Rat umbilical cord stern cells completely abolish rat mammary carcinomas with no evidence of metastasis or recurrence 100 days post-tumor cell inoculation

Cancer Research

Volumn 69, Issue 5, 2009, Pages 1815-1820

  Ganta, Chanran ^a   Chiyo, Doi ^a   Ayuzawa, Rie ^a   Rachakatla, Rajashekar ^a   Pyle, Marla ^a   Andrews, Gordon ^a   Weiss, Mark ^a   Tamura, Masaaki ^a   Troyer, Deryl ^a  

^a KANSAS STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DYE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BREAST CARCINOMA; CANCER RECURRENCE; CELL THERAPY; COMPARATIVE STUDY; CONTROLLED STUDY; CORD BLOOD STEM CELL TRANSPLANTATION; DNA MODIFICATION; DOSE RESPONSE; FEMALE; METASTASIS; NONHUMAN; PRIORITY JOURNAL; RAT; STEM CELL; TUMOR CELL; TUMOR REGRESSION; UMBILICAL CORD; ADENOCARCINOMA; ANIMAL; EXPERIMENTAL NEOPLASM; FISCHER 344 RAT; PATHOLOGY; TUMOR RECURRENCE;

ADENOCARCINOMA; ANIMALS; CORD BLOOD STEM CELL TRANSPLANTATION; FEMALE; MAMMARY NEOPLASMS, EXPERIMENTAL; NEOPLASM METASTASIS; NEOPLASM RECURRENCE, LOCAL; RATS; RATS, INBRED F344;

EID: 62449339080     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-08-2750     Document Type: Article

References (18)

1. Aboody KS, Brown A, Rainov NG, et al. Neural stem cells display extensive tropism for pathology in adult brain: evidence from intracranial gUomas. Proc Natl Acad Sd U S A 2000;97:12846-12851.
2. Nakamizo A, Marini F, Amano T, et al. Human bone marrow-derived mesenchymal stem, cells In the treat-ment of gliomas. Cancer Res 2005;65:3307-3318.
3. Rachakatla RS, Marini F, Weiss ML, et al. Development of human umbilical cord matrix, stem, cell-based gene therapy for experimental lung tumors. Cancer Gene Ther 2007;14:828-835.
4. Studeny M1 Marini FC, Champlln RE, et al. Bone marrow-derived mesenchymal stem cells as vehicles for interferon-ß delivery into tumors. Cancer Res 2002;62: 3603-3608.
5. Studeny M, Marini FC, Dembinskl JL, et al. Mesen-chymal stem cells: potential precursors for tumor stroma and targeted-deUvery vehicles for anticancer agents. J Natl Cancer Inst 2004;96:1.593-603.
6. Aboody KS, Najbauer J, Schmidt NO, et al. Targeting of melanoma brain, metastases using engineered neural stem/progenitor ceUs. Neuro Oncol 2006;8:119-126.
7. Aboody KS, Najbauer J, Danks MK, et al. Stem and progenitor ceU-mediated tumor selective gene therapy. Gene Ther 2008;15:739-752.
8. Kumar S, Chanda D, Ponnazhagan S, et al. Therapeutic potential of genetically modified mesenchymal stem cells. Gene Ther 2008;15:711-715.
9. Mitchell KE, Weiss ML, Mitchell BM, et al. Matrix cells from Wharton's jelly form neurons and glia. Stem CeUs 2003;21:50-60.
10. Law BK, Norgaard P, Gnudi L, et al. Inhibition of DNA synthesis by a farnesyltransferase inhibitor involves inhibition of the p70(s6k) pathway. J Biol Chem 1999; 274:4743-4748.
11. Brown. AB, Yang W, Schmidt NO, et al. Intravascular delivery of neural stem ceU Unes to target intracranial and extracranial tumors of neural and non-neural origin. Hum Gene Ther 2003;14:1777-1785
12. Müller A, Homey B, Soto H, et al. Involvement of chemokine receptors in breast cancer metastasis. Nature 2001;410:50-56.
13. Hall B, Dembinskl J, Sasser AK, et al. Mesen-chymal stem, cells in cancer: tumor-associated fibro-blasts and cell-based delivery vehicles. Int J Hematol 2007;86:8-16.
14. Arbab AS, Janic B, Knight RA, et al. Detection of migration of locally implanted A.C1.33+ stem, cells by ceUular magnetic resonance imaging with histological findings. FASEB J 2008;22:3234-3246.
15. Khakoo AY, Pati S, Anderson SA, et al. Human mesenchymal stem cells exert potent antitumorigenic effects in a model of Kaposi's sarcoma. J Exp Med 2006; 203:1235-1247.
16. Friedman. R, Betancur M, Boissel L, et al. Umbilical cord mesenchymal stem cells: adjuvants for human ceU transplantation. Biol Blood Marrow Transplant 2007:3: 1477-1486.
17. Clio PS, Messina DJ, Hirsh EL, et al. Immunogenicity of umbilical cord tissue derived cells. Blood 2008;11:430-438
18. Weiss ML, Mitchell KE, HIx JE, et al. Transplantation of porcine umbilical, cord matrix cells into the rat brain. Exp Neurol 2003;182:288-299