Soluble CD14 acts as a negative regulator of human T cell activation and function

European Journal of Immunology

Volumn 29, Issue 1, 1999, Pages 265-276

  Rey Nores, Julia E ^a   Bensussan, Armand ^b   Vita, Natalio ^c   Stelter, Felix ^d   Arias, Mauricio A ^a   Jones, Matthew ^a   Lefort, Sylvie ^c   Borysiewicz, Leszek K ^a   Ferrara, Pascual ^c   Labéta, Mario O ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b FACULTÉ DE MÉDECINE   (France)

^c SANOFI   (France)

^d UNIVERSITY OF GREIFSWALD   (Germany)

Author keywords

CD14; Cellular activation; Negative regulation; T lymphocytes

Indexed keywords

CD14 ANTIGEN; CD3 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; CYTOKINE; GAMMA INTERFERON; INHIBITOR PROTEIN; INTERLEUKIN 2; INTERLEUKIN 4;

ANIMAL CELL; ARTICLE; BIOTINYLATION; CELL CLONE; CELL DEATH; CELL PROLIFERATION; CONTROLLED STUDY; HELPER CELL; HUMAN; HUMAN CELL; INTERNALIZATION; LYMPHOCYTE FUNCTION; MONONUCLEAR CELL; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

EID: 0032895776     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-4141(199901)29:01<265::AID-IMMU265>3.0.CO;2-G     Document Type: Article

References (19)

1. Babbitt, B. P., Allen, P. M., Matsueda, G., Haber, E. and Unanue, E., Binding of immunogenic peptides to Ia histocompatibility molecules. Nature 1985. 317: 359-361.
2. Linsley, P. S., Brady, W., Grosmaire, L., Aruffo, A., Damle, N. K. and Ledbetter, J. A., Binding of the B cell activation antigen B7 to CD28 costimulates T cell proliferation and interleukin 2 mRNA accumulation. J. Exp. Med. 1991. 173: 721-730.
3. Waterhouse, P., Marengère, L. E., Mittrücker, H.-W. and Mak, T. W., CTLA-4, a negative regulator of T-lymphocyte activation. Immunol. Rev. 1996. 153: 183-207.
4. Linsley, P. S., Bradshaw, J., Urnes, M., Grosmaire, L. and Ledbetter, J. A., CD28 engagement by B7/BB-1 induces transient down-regulation of CD28 synthesis and prolonged unresponsiveness to CD28 signaling. J. Immunol. 1993. 150: 3161-3169.
5. Ziegler-Heitbrock, H. W. L. and Ulevitch, R. J., CD14: cell surface receptor and differentiation marker, Immunol. Today. 1993. 14: 121-125.
6. Bazil, V., Horejsi, V., Baudis, M., Kristofova, H., Strominger, J. L., Kostka, W. and Hilgert, I., Biochemical characterization of a soluble form of the 53-kDa monocyte surface antigen. Eur. J. Immunol. 1986. 16: 1583-1589.
7. Labéta, M. O., Durieux, J.-J., Fernandez, N., Herrman, R. and Ferrara, P., Release from a human monocyte-like cell line of two different soluble forms of the lipopolysaccharide receptor, CD14. Eur. J. Immunol. 1993. 23: 2144-2151.
8. Durieux, J.-J., Vita, N., Popescu, O., Guette, F., Calzada-Wack, J., Munker, R., Schmidt, R., Lupker, J., Ferrara, P., Ziegler-Heitbrock, H. W. L. and Labéta, M. O., The two soluble forms of the lipopolysaccharide receptor, CD14. Characterization and release by normal human monocytes. Eur. J. Immunol. 1994. 24: 2006-2012.
9. Ulevitch, R. J. and Tobias, P. S., Receptor-dependent mechanisms of cell stimulation by bacterial endotoxin. Annu. Rev. Immunol. 1995. 13: 437-457.
10. Lue, K.-H., Lauener, R. P., Winchester, R. J., Geha, R. S. and Vercelli, D., Engagement of CD14 on human monocytes terminates T cell proliferation by delivering a negative signal to T cells. J. Immunol. 1991. 147: 1134-1138.
11. May, M. and Ghosh, S., Signal transduction through NF-B. Immunol. Today 1998. 19: 80-88.
12. Cantrell, D. A. and Smith, K. A., The interleukin-2 T cell system: a new cell growth model. Science 1984. 224: 1312-1316.
13. Seder, R. A., Germain, R. N., Linsley, P. S. and Paul, W. E., CD28-mediated costimulation of interleukin 2 (IL-2) production plays a critical role in T cell priming for IL-4 and interferon gamma production. J. Exp. Med. 1994. 179: 299-304.
14. Vita, N., Lefort, S., Sozzani, P., Reeb, R., Richards, S., Borysiewicz, L. K., Ferrara, P. and Labéta, M. O., Detection and biochemical characteristics of the receptor for complexes of soluble CD14 and bacterial lipopolysaccharide. J. Immunol. 1997. 158: 3457-3462.
15. Tough, D. F., Sun, S. and Sprent, J., T cell stimulation in vivo by lipopolysaccharide (LPS). J. Exp. Med. 1997. 185: 2089-2094.
16. Devitt, A., Moffatt, O. D., Raykundalia, Ch., Capra, J. D., Simmons, D. L. and Gregory, C. D., Human CD14 mediates recognition and phagocytosis of apoptotic cells. Nature 1998. 392: 505-509.
17. + T-cell clones infiltrating a cutaneous T-cell lymphoma. Blood 1998. 91: 4331-4341.
18. Bensussan, A., Leca, G., Corvaïa, N. and Boumsell, L., Selective induction of autocytotoxic activity through the CD3 molecule. Eur J. Immunol. 1990. 20: 2615-2619.
19. Stelter, F., Bernheiden, M., Menzel, R., Jack, R. S., Witt, S., Fan, X., Pfister, M. and Schütt, Ch., Mutation of amino acids 39-44 of human CD14 abrogates binding of lipopolysaccharide and Escherichia coli. Eur. J. Biochem. 1997. 243: 100-109.