Edaravone protects against glutamate-induced PERK/EIF2α/ATF4 integrated stress response and activation of caspase-12

Brain Research

Volumn 1519, Issue , 2013, Pages 1-8

  Fan, Jin ^a   Long, Hao ^a   Li, Yiming ^a   Liu, Yuwen ^a   Zhou, Wei ^a   Li, Qingqing ^a   Yin, Guoyong ^a   Zhang, Ning ^a   Cai, Weihua ^a  

^a THE FIRST AFFILIATED HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; ATF4; Caspase 12; Edaravone; EIF2 ; PERK

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 4; CASPASE 12; GLUTAMIC ACID; INITIATION FACTOR 2ALPHA; NORPHENAZONE; PERK PROTEIN; PROTEIN SERINE THREONINE KINASE; SCAVENGER; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL STRUCTURE; CONTROLLED STUDY; ELECTRON MICROSCOPY; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; NERVE CELL CULTURE; NERVE CELL NECROSIS; NEUROPROTECTION; PRIORITY JOURNAL; ULTRASTRUCTURE; WESTERN BLOTTING;

ACTIVATING TRANSCRIPTION FACTOR 4; ANIMALS; ANNEXIN A5; ANTIPYRINE; APOPTOSIS; CASPASE 12; CELLS, CULTURED; CEREBRAL CORTEX; EMBRYO, MAMMALIAN; ENDOPLASMIC RETICULUM; FREE RADICAL SCAVENGERS; GLUTAMIC ACID; MICROSCOPY, ELECTRON, TRANSMISSION; MICROTUBULE-ASSOCIATED PROTEINS; NEURONS; RATS; RATS, WISTAR; SIGNAL TRANSDUCTION; STATISTICS, NONPARAMETRIC; TIME FACTORS;

ANIMALIA; EUKARYOTA;

EID: 84878748944     PISSN: 00068993     EISSN: 18726240     Source Type: Journal    
DOI: 10.1016/j.brainres.2013.04.037     Document Type: Article

References (26)

1. M. Ankarcrona, J.M. Dypbukt, E. Bonfoco, B. Zhivotovsky, S. Orrenius, S.A. Lipton, and P. Nicotera Glutamate-induced neuronal death: a succession of necrosis or apoptosis depending on mitochondrial function Neuron 15 1995 961 973
2. M.J. Berridge Neuronal calcium signaling Neuron 21 1998 13 26
3. M. Bi, C. Naczki, M. Koritzinsky, D. Fels, J. Blais, N. Hu, H. Harding, I. Novoa, M. Varia, J. Raleigh, D. Scheuner, R.J. Kaufman, J. Bell, D. Ron, B.G. Wouters, and C. Koumenis ER stress-regulated translation increases tolerance to extreme hypoxia and promotes tumor growth EMBO J. 24 2005 3470 3481
4. J.D. Blais, V. Filipenko, M. Bi, H.P. Harding, D. Ron, C. Koumenis, B.G. Wouters, and J.C. Bell Activating transcription factor 4 is translationally regulated by hypoxic stress Mol Cell. Biol. 24 2004 7469 7482
5. J. Fan, N. Zhang, G. Yin, Z. Zhang, G. Cheng, W. Qian, H. Long, and W. Cai Edaravone protects cortical neurons from apoptosis by inhibiting the translocation of BAX and Increasing the interaction between 14-3-3 and p-BAD Int. J. Neurosci. 122 2012 665 674
6. D. Guez-Barber, S. Fanous, S.A. Golden, R. Schrama, E. Koya, A.L. Stern, J.M. Bossert, B.K. Harvey, M.R. Picciotto, and B.T. Hope FACS identifies unique cocaine-induced gene regulation in selectively activated adult striatal neurons J. Neurosci. 31 2011 4251 4259
7. H.P. Harding, Y. Zhang, and D. Ron Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase Nature 397 1999 271 274
8. K. Hisano, M. Watanabe, and Y. Morimoto Protective effects of the free radical scavenger edaravone against glutamate neurotoxicity in nearly pure neuronal culture J. Anesth. 23 2009 363 369
9. Y. Kitao, K. Ozawa, M. Miyazaki, M. Tamatani, T. Kobayashi, H. Yanagi, M. Okabe, M. Ikawa, T. Yamashima, D.M. Stern, O. Hori, and S. Ogawa Expression of the endoplasmic reticulum molecular chaperone (ORP150) rescues hippocampal neurons from glutamate toxicity J Clin. Invest. 108 2001 1439 1450
10. K. Kucharz, M. Krogh, A.N. Ng, and H. Toresson NMDA receptor stimulation induces reversible fission of the neuronal endoplasmic reticulum PLoS One 4 2009 e5250
11. B.J. Lee, Y. Egi, K. van Leyen, E.H. Lo, and K. Arai Edaravone, a free radical scavenger, protects components of the neurovascular unit against oxidative stress in vitro Brain Res. 1307 2010 22 27
12. P.D. Lu, H.P. Harding, and D. Ron Translation reinitiation at alternative open reading frames regulates gene expression in an integrated stress response J. Cell Biol. 167 2004 27 33
13. P.D. Lu, C. Jousse, S.J. Marciniak, Y. Zhang, I. Novoa, D. Scheuner, R.J. Kaufman, D. Ron, and H.P. Harding Cytoprotection by pre-emptive conditional phosphorylation of translation initiation factor 2 EMBO J. 23 2004 169 179
14. S.J. Marciniak, L. Garcia-Bonilla, J. Hu, H.P. Harding, and D. Ron Activation-dependent substrate recruitment by the eukaryotic translation initiation factor 2 kinase PERK J. Cell Biol. 172 2006 201 209
15. M. Meng, W. Zhiling, Z. Hui, L. Shengfu, Y. Dan, and H. Jiping Cellular levels of TrkB and MAPK in the neuroprotective role of BDNF for embryonic rat cortical neurons against hypoxia in vitro Int. J. Dev. Neurosci. 23 2005 515 521
16. T. Nakagawa, H. Zhu, N. Morishima, E. Li, J. Xu, B.A. Yankner, and J. Yuan Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta Nature 403 2000 98 103
17. Y. Nishinaka, H. Mori, N. Endo, T. Miyoshi, K. Yamashita, S. Adachi, and T. Arai Edaravone directly reacts with singlet oxygen and protects cells from attack Life Sci. 86 2010 808 813
18. R.V. Rao, A. Peel, A. Logvinova, G. del Rio, E. Hermel, T. Yokota, P.C. Goldsmith, L.M. Ellerby, H.M. Ellerby, and D.E. Bredesen Coupling endoplasmic reticulum stress to the cell death program: role of the ER chaperone GRP78 FEBS Lett. 514 2002 122 128
19. A.L. Sokka, N. Putkonen, G. Mudo, E. Pryazhnikov, S. Reijonen, L. Khiroug, N. Belluardo, D. Lindholm, and L. Korhonen Endoplasmic reticulum stress inhibition protects against excitotoxic neuronal injury in the rat brain J. Neurosci. 27 2007 901 908
20. Y. Song, M. Li, J.C. Li, and E.Q. Wei Edaravone protects PC12 cells from ischemic-like injury via attenuating the damage to mitochondria J. Zhejiang Univ. Sci. B 7 2006 749 756
21. K. Toyoda, K. Fujii, M. Kamouchi, H. Nakane, S. Arihiro, Y. Okada, S. Ibayashi, and M. Iida Free radical scavenger, edaravone, in stroke with internal carotid artery occlusion J. Neurol. Sci. 221 2004 11 17
22. A. Verkhratsky Physiology and pathophysiology of the calcium store in the endoplasmic reticulum of neurons Physiol. Rev. 85 2005 201 279
23. R.C. Wek, H.Y. Jiang, and T.G. Anthony Coping with stress: eIF2 kinases and translational control Biochem. Soc. Trans. 34 2006 7 11
24. T. Wu, X.S. Ding, W. Wang, and J. Wu MCI-186 (3-methyl-1-phenyl-2- pyrazolin-5-one) attenuated simulated ischemia/reperfusion injury in cultured rat hippocampal cells Biol. Pharm. Bull. 29 2006 1613 1617
25. X. Xue, J.H. Piao, A. Nakajima, S. Sakon-Komazawa, Y. Kojima, K. Mori, H. Yagita, K. Okumura, H. Harding, and H. Nakano Tumor necrosis factor alpha (TNFalpha) induces the unfolded protein response (UPR) in a reactive oxygen species (ROS)-dependent fashion, and the UPR counteracts ROS accumulation by TNF alpha J. Biol. Chem. 280 2005 33917 33925
26. N. Zhang, M. Komine-Kobayashi, R. Tanaka, M. Liu, Y. Mizuno, and T. Urabe Edaravone reduces early accumulation of oxidative products and sequential inflammatory responses after transient focal ischemia in mice brain Stroke 36 2005 2220 2225