Functional differences between aggregated and dispersed insulin-producing cells

Diabetologia

Volumn 56, Issue 7, 2013, Pages 1557-1568

  Chowdhury, A ^a   Dyachok, O ^a   Tengholm, A ^a   Sandler, S ^a   Bergsten, P ^a  

^a UPPSALA UNIVERSITY   (Sweden)

Author keywords

Beta cell; Ca2+; Insulin secretion; IRS 1; Islets; Mitochondrial metabolism; PI3 kinase

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; 2 OXOISOCAPROIC ACID; CALCIUM ION; GLUCOSE; GLUCOSE TRANSPORTER 2; GLUTAMINE; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; INSULIN RECEPTOR SUBSTRATE 2; MESSENGER RNA; PHOSPHATIDYLINOSITOL 3 KINASE; PYRUVIC ACID; TRANSCRIPTION FACTOR PDX 1;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CELL AGGREGATION; CELL STRUCTURE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE; GLUCOSE OXIDATION; GLUT2 GENE; HUMAN; HUMAN CELL; INSULIN RELEASE; INSULIN RESPONSE; INTRACELLULAR SIGNALING; ISOTOPE LABELING; MICROFLUOROMETRY; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL FUNCTION; PDX 1 GENE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REAL TIME POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CALCIUM; CELL LINE, TUMOR; INSULIN; ISLETS OF LANGERHANS; MICE; PHOSPHATIDYLINOSITOL 3-KINASES; REAL-TIME POLYMERASE CHAIN REACTION;

EID: 84878877550     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-013-2903-3     Document Type: Article

References (50)

1. Orci L, Unger RH (1975) Functional subdivision of islets of Langerhans and possible role of D cells. Lancet 2:1243-1244
2. Miyazaki JI, Araki K, Yamato E et al (1990) Establishment of a pancreatic beta-cell line that retains glucose-inducible insulin-secretion: special reference to expression of glucose transporter isoforms. Endocrinology 127:126-132
3. Thörn K, Bergsten P (2010) Fatty acid-induced oxidation and triglyceride formation is higher in insulin-producing MIN6 cells exposed to oleate compared to palmitate. J Cell Biochem 111:497-507
4. Pipeleers D, Intveld P, Maes E, Vandewinkel M (1982) Glucose-induced insulin release depends on functional cooperation between islet cells. Proc Natl Acad Sci USA Biol Sci 79:7322-7325
5. Salomon D, Meda P (1986) Heterogeneity and contact-dependent regulation of hormone secretion by individual B cells. Exp Cell Res 162:507-520
6. Hopcroft DW, Mason DR, Scott RS (1985) Insulin secretion from perifused rat pancreatic pseudoislets. In Vitro Cell Dev Biol 21:421-427
7. Hauge-Evans AC, Squires PE, Persaud SJ, Jones PM (1999) Pancreatic beta-cell-to-beta-cell interactions are required for integrated responses to nutrient stimuli: enhanced Ca2+ and insulin secretory responses of MIN6 pseudoislets. Diabetes 48:1402-1408
8. Bergsten P, Hellman B (1993) Glucose-induced amplitude regulation of pulsatile insulin secretion from individual pancreatic islets. Diabetes 42:670-674
9. 2+ release by activation of inositol 1,4,5-trisphosphate receptors in primary pancreatic β-cells. Cell Calcium 36:1-9
10. Luther MJ, Hauge-Evans A, Souza KL et al (2006) MIN6 beta-cell-beta-cell interactions influence insulin secretory responses to nutrients and non-nutrients. Biochem Biophys Res Commun 343:99-104
11. Alejandro EU, Lim GE, Mehran AE et al (2011) Pancreatic beta-cell Raf-1 is required for glucose tolerance, insulin secretion, and insulin 2 transcription. FASEB J 25:3884-3895
12. Quintens R, Hendrickx N, Lemaire K, Schuit F (2008) Why expression of some genes is disallowed in beta-cells. Biochem Soc Trans 36:300-305
13. Ishihara H, Asano T, Tsukuda K et al (1993) Pancreatic beta cell line MIN6 exhibits characteristics of glucose metabolism and glucose-stimulated insulin secretion similar to those of normal islets. Diabetologia 36:1139-1145
14. Alessi DR, James SR, Downes CP et al (1997) Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha. Curr Biol 7:261-269
15. Stokoe D, Stephens LR, Copeland T et al (1997) Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B. Science 277:567-570
16. Kelly C, Guo H, McCluskey JT, Flatt PR, McClenaghan NH (2010) Comparison of insulin release from MIN6 pseudoislets and pancreatic islets of Langerhans reveals importance of homotypic cell interactions. Pancreas 39:1016-1023
17. Dahl U, Sjodin A, Semb H (1996) Cadherins regulate aggregation of pancreatic β-cells in vivo. Development 122:2895-2902
18. Rogers GJ, Hodgkin MN, Squires PE (2007) E-cadherin and cell adhesion: a role in architecture and function in the pancreatic islet. Cell Physiol Biochem 20:987-994
19. Roderigo-Milne H, Hauge-Evans AC, Persaud SJ, Jones PM (2002) Differential expression of insulin genes 1 and 2 in MIN6 cells and pseudoislets. Biochem Biophys Res Commun 296:589-595
20. Bergsten P, Hellman B (1993) Glucose-induced cycles of insulin release can be resolved into distinct periods of secretory activity. Biochem Biophys Res Commun 192:1182-1188
21. Lin JM, Fabregat ME, Gomis R, Bergsten P (2002) Pulsatile insulin release from islets isolated from three subjects with type 2 diabetes. Diabetes 51:988-993
22. Song SH, Kjems L, Ritzel R et al (2002) Pulsatile insulin secretion by human pancreatic islets. J Clin Endocrinol Metab 87:213-221
23. Tinto N, Zagari A, Capuano M et al (2008) Glucokinase gene mutations: structural and genotype-phenotype analyses in MODY children from South Italy. PLoS One 3:e1870
24. Ban N, Yamada Y, Someya Y et al (2002) Hepatocyte nuclear factor-1α recruits the transcriptional co-activator p300 on the GLUT2 gene promoter. Diabetes 51:1409-1418
25. Hauge-Evans AC, Squires PE, Belin VD et al (2002) Role of adenine nucleotides in insulin secretion from MIN6 pseudoislets. Mol Cell Endocrinol 191:167-176
26. Zhao C, Wilson MC, Schuit F, Halestrap AP, Rutter GA (2001) Expression and distribution of lactate/monocarboxylate transporter isoforms in pancreatic islets and the exocrine pancreas. Diabetes 50:361-366
27. Sekine N, Cirulli V, Regazzi R et al (1994) Low lactate-dehydrogenase and high mitochondrial glycerol phosphate dehydrogenase in pancreatic β-cells: potential role in nutrient sensing. J Biol Chem 269:4895-4902
28. Mohammed JS, Wang Y, Harvat TA, Oberholzer J, Eddington DT (2009) Microfluidic device for multimodal characterization of pancreatic islets. Lab Chip 9:97-106
29. MacDonald MJ (2002) Differences between mouse and rat pancreatic islets: succinate responsiveness, malic enzyme, and anaplerosis. Am J Physiol Endocrinol Metab 283:E302-E310
30. Welsh M, Hellerstrom C, Andersson A (1982) Respiration and insulin release in mouse pancreatic islets. Effects of L-leucine and 2-ketoisocaproate in combination with D-glucose and L-glutamine. Biochim Biophys Acta 721:178-184
31. Pipeleers D, Kiekens R, Ling Z, Wilikens A, Schuit F (1994) Physiologic relevance of heterogeneity in the pancreatic beta-cell population. Diabetologia 37(Suppl 2):S57-S64
32. Kuhara T, Ikeda S, Ohneda A, Sasaki Y (1991) Effects of intravenous infusion of 17 amino acids on the secretion of GH, glucagon, and insulin in sheep. Am J Physiol 260:E21-E26
33. Hellman B, Idahl LA, Lernmark A, Sehlin J, Taljedal IB (1974) The pancreatic beta-cell recognition of insulin secretagogues. Comparisons of glucose with glyceraldehyde isomers and dihydroxyacetone. Arch Biochem Biophys 162:448-457
34. Henquin JC, Dufrane D, Nenquin M (2006) Nutrient control of insulin secretion in isolated normal human islets. Diabetes 55:3470-3477
35. Brereton H, Carvell MJ, Persaud SJ, Jones PM (2007) Islet alpha-cells do not influence insulin secretion through cell-cell contact. Diabet Med 24:30-30
36. Leibiger IB, Brismar K, Berggren PO (2010) Novel aspects on pancreatic beta-cell signal-transduction. Biochem Biophys Res Commun 396:111-115
37. Burks DJ, White MF (2001) IRS proteins and beta-cell function. Diabetes 50(Suppl 1):S140-S145
38. Boura-Halfon S, Zick Y (2009) Phosphorylation of IRS proteins, insulin action, and insulin resistance. Am J Physiol Endocrinol Metab 296:E581-E591
39. Kulkarni RN, Winnay JN, Daniels M et al (1999) Altered function of insulin receptor substrate-1-deficient mouse islets and cultured beta-cell lines. J Clin Invest 104:R69-R75
40. Aspinwall CA, Qian WJ, Roper MG, Kulkarni RN, Kahn CR, Kennedy RT (2000) Roles of insulin receptor substrate-1, phosphatidylinositol 3-kinase, and release of intracellular Ca2+ stores in insulin-stimulated insulin secretion in beta-cells. J Biol Chem 275:22331-22338
41. Zick Y (2001) Insulin resistance: a phosphorylation-based uncoupling of insulin signaling. Trends Cell Biol 11:437-441
42. Bouzakri K, Roques M, Gual P et al (2003) Reduced activation of phosphatidylinositol-3 kinase and increased serine 636 phosphorylation of insulin receptor substrate-1 in primary culture of skeletal muscle cells from patients with type 2 diabetes. Diabetes 52:1319-1325
43. Aoyagi K, Ohara-Imaizumi M, Nishiwaki C, Nakamichi Y, Nagamatsu S (2010) Insulin/phosphoinositide 3-kinase pathway accelerates the glucose-induced first-phase insulin secretion through TrpV2 recruitment in pancreatic β-cells. Biochem J 432:375-386
44. El-Kholy W, MacDonald P, Lin JH et al (2003) The phosphatidylinositol 3-kinase inhibitor LY294002 potently blocks Kv currents in beta cells via a direct mechanism. Diabetes 52:A368-A368
45. Hagiwara S, Sakurai T, Tashiro F et al (1995) An inhibitory role for phosphatidylinositol 3-kinase in insulin secretion from pancreatic B cell line MIN6. Biochem Biophys Res Commun 214:51-59
46. 2+] elevation signals. Diabetes 51:87-97
47. Zawalich WS, Zawalich KC (2000) A link between insulin resistance and hyperinsulinemia: inhibitors of phosphatidylinositol 3-kinase augment glucose-induced insulin secretion from islets of lean, but not obese, rats. Endocrinology 141:3287-3295
48. Kaneko K, Ueki K, Takahashi N et al (2010) Class IA phosphatidylinositol 3-kinase in pancreatic β cells controls insulin secretion by multiple mechanisms. Cell Metab 12:619-632
49. MacDonald PE, Joseph JW, Yau D et al (2004) Impaired glucose-stimulated insulin secretion, enhanced intraperitoneal insulin tolerance, and increased β-cell mass in mice lacking the p110gamma isoform of phosphoinositide 3-kinase. Endocrinology 145:4078-4083
50. Gao Z, Konrad RJ, Collins H, Matschinsky FM, Rothenberg PL, Wolf BA (1996) Wortmannin inhibits insulin secretion in pancreatic islets and beta-TC3 cells independent of its inhibition of phosphatidylinositol 3-kinase. Diabetes 45:854-862