Mechanism of sustained activation of Ribosomal S6 Kinase (RSK) and ERK by Kaposi Sarcoma-associated herpesvirus ORF45: Multiprotein complexes retain active phosphorylated ERK and RSK and protect them from dephosphorylation

Journal of Biological Chemistry

Volumn 284, Issue 20, 2009, Pages 13958-13968

  Kuang, Ersheng ^a   Wu, Fayi ^a   Zhu, Fanxiu ^a  

^a FLORIDA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLULAR SIGNALING; DEPHOSPHORYLATION; EXTRACELLULAR SIGNAL-REGULATED KINASE; HIGH MOLECULAR MASS; INTRACELLULAR PARASITES; KAPOSI SARCOMA-ASSOCIATED HERPESVIRUS; KINASE ACTIVITY; MITOGEN-ACTIVATED PROTEINS; MULTI-PROTEIN COMPLEX; OPEN READING FRAME; P90 RIBOSOMAL S6 KINASE; PROTEIN COMPLEXES; S6 KINASE; SUSTAINED ACTIVATION;

COMPUTER VIRUSES; ENZYME ACTIVITY; MACHINERY;

TUMORS;

MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MULTIPROTEIN COMPLEX; OPEN READING FRAME 45 PROTEIN; S6 KINASE; UNCLASSIFIED DRUG; VIRUS PROTEIN; IMMEDIATE EARLY PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE KINASE; ORF45 PROTEIN, KAPOSI'S SARCOMA ASSOCIATED HERPESVIRUS; ORF45 PROTEIN, KAPOSI'S SARCOMA-ASSOCIATED HERPESVIRUS;

ARTICLE; BINDING AFFINITY; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME MECHANISM; HUMAN; HUMAN CELL; HUMAN HERPESVIRUS 8; MOLECULAR WEIGHT; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEPHOSPHORYLATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; VIRUS REPLICATION; CELL LINE; METABOLISM; PHYSIOLOGY;

HERPESVIRIDAE; HUMAN HERPESVIRUS 8;

CELL LINE; HERPESVIRUS 8, HUMAN; HUMANS; IMMEDIATE-EARLY PROTEINS; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MULTIPROTEIN COMPLEXES; RIBOSOMAL PROTEIN S6 KINASES, 90-KDA; VIRUS REPLICATION;

EID: 67649405057     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M900025200     Document Type: Article

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