메뉴 건너뛰기




Volumn 57, Issue 6, 2013, Pages 962-973

Metabolomic fingerprint in patients at high risk of cardiovascular disease by cocoa intervention

Author keywords

Carnitine metabolism; Cocoa intervention; Metabolomics; Polyphenols metabolism; Tyrosine O sulfate

Indexed keywords

BIOLOGICAL MARKER; PLANT MEDICINAL PRODUCT;

EID: 84878925814     PISSN: 16134125     EISSN: 16134133     Source Type: Journal    
DOI: 10.1002/mnfr.201200736     Document Type: Article
Times cited : (47)

References (63)
  • 1
    • 48949118698 scopus 로고    scopus 로고
    • Metabolomics: applications to food science and nutrition research
    • Wishart, D., Metabolomics: applications to food science and nutrition research. Trends Food Sci. Technol. 2008, 19, 482-493.
    • (2008) Trends Food Sci. Technol. , vol.19 , pp. 482-493
    • Wishart, D.1
  • 2
    • 84868268623 scopus 로고    scopus 로고
    • The relationship between BMI and metabolomic profiles: a focus on amino acids
    • Morris, C., O'Grada, C., Ryan, M., Roche, H. M. et al., The relationship between BMI and metabolomic profiles: a focus on amino acids. Proc. Nutr. Soc. 2012, 71, 634-638.
    • (2012) Proc. Nutr. Soc. , vol.71 , pp. 634-638
    • Morris, C.1    O'Grada, C.2    Ryan, M.3    Roche, H.M.4
  • 3
    • 70350008025 scopus 로고    scopus 로고
    • The complex links between dietary phytochemicals and human health deciphered by metabolomics
    • Manach, C., Hubert, J., Llorach, R., Scalbert, A., The complex links between dietary phytochemicals and human health deciphered by metabolomics. Mol. Nutr. Food Res. 2009, 53, 1303-1315.
    • (2009) Mol. Nutr. Food Res. , vol.53 , pp. 1303-1315
    • Manach, C.1    Hubert, J.2    Llorach, R.3    Scalbert, A.4
  • 4
    • 84855302031 scopus 로고    scopus 로고
    • Metabolomics for measuring phytochemicals, and assessing human and animal responses to phytochemicals, in food science
    • McGhie, T. K., Rowan, D. D., Metabolomics for measuring phytochemicals, and assessing human and animal responses to phytochemicals, in food science. Mol. Nutr. Food Res. 2012, 56, 147-158.
    • (2012) Mol. Nutr. Food Res. , vol.56 , pp. 147-158
    • McGhie, T.K.1    Rowan, D.D.2
  • 5
    • 84055216979 scopus 로고    scopus 로고
    • Foodomics: MS-based strategies in modern food science and nutrition
    • Herrero, M., Simo, C., Garcia-Canas, V., Ibanez, E. et al., Foodomics: MS-based strategies in modern food science and nutrition. Mass Spectrom. Rev. 2012, 31, 49-69.
    • (2012) Mass Spectrom. Rev. , vol.31 , pp. 49-69
    • Herrero, M.1    Simo, C.2    Garcia-Canas, V.3    Ibanez, E.4
  • 6
    • 33644599022 scopus 로고    scopus 로고
    • Cocoa intake, blood pressure, and cardiovascular mortality: the Zutphen Elderly Study
    • Buijsse, B., Feskens, E. J., Kok, F. J., Kromhout, D., Cocoa intake, blood pressure, and cardiovascular mortality: the Zutphen Elderly Study. Arch. Intern. Med. 2006, 166, 411-417.
    • (2006) Arch. Intern. Med. , vol.166 , pp. 411-417
    • Buijsse, B.1    Feskens, E.J.2    Kok, F.J.3    Kromhout, D.4
  • 7
    • 0036182939 scopus 로고    scopus 로고
    • Evidence that the antioxidant flavonoids in tea and cocoa are beneficial for cardiovascular health
    • Kris-Etherton, P. M., Keen, C. L., Evidence that the antioxidant flavonoids in tea and cocoa are beneficial for cardiovascular health. Curr. Opin. Lipidol. 2002, 13, 41-49.
    • (2002) Curr. Opin. Lipidol. , vol.13 , pp. 41-49
    • Kris-Etherton, P.M.1    Keen, C.L.2
  • 8
    • 46649098436 scopus 로고    scopus 로고
    • Flavonoids, flavonoid-rich foods, and cardiovascular risk: a meta-analysis of randomized controlled trials
    • Hooper, L., Kroon, P. A., Rimm, E. B., Cohn, J. S. et al., Flavonoids, flavonoid-rich foods, and cardiovascular risk: a meta-analysis of randomized controlled trials. Am. J. Clin. Nutr. 2008, 88, 38-50.
    • (2008) Am. J. Clin. Nutr. , vol.88 , pp. 38-50
    • Hooper, L.1    Kroon, P.A.2    Rimm, E.B.3    Cohn, J.S.4
  • 9
    • 33646072996 scopus 로고    scopus 로고
    • Chocolate and prevention of cardiovascular disease: a systematic review
    • Ding, E. L., Hutfless, S. M., Ding, X., Girotra, S., Chocolate and prevention of cardiovascular disease: a systematic review. Nutr. Metab. (Lond.). 2006, 3, 2-14.
    • (2006) Nutr. Metab. (Lond.). , vol.3 , pp. 2-14
    • Ding, E.L.1    Hutfless, S.M.2    Ding, X.3    Girotra, S.4
  • 10
    • 0034599153 scopus 로고    scopus 로고
    • The effect of cocoa procyanidins on the transcription and secretion of interleukin 1 beta in peripheral blood mononuclear cells
    • Mao, T. K., Powell, J., Van de Water, J., Keen, C. L. et al., The effect of cocoa procyanidins on the transcription and secretion of interleukin 1 beta in peripheral blood mononuclear cells. Life Sci. 2000, 66, 1377-1386.
    • (2000) Life Sci. , vol.66 , pp. 1377-1386
    • Mao, T.K.1    Powell, J.2    Van de Water, J.3    Keen, C.L.4
  • 11
    • 0031149619 scopus 로고    scopus 로고
    • Polyphenols in chocolate, which have antioxidant activity, modulate immune functions in humans in vitro
    • Sanbongi, C., Suzuki, N., Sakane, T., Polyphenols in chocolate, which have antioxidant activity, modulate immune functions in humans in vitro. Cell Immunol. 1997, 177, 129-136.
    • (1997) Cell Immunol. , vol.177 , pp. 129-136
    • Sanbongi, C.1    Suzuki, N.2    Sakane, T.3
  • 12
    • 41549088476 scopus 로고    scopus 로고
    • Daily consumption of a dark chocolate containing flavanols and added sterol esters affects cardiovascular risk factors in a normotensive population with elevated cholesterol
    • Allen, R. R., Carson, L., Kwik-Uribe, C., Evans, E. M. et al., Daily consumption of a dark chocolate containing flavanols and added sterol esters affects cardiovascular risk factors in a normotensive population with elevated cholesterol. J. Nutr. 2008, 138, 725-731.
    • (2008) J. Nutr. , vol.138 , pp. 725-731
    • Allen, R.R.1    Carson, L.2    Kwik-Uribe, C.3    Evans, E.M.4
  • 13
    • 33745792387 scopus 로고    scopus 로고
    • Acute and chronic effects of flavanol-rich cocoa on vascular function in subjects with coronary artery disease: a randomized double-blind placebo-controlled study
    • Farouque, H. M., Leung, M., Hope, S. A., Baldi, M. et al., Acute and chronic effects of flavanol-rich cocoa on vascular function in subjects with coronary artery disease: a randomized double-blind placebo-controlled study. Clin. Sci. (Lond.). 2006, 111, 71-80.
    • (2006) Clin. Sci. (Lond.). , vol.111 , pp. 71-80
    • Farouque, H.M.1    Leung, M.2    Hope, S.A.3    Baldi, M.4
  • 14
    • 33748491694 scopus 로고    scopus 로고
    • Chronic consumption of flavanol-rich cocoa improves endothelial function and decreases vascular cell adhesion molecule in hypercholesterolemic postmenopausal women
    • discussion S206-S179.
    • Wang-Polagruto, J. F., Villablanca, A. C., Polagruto, J. A., Lee, L. et al., Chronic consumption of flavanol-rich cocoa improves endothelial function and decreases vascular cell adhesion molecule in hypercholesterolemic postmenopausal women. J. Cardiovasc. Pharmacol. 2006, 47(Suppl 2), S177-S186; discussion S206-S179.
    • (2006) J. Cardiovasc. Pharmacol. , vol.47 , Issue.SUPPL. 2
    • Wang-Polagruto, J.F.1    Villablanca, A.C.2    Polagruto, J.A.3    Lee, L.4
  • 15
    • 84857892715 scopus 로고    scopus 로고
    • Effects of chocolate, cocoa, and flavan-3-ols on cardiovascular health: a systematic review and meta-analysis of randomized trials
    • Hooper, L., Kay, C., Abdelhamid, A., Kroon, P. A. et al., Effects of chocolate, cocoa, and flavan-3-ols on cardiovascular health: a systematic review and meta-analysis of randomized trials. Am. J. Clin. Nutr. 2012, 95, 740-751.
    • (2012) Am. J. Clin. Nutr. , vol.95 , pp. 740-751
    • Hooper, L.1    Kay, C.2    Abdelhamid, A.3    Kroon, P.A.4
  • 16
    • 84870441709 scopus 로고    scopus 로고
    • Regular consumption of cocoa powder with milk increases HDL cholesterol and reduces oxidized LDL levels in subjects at high-risk of cardiovascular disease
    • Khan, N., Monagas, M., Andres-Lacueva, C., Casas, R. et al., Regular consumption of cocoa powder with milk increases HDL cholesterol and reduces oxidized LDL levels in subjects at high-risk of cardiovascular disease. Nutr. Metab. Cardiovasc. Dis. 2012, 22, 1046-1053.
    • (2012) Nutr. Metab. Cardiovasc. Dis. , vol.22 , pp. 1046-1053
    • Khan, N.1    Monagas, M.2    Andres-Lacueva, C.3    Casas, R.4
  • 17
    • 70350675560 scopus 로고    scopus 로고
    • Effect of cocoa powder on the modulation of inflammatory biomarkers in patients at high risk of cardiovascular disease
    • Monagas, M., Khan, N., Andres-Lacueva, C., Casas, R. et al., Effect of cocoa powder on the modulation of inflammatory biomarkers in patients at high risk of cardiovascular disease. Am. J. Clin. Nutr. 2009, 90, 1144-1150.
    • (2009) Am. J. Clin. Nutr. , vol.90 , pp. 1144-1150
    • Monagas, M.1    Khan, N.2    Andres-Lacueva, C.3    Casas, R.4
  • 18
    • 0000359845 scopus 로고
    • Colorimetry of total phenolics with phosphomolibdicphosphotungstic acid reagent
    • Singleton, V., Rossi, J., Colorimetry of total phenolics with phosphomolibdicphosphotungstic acid reagent. Am. J. Enol. Vitic. 1965, 16, 144-158.
    • (1965) Am. J. Enol. Vitic. , vol.16 , pp. 144-158
    • Singleton, V.1    Rossi, J.2
  • 19
    • 0001533643 scopus 로고
    • Dosage des tannins du vin rouges et détermination du leur structure
    • Ribéreau-Gayon, P., Stonestreet, E., Dosage des tannins du vin rouges et détermination du leur structure. Chim. Anal. 1966, 48, 188-196.
    • (1966) Chim. Anal. , vol.48 , pp. 188-196
    • Ribéreau-Gayon, P.1    Stonestreet, E.2
  • 20
    • 44349124701 scopus 로고    scopus 로고
    • Flavanol and flavonol contents of cocoa powder products: influence of the manufacturing process
    • Andres-Lacueva, C., Monagas, M., Khan, N., Izquierdo-Pulido, M. et al., Flavanol and flavonol contents of cocoa powder products: influence of the manufacturing process. J. Agric. Food Chem. 2008, 56, 3111-3117.
    • (2008) J. Agric. Food Chem. , vol.56 , pp. 3111-3117
    • Andres-Lacueva, C.1    Monagas, M.2    Khan, N.3    Izquierdo-Pulido, M.4
  • 21
    • 9144256952 scopus 로고    scopus 로고
    • Monomeric, oligomeric, and polymeric flavan-3-ol composition of wines and grapes from Vitis vinifera L. Cv. Graciano, Tempranillo, and Cabernet Sauvignon
    • Monagas, M., Gomez-Cordoves, C., Bartolome, B., Laureano, O. et al., Monomeric, oligomeric, and polymeric flavan-3-ol composition of wines and grapes from Vitis vinifera L. Cv. Graciano, Tempranillo, and Cabernet Sauvignon. J. Agric. Food Chem. 2003, 51, 6475-6481.
    • (2003) J. Agric. Food Chem. , vol.51 , pp. 6475-6481
    • Monagas, M.1    Gomez-Cordoves, C.2    Bartolome, B.3    Laureano, O.4
  • 22
    • 70449426567 scopus 로고    scopus 로고
    • An LC-MS-based metabolomics approach for exploring urinary metabolome modifications after cocoa consumption
    • Llorach, R., Urpi-Sarda, M., Jauregui, O., Monagas, M. et al., An LC-MS-based metabolomics approach for exploring urinary metabolome modifications after cocoa consumption. J. Proteome Res. 2009, 8, 5060-5068.
    • (2009) J. Proteome Res. , vol.8 , pp. 5060-5068
    • Llorach, R.1    Urpi-Sarda, M.2    Jauregui, O.3    Monagas, M.4
  • 23
    • 21244447926 scopus 로고    scopus 로고
    • Identification of phosphorylation sites on phosducin-like protein by QTOF mass spectrometry
    • Carter, M. D., Southwick, K., Lukov, G., Willardson, B. M. et al., Identification of phosphorylation sites on phosducin-like protein by QTOF mass spectrometry. J. Biomol. Tech. 2004, 15, 257-264.
    • (2004) J. Biomol. Tech. , vol.15 , pp. 257-264
    • Carter, M.D.1    Southwick, K.2    Lukov, G.3    Willardson, B.M.4
  • 24
    • 41149120242 scopus 로고    scopus 로고
    • Visualization of GC/TOF-MS-based metabolomics data for identification of biochemically interesting compounds using OPLS class models
    • Wiklund, S., Johansson, E., Sjostrom, L., Mellerowicz, E. J. et al., Visualization of GC/TOF-MS-based metabolomics data for identification of biochemically interesting compounds using OPLS class models. Anal. Chem. 2008, 80, 115-122.
    • (2008) Anal. Chem. , vol.80 , pp. 115-122
    • Wiklund, S.1    Johansson, E.2    Sjostrom, L.3    Mellerowicz, E.J.4
  • 25
    • 84868014051 scopus 로고    scopus 로고
    • Crosstalk between above- and belowground herbivores is mediated by minute metabolic responses of the host Arabidopsis thaliana
    • Kutyniok, M., Muller, C., Crosstalk between above- and belowground herbivores is mediated by minute metabolic responses of the host Arabidopsis thaliana. J. Exp. Botany. 2012, 63, 6199-6210.
    • (2012) J. Exp. Botany. , vol.63 , pp. 6199-6210
    • Kutyniok, M.1    Muller, C.2
  • 26
    • 57149116166 scopus 로고    scopus 로고
    • CV-ANOVA for significance testing of PLS and OPLS® models
    • Eriksson, L., Trygg, J., Wold, S., CV-ANOVA for significance testing of PLS and OPLS® models. J. Chemom. 2008, 22, 594-600.
    • (2008) J. Chemom. , vol.22 , pp. 594-600
    • Eriksson, L.1    Trygg, J.2    Wold, S.3
  • 27
    • 84862236609 scopus 로고    scopus 로고
    • Combined multivariate and pathway analyses show that allergen-induced gene expression changes in CD4+ T cells are reversed by glucocorticoids
    • Zhao, Y., Wang, H., Gustafsson, M., Muraro, A. et al., Combined multivariate and pathway analyses show that allergen-induced gene expression changes in CD4+ T cells are reversed by glucocorticoids. PLoS ONE 2012, 7, e39016.
    • (2012) PLoS ONE , vol.7
    • Zhao, Y.1    Wang, H.2    Gustafsson, M.3    Muraro, A.4
  • 28
    • 0036913503 scopus 로고    scopus 로고
    • Rapid and noninvasive diagnosis of the presence and severity of coronary heart disease using 1H-NMR-based metabonomics
    • Brindle, J. T., Antti, H., Holmes, E., Tranter, G. et al., Rapid and noninvasive diagnosis of the presence and severity of coronary heart disease using 1H-NMR-based metabonomics. Nat. Med. 2002, 8, 1439-1444.
    • (2002) Nat. Med. , vol.8 , pp. 1439-1444
    • Brindle, J.T.1    Antti, H.2    Holmes, E.3    Tranter, G.4
  • 29
    • 58849131579 scopus 로고    scopus 로고
    • Application of a 1H nuclear magnetic resonance (NMR) metabolomics approach combined with orthogonal projections to latent structure-discriminant analysis as an efficient tool for discriminating between Korean and Chinese herbal medicines
    • Kang, J., Choi, M. Y., Kang, S., Kwon, H. N. et al., Application of a 1H nuclear magnetic resonance (NMR) metabolomics approach combined with orthogonal projections to latent structure-discriminant analysis as an efficient tool for discriminating between Korean and Chinese herbal medicines. J. Agric. Food Chem. 2008, 56, 11589-11595.
    • (2008) J. Agric. Food Chem. , vol.56 , pp. 11589-11595
    • Kang, J.1    Choi, M.Y.2    Kang, S.3    Kwon, H.N.4
  • 30
    • 80655131083 scopus 로고    scopus 로고
    • Metabolomics unveils urinary changes in subjects with metabolic syndrome following 12-week nut consumption
    • Tulipani, S., Llorach, R., Jauregui, O., Lopez-Uriarte, P. et al., Metabolomics unveils urinary changes in subjects with metabolic syndrome following 12-week nut consumption. J. Proteome Res. 2011, 10, 5047-5058.
    • (2011) J. Proteome Res. , vol.10 , pp. 5047-5058
    • Tulipani, S.1    Llorach, R.2    Jauregui, O.3    Lopez-Uriarte, P.4
  • 32
    • 84866123900 scopus 로고    scopus 로고
    • An accelerated workflow for untargeted metabolomics using the METLIN database
    • Tautenhahn, R., Cho, K., Uritboonthai, W., Zhu, Z. et al., An accelerated workflow for untargeted metabolomics using the METLIN database. Nat. Biotechnol. 2012, 30, 826-828.
    • (2012) Nat. Biotechnol. , vol.30 , pp. 826-828
    • Tautenhahn, R.1    Cho, K.2    Uritboonthai, W.3    Zhu, Z.4
  • 33
    • 77954439868 scopus 로고    scopus 로고
    • MassBank: a public repository for sharing mass spectral data for life sciences
    • Horai, H., Arita, M., Kanaya, S., Nihei, Y. et al., MassBank: a public repository for sharing mass spectral data for life sciences. J. Mass Spectrom. 2010, 45, 703-714.
    • (2010) J. Mass Spectrom. , vol.45 , pp. 703-714
    • Horai, H.1    Arita, M.2    Kanaya, S.3    Nihei, Y.4
  • 34
    • 84858983547 scopus 로고    scopus 로고
    • KEGG for integration and interpretation of large-scale molecular data sets
    • Kanehisa, M., Goto, S., Sato, Y., Furumichi, M. et al., KEGG for integration and interpretation of large-scale molecular data sets. Nucleic Acids Res. 2012, 40, D109-D114.
    • (2012) Nucleic Acids Res. , vol.40
    • Kanehisa, M.1    Goto, S.2    Sato, Y.3    Furumichi, M.4
  • 35
    • 84871877806 scopus 로고    scopus 로고
    • Phenol-Explorer 2.0: a major update of the Phenol-Explorer database integrating data on polyphenol metabolism and pharmacokinetics in humans and experimental animals
    • bas031
    • Rothwell, J. A., Urpi-Sarda, M., Boto-Ordonez, M., Knox, C. et al., Phenol-Explorer 2.0: a major update of the Phenol-Explorer database integrating data on polyphenol metabolism and pharmacokinetics in humans and experimental animals. Database (Oxford) 2012, 2012, bas031.
    • (2012) Database (Oxford) , vol.2012
    • Rothwell, J.A.1    Urpi-Sarda, M.2    Boto-Ordonez, M.3    Knox, C.4
  • 36
    • 16344389891 scopus 로고    scopus 로고
    • PermutMatrix: a graphical environment to arrange gene expression profiles in optimal linear order
    • Caraux, G., Pinloche, S., PermutMatrix: a graphical environment to arrange gene expression profiles in optimal linear order. Bioinformatics. 2005, 21, 1280-1281.
    • (2005) Bioinformatics. , vol.21 , pp. 1280-1281
    • Caraux, G.1    Pinloche, S.2
  • 37
    • 84878942935 scopus 로고    scopus 로고
    • Metabolomics-Fiehn-Lab mass spectrometry mass calculator. Available from
    • Metabolomics-Fiehn-Lab mass spectrometry mass calculator. Available from: http://fiehnlab.ucdavis.edu/staff/kind/Metabolomics/MS-Adduct-Calculator.
  • 38
    • 14944351414 scopus 로고    scopus 로고
    • Structure elucidation of phase II metabolites by tandem mass spectrometry: an overview
    • Levsen, K., Schiebel, H.-M., Behnke, B., Dötzer, R. et al., Structure elucidation of phase II metabolites by tandem mass spectrometry: an overview. J. Chromatogr. A 2005, 1067, 55-72.
    • (2005) J. Chromatogr. A , vol.1067 , pp. 55-72
    • Levsen, K.1    Schiebel, H.-M.2    Behnke, B.3    Dötzer, R.4
  • 39
    • 77952302069 scopus 로고    scopus 로고
    • In silico fragmentation for computer assisted identification of metabolite mass spectra
    • Wolf, S., Schmidt, S., Muller-Hannemann, M., Neumann, S., In silico fragmentation for computer assisted identification of metabolite mass spectra. BMC Bioinformatics 2010, 11, 148-160.
    • (2010) BMC Bioinformatics , vol.11 , pp. 148-160
    • Wolf, S.1    Schmidt, S.2    Muller-Hannemann, M.3    Neumann, S.4
  • 41
    • 0033858353 scopus 로고    scopus 로고
    • The biochemical metabolite screen in the Munich ENU Mouse Mutagenesis Project: determination of amino acids and acylcarnitines by tandem mass spectrometry
    • Rolinski, B., Arnecke, R., Dame, T., Kreischer, J. et al., The biochemical metabolite screen in the Munich ENU Mouse Mutagenesis Project: determination of amino acids and acylcarnitines by tandem mass spectrometry. Mamm. Genome 2000, 11, 547-551.
    • (2000) Mamm. Genome , vol.11 , pp. 547-551
    • Rolinski, B.1    Arnecke, R.2    Dame, T.3    Kreischer, J.4
  • 42
    • 74049151143 scopus 로고    scopus 로고
    • Targeted metabolic profiling of phenolics in urine and plasma after regular consumption of cocoa by liquid chromatography-tandem mass spectrometry
    • Urpi-Sarda, M., Monagas, M., Khan, N., Llorach, R. et al., Targeted metabolic profiling of phenolics in urine and plasma after regular consumption of cocoa by liquid chromatography-tandem mass spectrometry. J. Chromatogr. A 2009, 1216, 7258-7267.
    • (2009) J. Chromatogr. A , vol.1216 , pp. 7258-7267
    • Urpi-Sarda, M.1    Monagas, M.2    Khan, N.3    Llorach, R.4
  • 43
    • 0035167804 scopus 로고    scopus 로고
    • In vivo comparison of the bioavailability of (+)-catechin, (-)-epicatechin and their mixture in orally administered rats
    • Baba, S., Osakabe, N., Natsume, M., Muto, Y. et al., In vivo comparison of the bioavailability of (+)-catechin, (-)-epicatechin and their mixture in orally administered rats. J. Nutr. 2001, 131, 2885-2891.
    • (2001) J. Nutr. , vol.131 , pp. 2885-2891
    • Baba, S.1    Osakabe, N.2    Natsume, M.3    Muto, Y.4
  • 44
    • 0034493222 scopus 로고    scopus 로고
    • Bioavailability of (-)-epicatechin upon intake of chocolate and cocoa in human volunteers
    • Baba, S., Osakabe, N., Yasuda, A., Natsume, M. et al., Bioavailability of (-)-epicatechin upon intake of chocolate and cocoa in human volunteers. Free Radic. Res. 2000, 33, 635-641.
    • (2000) Free Radic. Res. , vol.33 , pp. 635-641
    • Baba, S.1    Osakabe, N.2    Yasuda, A.3    Natsume, M.4
  • 45
    • 78149388236 scopus 로고    scopus 로고
    • Metabolomics study of human urinary metabolome modifications after intake of almond (Prunus dulcis (Mill.) D.A. Webb) skin polyphenols
    • Llorach, R., Garrido, I., Monagas, M., Urpi-Sarda, M. et al., Metabolomics study of human urinary metabolome modifications after intake of almond (Prunus dulcis (Mill.) D.A. Webb) skin polyphenols. J. Proteome Res. 2010, 9, 5859-5867.
    • (2010) J. Proteome Res. , vol.9 , pp. 5859-5867
    • Llorach, R.1    Garrido, I.2    Monagas, M.3    Urpi-Sarda, M.4
  • 46
    • 77951276112 scopus 로고    scopus 로고
    • Effect of milk on the urinary excretion of microbial phenolic acids after cocoa powder consumption in humans
    • Urpi-Sarda, M., Llorach, R., Khan, N., Monagas, M. et al., Effect of milk on the urinary excretion of microbial phenolic acids after cocoa powder consumption in humans. J. Agric. Food Chem. 2010, 58, 4706-4711.
    • (2010) J. Agric. Food Chem. , vol.58 , pp. 4706-4711
    • Urpi-Sarda, M.1    Llorach, R.2    Khan, N.3    Monagas, M.4
  • 47
    • 0037392343 scopus 로고    scopus 로고
    • Chocolate intake increases urinary excretion of polyphenol-derived phenolic acids in healthy human subjects
    • Rios, L. Y., Gonthier, M. P., Remesy, C., Mila, I. et al., Chocolate intake increases urinary excretion of polyphenol-derived phenolic acids in healthy human subjects. Am. J. Clin. Nutr. 2003, 77, 912-918.
    • (2003) Am. J. Clin. Nutr. , vol.77 , pp. 912-918
    • Rios, L.Y.1    Gonthier, M.P.2    Remesy, C.3    Mila, I.4
  • 49
    • 55449128350 scopus 로고    scopus 로고
    • Absorption of N-phenylpropenoyl-L-amino acids in healthy humans by oral administration of cocoa (Theobroma cacao)
    • Stark, T., Lang, R., Keller, D., Hensel, A. et al., Absorption of N-phenylpropenoyl-L-amino acids in healthy humans by oral administration of cocoa (Theobroma cacao). Mol. Nutr. Food Res. 2008, 52, 1201-1214.
    • (2008) Mol. Nutr. Food Res. , vol.52 , pp. 1201-1214
    • Stark, T.1    Lang, R.2    Keller, D.3    Hensel, A.4
  • 50
    • 33746923393 scopus 로고    scopus 로고
    • Molecular definition of the taste of roasted cocoa nibs (Theobroma cacao) by means of quantitative studies and sensory experiments
    • Stark, T., Bareuther, S., Hofmann, T., Molecular definition of the taste of roasted cocoa nibs (Theobroma cacao) by means of quantitative studies and sensory experiments. J. Agric. Food Chem. 2006, 54, 5530-5539.
    • (2006) J. Agric. Food Chem. , vol.54 , pp. 5530-5539
    • Stark, T.1    Bareuther, S.2    Hofmann, T.3
  • 51
    • 52949150080 scopus 로고    scopus 로고
    • Matrix effects on flavour volatiles release in dark chocolates varying in particle size distribution and fat content using GC-mass spectrometry and GC-olfactometry
    • Afoakwa, E. O., Paterson, A., Fowler, M., Ryan, A., Matrix effects on flavour volatiles release in dark chocolates varying in particle size distribution and fat content using GC-mass spectrometry and GC-olfactometry. Food Chem. 2009, 113, 208-215.
    • (2009) Food Chem. , vol.113 , pp. 208-215
    • Afoakwa, E.O.1    Paterson, A.2    Fowler, M.3    Ryan, A.4
  • 53
    • 45249124053 scopus 로고    scopus 로고
    • Tyrosine sulfation is prevalent in human chemokine receptors important in lung disease
    • Liu, J., Louie, S., Hsu, W., Yu, K. M. et al., Tyrosine sulfation is prevalent in human chemokine receptors important in lung disease. Am. J. Respir. Cell Mol. Biol. 2008, 38, 738-743.
    • (2008) Am. J. Respir. Cell Mol. Biol. , vol.38 , pp. 738-743
    • Liu, J.1    Louie, S.2    Hsu, W.3    Yu, K.M.4
  • 54
    • 0015787402 scopus 로고
    • Determination and significance of l-tyrosine O-sulphate and its deaminated metabolites in normal human and mouse urine
    • Hext, P. M., Thomas, S., Rose, F. A., Dodgson, K. S., Determination and significance of l-tyrosine O-sulphate and its deaminated metabolites in normal human and mouse urine. Biochem. J. 1973, 134, 629-635.
    • (1973) Biochem. J. , vol.134 , pp. 629-635
    • Hext, P.M.1    Thomas, S.2    Rose, F.A.3    Dodgson, K.S.4
  • 55
    • 57649138441 scopus 로고    scopus 로고
    • P-selectin glycoprotein ligand-1 decameric repeats regulate selectin-dependent rolling under flow conditions
    • Tauxe, C., Xie, X., Joffraud, M., Martinez, M. et al., P-selectin glycoprotein ligand-1 decameric repeats regulate selectin-dependent rolling under flow conditions. J. Biol. Chem. 2008, 283, 28536-28545.
    • (2008) J. Biol. Chem. , vol.283 , pp. 28536-28545
    • Tauxe, C.1    Xie, X.2    Joffraud, M.3    Martinez, M.4
  • 56
    • 0033678401 scopus 로고    scopus 로고
    • Increased fibrinogen production in type 2 diabetic patients without detectable vascular complications: correlation with plasma glucagon concentrations
    • Barazzoni, R., Zanetti, M., Davanzo, G., Kiwanuka, E. et al., Increased fibrinogen production in type 2 diabetic patients without detectable vascular complications: correlation with plasma glucagon concentrations. J. Clin. Endocrinol. Metab. 2000, 85, 3121-3125.
    • (2000) J. Clin. Endocrinol. Metab. , vol.85 , pp. 3121-3125
    • Barazzoni, R.1    Zanetti, M.2    Davanzo, G.3    Kiwanuka, E.4
  • 57
    • 84856384386 scopus 로고    scopus 로고
    • Differential effects of polyphenols and alcohol of red wine on the expression of adhesion molecules and inflammatory cytokines related to atherosclerosis: a randomized clinical trial
    • Chiva-Blanch, G., Urpi-Sarda, M., Llorach, R., Rotches-Ribalta, M. et al., Differential effects of polyphenols and alcohol of red wine on the expression of adhesion molecules and inflammatory cytokines related to atherosclerosis: a randomized clinical trial. Am. J. Clin. Nutr. 2012, 95, 326-334.
    • (2012) Am. J. Clin. Nutr. , vol.95 , pp. 326-334
    • Chiva-Blanch, G.1    Urpi-Sarda, M.2    Llorach, R.3    Rotches-Ribalta, M.4
  • 58
    • 33947188634 scopus 로고    scopus 로고
    • Anti-inflammatory and anti-atherogenic effects of cathechin, caffeic acid and trans-resveratrol in apolipoprotein E deficient mice
    • Norata, G. D., Marchesi, P., Passamonti, S., Pirillo, A. et al., Anti-inflammatory and anti-atherogenic effects of cathechin, caffeic acid and trans-resveratrol in apolipoprotein E deficient mice. Atherosclerosis 2007, 191, 265-271.
    • (2007) Atherosclerosis , vol.191 , pp. 265-271
    • Norata, G.D.1    Marchesi, P.2    Passamonti, S.3    Pirillo, A.4
  • 59
    • 36148956147 scopus 로고    scopus 로고
    • Transport of butyryl-L-carnitine, a potential prodrug, via the carnitine transporter OCTN2 and the amino acid transporter ATB(0,+)
    • Srinivas, S. R., Prasad, P. D., Umapathy, N. S., Ganapathy, V. et al., Transport of butyryl-L-carnitine, a potential prodrug, via the carnitine transporter OCTN2 and the amino acid transporter ATB(0, +). Am. J. Physiol. Gastrointest. Liver Physiol. 2007, 293, G1046-G1053.
    • (2007) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.293
    • Srinivas, S.R.1    Prasad, P.D.2    Umapathy, N.S.3    Ganapathy, V.4
  • 60
    • 0025166251 scopus 로고
    • Carnitine deficiency in inherited organic acid disorders and Reye syndrome
    • Sugiyama, N., Kidouchi, K., Kobayashi, M., Wada, Y., Carnitine deficiency in inherited organic acid disorders and Reye syndrome. Acta Paediatr. Jpn. 1990, 32, 410-416.
    • (1990) Acta Paediatr. Jpn. , vol.32 , pp. 410-416
    • Sugiyama, N.1    Kidouchi, K.2    Kobayashi, M.3    Wada, Y.4
  • 61
    • 0022551590 scopus 로고
    • Identification of 3-methylglutarylcarnitine. A new diagnostic metabolite of 3-hydroxy-3-methylglutaryl-coenzyme A lyase deficiency
    • Roe, C. R., Millington, D. S., Maltby, D. A., Identification of 3-methylglutarylcarnitine. A new diagnostic metabolite of 3-hydroxy-3-methylglutaryl-coenzyme A lyase deficiency. J. Clin. Invest. 1986, 77, 1391-1394.
    • (1986) J. Clin. Invest. , vol.77 , pp. 1391-1394
    • Roe, C.R.1    Millington, D.S.2    Maltby, D.A.3
  • 62
    • 84892902535 scopus 로고    scopus 로고
    • Increased excretion of c4-carnitine species after a therapeutic acetylsalicylic acid dose: evidence for an inhibitory effect on short-chain Fatty Acid metabolism
    • Mels, C. M., Jansen van Rensburg, P., van der Westhuizen, F. H., Pretorius, P. J. et al., Increased excretion of c4-carnitine species after a therapeutic acetylsalicylic acid dose: evidence for an inhibitory effect on short-chain Fatty Acid metabolism. ISRN Pharmacol. 2011, 2011, 851870.
    • (2011) ISRN Pharmacol. , vol.2011 , pp. 851870
    • Mels, C.M.1    Jansen van Rensburg, P.2    van der Westhuizen, F.H.3    Pretorius, P.J.4
  • 63
    • 0036866660 scopus 로고    scopus 로고
    • Beneficial effects of tea catechins on diet-induced obesity: stimulation of lipid catabolism in the liver
    • Murase, T., Nagasawa, A., Suzuki, J., Hase, T. et al., Beneficial effects of tea catechins on diet-induced obesity: stimulation of lipid catabolism in the liver. Int. J. Obes. Relat. Metab. Disord. 2002, 26, 1459-1464.
    • (2002) Int. J. Obes. Relat. Metab. Disord. , vol.26 , pp. 1459-1464
    • Murase, T.1    Nagasawa, A.2    Suzuki, J.3    Hase, T.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.