Mesenchymal stem cells and umbilical cord as sources for schwann cell differentiation: Their potential in peripheral nerve repair

Open Tissue Engineering and Regenerative Medicine Journal

Volumn 4, Issue SPEC. ISSUE 1, 2011, Pages 54-63

  Kuroda, Yasumasa ^a   Kitada, Masaaki ^a   Wakao, Shohei ^a   Dezawa, Mari ^a  

^a TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Bone marrow; Differentiation; Fat tissue; Mesenchymal stem cells; Myelin; Nerve regeneration; Schwann cells; Umbilical cord

Indexed keywords

ADIPOSE DERIVED STEM CELL; CELL ACTIVATION; CELL DIFFERENTIATION; CELL LINEAGE; CELL PROLIFERATION; CELL TRANSDIFFERENTIATION; CELLULAR IMMUNITY; HEMATOPOIETIC STEM CELL; HUMAN; MESENCHYMAL STEM CELL; MESENCHYMAL STEM CELL TRANSPLANTATION; NERVE DEGENERATION; NERVE FIBER DEGENERATION; NERVE FIBER REGENERATION; NERVE INJURY; NERVE REGENERATION; NONHUMAN; PRIORITY JOURNAL; REMYELINIZATION; REVIEW; SCHWANN CELL; UMBILICAL CORD; ADIPOSE TISSUE; BONE MARROW; CELL ISOLATION; CENTRAL NERVOUS SYSTEM; HUMAN CELL; MESODERM; MICROENVIRONMENT; MYELINATION; PERIPHERAL NERVE; PERIPHERAL NERVOUS SYSTEM; REGENERATIVE MEDICINE;

EID: 84855777699     PISSN: None     EISSN: 18750435     Source Type: Journal    
DOI: 10.2174/1875043501104010054     Document Type: Review

References (109)

1. David S, Aguayo AJ. Axonal regeneration after crush injury of rat central nervous system fibres innervating peripheral nerve grafts. J Neurocytol 1985; 14(1): 1-12.
2. So KF, Aguayo AJ. Lengthy regrowth of cut axons from ganglion cells after peripheral nerve transplantation into the retina of adult rats. Brain Res 1985; 328(2): 349-54.
3. Dezawa M, Adachi-Usami E. Role of Schwann cells in retinal ganglion cell axon regeneration. Prog Retin Eye Res 2000; 19(2): 171-204.
4. Martini R. Expression and functional roles of neural cell surface molecules and extracellular matrix components during development and regeneration of peripheral nerves. J Neurocytol 1994; 23(1): 1-28.
5. Hall S. Nerve repair: a neurobiologist's view. J Hand Surg Br 2001; 26(2): 129-36.
6. Barrette B, Hebert MA, Filali M, et al. Requirement of myeloid cells for axon regeneration. J Neurosci 2008; 28(38): 9363-76.
7. Shen YJ, DeBellard ME, Salzer JL, Roder J, Filbin MT. Myelinassociated glycoprotein in myelin and expressed by Schwann cells inhibits axonal regeneration and branching. Mol Cell Neurosci 1998; 12(1-2): 79-91.
8. Llorens F, Gil V, del Rio JA. Emerging functions of myelinassociated proteins during development, neuronal plasticity, and neurodegeneration. FASEB J 2011; 25(2): 463-75.
9. Buffo A, Rite I, Tripathi P, et al. Origin and progeny of reactive gliosis: A source of multipotent cells in the injured brain. Proc Natl Acad Sci USA 2008; 105(9): 3581-6.
10. Zorner B, Schwab ME. Anti-Nogo on the go: from animal models to a clinical trial. Ann N Y Acad Sci 2010; 1198 (Suppl 1): E22-34.
11. Pekny M, Pekna M. Astrocyte intermediate filaments in CNS pathologies and regeneration. J Pathol 2004; 204(4): 428-37.
12. Bunge MB. Transplantation of purified populations of Schwann cells into lesioned adult rat spinal cord. J Neurol 1994; 242(1 Suppl 1): S36-9.
13. Harvey AR, Plant GW, Tan MM. Schwann cells and the regrowth of axons in the mammalian CNS: a review of transplantation studies in the rat visual system. Clin Exp Pharmacol Physiol 1995; 22(8): 569-79.
14. Ishikawa N, Suzuki Y, Ohta M, et al. Peripheral nerve regeneration through the space formed by a chitosan gel sponge. J Biomed Mater Res A 2007; 83(1): 33-40.
15. Ohta M, Suzuki Y, Chou H, et al. Novel heparin/alginate gel combined with basic fibroblast growth factor promotes nerve regeneration in rat sciatic nerve. J Biomed Mater Res A 2004; 71(4): 661-8.
16. Gu X, Ding F, Yang Y, Liu J. Construction of tissue engineered nerve grafts and their application in peripheral nerve regeneration. Prog Neurobiol 2011; 93(2): 204-30.
17. Ide C. Peripheral nerve regeneration. Neurosci Res 1996; 25(2): 101-21.
18. Dezawa M, Nagano T. Contacts between regenerating axons and the Schwann cells of sciatic nerve segments grafted to the optic nerve of adult rats. J Neurocytol 1993; 22(12): 1103-12.
19. Dezawa M, Kawana K, Adachi-Usami E. The role of Schwann cells during retinal ganglion cell regeneration induced by peripheral nerve transplantation. Invest Ophthalmol Vis Sci 1997; 38(7): 1401-10.
20. Dezawa M, Kawana K, Negishi H, Adachi-Usami E. Glial cells in degenerating and regenerating optic nerve of the adult rat. Brain Res Bull 1999; 48(6): 573-9.
21. Pittenger MF, Mackay AM, Beck SC, et al. Multilineage potential of adult human mesenchymal stem cells. Science 1999; 284(5411):143-7.
22. Dezawa M, Takahashi I, Esaki M, Takano M, Sawada H. Sciatic nerve regeneration in rats induced by transplantation of in vitro differentiated bone-marrow stromal cells. Eur J Neurosci 2001;14(11): 1771-6.
23. Dezawa M, Kanno H, Hoshino M, et al. Specific induction of neuronal cells from bone marrow stromal cells and application for autologous transplantation. J Clin Invest 2004; 113(12): 1701-10.
24. Dezawa M, Ishikawa H, Itokazu Y, et al. Bone marrow stromal cells generate muscle cells and repair muscle degeneration. Science 2005; 309(5732): 314-7.
25. Oyagi S, Hirose M, Kojima M, et al. Therapeutic effect of transplanting HGF-treated bone marrow mesenchymal cells into CCl4-injured rats. J Hepatol 2006; 44(4): 742-8.
26. Wang Y, Zhao L, Hantash BM. Support of human adipose-derived mesenchymal stem cell multipotency by a poloxamer-octapeptide hybrid hydrogel. Biomaterials 2010; 31(19): 5122-30.
27. Troyer DL, Weiss ML. Wharton's jelly-derived cells are a primitive stromal cell population. Stem Cells 2008; 26(3): 591-9.
28. Kingham PJ, Kalbermatten DF, Mahay D, Armstrong SJ, Wiberg M, Terenghi G. Adipose-derived stem cells differentiate into a Schwann cell phenotype and promote neurite outgrowth in vitro. Exp Neurol 2007; 207(2): 267-74.
29. Matsuse D, Kitada M, Kohama M, et al. Human umbilical cordderived mesenchymal stromal cells differentiate into functional Schwann cells that sustain peripheral nerve regeneration. J Neuropathol Exp Neurol 2010; 69(9): 973-85.
30. Soares HD, Chen SC, Morgan JI. Differential and prolonged expression of Fos-lacZ and Jun-lacZ in neurons, glia, and muscle following sciatic nerve damage. Exp Neurol 2001; 167(1): 1-14.
31. Glass JD, Culver DG, Levey AI, Nash NR. Very early activation of m-calpain in peripheral nerve during Wallerian degeneration. J Neurol Sci. 2002; 196(1-2): 9-20.
32. Coleman M. Axon degeneration mechanisms: commonality amid diversity. Nat Rev Neurosci 2005; 6(11): 889-98.
33. Stoll G, Griffin JW, Li CY, Trapp BD. Wallerian degeneration in the peripheral nervous system: participation of both Schwann cells and macrophages in myelin degradation. J Neurocytol 1989; 18(5): 671-83.
34. Bruck W. The role of macrophages in Wallerian degeneration. Brain Pathol 1997; 7(2): 741-52.
35. Stoll G, Muller HW. Nerve injury, axonal degeneration and neural regeneration: basic insights. Brain Pathol 1999; 9(2): 313-25.
36. Monk KR, Wu J, Williams JP, et al. Mast cells can contribute to axon-glial dissociation and fibrosis in peripheral nerve. Neuron Glia Biol 2007; 3(3): 233-44.
37. Zuo Y, Perkins NM, Tracey DJ, Geczy CL. Inflammation and hyperalgesia induced by nerve injury in the rat: a key role of mast cells. Pain 2003; 105(3): 467-79.
38. Moalem G, Xu K, Yu L. T lymphocytes play a role in neuropathic pain following peripheral nerve injury in rats. Neuroscience 2004; 129(3): 767-77.
39. Griffin JW, George R, Ho T. Macrophage systems in peripheral nerves. A review. J Neuropathol Exp Neurol 1993; 52(6): 553-60.
40. Monaco S, Gehrmann J, Raivich G, Kreutzberg GW. MHCpositive, ramified macrophages in the normal and injured rat peripheral nervous system. J Neurocytol. 1992; 21(9): 623-34.
41. Dijkstra CD, Damoiseaux JG. Macrophage heterogeneity established by immunocytochemistry. Prog Histochem Cytochem 1993; 27(2): 1-65.
42. Taskinen HS, Roytta M. The dynamics of macrophage recruitment after nerve transection. Acta Neuropathol 1997; 93(3): 252-9.
43. Mueller M, Leonhard C, Wacker K, et al. Macrophage response to peripheral nerve injury: the quantitative contribution of resident and hematogenous macrophages. Lab Invest 2003; 83(2): 175-85.
44. Omura T, Omura K, Sano M, Sawada T, Hasegawa T, Nagano A. Spatiotemporal quantification of recruit and resident macrophages after crush nerve injury utilizing immunohistochemistry. Brain Res 2005; 1057(1-2): 29-36.
45. Gillen C, Jander S, Stoll G. Sequential expression of mRNA for proinflammatory cytokines and interleukin-10 in the rat peripheral nervous system: comparison between immune-mediated demyelination and Wallerian degeneration. J Neurosci Res 1998; 51(4): 489-96.
46. Tofaris GK, Patterson PH, Jessen KR, Mirsky R. Denervated Schwann cells attract macrophages by secretion of leukemia inhibitory factor (LIF) and monocyte chemoattractant protein-1 in a process regulated by interleukin-6 and LIF. J Neurosci 2002; 22(15): 6696-703.
47. Taskinen HS, Roytta M. Increased expression of chemokines (MCP-1, MIP-1alpha, RANTES) after peripheral nerve transection. J Peripher Nerv Syst. 2000; 5(2): 75-81.
48. Toews AD, Barrett C, Morell P. Monocyte chemoattractant protein 1 is responsible for macrophage recruitment following injury to sciatic nerve. J Neurosci Res 1998; 53(2): 260-7.
49. Lindholm D, Heumann R, Meyer M, Thoenen H. Interleukin-1 regulates synthesis of nerve growth factor in non-neuronal cells of rat sciatic nerve. Nature 1987; 330(6149): 658-9.
50. Bolin LM, Shooter EM. Neurons regulate Schwann cell genes by diffusible molecules. J Cell Biol 1993; 123(1): 237-43.
51. Martinez AM. Distribution of sodium and potassium channels as well as myelin associated glycoprotein (MAG) during the early stages of Wallerian degeneration. J Submicrosc Cytol Pathol 1999; 31(1): 73-81.
52. Abe K, Namikawa K, Honma M, et al. Inhibition of Ras extracellular-signal-regulated kinase (ERK) mediated signaling promotes ciliary neurotrophic factor (CNTF) expression in Schwann cells. J Neurochem 2001; 77(2): 700-3.
53. Jander S, Bussini S, Neuen-Jacob E, et al. Osteopontin: a novel axon-regulated Schwann cell gene. J Neurosci Res 2002; 67(2): 156-66.
54. Dubovy P. Wallerian degeneration and peripheral nerve conditions for both axonal regeneration and neuropathic pain induction. Ann Anat 2011; 193(4): 267-75.
55. Goldberg JL, Barres BA. The relationship between neuronal survival and regeneration. Annu Rev Neurosci 2000; 23: 579-612.
56. Lonze BE, Riccio A, Cohen S, Ginty DD. Apoptosis, axonal growth defects, and degeneration of peripheral neurons in mice lacking CREB. Neuron 2002; 34(3): 371-85.
57. Chernousov MA, Carey DJ. Schwann cell extracellular matrix molecules and their receptors. Histol Histopathol 2000; 15(2): 593-601.
58. Zhang Y, Roslan R, Lang D, Schachner M, Lieberman AR, Anderson PN. Expression of CHL1 and L1 by neurons and glia following sciatic nerve and dorsal root injury. Mol Cell Neurosci 2000; 16(1): 71-86.
59. Dezawa M, Mutoh T, Dezawa A, Ishide T. Tight junctions between the axon and Schwann cell during PNS regeneration. Neuroreport 1996; 7(11): 1829-32.
60. Kawate K, Yajima H, Ohgushi H, et al. Tissue-engineered approach for the treatment of steroid-induced osteonecrosis of the femoral head: transplantation of autologous mesenchymal stem cells cultured with beta-tricalcium phosphate ceramics and free vascularized fibula. Artif Organs 2006; 30(12): 960-2.
61. Schachinger V, Erbs S, Elsasser A, et al. Intracoronary bone marrow-derived progenitor cells in acute myocardial infarction. N Engl J Med 2006; 355(12): 1210-21.
62. Makino S, Fukuda K, Miyoshi S, et al. Cardiomyocytes can be generated from marrow stromal cells in vitro. J Clin Invest 1999; 103(5): 697-705.
63. Spees JL, Olson SD, Ylostalo J, et al. Differentiation, cell fusion, and nuclear fusion during ex vivo repair of epithelium by human adult stem cells from bone marrow stroma. Proc Natl Acad Sci USA 2003; 100(5): 2397-402.
64. Kuroda Y, Kitada M, Wakao S, et al. Unique multipotent cells in adult human mesenchymal cell populations. Proc Natl Acad Sci USA 2010; 107(19): 8639-43.
65. Mimura T, Dezawa M, Kanno H, Sawada H, Yamamoto I. Peripheral nerve regeneration by transplantation of bone marrow stromal cell-derived Schwann cells in adult rats. J Neurosurg 2004; 101(5): 806-12.
66. Peng J, Wang Y, Zhang L, et al. Human umbilical cord Wharton's jelly-derived mesenchymal stem cells differentiate into a Schwanncell phenotype and promote neurite outgrowth in vitro. Brain Res Bull 2011; 84(3): 235-43.
67. Jiang TM, Yang ZJ, Kong CZ, Zhang HT. Schwann-like cells can be induction from human nestin-positive amniotic fluid mesenchymal stem cells. In vitro Cell Dev Biol Anim 2010; 46(9): 793-800.
68. Jiang L, Zhu JK, Liu XL, Xiang P, Hu J, Yu WH. Differentiation of rat adipose tissue-derived stem cells into Schwann-like cells in vitro. Neuroreport 2008; 19(10): 1015-9.
69. Kaewkhaw R, Scutt AM, Haycock JW. Anatomical site influences the differentiation of adipose-derived stem cells for Schwann-cell phenotype and function. Glia 2011; 59(5): 734-49.
70. Brohlin M, Mahay D, Novikov LN, et al. Characterisation of human mesenchymal stem cells following differentiation into Schwann cell-like cells. Neurosci Res 2009; 64(1): 41-9.
71. Mahay D, Terenghi G, Shawcross SG. Schwann cell mediated trophic effects by differentiated mesenchymal stem cells. Exp Cell Res 2008; 314(14): 2692-701.
72. Faroni A, Mantovani C, Shawcross SG, Motta M, Terenghi G, Magnaghi V. Schwann-like adult stem cells derived from bone marrow and adipose tissue express gamma-aminobutyric acid type B receptors. J Neurosci Res 2011.
73. Wang X, Luo E, Li Y, Hu J. Schwann-like mesenchymal stem cells within vein graft facilitate facial nerve regeneration and remyelination. Brain Res 2011; 1383: 71-80.
74. Ao Q, Fung CK, Tsui AY, et al. The regeneration of transected sciatic nerves of adult rats using chitosan nerve conduits seeded with bone marrow stromal cell-derived Schwann cells. Biomaterials 2011; 32(3): 787-96.
75. Krampera M, Marconi S, Pasini A, et al. Induction of neural-like differentiation in human mesenchymal stem cells derived from bone marrow, fat, spleen and thymus. Bone 2007; 40(2): 382-90.
76. Lin W, Chen X, Wang X, Liu J, Gu X. Adult rat bone marrow stromal cells differentiate into Schwann cell-like cells in vitro. In vitro Cell Dev Biol Anim 2008; 44(1-2): 31-40.
77. Shimizu S, Kitada M, Ishikawa H, Itokazu Y, Wakao S, Dezawa M. Peripheral nerve regeneration by the in vitro differentiatedhuman bone marrow stromal cells with Schwann cell property. Biochem Biophys Res Commun 2007; 359(4): 915-20.
78. Wakao S, Hayashi T, Kitada M, et al. Long-term observation of auto-cell transplantation in non-human primate reveals safety and efficiency of bone marrow stromal cell-derived Schwann cells in peripheral nerve regeneration. Exp Neurol 2010; 223(2): 537-47.
79. Bongso A, Fong CY, Gauthaman K. Taking stem cells to the clinic: Major challenges. J Cell Biochem 2008; 105(6): 1352-60.
80. Can A, Karahuseyinoglu S. Concise review: human umbilical cord stroma with regard to the source of fetus-derived stem cells. Stem Cells 2007; 25(11): 2886-95.
81. Wu KH, Zhou B, Lu SH, et al. In vitro and in vivo differentiation of human umbilical cord derived stem cells into endothelial cells. J Cell Biochem 2007; 100(3): 608-16.
82. Conconi MT, Burra P, Di Liddo R, et al. CD105(+) cells from Wharton's jelly show in vitro and in vivo myogenic differentiative potential. Int J Mol Med 2006; 18(6): 1089-96.
83. Fu YS, Shih YT, Cheng YC, Min MY. Transformation of human umbilical mesenchymal cells into neurons in vitro. J Biomed Sci 2004; 11(5): 652-60.
84. Nishiyama N, Miyoshi S, Hida N, et al. The significant cardiomyogenic potential of human umbilical cord blood-derived mesenchymal stem cells in vitro. Stem Cells 2007; 25(8): 2017-24.
85. Mitchell KE, Weiss ML, Mitchell BM, et al. Matrix cells from Wharton's jelly form neurons and glia. Stem Cells 2003; 21(1): 50-60.
86. Anzalone R, Lo Iacono M, Loria T, et al. Wharton's jelly mesenchymal stem cells as candidates for beta cells regeneration: extending the differentiative and immunomodulatory benefits of adult mesenchymal stem cells for the treatment of type 1 diabetes. Stem Cell Rev 2011; 7(2): 342-63.
87. Anzalone R, Lo Iacono M, Corrao S, et al. New emerging potentials for human Wharton's jelly mesenchymal stem cells: immunological features and hepatocyte-like differentiative capacity. Stem Cells Dev 2010; 19(4): 423-38.
88. Xu Q, Zhang HT, Liu K, et al. In vitro and in vivo magnetic resonance tracking of Sinerem-labeled human umbilical mesenchymal stromal cell-derived Schwann cells. Cell Mol Neurobiol 2011; 31(3): 365-75.
89. Gimble J, Guilak F. Adipose-derived adult stem cells: isolation, characterization, and differentiation potential. Cytotherapy 2003; 5(5): 362-9.
90. Gimble JM, Katz AJ, Bunnell BA. Adipose-derived stem cells for regenerative medicine. Circ Res 2007; 100(9): 1249-60.
91. Puglisi MA, Saulnier N, Piscaglia AC, Tondi P, Agnes S, Gasbarrini A. Adipose tissue-derived mesenchymal stem cells and hepatic differentiation: old concepts and future perspectives. Eur Rev Med Pharmacol Sci 2011; 15(4): 355-64.
92. Baer PC. Adipose-Derived Stem Cells and Their Potential to Differentiate into the Epithelial Lineage. Stem Cells Dev. 2011.
93. Radtke C, Schmitz B, Spies M, Kocsis JD, Vogt PM. Peripheral glial cell differentiation from neurospheres derived from adipose mesenchymal stem cells. Int J Dev Neurosci 2009; 27(8): 817-23.
94. Wei Y, Gong K, Zheng Z, et al. Schwann-like cell differentiation of rat adipose-derived stem cells by indirect co-culture with Schwann cells in vitro. Cell Prolif 2010; 43(6): 606-16.
95. Hung SC, Cheng H, Pan CY, Tsai MJ, Kao LS, Ma HL. In vitro differentiation of size-sieved stem cells into electrically active neural cells. Stem Cells 2002; 20(6): 522-9.
96. Neshati Z, Matin MM, Bahrami AR, Moghimi A. Differentiation of mesenchymal stem cells to insulin-producing cells and their impact on type 1 diabetic rats. J Physiol Biochem 2010; 66(2): 181-7.
97. Johnson JE, Zimmerman K, Saito T, Anderson DJ. Induction and repression of mammalian achaete-scute homologue (MASH) gene expression during neuronal differentiation of P19 embryonal carcinoma cells. Development 1992; 114(1): 75-87.
98. Takahashi J, Palmer TD, Gage FH. Retinoic acid and neurotrophins collaborate to regulate neurogenesis in adult-derived neural stem cell cultures. J Neurobiol 1999; 38(1): 65-81.
99. von Holst A, Rodriguez-Tebar A, Michaille JJ, et al. Retinoic acidmediated increase in TrkA expression is sufficient to elicit NGFdependent survival of sympathetic neurons. Mol Cell Neurosci 1995; 6(3): 185-98.
100. Jessen KR, Mirsky R. The origin and development of glial cells in peripheral nerves. Nat Rev Neurosci 2005; 6(9): 671-82.
101. Chaudhary LR, Avioli LV. Activation of extracellular signalregulated kinases 1 and 2 (ERK1 and ERK2) by FGF-2 and PDGFBB in normal human osteoblastic and bone marrow stromal cells: differences in mobility and in-gel renaturation of ERK1 in human, rat, and mouse osteoblastic cells. Biochem Biophys Res Commun 1997; 238(1): 134-9.
102. Davis JB, Stroobant P. Platelet-derived growth factors and fibroblast growth factors are mitogens for rat Schwann cells. J Cell Biol 1990; 110(4): 1353-60.
103. Kim HA, Ratner N, Roberts TM, Stiles CD. Schwann cell proliferative responses to cAMP and Nf1 are mediated by cyclin D1. J Neurosci 2001; 21(4): 1110-6.
104. McKenzie IA, Biernaskie J, Toma JG, Midha R, Miller FD. Skinderived precursors generate myelinating Schwann cells for the injured and dysmyelinated nervous system. J Neurosci 2006; 26(24): 6651-60.
105. Dezawa M. Systematic neuronal and muscle induction systems in bone marrow stromal cells: the potential for tissue reconstruction in neurodegenerative and muscle degenerative diseases. Med Mol Morphol 2008; 41(1): 14-9.
106. McGuirk JP, Weiss ML. Promising cellular therapeutics for prevention or management of graft-versus-host disease (a review). Placenta 2011; 32(Suppl 4): 5304-10.
107. Kamada T, Koda M, Dezawa M, et al. Transplantation of human bone marrow stromal cell-derived Schwann cells reduces cystic cavity and promotes functional recovery after contusion injury of adult rat spinal cord. Neuropathology 2011; 31(1): 48-58.
108. Kamada T, Koda M, Dezawa M, et al. Transplantation of bone marrow stromal cell-derived Schwann cells promotes axonal regeneration and functional recovery after complete transection of adult rat spinal cord. J Neuropathol Exp Neurol 2005; 64(1): 37-45.
109. Someya Y, Koda M, Dezawa M, et al. Reduction of cystic cavity, promotion of axonal regeneration and sparing, and functional recovery with transplanted bone marrow stromal cell-derived Schwann cells after contusion injury to the adult rat spinal cord. J Neurosurg Spine 2008; 9(6): 600-10.