Myricetin-mediated lifespan extension in caenorhabditis elegans is modulated by DAF-16

International Journal of Molecular Sciences

Volumn 14, Issue 6, 2013, Pages 11895-11914

  Büchter, Christian ^a,b   Ackermann, Daniela ^b   Havermann, Susannah ^a,b   Honnen, Sebastian ^b   Chovolou, Yvonni ^b   Fritz, Gerhard ^b   Kampkötter, Andreas ^b,c   Wätjen, Wim ^a,b  

^a MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

^b HEINRICH HEINE UNIVERSITY   (Germany)

^c BAYER AG   (Germany)

Author keywords

C. elegans; Daf 16; Flavonoid; Insulin like signalling; Lifespan; Myricetin; Oxidative stress; SKN 1

Indexed keywords

BIOLOGICAL MARKER; FLAVONOID; FLAVONOL; LIPOFUSCIN; MYRICETIN; PROTEIN; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR DAF 16; TRANSCRIPTION FACTOR NRF2; TRANSCRIPTION FACTOR SKN 1; UNCLASSIFIED DRUG; 6-HYDROXY-2,5,7,8-TETRAMETHYLCHROMAN-2-CARBOXYLIC ACID; ANTIOXIDANT; CAENORHABDITIS ELEGANS PROTEIN; CHROMAN DERIVATIVE; DAF-16 PROTEIN, C ELEGANS; DNA BINDING PROTEIN; FORKHEAD TRANSCRIPTION FACTOR; GREEN FLUORESCENT PROTEIN; SCAVENGER; SKN-1 PROTEIN, C ELEGANS;

AGING; ANTIOXIDANT ACTIVITY; ARTICLE; BIOACCUMULATION; CAENORHABDITIS ELEGANS; CONTROLLED STUDY; GENE FUNCTION; GENE TRANSLOCATION; GENETIC STRAIN; HUMAN; HUMAN CELL; LIFE EXTENSION; LONGEVITY; LOSS OF FUNCTION MUTATION; MUTANT; NONHUMAN; SEQUENCE HOMOLOGY; ANIMAL; CALORIC RESTRICTION; CELL FREE SYSTEM; CHEMISTRY; DRUG EFFECTS; HCT116 CELL LINE; HEAT; METABOLISM; OXIDATION REDUCTION REACTION; PHYSIOLOGICAL STRESS; PHYSIOLOGY; PROTEIN TRANSPORT;

CAENORHABDITIS ELEGANS;

ANIMALS; ANTIOXIDANTS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; CALORIC RESTRICTION; CELL-FREE SYSTEM; CHROMANS; DNA-BINDING PROTEINS; FLAVONOIDS; FORKHEAD TRANSCRIPTION FACTORS; FREE RADICAL SCAVENGERS; GREEN FLUORESCENT PROTEINS; HCT116 CELLS; HOT TEMPERATURE; HUMANS; LIPOFUSCIN; LONGEVITY; OXIDATION-REDUCTION; PROTEIN TRANSPORT; REACTIVE OXYGEN SPECIES; STRESS, PHYSIOLOGICAL; TRANSCRIPTION FACTORS;

EID: 84878837857     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms140611895     Document Type: Article

References (41)

1. Di Carlo, G.; Mascolo, N.; Izzo, A.A.; Capasso, F. Flavonoids: Old and new aspects of a class of natural therapeutic drugs. Life Sci. 1999, 65, 337-359.
2. Beecher G.R. Overview of dietary flavonoids: Nomenclature, occurrence and intake. J. Nutr. 2003, 133, 3248S-3254S.
3. Wätjen, W.; Chovolou, Y.; Kampkötter, A.; Kahl, R. Anti- and Prooxidative Effects of Flavonoids. In Leading Edge Antioxidants Research; Panglossi H.V., Ed.; Nova Science Publishers Inc.: New York, NY, USA, 2009; pp. 1-16.
4. Chobot, V.; Hadacek, F. Exploration of pro-oxidant and antioxidant activities of the flavonoid myricetin. Redox Rep. 2011, 16, 242-247.
5. Qin, S.; Chen, J.; Tanigawa, S.; Hou, D.X. Microarray and pathway analysis highlight Nrf2/ARE-mediated expression profiling by polyphenolic myricetin. Mol. Nutr. Food Res. 2013, 57, 435-446.
6. Phillips, P.A.; Sangwan, V.; Borja-Cacho, D.; Dudeja, V.; Vickers, S.M.; Saluja, A.K. Myricetin induces pancreatic cancer cell death via the induction of apoptosis and inhibition of the phosphatidylinositol 3-kinase (PI3K) signalling pathway. Cancer Lett. 2011, 308, 181-188.
7. Chen, W.; Li, Y.; Li, J.; Han, Q.; Ye, L.; Li, A. Myricetin affords protection against peroxynitrite-mediated DNA damage and hydroxyl radical formation. Food Chem. Toxicol. 2011, 49, 2439-2444.
8. Kang, N.J.; Jung, S.K.; Lee, K.W.; Lee, H.J. Myricetin is a potent chemopreventive phytochemical in skin carcinogenesis. Ann. N. Y. Acad. Sci. 2011, 1229, 124-132.
9. Duthie, G.; Morrice, P. Antioxidant capacity of flavonoids in hepatic microsomes is not reflected by antioxidant effects in vivo. Oxid. Med. Cell Longev. 2012, 2012, 165127.
10. Tzeng, T.F.; Liou, S.S.; Liu, I.M. Myricetin ameliorates defective post-receptor insulin signalling via β-endorphin signalling in the skeletal muscles of fructose-fed rats. Evid. Based Complement. Alternat. Med. 2011, 2011, 150752.
11. Kampkötter, A.; Timpel, C.; Zurawski, R.F.; Ruhl, S.; Chovolou, Y.; Proksch, P.; Wätjen, W. Increase of stress resistance and lifespan of Caenorhabditis elegans by quercetin. Comp. Biochem. Physiol. B Biochem. Mol Biol. 2008, 149, 314-323.
12. Saul, N.; Pietsch, K.; Menzel, R.; Steinberg, C.E. Quercetin-mediated longevity in Caenorhabditis elegans: Is DAF-16 involved? Mech. Ageing Dev. 2008, 129, 611-613.
13. Zarse, K.; Schmeisser, S.; Birringer, M.; Falk, E.; Schmoll, D.; Ristow, M. Differential effects of resveratrol and SRT1720 on lifespan of adult Caenorhabditis elegans. Horm. Metab. Res. 2010, 42, 837-839.
14. Morselli, E.; Maiuri, M.C.; Markaki, M.; Megalou, E.; Pasparaki, A.; Palikaras, K.; Criollo, A.; Galluzzi, L.; Malik, S.A.; Vitale, I.; et al. Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy. Cell Death Dis. 2010, 1, doi:10.1038/cddis.2009.8.
15. Viswanathan, M.; Kim, S.K.; Berdichevsky, A.; Guarente, L. A role for SIR-2.1 regulation of ER stress response genes in determining C. elegans life span. Dev. Cell 2005, 9, 605-615.
16. Bartholome, A.; Kampkötter, A.; Tanner, S.; Sies, H.; Klotz, L.O. Epigallocatechin gallate-induced modulation of FoxO signalling in mammalian cells and C. elegans: FoxO stimulation is masked via PI3K/Akt activation by hydrogen peroxide formed in cell culture. Arch. Biochem. Biophys. 2010, 501, 58-64.
17. Abbas, S.; Wink, M. Epigallocatechin gallate from green tea (Camellia sinensis) increases lifespan and stress resistance in Caenorhabditis elegans. Planta Med. 2009, 75, 216-221.
18. Saul, N.; Pietsch, K.; Menzel, R.; Stürzenbaum, S.R.; Steinberg, C.E. Catechin induced longevity in C. elegans: From key regulator genes to disposable soma. Mech. Ageing Dev. 2009, 130, 477-486.
19. Wilson, M.A.; Shukitt-Hale, B.; Kalt, W.; Ingram, D.K.; Joseph, J.A.; Wolkow, C.A. Blueberry polyphenols increase lifespan and thermotolerance in Caenorhabditis elegans. Aging Cell 2006, 5, 59-86.
20. Grünz, G.; Haas, K.; Soukup, S.; Klingenspor, M.; Kulling, S.E.; Daniel, H.; Spanier, B. Structural features and bioavailability of four flavonoids and their implications for lifespan-extending and antioxidant actions in C. elegans. Mech. Ageing Dev. 2012, 133, 1-10.
21. Ong, K.C.; Khoo, H.E. Biological effects of myricetin. Gen. Pharmacol. 1997, 29, 121-126.
22. Wang, Z.H.; Ah Kang, K.; Zhang, R.; Piao, M.J.; Jo, S.H.; Kim, J.S.; Kang, S.S.; Lee, J.S.; Park, D.H.; Hyun, J.W. Myricetin suppresses oxidative stress-induced cell damage via both direct and indirect antioxidant action. Environ. Toxicol. Pharmacol. 2010, 29, 12-18.
23. Kang, K.A.; Wang, Z.H.; Zhang, R.; Piao, M.J.; Kim, K.C.; Kang, S.S.; Kim, Y.W.; Lee, J.; Park, D.; Hyun, J.W. Myricetin protects cells against oxidative stress-induced apoptosis via regulation of PI3K/Akt and MAPK signalling pathways. Int. J. Mol. Sci. 2010, 11, 4348-4360.
24. Jung, T.; Bader, N.; Grune, T. Lipofuscin: Formation, distribution, and metabolic consequences. Ann. N. Y. Acad. Sci. 2007, 1119, 97-111.
25. Hosokawa, H.; Ishii, N.; Ishida, H.; Ichimori, K.; Nakazawa, H.; Suzuki, K. Rapid accumulation of fluorescent material with aging in an oxygen-sensitive mutant mev-1 of Caenorhabditis elegans. Mech. Ageing Dev. 1994, 74, 161-170.
26. Gerstbrein, B.; Stamatas, G.; Kollias. N.; Driscoll, M. In vivo spectrofluorimetry reveals endogenous biomarkers that report healthspan and dietary restriction in Caenorhabditis elegans. Aging Cell 2005, 4, 127-137.
27. Honnen, S.J.; Büchter, C.; Schröder, V.; Hoffmann, M.; Kohara, Y.; Kampkötter, A.; Bossinger, O. C. elegans VANG-1 modulates life span via insulin/IGF-1-like signalling. PLoS One 2012, 7, e32183.
28. Kampkötter, A.; Nkwonkam, C.G.; Zurawski, R.F.; Timpel, C.; Chovolou, Y.; Wätjen, W.; Kahl, R. Investigations of protective effects of the flavonoids quercetin and rutin on stress resistance in the model organism Caenorhabditis elegans. Toxicology 2007, 234, 113-123.
29. Kampkötter, A.; Gombitang Nkwonkam, C.; Zurawski, R.F.; Timpel, C.; Chovolou, Y.; Wätjen, W.; Kahl, R. Effects of the flavonoids kaempferol and fisetin on thermotolerance, oxidative stress and FoxO transcription factor DAF-16 in the model organism Caenorhabditis elegans. Arch. Toxicol. 2007, 81, 849-858.
30. Pietsch, K.; Saul, N.; Chakrabarti, S.; Stürzenbaum, S.R.; Menzel, R.; Steinberg, C.E. Hormetins, antioxidants and prooxidants: Defining quercetin-, caffeic acid- and rosmarinic acid-mediated life extension in C. elegans. Biogerontology 2011, 12, 329-347.
31. Kawasaki, I.; Jeong, M.H.; Oh, B.K.; Shim, Y.H. Apigenin inhibits larval growth of Caenorhabditis elegans through DAF-16 activation. FEBS Lett. 2010, 584, 3587-3591.
32. Havermann, S.; Rohrig, R.; Chovolou, Y.; Humpf, H.U.; Wätjen, W. Molecular effects of baicalein in Hct116 cells and Caenorhabditis elegans: Activation of the Nrf2 signalling pathway and prolongation of lifespan. J. Agric. Food Chem. 2013, 61, 2158-2164.
33. Zhang, L.; Jie, G.; Zhang, J.; Zhao, B. Significant longevity-extending effects of EGCG on Caenorhabditis elegans under stress. Free Radic. Biol. Med. 2009, 46, 414-421.
34. Liao, V.H.C.; Yu, C.W.; Chu, Y.J.; Li, W.H.; Hsieh, Y.C.; Wang, T.T. Curcumin-mediated lifespan extension in Caenorhabditis elegans. Mech. Ageing Dev. 2011, 132, 480-487.
35. Houthoofd, K.; Johnson, T.E.; Vanfleteren, J.R. Dietary restriction in the nematode Caenorhabditis elegans. J. Gerontol. A Biol. Sci. Med. Sci. 2005, 60, 1125-1131.
36. Piper, M.D.; Bartke, A. Diet and aging. Cell Metab. 2008, 8, 99-104.
37. Brenner, S. The genetics of Caenorhabditis elegans. Genetics 1974, 77, 71-94.
38. Re, R.; Pellegrini, N.; Proteggente, A.; Pannala, A.; Yang, M.; Rice-Evans, C. Antioxidant activity applying an improved ABTS radical cation decolorization assay. Free Radic. Biol. Med. 1999, 26, 1231-1237.
39. Gill, M.S.; Olsen, A.; Sampayo, J.N.; Lithgow, G.J. An automated high-throughput assay for survival of the nematode Caenorhabditis elegans. Free Radic. Biol. Med. 2003, 35, 558-565.
40. Kampkötter, A.; Pielarski, T.; Rohrig, R.; Timpel, C.; Chovolou, Y.; Wätjen, W.; Kahl, R. The Ginkgo biloba extract EGb761 reduces stress sensitivity, ROS accumulation and expression of catalase and glutathione S-transferase 4 in Caenorhabditis elegans. Pharmacol. Res. 2007, 55, 139-147.
41. Raizen, D.M.; Lee, R.Y.; Avery, L. Interacting genes required for pharyngeal excitation by motor neuron MC in Caenorhabditis elegans. Genetics 1995, 141, 1365-1382.