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Volumn 8, Issue 6, 2013, Pages

Phosphorylation of the Leukemic Oncoprotein EVI1 on Serine 196 Modulates DNA Binding, Transcriptional Repression and Transforming Ability

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; ASPARTIC ACID; DNA; LEUKEMIC ONCOPROTEIN ECOTROPIC VIRAL INTEGRATION SITE 1; ONCOPROTEIN; SERINE; UNCLASSIFIED DRUG; ZINC FINGER PROTEIN;

EID: 84878906820     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0066510     Document Type: Article
Times cited : (14)

References (49)
  • 1
    • 48149095026 scopus 로고    scopus 로고
    • Evi-1 is a critical regulator for hematopoietic stem cells and transformed leukemic cells
    • Goyama S, Yamamoto G, Shimabe M, Sato T, Ichikawa M, et al. (2008) Evi-1 is a critical regulator for hematopoietic stem cells and transformed leukemic cells. Cell Stem Cell 3: 207-220.
    • (2008) Cell Stem Cell , vol.3 , pp. 207-220
    • Goyama, S.1    Yamamoto, G.2    Shimabe, M.3    Sato, T.4    Ichikawa, M.5
  • 3
    • 42949122111 scopus 로고    scopus 로고
    • High EVI1 levels predict adverse outcome in acute myeloid leukemia: prevalence of EVI1 overexpression and chromosome 3q26 abnormalities underestimated
    • Lugthart S, van Drunen E, van Norden Y, van Hoven A, Erpelinck CA, et al. (2008) High EVI1 levels predict adverse outcome in acute myeloid leukemia: prevalence of EVI1 overexpression and chromosome 3q26 abnormalities underestimated. Blood 111: 4329-4337.
    • (2008) Blood , vol.111 , pp. 4329-4337
    • Lugthart, S.1    van Drunen, E.2    van Norden, Y.3    van Hoven, A.4    Erpelinck, C.A.5
  • 4
    • 79957978959 scopus 로고    scopus 로고
    • Fanconi anemia (FA)-associated 3q gains in leukemic transformation consistently target EVI1, but do not affect low TERC expression in FA
    • Meyer S, Bristow C, Wappett M, Pepper S, Whetton AD, et al. (2011) Fanconi anemia (FA)-associated 3q gains in leukemic transformation consistently target EVI1, but do not affect low TERC expression in FA. Blood 117: 6047-6050.
    • (2011) Blood , vol.117 , pp. 6047-6050
    • Meyer, S.1    Bristow, C.2    Wappett, M.3    Pepper, S.4    Whetton, A.D.5
  • 5
    • 33947175473 scopus 로고    scopus 로고
    • Amplification and translocation of 3q26 with overexpression of EVI1 in Fanconi anemia-derived childhood acute myeloid leukemia with biallelic FANCD1/BRCA2 disruption
    • Meyer S, Fergusson WD, Whetton AD, Moreira-Leite F, Pepper SD, et al. (2007) Amplification and translocation of 3q26 with overexpression of EVI1 in Fanconi anemia-derived childhood acute myeloid leukemia with biallelic FANCD1/BRCA2 disruption. Genes Chromosomes Cancer 46: 359-372.
    • (2007) Genes Chromosomes Cancer , vol.46 , pp. 359-372
    • Meyer, S.1    Fergusson, W.D.2    Whetton, A.D.3    Moreira-Leite, F.4    Pepper, S.D.5
  • 6
    • 0027232223 scopus 로고
    • Four of the seven zinc fingers of the Evi-1 myeloid-transforming gene are required for sequence-specific binding to GA(C/T)AAGA(T/C)AAGATAA
    • Delwel R, Funabiki T, Kreider BL, Morishita K, Ihle JN, (1993) Four of the seven zinc fingers of the Evi-1 myeloid-transforming gene are required for sequence-specific binding to GA(C/T)AAGA(T/C)AAGATAA. Mol Cell Biol 13: 4291-4300.
    • (1993) Mol Cell Biol , vol.13 , pp. 4291-4300
    • Delwel, R.1    Funabiki, T.2    Kreider, B.L.3    Morishita, K.4    Ihle, J.N.5
  • 7
    • 0028241701 scopus 로고
    • The carboxyl domain of zinc fingers of the Evi-1 myeloid transforming gene binds a consensus sequence of GAAGATGAG
    • Funabiki T, Kreider BL, Ihle JN, (1994) The carboxyl domain of zinc fingers of the Evi-1 myeloid transforming gene binds a consensus sequence of GAAGATGAG. Oncogene 9: 1575-1581.
    • (1994) Oncogene , vol.9 , pp. 1575-1581
    • Funabiki, T.1    Kreider, B.L.2    Ihle, J.N.3
  • 8
    • 78650983952 scopus 로고    scopus 로고
    • Aberrant DNA hypermethylation signature in acute myeloid leukemia directed by EVI1
    • Lugthart S, Figueroa ME, Bindels E, Skrabanek L, Valk PJ, et al. (2011) Aberrant DNA hypermethylation signature in acute myeloid leukemia directed by EVI1. Blood 117: 234-241.
    • (2011) Blood , vol.117 , pp. 234-241
    • Lugthart, S.1    Figueroa, M.E.2    Bindels, E.3    Skrabanek, L.4    Valk, P.J.5
  • 9
    • 77952765376 scopus 로고    scopus 로고
    • Acetylation of lysine 564 adjacent to the C-terminal binding protein-binding motif in EVI1 is crucial for transcriptional activation of GATA2
    • Shimahara A, Yamakawa N, Nishikata I, Morishita K, (2010) Acetylation of lysine 564 adjacent to the C-terminal binding protein-binding motif in EVI1 is crucial for transcriptional activation of GATA2. J Biol Chem 285: 16967-16977.
    • (2010) J Biol Chem , vol.285 , pp. 16967-16977
    • Shimahara, A.1    Yamakawa, N.2    Nishikata, I.3    Morishita, K.4
  • 10
    • 79953683693 scopus 로고    scopus 로고
    • Evi1 represses PTEN expression and activates PI3K/AKT/mTOR via interactions with polycomb proteins
    • Yoshimi A, Goyama S, Watanabe-Okochi N, Yoshiki Y, Nannya Y, et al. (2011) Evi1 represses PTEN expression and activates PI3K/AKT/mTOR via interactions with polycomb proteins. Blood 117: 3617-3628.
    • (2011) Blood , vol.117 , pp. 3617-3628
    • Yoshimi, A.1    Goyama, S.2    Watanabe-Okochi, N.3    Yoshiki, Y.4    Nannya, Y.5
  • 11
    • 84857127210 scopus 로고    scopus 로고
    • Ecotopic viral integration site 1 (EVI1) regulates multiple cellular processes important for cancer and is a synergistic partner for FOS protein in invasive tumors
    • Bard-Chapeau EA, Jeyakani J, Kok CH, Muller J, Chua BQ, et al. (2012) Ecotopic viral integration site 1 (EVI1) regulates multiple cellular processes important for cancer and is a synergistic partner for FOS protein in invasive tumors. Proc Natl Acad Sci U S A 109: 2168-2173.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 2168-2173
    • Bard-Chapeau, E.A.1    Jeyakani, J.2    Kok, C.H.3    Muller, J.4    Chua, B.Q.5
  • 12
    • 72049121456 scopus 로고    scopus 로고
    • Pbx1 is a downstream target of Evi-1 in hematopoietic stem/progenitors and leukemic cells
    • Shimabe M, Goyama S, Watanabe-Okochi N, Yoshimi A, Ichikawa M, et al. (2009) Pbx1 is a downstream target of Evi-1 in hematopoietic stem/progenitors and leukemic cells. Oncogene 28: 4364-4374.
    • (2009) Oncogene , vol.28 , pp. 4364-4374
    • Shimabe, M.1    Goyama, S.2    Watanabe-Okochi, N.3    Yoshimi, A.4    Ichikawa, M.5
  • 13
    • 0031040314 scopus 로고    scopus 로고
    • The Evi-1 proto-oncogene encodes a transcriptional repressor activity associated with transformation
    • Bartholomew C, Kilbey A, Clark AM, Walker M, (1997) The Evi-1 proto-oncogene encodes a transcriptional repressor activity associated with transformation. Oncogene 14: 569-577.
    • (1997) Oncogene , vol.14 , pp. 569-577
    • Bartholomew, C.1    Kilbey, A.2    Clark, A.M.3    Walker, M.4
  • 14
    • 85047694750 scopus 로고    scopus 로고
    • EVI1 induces myelodysplastic syndrome in mice
    • Buonamici S, Li D, Chi Y, Zhao R, Wang X, et al. (2004) EVI1 induces myelodysplastic syndrome in mice. J Clin Invest 114: 713-719.
    • (2004) J Clin Invest , vol.114 , pp. 713-719
    • Buonamici, S.1    Li, D.2    Chi, Y.3    Zhao, R.4    Wang, X.5
  • 15
    • 27944449787 scopus 로고    scopus 로고
    • Insertional mutagenesis identifies genes that promote the immortalization of primary bone marrow progenitor cells
    • Du Y, Jenkins NA, Copeland NG, (2005) Insertional mutagenesis identifies genes that promote the immortalization of primary bone marrow progenitor cells. Blood 106: 3932-3939.
    • (2005) Blood , vol.106 , pp. 3932-3939
    • Du, Y.1    Jenkins, N.A.2    Copeland, N.G.3
  • 16
    • 77953087435 scopus 로고    scopus 로고
    • Methylation and silencing of miRNA-124 by EVI1 and self-renewal exhaustion of hematopoietic stem cells in murine myelodysplastic syndrome
    • Dickstein J, Senyuk V, Premanand K, Laricchia-Robbio L, Xu P, et al. (2010) Methylation and silencing of miRNA-124 by EVI1 and self-renewal exhaustion of hematopoietic stem cells in murine myelodysplastic syndrome. Proc Natl Acad Sci U S A 107: 9783-9788.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 9783-9788
    • Dickstein, J.1    Senyuk, V.2    Premanand, K.3    Laricchia-Robbio, L.4    Xu, P.5
  • 17
    • 0035854745 scopus 로고    scopus 로고
    • Evi-1 transforming and repressor activities are mediated by CtBP co-repressor proteins
    • Palmer S, Brouillet JP, Kilbey A, Fulton R, Walker M, et al. (2001) Evi-1 transforming and repressor activities are mediated by CtBP co-repressor proteins. J Biol Chem 276: 25834-25840.
    • (2001) J Biol Chem , vol.276 , pp. 25834-25840
    • Palmer, S.1    Brouillet, J.P.2    Kilbey, A.3    Fulton, R.4    Walker, M.5
  • 18
    • 1942518374 scopus 로고    scopus 로고
    • Protein kinase C-mediated phosphorylation of the leukemia-associated HOXA9 protein impairs its DNA binding ability and induces myeloid differentiation
    • Vijapurkar U, Fischbach N, Shen W, Brandts C, Stokoe D, et al. (2004) Protein kinase C-mediated phosphorylation of the leukemia-associated HOXA9 protein impairs its DNA binding ability and induces myeloid differentiation. Mol Cell Biol 24: 3827-3837.
    • (2004) Mol Cell Biol , vol.24 , pp. 3827-3837
    • Vijapurkar, U.1    Fischbach, N.2    Shen, W.3    Brandts, C.4    Stokoe, D.5
  • 19
    • 38049185075 scopus 로고    scopus 로고
    • Protein kinase B (c-akt) regulates hematopoietic lineage choice decisions during myelopoiesis
    • Buitenhuis M, Verhagen LP, van Deutekom HW, Castor A, Verploegen S, et al. (2008) Protein kinase B (c-akt) regulates hematopoietic lineage choice decisions during myelopoiesis. Blood 111: 112-121.
    • (2008) Blood , vol.111 , pp. 112-121
    • Buitenhuis, M.1    Verhagen, L.P.2    van Deutekom, H.W.3    Castor, A.4    Verploegen, S.5
  • 20
    • 45549091159 scopus 로고    scopus 로고
    • Cyclin-dependent kinase antagonizes promyelocytic leukemia zinc-finger through phosphorylation
    • Costoya JA, Hobbs RM, Pandolfi PP, (2008) Cyclin-dependent kinase antagonizes promyelocytic leukemia zinc-finger through phosphorylation. Oncogene 27: 3789-3796.
    • (2008) Oncogene , vol.27 , pp. 3789-3796
    • Costoya, J.A.1    Hobbs, R.M.2    Pandolfi, P.P.3
  • 21
    • 0025037872 scopus 로고
    • Identification, nuclear localization, and DNA-binding activity of the zinc finger protein encoded by the Evi-1 myeloid transforming gene
    • Matsugi T, Morishita K, Ihle JN, (1990) Identification, nuclear localization, and DNA-binding activity of the zinc finger protein encoded by the Evi-1 myeloid transforming gene. Mol Cell Biol 10: 1259-1264.
    • (1990) Mol Cell Biol , vol.10 , pp. 1259-1264
    • Matsugi, T.1    Morishita, K.2    Ihle, J.N.3
  • 22
    • 34249947699 scopus 로고    scopus 로고
    • ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage
    • Matsuoka S, Ballif BA, Smogorzewska A, McDonald ER 3rd, Hurov KE, et al (2007) ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science 316: 1160-1166.
    • (2007) Science , vol.316 , pp. 1160-1166
    • Matsuoka, S.1    Ballif, B.A.2    Smogorzewska, A.3    McDonald 3rd, E.R.4    Hurov, K.E.5
  • 23
    • 33750456519 scopus 로고    scopus 로고
    • Global, in vivo, and site-specific phosphorylation dynamics in signaling networks
    • Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, et al. (2006) Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. Cell 127: 635-648.
    • (2006) Cell , vol.127 , pp. 635-648
    • Olsen, J.V.1    Blagoev, B.2    Gnad, F.3    Macek, B.4    Kumar, C.5
  • 24
    • 77951644400 scopus 로고    scopus 로고
    • Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis
    • Olsen JV, Vermeulen M, Santamaria A, Kumar C, Miller ML, et al. (2010) Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci Signal 3: ra3.
    • (2010) Sci Signal , vol.3
    • Olsen, J.V.1    Vermeulen, M.2    Santamaria, A.3    Kumar, C.4    Miller, M.L.5
  • 25
    • 0036736530 scopus 로고    scopus 로고
    • The human promyelocytic leukemia zinc finger gene is regulated by the Evi-1 oncoprotein and a novel guanine-rich site binding protein
    • Takahashi S, Licht JD, (2002) The human promyelocytic leukemia zinc finger gene is regulated by the Evi-1 oncoprotein and a novel guanine-rich site binding protein. Leukemia 16: 1755-1762.
    • (2002) Leukemia , vol.16 , pp. 1755-1762
    • Takahashi, S.1    Licht, J.D.2
  • 26
    • 0029091464 scopus 로고
    • The AML1/Evi-1 fusion protein in the t(3;21) translocation exhibits transforming activity on Rat1 fibroblasts with dependence on the Evi-1 sequence
    • Kurokawa M, Ogawa S, Tanaka T, Mitani K, Yazaki Y, et al. (1995) The AML1/Evi-1 fusion protein in the t(3;21) translocation exhibits transforming activity on Rat1 fibroblasts with dependence on the Evi-1 sequence. Oncogene 11: 833-840.
    • (1995) Oncogene , vol.11 , pp. 833-840
    • Kurokawa, M.1    Ogawa, S.2    Tanaka, T.3    Mitani, K.4    Yazaki, Y.5
  • 27
    • 13944271408 scopus 로고    scopus 로고
    • A cross-linker-sensitive myeloid leukemia cell line from a 2-year-old boy with severe Fanconi anemia and biallelic FANCD1/BRCA2 mutations
    • Meyer S, Fergusson WD, Oostra AB, Medhurst AL, Waisfisz Q, et al. (2005) A cross-linker-sensitive myeloid leukemia cell line from a 2-year-old boy with severe Fanconi anemia and biallelic FANCD1/BRCA2 mutations. Genes Chromosomes Cancer 42: 404-415.
    • (2005) Genes Chromosomes Cancer , vol.42 , pp. 404-415
    • Meyer, S.1    Fergusson, W.D.2    Oostra, A.B.3    Medhurst, A.L.4    Waisfisz, Q.5
  • 28
    • 0038603848 scopus 로고    scopus 로고
    • Clonal chromosomal aberrations in bone marrow cells of Fanconi anemia patients: gains of the chromosomal segment 3q26q29 as an adverse risk factor
    • Tonnies H, Huber S, Kuhl JS, Gerlach A, Ebell W, et al. (2003) Clonal chromosomal aberrations in bone marrow cells of Fanconi anemia patients: gains of the chromosomal segment 3q26q29 as an adverse risk factor. Blood 101: 3872-3874.
    • (2003) Blood , vol.101 , pp. 3872-3874
    • Tonnies, H.1    Huber, S.2    Kuhl, J.S.3    Gerlach, A.4    Ebell, W.5
  • 30
    • 79955096891 scopus 로고    scopus 로고
    • Coordinated action of the Fanconi anemia and ataxia telangiectasia pathways in response to oxidative damage
    • Castillo P, Bogliolo M, Surralles J, (2011) Coordinated action of the Fanconi anemia and ataxia telangiectasia pathways in response to oxidative damage. DNA Repair (Amst) 10: 518-525.
    • (2011) DNA Repair (Amst) , vol.10 , pp. 518-525
    • Castillo, P.1    Bogliolo, M.2    Surralles, J.3
  • 31
    • 79955519714 scopus 로고    scopus 로고
    • Congenital bone marrow failure in DNA-PKcs mutant mice associated with deficiencies in DNA repair
    • Zhang S, Yajima H, Huynh H, Zheng J, Callen E, et al. (2011) Congenital bone marrow failure in DNA-PKcs mutant mice associated with deficiencies in DNA repair. J Cell Biol 193: 295-305.
    • (2011) J Cell Biol , vol.193 , pp. 295-305
    • Zhang, S.1    Yajima, H.2    Huynh, H.3    Zheng, J.4    Callen, E.5
  • 32
    • 84878902275 scopus 로고    scopus 로고
    • Activation of Evi1 inhibits cell cycle progression and differentiation of hematopoietic progenitor cells
    • Kustikova OS, Schwarzer A, Stahlhut M, Brugman MH, Neumann T, et al. (2012) Activation of Evi1 inhibits cell cycle progression and differentiation of hematopoietic progenitor cells. Leukemia.
    • (2012) Leukemia
    • Kustikova, O.S.1    Schwarzer, A.2    Stahlhut, M.3    Brugman, M.H.4    Neumann, T.5
  • 33
    • 0033555521 scopus 로고    scopus 로고
    • Growth/cell cycle regulation of Sp1 phosphorylation
    • Black AR, Jensen D, Lin SY, Azizkhan JC, (1999) Growth/cell cycle regulation of Sp1 phosphorylation. J Biol Chem 274: 1207-1215.
    • (1999) J Biol Chem , vol.274 , pp. 1207-1215
    • Black, A.R.1    Jensen, D.2    Lin, S.Y.3    Azizkhan, J.C.4
  • 34
    • 0030665666 scopus 로고    scopus 로고
    • Inhibition of the DNA-binding and transcriptional repression activity of the Wilms' tumor gene product, WT1, by cAMP-dependent protein kinase-mediated phosphorylation of Ser-365 and Ser-393 in the zinc finger domain
    • Sakamoto Y, Yoshida M, Semba K, Hunter T, (1997) Inhibition of the DNA-binding and transcriptional repression activity of the Wilms' tumor gene product, WT1, by cAMP-dependent protein kinase-mediated phosphorylation of Ser-365 and Ser-393 in the zinc finger domain. Oncogene 15: 2001-2012.
    • (1997) Oncogene , vol.15 , pp. 2001-2012
    • Sakamoto, Y.1    Yoshida, M.2    Semba, K.3    Hunter, T.4
  • 35
    • 34247391073 scopus 로고    scopus 로고
    • Trib1 and Evi1 cooperate with Hoxa and Meis1 in myeloid leukemogenesis
    • Jin G, Yamazaki Y, Takuwa M, Takahara T, Kaneko K, et al. (2007) Trib1 and Evi1 cooperate with Hoxa and Meis1 in myeloid leukemogenesis. Blood 109: 3998-4005.
    • (2007) Blood , vol.109 , pp. 3998-4005
    • Jin, G.1    Yamazaki, Y.2    Takuwa, M.3    Takahara, T.4    Kaneko, K.5
  • 36
    • 80053252121 scopus 로고    scopus 로고
    • Acetylation of the proto-oncogene EVI1 abrogates Bcl-xL promoter binding and induces apoptosis
    • Pradhan AK, Mohapatra AD, Nayak KB, Chakraborty S, (2011) Acetylation of the proto-oncogene EVI1 abrogates Bcl-xL promoter binding and induces apoptosis. PLoS One 6: e25370.
    • (2011) PLoS One , vol.6
    • Pradhan, A.K.1    Mohapatra, A.D.2    Nayak, K.B.3    Chakraborty, S.4
  • 37
    • 0032580370 scopus 로고    scopus 로고
    • Evi-1 ZF1 DNA binding activity and a second distinct transcriptional repressor region are both required for optimal transformation of Rat1 fibroblasts
    • Kilbey A, Bartholomew C, (1998) Evi-1 ZF1 DNA binding activity and a second distinct transcriptional repressor region are both required for optimal transformation of Rat1 fibroblasts. Oncogene 16: 2287-2291.
    • (1998) Oncogene , vol.16 , pp. 2287-2291
    • Kilbey, A.1    Bartholomew, C.2
  • 38
    • 0032849789 scopus 로고    scopus 로고
    • Loss of cell cycle control by deregulation of cyclin-dependent kinase 2 kinase activity in Evi-1 transformed fibroblasts
    • Kilbey A, Stephens V, Bartholomew C, (1999) Loss of cell cycle control by deregulation of cyclin-dependent kinase 2 kinase activity in Evi-1 transformed fibroblasts. Cell Growth Differ 10: 601-610.
    • (1999) Cell Growth Differ , vol.10 , pp. 601-610
    • Kilbey, A.1    Stephens, V.2    Bartholomew, C.3
  • 39
    • 0034046944 scopus 로고    scopus 로고
    • Plat-E: an efficient and stable system for transient packaging of retroviruses
    • Morita S, Kojima T, Kitamura T, (2000) Plat-E: an efficient and stable system for transient packaging of retroviruses. Gene Ther 7: 1063-1066.
    • (2000) Gene Ther , vol.7 , pp. 1063-1066
    • Morita, S.1    Kojima, T.2    Kitamura, T.3
  • 40
    • 0026342692 scopus 로고
    • Evi-1, a murine zinc finger proto-oncogene, encodes a sequence-specific DNA-binding protein
    • Perkins AS, Fishel R, Jenkins NA, Copeland NG, (1991) Evi-1, a murine zinc finger proto-oncogene, encodes a sequence-specific DNA-binding protein. Mol Cell Biol 11: 2665-2674.
    • (1991) Mol Cell Biol , vol.11 , pp. 2665-2674
    • Perkins, A.S.1    Fishel, R.2    Jenkins, N.A.3    Copeland, N.G.4
  • 41
    • 24044553566 scopus 로고    scopus 로고
    • Multiple reaction monitoring to identify sites of protein phosphorylation with high sensitivity
    • Unwin RD, Griffiths JR, Leverentz MK, Grallert A, Hagan IM, et al. (2005) Multiple reaction monitoring to identify sites of protein phosphorylation with high sensitivity. Mol Cell Proteomics 4: 1134-1144.
    • (2005) Mol Cell Proteomics , vol.4 , pp. 1134-1144
    • Unwin, R.D.1    Griffiths, J.R.2    Leverentz, M.K.3    Grallert, A.4    Hagan, I.M.5
  • 42
    • 66749165277 scopus 로고    scopus 로고
    • A sensitive mass spectrometric method for hypothesis-driven detection of peptide post-translational modifications: multiple reaction monitoring-initiated detection and sequencing (MIDAS)
    • Unwin RD, Griffiths JR, Whetton AD, (2009) A sensitive mass spectrometric method for hypothesis-driven detection of peptide post-translational modifications: multiple reaction monitoring-initiated detection and sequencing (MIDAS). Nat Protoc 4: 870-877.
    • (2009) Nat Protoc , vol.4 , pp. 870-877
    • Unwin, R.D.1    Griffiths, J.R.2    Whetton, A.D.3
  • 44
    • 0027136282 scopus 로고
    • Comparative protein modelling by satisfaction of spatial restraints
    • Sali A, Blundell TL, (1993) Comparative protein modelling by satisfaction of spatial restraints. J Mol Biol 234: 779-815.
    • (1993) J Mol Biol , vol.234 , pp. 779-815
    • Sali, A.1    Blundell, T.L.2
  • 45
    • 70350509577 scopus 로고    scopus 로고
    • KING (Kinemage, Next Generation): a versatile interactive molecular and scientific visualization program
    • Chen VB, Davis IW, Richardson DC, (2009) KING (Kinemage, Next Generation): a versatile interactive molecular and scientific visualization program. Protein Sci 18: 2403-2409.
    • (2009) Protein Sci , vol.18 , pp. 2403-2409
    • Chen, V.B.1    Davis, I.W.2    Richardson, D.C.3
  • 47
    • 58949102947 scopus 로고    scopus 로고
    • Hierarchical maintenance of MLL myeloid leukemia stem cells employs a transcriptional program shared with embryonic rather than adult stem cells
    • Somervaille TC, Matheny CJ, Spencer GJ, Iwasaki M, Rinn JL, et al. (2009) Hierarchical maintenance of MLL myeloid leukemia stem cells employs a transcriptional program shared with embryonic rather than adult stem cells. Cell Stem Cell 4: 129-140.
    • (2009) Cell Stem Cell , vol.4 , pp. 129-140
    • Somervaille, T.C.1    Matheny, C.J.2    Spencer, G.J.3    Iwasaki, M.4    Rinn, J.L.5
  • 48
    • 39849093718 scopus 로고    scopus 로고
    • The MDS1-EVI1 gene complex as a retrovirus integration site: impact on behavior of hematopoietic cells and implications for gene therapy
    • Metais JY, Dunbar CE, (2008) The MDS1-EVI1 gene complex as a retrovirus integration site: impact on behavior of hematopoietic cells and implications for gene therapy. Mol Ther 16: 439-449.
    • (2008) Mol Ther , vol.16 , pp. 439-449
    • Metais, J.Y.1    Dunbar, C.E.2
  • 49
    • 0034623005 scopus 로고    scopus 로고
    • T-Coffee: A novel method for fast and accurate multiple sequence alignment
    • Notredame C, Higgins DG, Heringa J, (2000) T-Coffee: A novel method for fast and accurate multiple sequence alignment. J Mol Biol 302: 205-217.
    • (2000) J Mol Biol , vol.302 , pp. 205-217
    • Notredame, C.1    Higgins, D.G.2    Heringa, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.