Acetylation of the Proto-Oncogene EVI1 abrogates BcL-xL promoter binding and induces apoptosis

PLoS ONE

Volumn 6, Issue 9, 2011, Pages

  Pradhan, Anjan Kumar ^a   Mohapatra, Aloks Das ^a   Nayak, Kasturi Bala ^a   Chakraborty, Soumen ^a  

^a INSTITUTE OF LIFE SCIENCES   (India)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN BCL XL; DNA BINDING PROTEIN; HISTONE ACETYLTRANSFERASE PCAF; P300-CBP-ASSOCIATED FACTOR; PROTEIN BCL X; ZINC FINGER PROTEIN;

ACETYLATION; AMPLICON; ANIMAL CELL; APOPTOSIS; ARTICLE; BINDING AFFINITY; BINDING SITE; CELL CYCLE PROGRESSION; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DOWN REGULATION; EVI1 GENE; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; ONCOGENE; PROMOTER REGION; PROTEIN BINDING; PROTEIN PROCESSING; SIGNAL TRANSDUCTION; START CODON; TRANSCRIPTION REGULATION; UPREGULATION; ANIMAL; CATTLE; CELL STRAIN 3T3; CELL STRAIN HEK293; CELL STRAIN HT29; CHEMISTRY; DOG; GENETIC TRANSCRIPTION; GENETICS; METABOLISM; MOLECULAR GENETICS; PROTO ONCOGENE; RAT;

ACETYLATION; ANIMALS; APOPTOSIS; BASE SEQUENCE; BCL-X PROTEIN; CATTLE; DNA-BINDING PROTEINS; DOGS; DOWN-REGULATION; HEK293 CELLS; HT29 CELLS; HUMANS; MICE; MOLECULAR SEQUENCE DATA; NIH 3T3 CELLS; P300-CBP TRANSCRIPTION FACTORS; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; PROTO-ONCOGENES; RATS; TRANSCRIPTION, GENETIC; UP-REGULATION; ZINC FINGERS;

EID: 80053252121     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0025370     Document Type: Article

References (42)

1. Morishita K, Parker DS, Mucenski ML, Jenkins NA, Copeland NG, et al. (1988) Retroviral activation of a novel gene encoding a zinc finger protein in IL-3-dependent myeloid leukemia cell lines. Cell 54: 831-840.
2. Ogawa S, Kurokawa M, Tanaka T, Tanaka K, Hangaishi A, et al. (1996) Increased Evi-1 expression is frequently observed in blastic crisis of chronic myelocytic leukemia. Leukemia 10: 788-794.
3. Wieser R, (2007) The oncogene and developmental regulator EVI1: expression, biochemical properties, and biological functions. Gene 396: 346-357.
4. Russell M, List A, Greenberg P, Woodward S, Glinsmann B, et al. (1994) Expression of EVI1 in myelodysplastic syndromes and other hematologic malignancies without 3q26 translocations. Blood 84: 1243-1248.
5. Ohyashiki JH, Ohyashiki K, Shimamoto T, Kawakubo K, Fujimura T, et al. (1995) Ecotropic virus integration site-1 gene preferentially expressed in post-myelodysplasia acute myeloid leukemia: possible association with GATA-1, GATA-2, and stem cell leukemia gene expression. Blood 85: 3713-3718.
6. Dreyfus F, Bouscary D, Melle J, Ribrag V, Guesnu M, et al. (1995) Expression of the Evi-1 gene in myelodysplastic syndromes. Leukemia 9: 203-205.
7. Lugthart S, van Drunen E, van Norden Y, van Hoven A, Erpelinck CA, et al. (2008) High EVI1 levels predict adverse outcome in acute myeloid leukemia: prevalence of EVI1 overexpression and chromosome 3q26 abnormalities underestimated. Blood 111: 4329-4337.
8. Liu Y, Chen L, Ko TC, Fields AP, Thompson EA, (2006) Evi1 is a survival factor which conveys resistance to both TGFbeta- and taxol-mediated cell death via PI3K/AKT. Oncogene 25: 3565-3575.
9. Morishita K, Parganas E, Douglass EC, Ihle JN, (1990) Unique expression of the human Evi-1 gene in an endometrial carcinoma cell line: sequence of cDNAs and structure of alternatively spliced transcripts. Oncogene 5: 963-971.
10. Bartholomew C, Clark AM, (1994) Induction of two alternatively spliced evi-1 proto-oncogene transcripts by cAMP in kidney cells. Oncogene 9: 939-942.
11. Shimabe M, Goyama S, Watanabe-Okochi N, Yoshimi A, Ichikawa M, et al. (2009) Pbx1 is a downstream target of Evi-1 in hematopoietic stem/progenitors and leukemic cells. Oncogene 28: 4364-4374.
12. Roy P, Reavey E, Rayne M, Roy S, Abed El Baky M, et al. (2010) Enhanced sensitivity to hydrogen peroxide-induced apoptosis in Evi1 transformed Rat1 fibroblasts due to repression of carbonic anhydrase III. Febs J 277: 441-452.
13. Qiu Y, Lynch J, Guo L, Yatsula B, Perkins AS, et al. (2008) Regulation of the calreticulin gene by GATA6 and Evi-1 transcription factors. Biochemistry 47: 3697-3704.
14. Yuasa H, Oike Y, Iwama A, Nishikata I, Sugiyama D, et al. (2005) Oncogenic transcription factor Evi1 regulates hematopoietic stem cell proliferation through GATA-2 expression. Embo J 24: 1976-1987.
15. Hanahan D, Weinberg RA, (2000) The hallmarks of cancer. Cell 100: 57-70.
16. Cory S, Adams JM, (2002) The Bcl2 family: regulators of the cellular life-or-death switch. Nat Rev Cancer 2: 647-656.
17. Chen N, Chen X, Huang R, Zeng H, Gong J, et al. (2009) BCL-xL is a target gene regulated by hypoxia-inducible factor-1{alpha}. J Biol Chem 284: 10004-10012.
18. Konrad TA, Karger A, Hackl H, Schwarzinger I, Herbacek I, et al. (2009) Inducible expression of EVI1 in human myeloid cells causes phenotypes consistent with its role in myelodysplastic syndromes. J Leukoc Biol 86: 813-822.
19. Chakraborty S, Senyuk V, Sitailo S, Chi Y, Nucifora G, (2001) Interaction of EVI1 with cAMP-responsive element-binding protein-binding protein (CBP) and p300/CBP-associated factor (P/CAF) results in reversible acetylation of EVI1 and in co-localization in nuclear speckles. J Biol Chem 276: 44936-44943.
20. Buonamici S, Li D, Chi Y, Zhao R, Wang X, et al. (2004) EVI1 induces myelodysplastic syndrome in mice. J Clin Invest 114: 713-719.
21. Kurokawa M, Mitani K, Yamagata T, Takahashi T, Izutsu K, et al. (2000) The evi-1 oncoprotein inhibits c-Jun N-terminal kinase and prevents stress-induced cell death. Embo J 19: 2958-2968.
22. Grillot DA, Gonzalez-Garcia M, Ekhterae D, Duan L, Inohara N, et al. (1997) Genomic organization, promoter region analysis, and chromosome localization of the mouse bcl-x gene. J Immunol 158: 4750-4757.
23. Valks DM, Kemp TJ, Clerk A, (2003) Regulation of Bcl-xL expression by H2O2 in cardiac myocytes. J Biol Chem 278: 25542-25547.
24. Gregory T, Yu C, Ma A, Orkin SH, Blobel GA, et al. (1999) GATA-1 and erythropoietin cooperate to promote erythroid cell survival by regulating bcl-xL expression. Blood 94: 87-96.
25. Kuo YY, Chang ZF, (2007) GATA-1 and Gfi-1B interplay to regulate Bcl-xL transcription. Mol Cell Biol 27: 4261-4272.
26. Laricchia-Robbio L, Fazzina R, Li D, Rinaldi CR, Sinha KK, et al. (2006) Point mutations in two EVI1 Zn fingers abolish EVI1-GATA1 interaction and allow erythroid differentiation of murine bone marrow cells. Mol Cell Biol 26: 7658-7666.
27. Buonamici S, Li D, Mikhail FM, Sassano A, Platanias LC, et al. (2005) EVI1 abrogates interferon-alpha response by selectively blocking PML induction. J Biol Chem 280: 428-436.
28. Ravindra KC, Selvi BR, Arif M, Reddy BA, Thanuja GR, et al. (2009) Inhibition of lysine acetyltransferase KAT3B/p300 activity by a naturally occurring hydroxynaphthoquinone, plumbagin. J Biol Chem 284: 24453-24464.
29. Reed JC, (1999) Dysregulation of apoptosis in cancer. J Clin Oncol 17: 2941-2953.
30. Raff MC, (1992) Social controls on cell survival and cell death. Nature 356: 397-400.
31. Evan G, Littlewood T, (1998) A matter of life and cell death. Science 281: 1317-1322.
32. Amundson SA, Myers TG, Scudiero D, Kitada S, Reed JC, et al. (2000) An informatics approach identifying markers of chemosensitivity in human cancer cell lines. Cancer Res 60: 6101-6110.
33. Fujio Y, Kunisada K, Hirota H, Yamauchi-Takihara K, Kishimoto T, (1997) Signals through gp130 upregulate bcl-x gene expression via STAT1-binding cis-element in cardiac myocytes. J Clin Invest 99: 2898-2905.
34. Chen C, Edelstein LC, Gelinas C, (2000) The Rel/NF-kappaB family directly activates expression of the apoptosis inhibitor Bcl-x(L). Mol Cell Biol 20: 2687-2695.
35. Sevilla L, Aperlo C, Dulic V, Chambard JC, Boutonnet C, et al. (1999) The Ets2 transcription factor inhibits apoptosis induced by colony-stimulating factor 1 deprivation of macrophages through a Bcl-xL-dependent mechanism. Mol Cell Biol 19: 2624-2634.
36. Cherbonnel-Lasserre C, Gauny S, Kronenberg A, (1996) Suppression of apoptosis by Bcl-2 or Bcl-xL promotes susceptibility to mutagenesis. Oncogene 13: 1489-1497.
37. Cohen HY, Lavu S, Bitterman KJ, Hekking B, Imahiyerobo TA, et al. (2004) Acetylation of the C terminus of Ku70 by CBP and PCAF controls Bax-mediated apoptosis. Mol Cell 13: 627-638.
38. Yang Y, Zhao Y, Liao W, Yang J, Wu L, et al. (2009) Acetylation of FoxO1 activates Bim expression to induce apoptosis in response to histone deacetylase inhibitor depsipeptide treatment. Neoplasia 11: 313-324.
39. Brunet A, Sweeney LB, Sturgill JF, Chua KF, Greer PL, et al. (2004) Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science 303: 2011-2015.
40. Sykes SM, Mellert HS, Holbert MA, Li K, Marmorstein R, et al. (2006) Acetylation of the p53 DNA-binding domain regulates apoptosis induction. Mol Cell 24: 841-851.
41. Caillaud A, Prakash A, Smith E, Masumi A, Hovanessian AG, et al. (2002) Acetylation of interferon regulatory factor-7 by p300/CREB-binding protein (CBP)-associated factor (PCAF) impairs its DNA binding. J Biol Chem 277: 49417-49421.
42. Westerheide SD, Anckar J, Stevens SM Jr, Sistonen L, Morimoto RI, (2009) Stress-inducible regulation of heat shock factor 1 by the deacetylase SIRT1. Science 323: 1063-1066.