In vitro preprogramming of marrow stromal cells for myocardial regeneration

Annals of Thoracic Surgery

Volumn 74, Issue 4, 2002, Pages 1154-1160

  Bittira, Bindu ^a   Kuang, Jin Qiang ^a   Al Khaldi, Abdulaziz ^a   Shum Tim, Dominique ^a   Chiu, Ray C J ^a,b  

^a MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

^b MONTREAL GENERAL HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; BETA GALACTOSIDASE; TROPONIN C; TROPONIN I;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; BONE MARROW CELL; CARDIOMYOPLASTY; CELL DIFFERENTIATION; COLD INJURY; CONFERENCE PAPER; HEART MUSCLE; IMMUNOHISTOCHEMISTRY; IMPLANTATION; LACTOSE OPERON; MALE; MORPHOLOGY; MUSCLE DEVELOPMENT; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RAT; STROMA CELL; TISSUE REGENERATION;

ANIMALS; BETA-GALACTOSIDASE; BONE MARROW CELLS; BONE MARROW TRANSPLANTATION; CELL DIFFERENTIATION; DEOXYCYTIDINE; HEART; IMMUNOHISTOCHEMISTRY; MALE; RATS; RATS, INBRED LEW; REGENERATION; STROMAL CELLS; TRANSFECTION; TROPONIN;

EID: 0036797744     PISSN: 00034975     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0003-4975(02)03857-2     Document Type: Conference Paper

References (19)

1. Chiu RCJ, Zibaitis A, Kao RL. Cellular cardiomyoplasty: myocardial regeneration with satellite cell implantation. Ann Thorac Surg 1995;60:12-8.
2. Kehat I, Kenyagin-Karsenti D, Snir M, et al. Human embryonic stem cells can differentiate into myocytes with structural and functional properties of cardiomyocytes. J Clin Invest 2001;108:407-14.
3. Klug MG, Soonpaa MH, Koh GY, Field LJ. Genetically selected cardiomyocytes from differentiating embryonic stem cells form stable intracardiac grafts. J Clin Invest 1996;98:216-24.
4. Menache P, Vilquin J-T, Desnos M, et al. Early results of autologous skeletal myoblast transplantation in patients with severe ischemic heart failure. Circulation 2001;104:II-598-604.
5. Taylor DA, Atkins BZ, Hungspreugs P, et al. Regenerating functional myocardium: improved performance after skeletal myoblast transplantation. Nature Med 1998;4:929-33.
6. Pittenger MF, Mackay AM, Beck SC, et al. Multilineage potential of adult human mesenchymal stem cells. Science 1999;284:143-5.
7. Makino S, Fukuda K, Miyoshi S, et al. Cardiomyocytes can be generated from marrow stromal cells in vitro. J Clin Invest 1999;103:697-705.
8. Wang JS, Shum-Tim D, Galipeau J, Chedrawy E, Eliopoulos N, Chiu RCJ. Marrow stromal cells for cellular cardiomyoplasty: feasibility and potential clinical advantages. J Thorac Cardiovasc Surg 2000;120:999-1006.
9. Edelman GM. Topobiology: an introduction to molecular embryology. New York: Basic Books, Publ., 1988.
10. Wakitani S, Saito T, Caplan AI. Myogenic cells derived from rat bone marrow mesenchymal stem cells exposed to 5-azacytidine. Muscle Nerve. 1995:18;1417-29.
11. Tomita S, Li R-K, Weisel RD, et al. Autologous transplantation of bone marrow cells improves damaged heart function. Circulation 1999;100(Suppl II): 247-56.
12. Konieczny SF, Emerson CP Jr. 5-Azacytidine induction of stable mesodermal stem cell lineages from 10T1/2 cells: evidence for regulatory genes controlling determination. Cell 1984;38:791-800.
13. Caplan AI. Mesenchymal stem cells. J Orthop Res 1991;9:641-50.
14. Adams JED, Bodor GS, Davila-Roman VG. Cardiac troponin I: a marker with high specificity for cardiac injury. Circulation 1993;88:101-6.
15. Bittira B, Kuang J-Q, Piquer S, Shum-Tim D, Al-Khaldi A, Chiu RCJ. The pathophysiological roles of bone marrow stromal cells (MSCs) in myocardial infarction. Circulation 2001;104(Suppl II):523-9.
16. Wang J-S, Shum-Tim D, Chedrawy E, Chiu RCJ. The coronary delivery of marrow stromal cells for myocardial regeneration: pathophysiologic and therapeutic implications. J Thorac Cardiovasc Surg 2001;122:699-705.
17. Orlic D, Kajstura J, Chiment S, et al. Bone marrow cells regenerate infarcted myocardium. Nature 2001;410:701-5.
18. Chiu RCJ. Therapeutic cardiac angiogenesis and myogenesis: the promises and challenges on a new frontier [Editorial]. J Thorac Cardiovasc Surg 2001;122:851-2.
19. Matsushita T, Oyamada M, Kurata H, et al. Formation of cell junctions between grafted and host cardiomyocytes at the border zone of rat myocardial infarction. Circulation 1999;100(Suppl II):262-8.