Ecotopic viral integration site 1 (EVI1) regulates multiple cellular processes important for cancer and is a synergistic partner for FOS protein in invasive tumors

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 6, 2012, Pages 2168-2173

  Bard Chapeau, Emilie A ^a   Jeyakani, Justin ^b   Kok, Chung H ^c   Muller, Julius ^a   Chua, Belinda Q ^a   Gunaratne, Jayantha ^a   Batagov, Arsen ^d   Jenjaroenpun, Piroon ^d   Kuznetsov, Vladimir A ^d   Wei, Chia Lin ^b   D'Andrea, Richard J ^c   Bourque, Guillaume ^b   Jenkins, Nancy A ^a,e   Copeland, Neal G ^a,e  

^a INSTITUTE OF MOLECULAR AND CELL BIOLOGY   (Singapore)

^b GENOME INSTITUTE OF SINGAPORE   (Singapore)

^c UNIVERSITY OF ADELAIDE   (Australia)

^d BIOINFORMATICS INSTITUTE   (Singapore)

^e HOUSTON METHODIST RESEARCH INSTITUTE   (United States)

Author keywords

Comparative genomics; DNA binding motif; MDS1 and EVI1 complex locus (MECOM); Paired box 2 (PAX2); Yin and Yang 1 (YY1)

Indexed keywords

DNA; ECOTOPIC VIRAL INTEGRATION SITE 1; HYPOXIA INDUCIBLE FACTOR 1BETA; PROTEIN C JUN; PROTEIN FOS; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR CTCF; TRANSCRIPTION FACTOR ELK 1; TRANSCRIPTION FACTOR ELK 4; TRANSCRIPTION FACTOR PAX2; TRANSCRIPTION FACTOR YY1; UNCLASSIFIED DRUG; ZINC FINGER PROTEIN;

ARTICLE; BINDING SITE; CANCER CELL CULTURE; CANCER INVASION; CELL ADHESION; CELL PROLIFERATION; COLONY FORMATION; CONTROLLED STUDY; DNA BINDING; DNA SEQUENCE; GENE EXPRESSION; HUMAN; HUMAN CELL; OVARY CARCINOMA; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN PROTEIN INTERACTION;

BINDING SITES; CELL ADHESION; CHROMATIN IMMUNOPRECIPITATION; DNA; DNA-BINDING PROTEINS; EPITHELIAL CELLS; GENE EXPRESSION REGULATION; HELA CELLS; HUMANS; NEOPLASM INVASIVENESS; NEOPLASMS; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-FOS; PROTO-ONCOGENES; TRANSCRIPTION FACTORS;

EID: 84857127210     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1119229109     Document Type: Article

References (40)

1. Ogawa S, et al. (1996) Increased Evi-1 expression is frequently observed in blastic crisis of chronic myelocytic leukemia. Leukemia 10:788-794. (Pubitemid 26168395)
2. Lugthart S, et al. (2008) High EVI1 levels predict adverse outcome in acute myeloid leukemia: Prevalence of EVI1 overexpression and chromosome 3q26 abnormalities underestimated. Blood 111:4329-4337.
3. Goyama S, Kurokawa M (2009) Pathogenetic significance of ecotropic viral integration site-1 in hematological malignancies. Cancer Sci 100:990-995.
4. Bei JX, et al. (2010) A genome-wide association study of nasopharyngeal carcinoma identifies three new susceptibility loci. Nat Genet 42:599-603.
5. Choi YW, et al. (2007) Comparative genomic hybridization array analysis and real time PCR reveals genomic alterations in squamous cell carcinomas of the lung. Lung Cancer 55:43-51.
6. Goyama S, et al. (2008) Evi-1 is a critical regulator for hematopoietic stem cells and transformed leukemic cells. Cell Stem Cell 3:207-220.
7. Koos B, et al. (2011) The transcription factor Evi-1 is overexpressed, promotes proliferation and is prognostically unfavorable in infratentorial ependymomas. Clin Cancer Res 17:3631-3637.
8. Starr TK, et al. (2009) A transposon-based genetic screen in mice identifies genes altered in colorectal cancer. Science 323:1747-1750.
9. Yokoi S, et al. (2003) TERC identified as a probable target within the 3q26 amplicon that is detected frequently in non-small cell lung cancers. Clin Cancer Res 9:4705-4713. (Pubitemid 37323272)
10. Nanjundan M, et al. (2007) Amplification of MDS1/EVI1 and EVI1, located in the 3q26.2 amplicon, is associated with favorable patient prognosis in ovarian cancer. Cancer Res 67:3074-3084. (Pubitemid 46724844)
11. Osterberg L, et al. (2009) Potential predictive markers of chemotherapy resistance in stage III ovarian serous carcinomas. BMC Cancer 9:368.
12. Yuasa H, et al. (2005) Oncogenic transcription factor Evi1 regulates hematopoietic stem cell proliferation through GATA-2 expression. EMBO J 24:1976-1987. (Pubitemid 40896169)
13. Nucifora G, Laricchia-Robbio L, Senyuk V (2006) EVI1 and hematopoietic disorders: History and perspectives. Gene 368:1-11. (Pubitemid 43290136)
14. Delwel R, Funabiki T, Kreider BL, Morishita K, Ihle JN (1993) Four of the seven zinc fingers of the Evi-1 myeloid-transforming gene are required for sequence-specific binding to GA(C/T)AAGA(T/C)AAGATAA. Mol Cell Biol 13:4291-4300. (Pubitemid 23187658)
15. Funabiki T, Kreider BL, Ihle JN (1994) The carboxyl domain of zinc fingers of the Evi-1 myeloid transforming gene binds a consensus sequence of GAAGATGAG. Oncogene 9:1575-1581. (Pubitemid 24163382)
16. Morishita K, et al. (1988) Retroviral activation of a novel gene encoding a zinc finger protein in IL-3-dependent myeloid leukemia cell lines. Cell 54:831-840.
17. Mucenski ML, et al. (1988) Identification of a common ecotropic viral integration site, Evi-1, in the DNA of AKXD murine myeloid tumors. Mol Cell Biol 8:301-308. (Pubitemid 18015584)
18. Buonamici S, et al. (2005) EVI1 abrogates interferon-alpha response by selectively blocking PML induction. J Biol Chem 280:428-436. (Pubitemid 40173964)
19. Tanaka T, et al. (1994) Evi-1 raises AP-1 activity and stimulates c-fos promoter transactivation with dependence on the second zinc finger domain. J Biol Chem 269:24020-24026. (Pubitemid 24300933)
20. Yatsula B, et al. (2005) Identification of binding sites of EVI1 in mammalian cells. J Biol Chem 280:30712-30722. (Pubitemid 41291800)
21. Shimanara A, Yamakawa N, Nishikata I, Morishita K (2010) Acetylation of lysine564 adjacent to the CTBP-binding motif in EVI1 is crucial for transcriptional activation of GATA2. J Biol Chem 285:16967-16977.
22. Chen X, et al. (2008) Integration of external signaling pathways with the core transcriptional network in embryonic stem cells. Cell 133:1106-1117. (Pubitemid 351787745)
23. Futreal PA, et al. (2004) A census of human cancer genes. Nat Rev Cancer 4:177-183. (Pubitemid 38337497)
24. Valk PJ, et al. (2004) Prognostically useful gene-expression profiles in acute myeloid leukemia. N Engl J Med 350:1617-1628. (Pubitemid 38528701)
25. Yoshimi A, et al. (2011) Evi1 represses PTEN expression and activates PI3K/AKT/mTOR via interactions with polycomb proteins. Blood 117:3617-3628.
26. Mittler G, Butter F, Mann M (2009) A SILAC-based DNA protein interaction screen that identifies candidate binding proteins to functional DNA elements. Genome Res 19:284-293.
27. Laricchia-Robbio L, et al. (2006) Point mutations in two EVI1 Zn fingers abolish EVI1-GATA1 interaction and allow erythroid differentiation of murine bone marrow cells. Mol Cell Biol 26:7658-7666. (Pubitemid 44547713)
28. Laricchia-Robbio L, Premanand K, Rinaldi CR, Nucifora G (2009) EVI1 Impairs myelopoiesis by deregulation of PU.1 function. Cancer Res 69:1633-1642.
29. Eferl R, Wagner EF (2003) AP-1: A double-edged sword in tumorigenesis. Nat Rev Cancer 3:859-868. (Pubitemid 37383716)
30. Raha D, et al. (2010) Close association of RNA polymerase II and many transcription factors with Pol III genes. Proc Natl Acad Sci USA 107:3639-3644.
31. Bonome T, et al. (2008) A gene signature predicting for survival in suboptimally debulked patients with ovarian cancer. Cancer Res 68:5478-5486.
32. Hoyt PR, et al. (1997) The Evi1 proto-oncogene is required at midgestation for neural, heart, and paraxial mesenchyme development. Mech Dev 65:55-70. (Pubitemid 27314591)
33. Wieser R (2007) The oncogene and developmental regulator EVI1: Expression, biochemical properties, and biological functions. Gene 396:346-357.
34. Mok SC, et al. (2009) A gene signature predictive for outcome in advanced ovarian cancer identifies a survival factor: Microfibril-associated glycoprotein 2. Cancer Cell 16:521-532.
35. Verbruggen V, et al. (2010) The Pax6b homeodomain is dispensable for pancreatic endocrine cell differentiation in zebrafish. J Biol Chem 285:13863-13873.
36. Wei GH, et al. (2010) Genome-wide analysis of ETS-family DNA-binding in vitro and in vivo. EMBO J 29:2147-2160.
37. Mitani K (2004) Molecular mechanisms of leukemogenesis by AML1/EVI-1. Oncogene 23:4263-4269.
38. Jochum W, Passegué E, Wagner EF (2001) AP-1 in mouse development and tumorigenesis. Oncogene 20:2401-2412. (Pubitemid 32531298)
39. Kunarso G, et al. (2010) Transposable elements have rewired the core regulatory network of human embryonic stem cells. Nat Genet 42:631-634.
40. Lin CY, et al. (2007) Whole-genome cartography of estrogen receptor alpha binding sites. PLoS Genet 3:e87.