The Ginkgo biloba extract EGb761 reduces stress sensitivity, ROS accumulation and expression of catalase and glutathione S-transferase 4 in Caenorhabditis elegans

Pharmacological Research

Volumn 55, Issue 2, 2007, Pages 139-147

  Kampkotter A ^a   Pielarski, T ^a   Rohrig, R ^a   Timpel, C ^a   Chovolou, Y ^a   Watjen W ^a   Kahl, R ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

Caenorhabditis elegans; Catalase; EGb761; Glutathione S transferase 4; Stress

Indexed keywords

CATALASE; GINKGO BILOBA EXTRACT; GLUTATHIONE TRANSFERASE; REACTIVE OXYGEN METABOLITE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY SIZE; BRAIN DYSFUNCTION; CAENORHABDITIS ELEGANS; CONTROLLED STUDY; DRUG EFFICACY; FLUORESCENCE; GINKGO BILOBA; LIFESPAN; MICROTITER PLATE ASSAY; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PLANT LEAF; PRIORITY JOURNAL; REPORTER GENE; TEMPERATURE STRESS; TRANSCRIPTION INITIATION; WORM;

ANIMALS; ANTIOXIDANTS; BLOTTING, NORTHERN; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; CATALASE; GENES, REPORTER; GINKGO BILOBA; GLUTATHIONE TRANSFERASE; HEAT; LONGEVITY; OXIDATIVE STRESS; PLANT EXTRACTS; REACTIVE OXYGEN SPECIES; REPRODUCTION; RNA;

EID: 33846586683     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2006.11.006     Document Type: Article

References (53)

1. Cross A.R., and Jones O.T. Enzymic mechanisms of superoxide production. Biochim Biophys Acta 1057 3 (1991) 281-298
2. Patel M., and Day B.J. Metalloporphyrin class of therapeutic catalytic antioxidants. Trends Pharmacol Sci 20 9 (1999) 359-364
3. Colton C., and Zahari S. Role of free radicals in alcohol-induced tissue injury. In: Baskin S.I., and Salem H. (Eds). Oxidants, antioxidants and free radicals (1997), Taylor and Francis, Washington and London 259-271
4. Gutteridge J.M., and Halliwell B. Free radicals and antioxidants in the year 2000. A historical look to the future. Ann N Y Acad Sci 899 (2000) 136-147
5. Halliwell B., and Gutteridge J.M.C. Free radicals in biology and medicine. 3rd ed. (1999), Clarendon Press, Oxford
6. Bruskov V.I., Malakhova L.V., Masalimov Z.K., and Chernikov A.V. Heat-induced formation of reactive oxygen species and 8-oxoguanine, a biomarker of damage to DNA. Nucl Acids Res 30 6 (2002) 1354-1363
7. Finkel T., and Holbrook N.J. Oxidants, oxidative stress and the biology of ageing. Nature 408 6809 (2000) 239-247
8. Wallace D.C., and Melov S. Radicals r'aging. Nat Genet 19 2 (1998) 105-106
9. Bast A., and Goris R.J. Oxidative stress. Biochemistry and human disease. Pharm Weekbl Sci 11 6 (1989) 199-206
10. Forsberg L., de Faire U., and Morgenstern R. Oxidative stress, human genetic variation, and disease. Arch Biochem Biophys 389 1 (2001) 84-93
11. Wallace D.C. Mitochondrial genetics: a paradigm for aging and degenerative diseases?. Science 256 5057 (1992) 628-632
12. Warner H.R. Superoxide dismutase, aging, and degenerative disease. Free Radic Biol Med 17 3 (1994) 249-258
13. Davies K.J. Oxidative stress: the paradox of aerobic life. Biochem Soc Symp 61 (1995) 1-31
14. Sayre L.M., Smith M.A., and Perry G. Chemistry and biochemistry of oxidative stress in neurodegenerative disease. Curr Med Chem 8 7 (2001) 721-738
15. Penta J.S., Johnson F.M., Wachsman J.T., and Copeland W.C. Mitochondrial DNA in human malignancy. Mutat Res 488 2 (2001) 119-133
16. Prusiner S.B. Shattuck lecture-neurodegenerative diseases and prions. N Engl J Med 344 20 (2001) 1516-1526
17. Harman D. Aging: a theory based on free radical and radiation chemistry. J Gerontol 2 (1957) 298-300
18. de Grey A.D. A proposed refinement of the mitochondrial free radical theory of aging. Bioessays 19 2 (1997) 161-166
19. de Grey A.D. The reductive hotspot hypothesis: an update. Arch Biochem Biophys 373 1 (2000) 295-301
20. Choi H.J., Kang S.W., Yang C.H., Rhee S.G., and Ryu S.E. Crystal structure of a novel human peroxidase enzyme at 2.0 A resolution. Nat Struct Biol 5 5 (1998) 400-406
21. DeFeudis F.V. Effects of Ginkgo biloba extract (EGb 761) on gene expression: possible relevance to neurological disorders and age-associated cognitive impairment. Drug Dev Res 54 (2002) 214-235
22. Wu Z., Smith J.V., Paramasivam V., Butko P., Khan I., Cypser J.R., et al. Ginkgo biloba extract EGb 761 increases stress resistance and extends lifespan of Caenorabditis elegans. Cell Mol Biol (Noisy-le-grand) 48 6 (2002) 725-731
23. Strayer A., Wu Z., ChristenY, Link C.D., and Luo Y. Expression of the small heat shock protein Hsp-16-2 in Caenorhabditis elegans is suppressed by Ginkgo biloba extract EGb 761. FASEB J 17 15 (2003) 2305-2307
24. Smith J.V., and Luo Y. Studies on molecular mechanisms of Ginkgo biloba extract. Appl Microbiol Biotechnol 64 4 (2004) 465-472
25. Gohil K. Genomic responses to herbal extracts: lessons from in vitro and in vivo studies with an extract of Ginkgo biloba. Biochem Pharmacol 64 5/6 (2002) 913-917
26. Kaletta T., and Hengartner M.O. Finding function in novel targets: C. elegans as a model organism. Nat Rev Drug Discov 5 5 (2006) 387-399
27. The C. elegans Sequencing Consortium. Genome sequence of the nematode C. elegans: a platform for investigating biology. Science 1998;282(5396):2012-8.
28. Gill M.S. Endocrine targets for pharmacological intervention in aging in Caenorhabditis elegans. Aging Cell 5 1 (2006) 23-30
29. Gill M.S., Olsen A., Sampayo J.N., and Lithgow G.J. An automated high-throughput assay for survival of the nematode Caenorhabditis elegans. Free Radic Biol Med 35 6 (2003) 558-565
30. Leiers B., Kampkotter A., Grevelding C.G., Link C.D., Johnson T.E., and Henkle-Duhrsen K. A stress-responsive glutathione S-transferase confers resistance to oxidative stress in Caenorhabditis elegans. Free Radic Biol Med 34 11 (2003) 1405-1415
31. Lewis J.A., and Fleming J.T. Caenorhabditis elegans: modern biological analysis of an organism. 1st ed. (1995), Academic Press Inc., New York
32. Lithgow G.J., White T.M., Melov S., and Johnson T.E. Thermotolerance and extended life-span conferred by single-gene mutations and induced by thermal stress. Proc Natl Acad Sci USA 92 16 (1995) 7540-7544
33. Sambrook J., Fritsch E.F., and Maniatis T. Molecular cloning: a laboratory manual. 2nd ed. (1989), Cold Spring Harbor Laboratory Press, New York
34. Mates M.J. Effects of antioxidant enzymes in the molecular control of reactive oxygen species toxicology. Toxicology 153 1-3 (2000) 83-104
35. Murphy C.T., McCarroll S.A., Bargmann C.I., Fraser A., Kamath R.S., Ahringer J., et al. Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans. Nature 424 6946 (2003) 277-283
36. Rohrdanz E., Schmuck G., Ohler S., Tran-Thi Q.H., and Kahl R. Changes in antioxidant enzyme expression in response to hydrogen peroxide in rat astroglial cells. Arch Toxicol 75 3 (2001) 150-158
37. Rohrdanz E., and Kahl R. Alterations of antioxidant enzyme expression in response to hydrogen peroxide. Free Radic Biol Med 24 1 (1998) 27-38
38. Taub J., Lau J.F., Ma C., Hahn J.H., Hoque R., Rothblatt J., et al. A cytosolic catalase is needed to extend adult lifespan in C. elegans daf-C and clk-1 mutants. Nature 399 6732 (1999) 162-166
39. Larsen P.L. Aging and resistance to oxidative damage in Caenorhabditis elegans. Proc Natl Acad Sci USA 90 19 (1993) 8905-8909
40. Vanfleteren J.R. Oxidative stress and ageing in Caenorhabditis elegans. Biochem J 292 Pt 2 (1993) 605-608
41. Sampayo J.N., Jenkins N.L., and Lithgow G.J. Using stress resistance to isolate novel longevity mutations in Caenorhabditis elegans. Ann N Y Acad Sci 908 (2000) 324-326
42. Munoz M.J., and Riddle D.L. Positive selection of Caenorhabditis elegans mutants with increased stress resistance and longevity. Genetics 163 1 (2003) 171-180
43. de Castro E., de Castro S.H., and Johnson T.E. Isolation of long-lived mutants in Caenorhabditis elegans using selection for resistance to juglone. Free Radic Biol Med 37 2 (2004) 139-145
44. Smith J.V., and Luo Y. Elevation of oxidative free radicals in Alzheimer's disease models can be attenuated by Ginkgo biloba extract EGb 761. J Alzheimers Dis 5 4 (2003) 287-300
45. Luo Y. Alzheimer's disease, the nematode Caenorhabditis elegans, and ginkgo biloba leaf extract. Life Sci 78 18 (2006) 2066-2072
46. Thierry-Mieg D, Thierry-Mieg J, Potdevin M, Sienkiewicz M. AceView: Identification and functional annotation of cDNA-supported genes in higher organisms. The AceView genes: http://www.ncbi.nlm.nih.gov/IEB/Research/Acembly, unpublished.
47. Curran S.P., Leverich E.P., Koehler C.M., and Larsen P.L. Defective mitochondrial protein translocation precludes normal Caenorhabditis elegans development. J Biol Chem 279 52 (2004) 54655-54662
48. Ventura N., Rea S., Henderson S.T., Condo I., Johnson T.E., and Testi R. Reduced expression of frataxin extends the lifespan of Caenorhabditis elegans. Aging Cell 4 2 (2005) 109-112
49. Houthoofd K., Fidalgo M.A., Hoogewijs D., Braeckman B.P., Lenaerts I., Brys K., et al. Metabolism, physiology and stress defense in three aging Ins/IGF-1 mutants of the nematode Caenorhabditis elegans. Aging Cell 4 2 (2005) 87-95
50. Lozano E., Saez A.G., Flemming A.J., Cunha A., and Leroi A.M. Regulation of growth by ploidy in Caenorhabditis elegans. Curr Biol 16 5 (2006) 493-498
51. Wang J., Mohler W.A., and Savage-Dunn C. C-terminal mutants of C. elegans Smads reveal tissue-specific requirements for protein activation by TGF-beta signaling. Development 132 15 (2005) 3505-3513
52. Ji Y.J., Nam S., Jin Y.H., Cha E.J., Lee K.S., Choi K.Y., et al. RNT-1, the C. elegans homologue of mammalian RUNX transcription factors, regulates body size and male tail development. Dev Biol 274 2 (2004) 402-412
53. Ji Y.J., Singaravelu G., and Ahnn J. RNT-1 regulation in C. elegans. J Cell Biochem 96 1 (2005) 8-15