Neuroprotective Effects of Raloxifene on Aβ25-35-induced Damages in PC12 Cells via Mitogen-activated Protein Kinase Signaling Pathway

Journal of Reproduction and Contraception

Volumn 23, Issue 1, 2012, Pages 1-16

  Dai, Xue ^a   Wu, Jie ^b   Sun, Xue ping ^b   Gao, Li ^b   Cui, Yu gui ^b   Liu, Jia yin ^b  

^a THE SECOND AFFILIATED HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

^b NANJING MEDICAL UNIVERSITY   (China)

Author keywords

A 25 35; Alzheimer's disease; Apoptosis; MAPK signaling pathway; Mitogen activated protein kinase (MAPK); Raloxifene

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; AMYLOID BETA PROTEIN[25-35]; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; CASPASE 9; FLUORESCEIN ISOTHIOCYANATE; LIPOCORTIN 5; MITOGEN ACTIVATED PROTEIN KINASE; RALOXIFENE;

ANIMAL CELL; ANIMAL CELL CULTURE; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL COUNT; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; FLOW CYTOMETRY; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

EID: 84878958871     PISSN: 10017844     EISSN: 18767966     Source Type: Journal    
DOI: 10.1016/S1001-7844(13)60001-2     Document Type: Article

References (49)

1. Panza F, D'Introno A, Colacicco AM, et al. Cognitive frailty: Predementia syndrome and vascular risk factors. Neurobiol Aging 2006, 27(7):933-940.
2. Bayer TA, Wirths O Intracellular accumulation of amyloid-beta- a predictor for synaptic dysfunction and neuron loss in Alzheimer's disease. Front Aging Neurosci 2010, 2:8.
3. Xu J, Chen S, Ku G, et al. Amyloid beta peptide-induced cerebral endothelial cell death involves mitochondrial dysfunction and caspase activation. J Cereb Blood Flow Metab 2001, 21(6):702-710.
4. Tan Z, Shi L, Schreiber SS Differential expression of redox factor-1 associated with beta-amyloid-mediated neurotoxicity. Open Neurosci J 2009, 3(1):26-34.
5. Movsesyan VA, Stoica BA, Faden AI MGLuR5 activation reduces beta-amyloid-induced cell death in primary neuronal cultures and attenuates translocation of cytochrome C and apoptosis-inducing factor. J Neurochem 2004, 89(6):1528-1536.
6. Neal-Perry G, Nejat E, Dicken C The neuroendocrine physiology of female reproductive aging: an update. Maturitas 2010, 67(1):34-38.
7. Cholerton B, Gleason CE, Baker LD, et al. Estrogen and Alzheimer's disease: the story so far. Drugs Aging 2002, 19(6):405-427.
8. Voytko ML, Murray R, Higgs CJ Executive function and attention are preserved in older surgically menopausal monkeys receiving estrogen or estrogen plus progesterone. J Neurosci 2009, 29(33):10362-10370.
9. Raval AP, Saul I, Dave KR, et al. Pretreatment with a single estradiol-17beta bolus activates cyclic-AMP response element binding protein and protects CA1 neurons against global cerebral ischemia. Neuroscience 2009, 160(2):307-318.
10. Sales S, Ureshino RP, Pereira RT, et al. Effects of 17beta-estradiol replacement on the apoptotic effects caused by ovariectomy in the rat hippocampus. Life Sci 2010, 86(21-22):832-838.
11. Rattanajarasroj S, Unchern S Comparable attenuation of Abeta (25-35)-induced neurotoxicity by quercitrin and 17 beta-estradiol in cultured rat hippocampal neurons. Neurochem Res 2010, 35(8):1196-1205.
12. Kim EK, Choi EJ Pathological roles of MAPK signaling pathways in human diseases. Biochim Biophys Acta 2010, 1802(4):396-405.
13. Matos M, Augusto E, Oliveira CR, et al. Amyloid-beta peptide decreases glutamate uptake in cultured astrocytes: involvement of oxidative stress and mitogen-activated protein kinase cascades. Neuroscience 2008, 156(4):898-910.
14. Origlia N, Righi M, Capsoni S, et al. Receptor for advanced glycation end product-dependent activation of p38 mitogen-activated protein kinase contributes to amyloid-beta-mediated cortical synaptic dysfunction. J Neurosci 2008, 28(13):3521-3530.
15. Jover-Mengual T, Zukin RS, Etgen AM MAPK signaling is critical to estradiol protection of CA1 neurons in global ischemia. Endocrinology 2007, 148(3):1131-1143.
16. Valles SL, Borras C, Gambini J, et al. Oestradiol or genistein rescues neurons from amyloid beta-induced cell death by inhibiting activation of p38. Aging Cell 2008, 7(1):112-118.
17. Orrenius S Mitochondrial regulation of apoptotic cell death. Toxicol Lett 2004, 149(1-3):19-23.
18. Hauptmann S, Scherping I, Drose S, et al. Mitochondrial dysfunction: an early event in Alzheimer pathology accumulates with age in AD transgenic mice. Neurobiol Aging 2009, 30(10):1574-1586.
19. Colell A, Fernandez A, Fernandez-Checa JC Mitochondria, cholesterol and amyloid beta peptide: a dangerous trio in Alzheimer disease. J Bioenerg Biomembr 2009, 41(5):417-423.
20. Jin H, Liu T, Wang WX, et al. Protective effects of [Gly14]-Humanin on beta-amyloid-induced PC12 cell death by preventing mitochondrial dysfunction. Neurochem Int 2010, 56(3):417-423.
21. Atlante A, Bobba A, Paventi G, et al. Genistein and daidzein prevent low potassium-dependent apoptosis of cerebellar granule cells. Biochem Pharmacol 2010, 79(5):758-767.
22. Guo J, Krause DN, Horne J, et al. Estrogen-receptor mediated protection of cerebral endothelial cell viability and mitochondrial function after ischemic insult in vitro. J Cereb Blood Flow Metab 2010, 30(3):545-554.
23. Kozlov AV, Duvigneau JC, Hyatt TC, et al. Effect of estrogen on mitochondrial function and intracellular stress markers in rat liver and kidney following trauma-hemorrhagic shock and prolonged hypotension. Mol Med 2010, 16(7-8):254-261.
24. Moskowitz D A comprehensive review of the safety and efficacy of bioidentical hormones for the management of menopause and related health risks. Altern Med Rev 2006, 11(3):208-223.
25. Nogueira LT, da SBB Effects of raloxifene on the mammary epithelium of female rats in persistent estrus. Gynecol Endocrinol 2009, 25(6):357-361.
26. Yaffe K, Krueger K, Cummings SR, et al. Effect of raloxifene on prevention of dementia and cognitive impairment in older women: the Multiple Outcomes of Raloxifene Evaluation (MORE) randomized trial. Am J Psychiatry 2005, 162(4):683-690.
27. Wu J, Zhu Y, Wu J Effects of estrogen and estrogenic compounds on cognition in ovariectomized rats. Climacteric 2008, 11(3):212-220.
28. Ma R, Xiong N, Huang C, et al. Erythropoietin protects PC12 cells from beta-amyloid (25-35)-induced apoptosis via PI3K/Akt signaling pathway. Neuropharmacology 2009, 56(6-7):1027-1034.
29. Kubo T, Nishimura S, Kumagae Y, et al. In vivo conversion of racemized beta-amyloid ([D-Ser 26] A beta 1-40) to truncated and toxic fragments ([D-Ser 26]A beta 25-35/40) and fragment presence in the brains of Alzheimer's patients. J Neurosci Res 2002, 70(3):474-483.
30. Frozza RL, Horn AP, Hoppe JB, et al. A comparative study of beta-amyloid peptides Abeta1-42 and Abeta25-35 toxicity in organotypic hippocampal slice cultures. Neurochem Res 2009, 34(2):295-303.
31. Qin XY, Cheng Y, Cui J, et al. Potential protection of curcumin against amyloid beta induced toxicity on cultured rat prefrontal cortical neurons. Neurosci Lett 2009, 463(2):158-161.
32. Salvioli S, Ardizzoni A, Franceschi C, et al. JC-1, but not DiOC6 (3) or rhodamine 123, is a reliable fluorescent probe to assess delta psi changes in intact cells: implications for studies on mitochondrial functionality during apoptosis. FEBS Lett 1997, 411(1):77-82.
33. Sennepin AD, Charpentier S, Normand T, et al. Multiple reprobing of Western blots after inactivation of peroxidase activity by its substrate, hydrogen peroxide. Anal Biochem 2009, 393(1):129-131.
34. Charlier TD Importance of steroid receptor coactivators in the modulation of steroid action on brain and behavior. Psychoneuroendocrinology 2009, 34(Suppl1):S20-S29.
35. Ball LJ, Levy N, Zhao X, et al. Cell type- and estrogen receptor-subtype specific regulation of selective estrogen receptor modulator regulatory elements. Mol Cell Endocrinol 2009, 299(2):204-211.
36. Weatherman RV, Clegg NJ, Scanlan TS Differential SERM activation of the estrogen receptors (ERalpha and ERbeta) at AP-1 sites. Chem Biol 2001, 8(5):427-436.
37. Nettles KW, Greene GL Ligand control of coregulator recruitment to nuclear receptors. Annu Rev Physiol 2005, 67:309-333.
38. Vasudevan N, Pfaff DW Non- genomic actions of estrogens and their interaction with genomic actions in the brain. Front Neuroendocrinol 2008, 29(2):238-257.
39. Sirianni R, Chimento A, Ruggiero C, et al. The novel estrogen receptor, G protein-coupled receptor 30, mediates the proliferative effects induced by 17beta-estradiol on mouse spermatogonial GC-1 cell line. Endocrinology 2008, 149(10):5043-5051.
40. Bouchier-Hayes L, Munoz-Pinedo C, Connell S, et al. Measuring apoptosis at the single cell level. Methods 2008, 44(3):222-228.
41. Lopez-Armada MJ, Carames B, Martin MA, et al. Mitochondrial activity is modulated by TNF alpha and IL-1beta in normal human chondrocyte cells. Osteoarthritis Cartilage 2006, 14(10):1011-1022.
42. Lebesgue D, Chevaleyre V, Zukin RS, et al. Estradiol rescues neurons from global ischemia-induced cell death: multiple cellular pathways of neuroprotection. Steroids 2009, 74(7):555-561.
43. Miloso M, Scuteri A, Foudah D, et al. MAPKs as mediators of cell fate determination: an approach to neurodegenerative diseases. Curr Med Chem 2008, 15(6):538-548.
44. 2+ efflux from rat hepatocytes. J Biol Chem 2010, 285(35):27201-27212.
45. Liu CJ, Lo JF, Kuo CH, et al. Akt Mediates 17beta-estradiol and/or estrogen receptor alpha inhibition of lps-induced tumor necrosis factor-alpha expression and myocardial cell apoptosis by suppressing the JNK1/2-NFkappaB pathway. J Cell Mol Med 2009, 13(9B):3655-3667.
46. Yu J, Eto M, Akishita M, et al. A selective estrogen receptor modulator inhibits TNF-alpha-induced apoptosis by activating ERK1/2 signaling pathway in vascular endothelial cells. Vascul Pharmacol 2009, 51(1):21-28.
47. Barone FC, Irving EA, Ray AM, et al. SB 239063, a second-generation p38 mitogen-activated protein kinase inhibitor, reduces brain injury and neurological deficits in cerebral focal ischemia. J Pharmacol Exp Ther 2001, 296(2):312-321.
48. Tai LM, Holloway KA, Male DK, et al. Amyloid-beta-induced occludin down-regulation and increased permeability in human brain endothelial cells is mediated by MAPK activation. J Cell Mol Med 2010, 14(5):1101-1112.
49. Munoz L, Ranaivo HR, Roy SM, et al. A novel p38 alpha MAPK inhibitor suppresses brain proinflammatory cytokine up-regulation and attenuates synaptic dysfunction and behavioral deficits in an Alzheimer's disease mouse model. J Neuroinflammation 2007, 4:21.