Butyrate, a histone deacetylase inhibitor, activates the human IGF binding protein-3 promoter in breast cancer cells: Molecular mechanism involves an Sp1/Sp3 multiprotein complex

Endocrinology

Volumn 142, Issue 9, 2001, Pages 3817-3827

  Walker, Gillian E ^a   Wilson, Elizabeth M ^a   Powell, David ^b   Oh, Youngman ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BUTYRIC ACID; HISTONE DEACETYLASE; HISTONE DEACETYLASE INHIBITOR; PROTEIN P300; SOMATOMEDIN BINDING PROTEIN 3; TRANSCRIPTION FACTOR AP 2; TRANSCRIPTION FACTOR SP1; TRANSCRIPTION FACTOR SP3;

ARTICLE; BREAST CANCER; CANCER INHIBITION; CELL DIFFERENTIATION; CELL STRAIN MCF 7; CONTROLLED STUDY; ENZYME INHIBITION; GROWTH REGULATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROMOTER REGION; SIGNAL TRANSDUCTION;

EID: 0034868293     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.142.9.8380     Document Type: Article

References (63)

1. Growth, differentiation, and survival: Multiple physiological functions for insulin-like growth factors
2. Insulin-like growth factors and their binding proteins: Biological actions
3. Insulin-like growth factor binding protein I stimulates cell migration and binds to the α 5 β 1 integrin by means of its Arg-Gly-Asp sequence
4. Insulin-like growth factor (IGF)-independent action of IGF-binding protein-3 in Hs578T human breast cancer cells. Cell surface binding and growth inhibition
5. Studies on the mechanisms by which insulin-like growth factor (IGF) binding protein-4 (IGFBP-4) and IGFBP-5 modulate IGF actions in bone cells
6. Structure of the Mr 140,000 growth hormone-dependent insulin-like growth factor binding protein complex: Determination by reconstitution and affinity-labeling
7. Binding proteins for the insulin-like growth factors: Structure, regulation and function
8. Identification of insulin-like growth factor binding proteins in breast cancer cells
9. Insulin-like growth factor I (IGF-I)-binding protein complex is a better mitogen than free IGF-I
10. Insulin-like growth factor (IGF) binding protein-3 potentiation of IGF action is mediated through the phosphatidylinositol-3-kinase pathway and is associated with alteration in protein kinase B/ AKT sensitivity
11. Insulin-like growth factor (IGF)-binding protein-3 induces apoptosis and mediates the effects of transforming growth factor-β1 on programmed cell death through a p53- and IGF-independent mechanism
12. Insulin-like growth factor-binding protein-3 production by MCF-7 breast cancer cells: Stimulation by retinoic acid and cyclic adenosine monophosphate and differential effects of estradiol
13. Direct functional interactions between insulin-like growth factor-binding protein-3 and retinoid X receptor-α regulate transcriptional signaling and apoptosis
14. The type V transforming growth factor β receptor is the putative insulin-like growth factor-binding protein 3 receptor
15. Nuclear import of insulin-like growth factor-binding protein-3 and -5 is mediated by the importin β subunit
16. Transforming growth factor-β-induced cell growth inhibition in human breast cancer cells is mediated through insulin-like growth factor-binding protein-3 action
17. Insulin-like growth factor binding protein 3 mediates retinoic acid- and transforming growth factor β2-induced growth inhibition in human breast cancer cells
18. Regulation of insulin-like growth factor I receptor expression by the pure antiestrogen ICI 182780
19. Growth inhibition of both MCF-7 and Hs578T human breast cancer cell lines by vitamin D analogues is associated with increased expression of insulin-like growth factor binding protein-3
20. Antiproliferative action of tumor necrosis factor-α on MCF-7 breast cancer cells is associated with increased insulin-like growth factor binding protein-3 accumulation
21. Estrogen and antiestrogen modulation of MCF7 human breast cancer cell proliferation is associated with specific alterations in accumulation of insulin-like growth factor-binding proteins in conditioned media
22. Estradiol and antiestrogens regulate a growth inhibitory insulin-like growth factor binding protein 3 autocrine loop in human breast cancer cells
23. Induction of the growth inhibitor IGF-binding protein 3 by p53
24. Effects of sodium butyrate on expression of members of the insulin-like growth factor binding protein superfamily in human mammary epithelial cells
25. Modulating IGFBP-3 expression by trichostatin A: Potential therapeutic role in the treatment of hepatocellular carcinoma
26. Insulin-Like growth factor I (IGF-I) and cyclic adenosine 3′,5′-monophosphate regulate IGF-binding protein-3 gene expression by transcriptional and posttranscriptional mechanisms in mammary epithelial cells
27. Insulin-like growth factor binding protein-3. Organization of the human chromosomal gene and demonstration of promoter activity
28. Efficient site-directed mutagenesis using uracil-containing DNA
29. Metal-dependent binding of a nuclear factor to the rat metallothionein-I promoter
30. Transcriptional regulation by the Sp family proteins
31. Transcription factor ZBP-89 cooperates with histone acetyltransferase p300 during butyrate activation of p21waf1 transcription in human cells
32. Butyrate. Potential role in colon cancer prevention and treatment
33. Butyrate rapidly induces growth inhibition and differentiation in HT-29 cells
34. Effect of sodium butyrate on human breast cancer cell lines
35. Phenylbutyrate induces apoptosis in human prostate cancer and is more potent than phenylacetate
36. Sodium butyrate inhibits histone deacetylation in cultured cells
37. Effects of sodium butyrate on the synthesis and methylation of DNA in normal cells and their transformed counterparts
38. Sodium butyrate induces retinoblastoma protein dephosphorylation, p16 expression and growth arrest of colon cancer cells
39. Histone deacetylase: A regulator of transcription
40. Histone acetylation in chromatin structure and transcription
41. p21(WAF1) is required for butyrate-mediated growth inhibition of human colon cancer cells
42. A novel cytotoxic agent for human carcinoid tumors
43. Butyrate-induced G1 arrest results from p21-independent disruption of retinoblastoma protein-mediated signals
44. Direct inhibition of the expression of cyclin D1 gene by sodium butyrate
45. Bcl-2 expression regulates sodium butyrate-induced apoptosis in human MCF-7 breast cancer cells
46. Bcl-2 and bak may play a pivotal role in sodium butyrate-induced apoptosis in colonic epithelial cells; however overexpression of bcl-2 does not protect against bak-mediated apoptosis
47. Butyrate activates the WAF1/Cip1 gene promoter through Sp1 sites in a p53-negative human colon cancer cell line
48. Histone deacetylase inhibitor activates the WAF1/Cip1 gene promoter through the Sp1 sites
49. Nerve growth factor induces transcription of the p21 WAF1/CIP1 and cyclin D1 genes in PC12 cells by activating the Sp1 transcription factor
50. Functional analysis of the transforming growth factor β responsive elements in the WAF1/Cip1/p21 promoter
51. Transforming growth factor β activates the promoter of cyclin-dependent kinase inhibitor p15INK4B through an Sp1 consensus site
52. Sp1 trans-activation of cell cycle regulated promoters is selectively repressed by Sp3
53. DNA-binding properties of the E1A-associated 300-kilodalton protein
54. Functional interactions between the retinoblastoma (Rb) protein and Sp-family members: Superactivation by Rb requires amino acids necessary for growth suppression
55. Regulation of the human p21/WAF1/Cip1 promoter in hepatic cells by functional interactions between Sp1 and Smad family members
56. Cooperation of Sp1 and p300 in the induction of the CDK inhibitor p21WAF1/CIP1 during NGF-mediated neuronal differentiation
57. Progesterone regulates transcription of the p21(WAF1) cyclin-dependent kinase inhibitor gene through Sp1 and CBP/p300
58. p300 collaborates with Sp1 and Sp3 in p21(waf1/cip1) promoter activation induced by histone deacetylase inhibitor
59. Analysis of E1A-mediated growth regulation functions: Binding of the 300-kilodalton cellular product correlates with E1A enhancer repression function and DNA synthesis-inducing activity
60. Inhibition of p53-mediated transactivation and cell cycle arrest by E1A through its p300/CBP-interacting region
61. Adenovirus E1A downregulates cJun- and JunB-mediated transcription by targeting their coactivator p300
62. Human p300 protein is a coactivator for the transcription factor MyoD
63. Histone deacetylase 1 can repress transcription by binding to Sp1