  • 4
    • 0042101601 scopus 로고
    • Architecture of distended and nondistended human umbilical cord tissues, with special reference to the arteries and veins
    • Chacko, A.W.; Reynolds, S.R.M. Architecture of distended and nondistended human umbilical cord tissues, with special reference to the arteries and veins. Contrib. Embryol. 1954, 35, 135-150.
    • (1954) Contrib. Embryol , vol.35 , pp. 135-150
    • Chacko, A.W.1    Reynolds, S.R.M.2
  • 8
    • 13744253635 scopus 로고    scopus 로고
    • Cells isolated from wharton's jelly of the human umbilical cord develop a cartilage phenotype when treated with tgf-β in vitro
    • Naughton, B.A.; San Roman, J.; Liu, K.; Purchio, A.; Pavelec, R.; Rekettye, L. Cells isolated from wharton's jelly of the human umbilical cord develop a cartilage phenotype when treated with tgf-β in vitro. FASEB J. 1997, 11, A19.
    • (1997) FASEB J , vol.11
    • Naughton, B.A.1    San, R.J.2    Liu, K.3    Purchio, A.4    Pavelec, R.5    Rekettye, L.6
  • 10
    • 0037240649 scopus 로고    scopus 로고
    • Searching for alternative sources of postnatal human mesenchymal stem cells: Candidate msc-like cells from umbilical cord
    • Romanov, Y.A.; Svintsitskaya, V.A.; Smirnov, V.N. Searching for alternative sources of postnatal human mesenchymal stem cells: Candidate msc-like cells from umbilical cord. Stem Cells 2003, 21, 105-110.
    • (2003) Stem Cells , vol.21 , pp. 105-110
    • Romanov, Y.A.1    Svintsitskaya, V.A.2    Smirnov, V.N.3
  • 11
    • 0027230799 scopus 로고
    • Ultrastructural and immunohistochemical studies of wharton's jelly umbilical cord cells
    • Takechi, K.; Kuwabara, Y.; Mizuno, M. Ultrastructural and immunohistochemical studies of wharton's jelly umbilical cord cells. Placenta 1993, 14, 235-245.
    • (1993) Placenta , vol.14 , pp. 235-245
    • Takechi, K.1    Kuwabara, Y.2    Mizuno, M.3
  • 12
    • 0032504070 scopus 로고    scopus 로고
    • Study on myofibroblast differentiation in the stromal cells of wharton's jelly: Expression and localization of alpha-smooth muscle actin
    • Kobayashi, K.; Kubota, T.; Aso, T. Study on myofibroblast differentiation in the stromal cells of wharton's jelly: Expression and localization of alpha-smooth muscle actin. Early Hum. Dev. 1998, 51, 223-233.
    • (1998) Early Hum. Dev , vol.51 , pp. 223-233
    • Kobayashi, K.1    Kubota, T.2    Aso, T.3
  • 13
    • 33847682993 scopus 로고    scopus 로고
    • Identification of cord blood-derived mesenchymal stem/stromal cell populations with distinct growth kinetics, differentiation potentials, and gene expression profiles
    • Markov, V.; Kusumi, K.; Tadesse, M.G.; William, D.A.; Hall, D.M.; Lounev, V.; Carlton, A.; Leonard, J.; Cohen, R.I.; Rappaport, E.F.; et al. Identification of cord blood-derived mesenchymal stem/stromal cell populations with distinct growth kinetics, differentiation potentials, and gene expression profiles. Stem Cells Dev. 2007, 16, 53-73.
    • (2007) Stem Cells Dev , vol.16 , pp. 53-73
    • Markov, V.1    Kusumi, K.2    Tadesse, M.G.3    William, D.A.4    Hall, D.M.5    Lounev, V.6    Carlton, A.7    Leonard, J.8    Cohen, R.I.9    Rappaport, E.F.10
  • 14
    • 34347217526 scopus 로고    scopus 로고
    • A protocol for isolation and culture of human umbilical vein endothelial cells
    • Baudin, B.; Bruneel, A.; Bosselut, N.; Vaubourdolle, M. A protocol for isolation and culture of human umbilical vein endothelial cells. Nat. Protoc. 2007, 2, 481-485.
    • (2007) Nat. Protoc , vol.2 , pp. 481-485
    • Baudin, B.1    Bruneel, A.2    Bosselut, N.3    Vaubourdolle, M.4
  • 15
    • 41349123068 scopus 로고    scopus 로고
    • Identification of mesenchymal stem cells in aorta-gonad-mesonephros and yolk sac of human embryos
    • Wang, X.Y.; Lan, Y.; He, W.Y.; Zhang, L.; Yao, H.Y.; Hou, C.M.; Tong, Y.; Liu, Y.L.; Yang, G.; Liu, X.D. et al. Identification of mesenchymal stem cells in aorta-gonad-mesonephros and yolk sac of human embryos. Blood 2008, 111, 2436-2443.
    • (2008) Blood , vol.111 , pp. 2436-2443
    • Wang, X.Y.1    Lan, Y.2    He, W.Y.3    Zhang, L.4    Yao, H.Y.5    Hou, C.M.6    Tong, Y.7    Liu, Y.L.8    Yang, G.9    Liu, X.D.10
  • 16
    • 84875585472 scopus 로고    scopus 로고
    • The therapeutic potential, challenges and future clinical directions of stem cells from the wharton's jelly of the human umbilical cord
    • Bongso, A.; Fong, C.Y. The therapeutic potential, challenges and future clinical directions of stem cells from the wharton's jelly of the human umbilical cord. Stem Cell Rev. 2013, 9, 226-240.
    • (2013) Stem Cell Rev , vol.9 , pp. 226-240
    • Bongso, A.1    Fong, C.Y.2
  • 17
    • 84855772740 scopus 로고    scopus 로고
    • Umbilical cord lining membrane and wharton's jelly-derived mesenchymal stem cells: The similarities and differences
    • Jeschke, M.G.; Gauglitz, G.G.; Phan, T.T.; Herndon, D.N.; Kita, K. Umbilical cord lining membrane and wharton's jelly-derived mesenchymal stem cells: The similarities and differences. Open Tissue Eng. Regen. Med. J. 2011, 4, 21-27.
    • (2011) Open Tissue Eng. Regen. Med. J , vol.4 , pp. 21-27
    • Jeschke, M.G.1    Gauglitz, G.G.2    Phan, T.T.3    Herndon, D.N.4    Kita, K.5
  • 18
    • 84855784148 scopus 로고    scopus 로고
    • Wharton's jelly mesenchymal stem cells as off-the -shelf cellular therapeutics: A closer look into their regenerative and immunomodulatory properties
    • Prasanna, S.J.; Jahnavi, V.S. Wharton's jelly mesenchymal stem cells as off-the -shelf cellular therapeutics: A closer look into their regenerative and immunomodulatory properties. Open Tissue Eng. Regen. Med. J. 2011, 4, 28-38.
    • (2011) Open Tissue Eng. Regen. Med. J , vol.4 , pp. 28-38
    • Prasanna, S.J.1    Jahnavi, V.S.2
  • 19
    • 43049151898 scopus 로고    scopus 로고
    • Wharton's jelly-derived cells are a primitive stromal cell population
    • Troyer, D.L.; Weiss, M.L. Wharton's jelly-derived cells are a primitive stromal cell population. Stem Cells 2008, 26, 591-599.
    • (2008) Stem Cells , vol.26 , pp. 591-599
    • Troyer, D.L.1    Weiss, M.L.2
  • 22
    • 36249001191 scopus 로고    scopus 로고
    • Concise review: Human umbilical cord stroma with regard to the source of fetus-derived stem cells
    • Can, A.; Karahuseyinoglu, S. Concise review: Human umbilical cord stroma with regard to the source of fetus-derived stem cells. Stem Cells 2007, 25, 2886-2895.
    • (2007) Stem Cells , vol.25 , pp. 2886-2895
    • Can, A.1    Karahuseyinoglu, S.2
  • 23
    • 34547122719 scopus 로고    scopus 로고
    • Comparison of proliferative and multilineage differentiation potential of human mesenchymal stem cells derived from umbilical cord and bone marrow
    • Baksh, D.; Yao, R.; Tuan, R.S. Comparison of proliferative and multilineage differentiation potential of human mesenchymal stem cells derived from umbilical cord and bone marrow. Stem Cells 2007, 25, 1384-1392.
    • (2007) Stem Cells , vol.25 , pp. 1384-1392
    • Baksh, D.1    Yao, R.2    Tuan, R.S.3
  • 24
    • 13744254666 scopus 로고    scopus 로고
    • Human umbilical cord perivascular (hucpv) cells: A source of mesenchymal progenitors
    • Sarugaser, R.; Lickorish, D.; Baksh, D.; Hosseini, M.M.; Davies, J.E. Human umbilical cord perivascular (hucpv) cells: A source of mesenchymal progenitors. Stem Cells 2005, 23, 220-229.
    • (2005) Stem Cells , vol.23 , pp. 220-229
    • Sarugaser, R.1    Lickorish, D.2    Baksh, D.3    Hosseini, M.M.4    Davies, J.E.5
  • 25
    • 77950612596 scopus 로고    scopus 로고
    • Isolation and characterization of mesenchymal stem cells from the sub-amniotic human umbilical cord lining membrane
    • Kita, K.; Gauglitz, G.G.; Phan, T.T.; Herndon, D.N.; Jeschke, M.G. Isolation and characterization of mesenchymal stem cells from the sub-amniotic human umbilical cord lining membrane. Stem Cells Dev. 2010, 19, 491-502.
    • (2010) Stem Cells Dev , vol.19 , pp. 491-502
    • Kita, K.1    Gauglitz, G.G.2    Phan, T.T.3    Herndon, D.N.4    Jeschke, M.G.5
  • 27
    • 64049087007 scopus 로고    scopus 로고
    • Morality and human embryo research. Introduction to the talking point on morality and human embryo research
    • Baldwin, T. Morality and human embryo research. Introduction to the talking point on morality and human embryo research. EMBO Rep. 2009, 10, 299-300.
    • (2009) EMBO Rep , vol.10 , pp. 299-300
    • Baldwin, T.1
  • 28
    • 78650971216 scopus 로고    scopus 로고
    • Dynamic changes in the copy number of pluripotency and cell proliferation genes in human escs and ipscs during reprogramming and time in culture
    • Laurent, L.C.; Ulitsky, I.; Slavin, I.; Tran, H.; Schork, A.; Morey, R.; Lynch, C.; Harness, J.V.; Lee, S.; Barrero, M.J. et al. Dynamic changes in the copy number of pluripotency and cell proliferation genes in human escs and ipscs during reprogramming and time in culture. Cell Stem Cell 2011, 8, 106-118.
    • (2011) Cell Stem Cell , vol.8 , pp. 106-118
    • Laurent, L.C.1    Ulitsky, I.2    Slavin, I.3    Tran, H.4    Schork, A.5    Morey, R.6    Lynch, C.7    Harness, J.V.8    Lee, S.9    Barrero, M.J.10
  • 29
    • 33747195353 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
    • Takahashi, K.; Yamanaka, S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006, 126, 663-676.
    • (2006) Cell , vol.126 , pp. 663-676
    • Takahashi, K.1    Yamanaka, S.2
  • 31
    • 84877126235 scopus 로고    scopus 로고
    • Hematopoietic stem cells are pluripotent and not just "hematopoietic"
    • Ogawa, M.; Larue, A.C.; Mehrotra, M. Hematopoietic stem cells are pluripotent and not just "hematopoietic". Blood Cells Mol. Dis. 2013, 51, 3-8.
    • (2013) Blood Cells Mol. Dis , vol.51 , pp. 3-8
    • Ogawa, M.1    Larue, A.C.2    Mehrotra, M.3
  • 33
    • 45849112916 scopus 로고    scopus 로고
    • Adipose-derived stem cells: Isolation, expansion and differentiation
    • Bunnell, B.A.; Flaat, M.; Gagliardi, C.; Patel, B.; Ripoll, C. Adipose-derived stem cells: Isolation, expansion and differentiation. Methods 2008, 45, 115-120.
    • (2008) Methods , vol.45 , pp. 115-120
    • Bunnell, B.A.1    Flaat, M.2    Gagliardi, C.3    Patel, B.4    Ripoll, C.5
  • 34
    • 74749093962 scopus 로고    scopus 로고
    • Multipotent mesenchymal stem cells from human placenta: Critical parameters for isolation and maintenance of stemness after isolation
    • Semenov, O.V.; Koestenbauer, S.; Riegel, M.; Zech, N.; Zimmermann, R.; Zisch, A.H.; Malek, A. Multipotent mesenchymal stem cells from human placenta: Critical parameters for isolation and maintenance of stemness after isolation. Am. J. Obstet. Gynecol. 2010, 202, e191-e193.
    • (2010) Am. J. Obstet. Gynecol , vol.202
    • Semenov, O.V.1    Koestenbauer, S.2    Riegel, M.3    Zech, N.4    Zimmermann, R.5    Zisch, A.H.6    Malek, A.7
  • 35
    • 57649200642 scopus 로고    scopus 로고
    • Human fetal membranes: A source of stem cells for tissue regeneration and repair?
    • Ilancheran, S.; Moodley, Y.; Manuelpillai, U. Human fetal membranes: A source of stem cells for tissue regeneration and repair? Placenta 2009, 30, 2-10.
    • (2009) Placenta , vol.30 , pp. 2-10
    • Ilancheran, S.1    Moodley, Y.2    Manuelpillai, U.3
  • 36
    • 43549120958 scopus 로고    scopus 로고
    • Multipotent properties of myofibroblast cells derived from human placenta
    • Strakova, Z.; Livak, M.; Krezalek, M.; Ihnatovych, I. Multipotent properties of myofibroblast cells derived from human placenta. Cell Tissue Res. 2008, 332, 479-488.
    • (2008) Cell Tissue Res , vol.332 , pp. 479-488
    • Strakova, Z.1    Livak, M.2    Krezalek, M.3    Ihnatovych, I.4
  • 37
    • 68049144834 scopus 로고    scopus 로고
    • Novel sources of fetal stem cells: Where do they fit on the developmental continuum?
    • Pappa, K.I.; Anagnou, N.P. Novel sources of fetal stem cells: Where do they fit on the developmental continuum? Regen. Med. 2009, 4, 423-433.
    • (2009) Regen. Med , vol.4 , pp. 423-433
    • Pappa, K.I.1    Anagnou, N.P.2
  • 38
    • 44149105394 scopus 로고    scopus 로고
    • Fetal stem cells from extra-embryonic tissues: Do not discard
    • Marcus, A.J.; Woodbury, D. Fetal stem cells from extra-embryonic tissues: Do not discard. J. Cell. Mol. Med. 2008, 12, 730-742.
    • (2008) J. Cell. Mol. Med , vol.12 , pp. 730-742
    • Marcus, A.J.1    Woodbury, D.2
  • 39
    • 77949308137 scopus 로고    scopus 로고
    • Pro-inflammatory cytokines, ifngamma and tnfalpha, influence immune properties of human bone marrow and wharton jelly mesenchymal stem cells differentially
    • Prasanna, S.J.; Gopalakrishnan, D.; Shankar, S.R.; Vasandan, A.B. Pro-inflammatory cytokines, ifngamma and tnfalpha, influence immune properties of human bone marrow and wharton jelly mesenchymal stem cells differentially. PLoS One 2010, 5, e9016.
    • (2010) PLoS One , vol.5
    • Prasanna, S.J.1    Gopalakrishnan, D.2    Shankar, S.R.3    Vasandan, A.B.4
  • 40
    • 58149330600 scopus 로고    scopus 로고
    • Isolation and characterization of oct-4+/hla-g+ mesenchymal stem cells from human umbilical cord matrix: Differentiation potential and detection of new markers
    • La Rocca, G.; Anzalone, R.; Corrao, S.; Magno, F.; Loria, T.; Lo Iacono, M.; Di Stefano, A.; Giannuzzi, P.; Marasa, L.; Cappello, F. et al. Isolation and characterization of oct-4+/hla-g+ mesenchymal stem cells from human umbilical cord matrix: Differentiation potential and detection of new markers. Histochem. Cell Biol. 2009, 131, 267-282.
    • (2009) Histochem. Cell Biol , vol.131 , pp. 267-282
    • la Rocca, G.1    Anzalone, R.2    Corrao, S.3    Magno, F.4    Loria, T.5    Lo Iacono, M.6    Di Stefano, A.7    Giannuzzi, P.8    Marasa, L.9    Cappello, F.10
  • 41
    • 48249135508 scopus 로고    scopus 로고
    • Combination treatment of human umbilical cord matrix stem cell-based interferon-beta gene therapy and 5-fluorouracil significantly reduces growth of metastatic human breast cancer in scid mouse lungs
    • Rachakatla, R.S.; Pyle, M.M.; Ayuzawa, R.; Edwards, S.M.; Marini, F.C.; Weiss, M.L.; Tamura, M.; Troyer, D. Combination treatment of human umbilical cord matrix stem cell-based interferon-beta gene therapy and 5-fluorouracil significantly reduces growth of metastatic human breast cancer in scid mouse lungs. Cancer Investig. 2008, 26, 662-670.
    • (2008) Cancer Investig , vol.26 , pp. 662-670
    • Rachakatla, R.S.1    Pyle, M.M.2    Ayuzawa, R.3    Edwards, S.M.4    Marini, F.C.5    Weiss, M.L.6    Tamura, M.7    Troyer, D.8
  • 44
    • 38349053355 scopus 로고    scopus 로고
    • Human leukocyte antigen-g5 secretion by human mesenchymal stem cells is required to suppress t lymphocyte and natural killer function and to induce cd4+cd25highfoxp3+ regulatory t cells
    • Selmani, Z.; Naji, A.; Zidi, I.; Favier, B.; Gaiffe, E.; Obert, L.; Borg, C.; Saas, P.; Tiberghien, P.; Rouas-Freiss, N. et al. Human leukocyte antigen-g5 secretion by human mesenchymal stem cells is required to suppress t lymphocyte and natural killer function and to induce cd4+cd25highfoxp3+ regulatory t cells. Stem Cells 2008, 26, 212-222.
    • (2008) Stem Cells , vol.26 , pp. 212-222
    • Selmani, Z.1    Naji, A.2    Zidi, I.3    Favier, B.4    Gaiffe, E.5    Obert, L.6    Borg, C.7    Saas, P.8    Tiberghien, P.9    Rouas-Freiss, N.10
  • 45
    • 78649374199 scopus 로고    scopus 로고
    • Immunological aspects of allogeneic mesenchymal stem cell therapies
    • Griffin, M.D.; Ritter, T.; Mahon, B.P. Immunological aspects of allogeneic mesenchymal stem cell therapies. Hum. Gene Ther. 2010, 21, 1641-1655.
    • (2010) Hum. Gene Ther , vol.21 , pp. 1641-1655
    • Griffin, M.D.1    Ritter, T.2    Mahon, B.P.3
  • 49
    • 0037093058 scopus 로고    scopus 로고
    • Human bone marrow stromal cells suppress t-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli
    • Di Nicola, M.; Carlo-Stella, C.; Magni, M.; Milanesi, M.; Longoni, P.D.; Matteucci, P.; Grisanti, S.; Gianni, A.M. Human bone marrow stromal cells suppress t-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli. Blood 2002, 99, 3838-3843.
    • (2002) Blood , vol.99 , pp. 3838-3843
    • Di Nicola, M.1    Carlo-Stella, C.2    Magni, M.3    Milanesi, M.4    Longoni, P.D.5    Matteucci, P.6    Grisanti, S.7    Gianni, A.M.8
  • 50
    • 13544249606 scopus 로고    scopus 로고
    • Human mesenchymal stem cells modulate allogeneic immune cell responses
    • Aggarwal, S.; Pittenger, M.F. Human mesenchymal stem cells modulate allogeneic immune cell responses. Blood 2005, 105, 1815-1822.
    • (2005) Blood , vol.105 , pp. 1815-1822
    • Aggarwal, S.1    Pittenger, M.F.2
  • 51
    • 70849116391 scopus 로고    scopus 로고
    • Mesenchymal stromal cells promote or suppress the proliferation of t lymphocytes from cord blood and peripheral blood: The importance of low cell ratio and role of interleukin-6
    • Najar, M.; Rouas, R.; Raicevic, G.; Boufker, H.I.; Lewalle, P.; Meuleman, N.; Bron, D.; Toungouz, M.; Martiat, P.; Lagneaux, L. Mesenchymal stromal cells promote or suppress the proliferation of t lymphocytes from cord blood and peripheral blood: The importance of low cell ratio and role of interleukin-6. Cytotherapy 2009, 11, 570-583.
    • (2009) Cytotherapy , vol.11 , pp. 570-583
    • Najar, M.1    Rouas, R.2    Raicevic, G.3    Boufker, H.I.4    Lewalle, P.5    Meuleman, N.6    Bron, D.7    Toungouz, M.8    Martiat, P.9    Lagneaux, L.10
  • 53
    • 78649333063 scopus 로고    scopus 로고
    • Immunosuppressive properties of human umbilical cord-derived mesenchymal stem cells: Role of b7-h1 and ido
    • Tipnis, S.; Viswanathan, C.; Majumdar, A.S. Immunosuppressive properties of human umbilical cord-derived mesenchymal stem cells: Role of b7-h1 and ido. Immunol. Cell Biol. 2010, 88, 795-806.
    • (2010) Immunol. Cell Biol , vol.88 , pp. 795-806
    • Tipnis, S.1    Viswanathan, C.2    Majumdar, A.S.3
  • 54
    • 84855781186 scopus 로고    scopus 로고
    • Phenotype and differentiation potential of stromal populations obtained from various zones of human umbilical cord: An overview
    • Conconi, M.T.; Di Liddo, R.; Tommasini, M.; Calore, C.; Parnigotto, P.P. Phenotype and differentiation potential of stromal populations obtained from various zones of human umbilical cord: An overview. Open Tissue Eng. Regen. Med. J. 2011, 4, 6-20.
    • (2011) Open Tissue Eng. Regen. Med. J , vol.4 , pp. 6-20
    • Conconi, M.T.1    Di Liddo, R.2    Tommasini, M.3    Calore, C.4    Parnigotto, P.P.5
  • 57
    • 0034794325 scopus 로고    scopus 로고
    • Intrauterine diabetic environment confers risks for type 2 diabetes mellitus and obesity in the offspring, in addition to genetic susceptibility
    • Dabelea, D.; Pettitt, D.J. Intrauterine diabetic environment confers risks for type 2 diabetes mellitus and obesity in the offspring, in addition to genetic susceptibility. J. Pediatr. Endocrinol. Metab. 2001, 14, 1085-1091.
    • (2001) J. Pediatr. Endocrinol. Metab , vol.14 , pp. 1085-1091
    • Dabelea, D.1    Pettitt, D.J.2
  • 59
    • 38949211488 scopus 로고    scopus 로고
    • High prevalence of type 2 diabetes and pre-diabetes in adult offspring of women with gestational diabetes mellitus or type 1 diabetes: The role of intrauterine hyperglycemia
    • Clausen, T.D.; Mathiesen, E.R.; Hansen, T.; Pedersen, O.; Jensen, D.M.; Lauenborg, J.; Damm, P. High prevalence of type 2 diabetes and pre-diabetes in adult offspring of women with gestational diabetes mellitus or type 1 diabetes: The role of intrauterine hyperglycemia. Diabetes Care 2008, 31, 340-346.
    • (2008) Diabetes Care , vol.31 , pp. 340-346
    • Clausen, T.D.1    Mathiesen, E.R.2    Hansen, T.3    Pedersen, O.4    Jensen, D.M.5    Lauenborg, J.6    Damm, P.7
  • 61
    • 33845926925 scopus 로고    scopus 로고
    • Committed subcutaneous preadipocytes are reduced in human obesity
    • Tchoukalova, Y.; Koutsari, C.; Jensen, M. Committed subcutaneous preadipocytes are reduced in human obesity. Diabetologia 2007, 50, 151-157.
    • (2007) Diabetologia , vol.50 , pp. 151-157
    • Tchoukalova, Y.1    Koutsari, C.2    Jensen, M.3
  • 63
    • 67349163717 scopus 로고    scopus 로고
    • Naive human umbilical cord matrix derived stem cells significantly attenuate growth of human breast cancer cells in vitro and in vivo
    • Ayuzawa, R.; Doi, C.; Rachakatla, R.S.; Pyle, M.M.; Maurya, D.K.; Troyer, D.; Tamura, M. Naive human umbilical cord matrix derived stem cells significantly attenuate growth of human breast cancer cells in vitro and in vivo. Cancer Lett. 2009, 280, 31-37.
    • (2009) Cancer Lett , vol.280 , pp. 31-37
    • Ayuzawa, R.1    Doi, C.2    Rachakatla, R.S.3    Pyle, M.M.4    Maurya, D.K.5    Troyer, D.6    Tamura, M.7
  • 64
    • 62449339080 scopus 로고    scopus 로고
    • Rat umbilical cord stem cells completely abolish rat mammary carcinomas with no evidence of metastasis or recurrence 100 days post-tumor cell inoculation
    • Ganta, C.; Chiyo, D.; Ayuzawa, R.; Rachakatla, R.; Pyle, M.; Andrews, G.; Weiss, M.; Tamura, M.; Troyer, D. Rat umbilical cord stem cells completely abolish rat mammary carcinomas with no evidence of metastasis or recurrence 100 days post-tumor cell inoculation. Cancer Res. 2009, 69, 1815-1820.
    • (2009) Cancer Res , vol.69 , pp. 1815-1820
    • Ganta, C.1    Chiyo, D.2    Ayuzawa, R.3    Rachakatla, R.4    Pyle, M.5    Andrews, G.6    Weiss, M.7    Tamura, M.8    Troyer, D.9
  • 67
    • 34548621387 scopus 로고    scopus 로고
    • Development of human umbilical cord matrix stem cell-based gene therapy for experimental lung tumors
    • Rachakatla, R.S.; Marini, F.; Weiss, M.L.; Tamura, M.; Troyer, D. Development of human umbilical cord matrix stem cell-based gene therapy for experimental lung tumors. Cancer Gene Ther. 2007, 14, 828-835.
    • (2007) Cancer Gene Ther , vol.14 , pp. 828-835
    • Rachakatla, R.S.1    Marini, F.2    Weiss, M.L.3    Tamura, M.4    Troyer, D.5
  • 68
    • 77956187466 scopus 로고    scopus 로고
    • Human umbilical cord matrix-derived stem cells expressing interferon-beta gene significantly attenuate bronchioloalveolar carcinoma xenografts in scid mice
    • Matsuzuka, T.; Rachakatla, R.S.; Doi, C.; Maurya, D.K.; Ohta, N.; Kawabata, A.; Pyle, M.M.; Pickel, L.; Reischman, J.; Marini, F.; et al. Human umbilical cord matrix-derived stem cells expressing interferon-beta gene significantly attenuate bronchioloalveolar carcinoma xenografts in scid mice. Lung Cancer 2010, 70, 28-36.
    • (2010) Lung Cancer , vol.70 , pp. 28-36
    • Matsuzuka, T.1    Rachakatla, R.S.2    Doi, C.3    Maurya, D.K.4    Ohta, N.5    Kawabata, A.6    Pyle, M.M.7    Pickel, L.8    Reischman, J.9    Marini, F.10
  • 69
    • 84855798289 scopus 로고    scopus 로고
    • Cell therapy for the treatment of metabolic liver disease: An update on the umbilical cord derived stem cells candidates
    • Scheers, I.; Lombard, C.; Najimi, M.; Sokal, E. Cell therapy for the treatment of metabolic liver disease: An update on the umbilical cord derived stem cells candidates. Open Tissue Eng. Regen. Med. J. 2011, 4, 48-53.
    • (2011) Open Tissue Eng. Regen. Med. J , vol.4 , pp. 48-53
    • Scheers, I.1    Lombard, C.2    Najimi, M.3    Sokal, E.4
  • 70
    • 39749171878 scopus 로고    scopus 로고
    • Native umbilical cord matrix stem cells express hepatic markers and differentiate into hepatocyte-like cells
    • Campard, D.; Lysy, P.A.; Najimi, M.; Sokal, E.M. Native umbilical cord matrix stem cells express hepatic markers and differentiate into hepatocyte-like cells. Gastroenterology 2008, 134, 833-848.
    • (2008) Gastroenterology , vol.134 , pp. 833-848
    • Campard, D.1    Lysy, P.A.2    Najimi, M.3    Sokal, E.M.4
  • 71
    • 77950603767 scopus 로고    scopus 로고
    • New emerging potentials for human wharton's jelly mesenchymal stem cells: Immunological features and hepatocyte-like differentiative capacity
    • Anzalone, R.; Lo Iacono, M.; Corrao, S.; Magno, F.; Loria, T.; Cappello, F.; Zummo, G.; Farina, F.; La Rocca, G. New emerging potentials for human wharton's jelly mesenchymal stem cells: Immunological features and hepatocyte-like differentiative capacity. Stem Cells Dev. 2010, 19, 423-438.
    • (2010) Stem Cells Dev , vol.19 , pp. 423-438
    • Anzalone, R.1    Lo Iacono, M.2    Corrao, S.3    Magno, F.4    Loria, T.5    Cappello, F.6    Zummo, G.7    Farina, F.8    la Rocca, G.9
  • 72
    • 84855758545 scopus 로고    scopus 로고
    • Mesenchymal stem cells derived from wharton's jelly and their potential for cardio-vascular tissue engineering
    • Semenov, O.; Breymann, C. Mesenchymal stem cells derived from wharton's jelly and their potential for cardio-vascular tissue engineering. Open Tissue Eng. Regen. Med. J. 2011, 4, 64-71.
    • (2011) Open Tissue Eng. Regen. Med. J , vol.4 , pp. 64-71
    • Semenov, O.1    Breymann, C.2
  • 73
    • 0029339215 scopus 로고
    • Uses of homograft conduits for right ventricle to pulmonary artery connections in the neonatal period
    • Mayer, J.E., Jr. Uses of homograft conduits for right ventricle to pulmonary artery connections in the neonatal period. Semin. Thorac. Cardiovasc. Surg. 1995, 7, 130-132.
    • (1995) Semin. Thorac. Cardiovasc. Surg , vol.7 , pp. 130-132
    • Mayer Jr., J.E.1
  • 74
    • 0033572873 scopus 로고    scopus 로고
    • Tissue heart valves: Current challenges and future research perspectives
    • Schoen, F.J.; Levy, R.J. Tissue heart valves: Current challenges and future research perspectives. J. Biomed. Mater. Res. 1999, 47, 439-465.
    • (1999) J. Biomed. Mater. Res , vol.47 , pp. 439-465
    • Schoen, F.J.1    Levy, R.J.2
  • 76
    • 79956319699 scopus 로고    scopus 로고
    • A 3d aligned microfibrous myocardial tissue construct cultured under transient perfusion
    • Kenar, H.; Kose, G.T.; Toner, M.; Kaplan, D.L.; Hasirci, V. A 3d aligned microfibrous myocardial tissue construct cultured under transient perfusion. Biomaterials 2011, 32, 5320-5329.
    • (2011) Biomaterials , vol.32 , pp. 5320-5329
    • Kenar, H.1    Kose, G.T.2    Toner, M.3    Kaplan, D.L.4    Hasirci, V.5
  • 78
    • 79959849772 scopus 로고    scopus 로고
    • Analysis of the chondrogenic potential and secretome of mesenchymal stem cells derived from human umbilical cord stroma
    • Arufe, M.C.; De la Fuente, A.; Mateos, J.; Fuentes, I.; de Toro, F.J.; Blanco, F.J. Analysis of the chondrogenic potential and secretome of mesenchymal stem cells derived from human umbilical cord stroma. Stem Cells Dev. 2011, 20, 1199-1212.
    • (2011) Stem Cells Dev , vol.20 , pp. 1199-1212
    • Arufe, M.C.1    De la Fuente, A.2    Mateos, J.3    Fuentes, I.4    de Toro, F.J.5    Blanco, F.J.6
  • 79
    • 66249135675 scopus 로고    scopus 로고
    • Effect of initial seeding density on human umbilical cord mesenchymal stromal cells for fibrocartilage tissue engineering
    • Wang, L.; Seshareddy, K.; Weiss, M.L.; Detamore, M.S. Effect of initial seeding density on human umbilical cord mesenchymal stromal cells for fibrocartilage tissue engineering. Tissue Eng. A 2009, 15, 1009-1017.
    • (2009) Tissue Eng. A , vol.15 , pp. 1009-1017
    • Wang, L.1    Seshareddy, K.2    Weiss, M.L.3    Detamore, M.S.4
  • 80
    • 84857653324 scopus 로고    scopus 로고
    • Human umbilical cord wharton's jelly stem cells undergo enhanced chondrogenic differentiation when grown on nanofibrous scaffolds and in a sequential two-stage culture medium environment
    • Fong, C.Y.; Subramanian, A.; Gauthaman, K.; Venugopal, J.; Biswas, A.; Ramakrishna, S.; Bongso, A. Human umbilical cord wharton's jelly stem cells undergo enhanced chondrogenic differentiation when grown on nanofibrous scaffolds and in a sequential two-stage culture medium environment. Stem Cell Rev. 2012, 8, 195-209.
    • (2012) Stem Cell Rev , vol.8 , pp. 195-209
    • Fong, C.Y.1    Subramanian, A.2    Gauthaman, K.3    Venugopal, J.4    Biswas, A.5    Ramakrishna, S.6    Bongso, A.7
  • 81
    • 80053160830 scopus 로고    scopus 로고
    • Human umbilical cord mesenchymal stromal cells in a sandwich approach for osteochondral tissue engineering
    • Wang, L.; Zhao, L.; Detamore, M.S. Human umbilical cord mesenchymal stromal cells in a sandwich approach for osteochondral tissue engineering. J. Tissue Eng. Regen. Med. 2011, 5, 712-721.
    • (2011) J. Tissue Eng. Regen. Med , vol.5 , pp. 712-721
    • Wang, L.1    Zhao, L.2    Detamore, M.S.3
  • 84
    • 0035060291 scopus 로고    scopus 로고
    • Nerve repair: A neurobiologist's view
    • Hall, S., Nerve repair: A neurobiologist's view. J. Hand Surg. 2001, 26, 129-136.
    • (2001) J. Hand Surg , vol.26 , pp. 129-136
    • Hall, S.1
  • 85
    • 0035783938 scopus 로고    scopus 로고
    • Sciatic nerve regeneration in rats induced by transplantation of in vitro differentiated bone-marrow stromal cells
    • Dezawa, M.; Takahashi, I.; Esaki, M.; Takano, M.; Sawada, H. Sciatic nerve regeneration in rats induced by transplantation of in vitro differentiated bone-marrow stromal cells. Eur. J. Neurosci. 2001, 14, 1771-1776.
    • (2001) Eur. J. Neurosci , vol.14 , pp. 1771-1776
    • Dezawa, M.1    Takahashi, I.2    Esaki, M.3    Takano, M.4    Sawada, H.5
  • 87
    • 84855777699 scopus 로고    scopus 로고
    • Mesenchymal stem cells and umbilical cord as sources for schwann cell differentiation: Their potential in peripheral nerve repair
    • Kuroda, Y.; Kitada, M.; Wakao, S.; Dezawa, M. Mesenchymal stem cells and umbilical cord as sources for schwann cell differentiation: Their potential in peripheral nerve repair. Open Tissue Eng. Regen. Med. J. 2011, 4, 54-63.
    • (2011) Open Tissue Eng. Regen. Med. J , vol.4 , pp. 54-63
    • Kuroda, Y.1    Kitada, M.2    Wakao, S.3    Dezawa, M.4
  • 88
    • 79951682799 scopus 로고    scopus 로고
    • Human umbilical cord wharton's jelly-derived mesenchymal stem cells differentiate into a schwann-cell phenotype and promote neurite outgrowth in vitro
    • Peng, J.; Wang, Y.; Zhang, L.; Zhao, B.; Zhao, Z.; Chen, J.; Guo, Q.; Liu, S.; Sui, X.; Xu, W. et al. Human umbilical cord wharton's jelly-derived mesenchymal stem cells differentiate into a schwann-cell phenotype and promote neurite outgrowth in vitro. Brain res. Bull. 2011, 84, 235-243.
    • (2011) Brain Res. Bull , vol.84 , pp. 235-243
    • Peng, J.1    Wang, Y.2    Zhang, L.3    Zhao, B.4    Zhao, Z.5    Chen, J.6    Guo, Q.7    Liu, S.8    Sui, X.9    Xu, W.10
  • 89
    • 79955560030 scopus 로고    scopus 로고
    • In vitro and in vivo magnetic resonance tracking of sinerem-labeled human umbilical mesenchymal stromal cell-derived schwann cells
    • Xu, Q.; Zhang, H.T.; Liu, K.; Rao, J.H.; Liu, X.M.; Wu, L.; Xu, B.N. In vitro and in vivo magnetic resonance tracking of sinerem-labeled human umbilical mesenchymal stromal cell-derived schwann cells. Cell. Mol. Neurobiol. 2011, 31, 365-375.
    • (2011) Cell. Mol. Neurobiol , vol.31 , pp. 365-375
    • Xu, Q.1    Zhang, H.T.2    Liu, K.3    Rao, J.H.4    Liu, X.M.5    Wu, L.6    Xu, B.N.7
  • 90
    • 84855767181 scopus 로고    scopus 로고
    • Evaluating the impact of oxygen concentration and plating density on human wharton's jelly-derived mesenchymal stromal cells
    • López, Y.; Seshareddy, K.; Trevino, E.; Cox, J.; Weiss, M.L. Evaluating the impact of oxygen concentration and plating density on human wharton's jelly-derived mesenchymal stromal cells. Open Tissue Eng. Regen. Med. J. 2011, 4, 82-94.
    • (2011) Open Tissue Eng. Regen. Med. J , vol.4 , pp. 82-94
    • López, Y.1    Seshareddy, K.2    Trevino, E.3    Cox, J.4    Weiss, M.L.5
  • 92
    • 0036797744 scopus 로고    scopus 로고
    • In vitro preprogramming of marrow stromal cells for myocardial regeneration
    • discussion 1159-1160
    • Bittira, B.; Kuang, J.Q.; Al-Khaldi, A.; Shum-Tim, D.; Chiu, R.C. In vitro preprogramming of marrow stromal cells for myocardial regeneration. Ann. Thorac. Surg. 2002, 74, 1154-1159; discussion 1159-1160.
    • (2002) Ann. Thorac. Surg , vol.74 , pp. 1154-1159
    • Bittira, B.1    Kuang, J.Q.2    Al-Khaldi, A.3    Shum-Tim, D.4    Chiu, R.C.5
  • 93
    • 0036621669 scopus 로고    scopus 로고
    • Improved heart function with myogenesis and angiogenesis after autologous porcine bone marrow stromal cell transplantation
    • Tomita, S.; Mickle, D.A.; Weisel, R.D.; Jia, Z.Q.; Tumiati, L.C.; Allidina, Y.; Liu, P.; Li, R.K. Improved heart function with myogenesis and angiogenesis after autologous porcine bone marrow stromal cell transplantation. J. Thorac. Cardiovasc. Surg. 2002, 123, 1132-1140.
    • (2002) J. Thorac. Cardiovasc. Surg , vol.123 , pp. 1132-1140
    • Tomita, S.1    Mickle, D.A.2    Weisel, R.D.3    Jia, Z.Q.4    Tumiati, L.C.5    Allidina, Y.6    Liu, P.7    Li, R.K.8
  • 96
    • 0027718107 scopus 로고
    • Embryonic stem cells differentiate in vitro into cardiomyocytes representing sinusnodal, atrial and ventricular cell types
    • Maltsev, V.A.; Rohwedel, J.; Hescheler, J.; Wobus, A.M. Embryonic stem cells differentiate in vitro into cardiomyocytes representing sinusnodal, atrial and ventricular cell types. Mechan. Dev. 1993, 44, 41-50.
    • (1993) Mechan. Dev , vol.44 , pp. 41-50
    • Maltsev, V.A.1    Rohwedel, J.2    Hescheler, J.3    Wobus, A.M.4
  • 99
    • 84877070464 scopus 로고    scopus 로고
    • Wharton's jelly or bone marrow mesenchymal stromal cells improve cardiac function following myocardial infarction for more than 32 weeks in a rat model: A preliminary report
    • Lopez, Y.; Lutjemeier, B.; Seshareddy, K.; Trevino, E.M.; Hageman, K.S.; Musch, T.I.; Borgarelli, M.; Weiss, M.L. Wharton's jelly or bone marrow mesenchymal stromal cells improve cardiac function following myocardial infarction for more than 32 weeks in a rat model: A preliminary report. Curr. Stem Cell Res. Ther. 2013, 8, 46-59.
    • (2013) Curr. Stem Cell Res. Ther , vol.8 , pp. 46-59
    • Lopez, Y.1    Lutjemeier, B.2    Seshareddy, K.3    Trevino, E.M.4    Hageman, K.S.5    Musch, T.I.6    Borgarelli, M.7    Weiss, M.L.8
  • 102
    • 68349128436 scopus 로고    scopus 로고
    • Human mesenchymal stem cells self-renew and differentiate according to a deterministic hierarchy
    • Sarugaser, R.; Hanoun, L.; Keating, A.; Stanford, W.L.; Davies, J.E. Human mesenchymal stem cells self-renew and differentiate according to a deterministic hierarchy. PLoS One 2009, 4, e6498.
    • (2009) PLoS One , pp. 4
    • Sarugaser, R.1    Hanoun, L.2    Keating, A.3    Stanford, W.L.4    Davies, J.E.5
  • 103
    • 59749097201 scopus 로고    scopus 로고
    • Isolation, propagation, and characterization of human umbilical cord perivascular cells (hucpvcs)
    • Sarugaser, R.; Ennis, J.; Stanford, W.L.; Davies, J.E. Isolation, propagation, and characterization of human umbilical cord perivascular cells (hucpvcs). Methods Mol. Biol. 2009, 482, 269-279.
    • (2009) Methods Mol. Biol , vol.482 , pp. 269-279
    • Sarugaser, R.1    Ennis, J.2    Stanford, W.L.3    Davies, J.E.4
  • 104
    • 84855819751 scopus 로고    scopus 로고
    • In vitro studies of horse umbilical cord matrix-derived cells: From characterization to labeling for magnetic resonance imaging
    • Lange-Consiglio, A.; Corradetti, B.; Rutigliano, L.; Cremonesi, F.; Bizzarro, D. In vitro studies of horse umbilical cord matrix-derived cells: From characterization to labeling for magnetic resonance imaging. Open Tissue Eng. Regen. Med. J. 2011, 4, 120-133.
    • (2011) Open Tissue Eng. Regen. Med. J , vol.4 , pp. 120-133
    • Lange-Consiglio, A.1    Corradetti, B.2    Rutigliano, L.3    Cremonesi, F.4    Bizzarro, D.5


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