Activation-dependent substrate recruitment by the eukaryotic translation initiation factor 2 kinase PERK

Journal of Cell Biology

Volumn 172, Issue 2, 2006, Pages 201-209

  Marciniak, Stefan J ^a,b   Garcia Bonilla, Lidia ^a   Hu, Junjie ^a   Harding, Heather P ^a   Ron, David ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ADDENBROOKE S HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

INITIATION FACTOR 2; PHOSPHOSERINE; PHOSPHOTHREONINE; STRESS ACTIVATED PROTEIN KINASE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME BINDING; ENZYME CONFORMATION; ENZYME SUBSTRATE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN MODIFICATION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS;

ANIMALS; BINDING SITES; CHO CELLS; CRICETINAE; EIF-2 KINASE; ENDOPLASMIC RETICULUM; ENZYME ACTIVATION; EUKARYOTIC INITIATION FACTOR-2; HUMANS; MICE; MODELS, BIOLOGICAL; PHOSPHORYLATION; PROTEIN CONFORMATION; RECOMBINANT FUSION PROTEINS;

ANIMALIA; EUKARYOTA;

EID: 30944458057     PISSN: 00219525     EISSN: 00219525     Source Type: Journal    
DOI: 10.1083/jcb.200508099     Document Type: Article

References (28)

1. Baumann, O., and B. Walz. 2001. Endoplasmic reticulum of animal cells and its organization into structural and functional domains. Int. Rev. Cytol. 205:149-214.
2. Bertolotti, A., Y. Zhang, L. Hendershot, H. Harding, and D. Ron. 2000. Dynamic interaction of BiP and the ER stress transducers in the unfolded protein response. Nat. Cell Biol. 2:326-332.
3. Campbell, S.G., N.P. Hoyle, and M.P. Ashe. 2005. Dynamic cycling of eIF2 through a large eIF2B-containing cytoplasmic body: implications for translation control. J. Cell Biol. 170:925-934.
4. Deng, J., P.D. Lu, Y. Zhang, D. Scheuner, R.J. Kaufman, N. Sonenberg, H.P. Harding, and D. Ron. 2004. Translational repression mediates activation of Nuclear Factor kappa B by phosphorylated translation initiation factor 2. Mol. Cell. Biol. 24:10161-10168.
5. Dey, M., B. Trieselmann, E.G. Locke, J. Lu, C. Cao, A.C. Dar, T. Krishnamoorthy, J. Dong, F. Sicheri, and T.E. Dever. 2005. PKR and GCN2 kinases and guanine nucleotide exchange factor eukaryotic translation initiation factor 2B (eIF2B) recognize overlapping surfaces on eIF2alpha. Mol. Cell. Biol. 25:3063-3075.
6. Fewell, S.W., K.J. Travers, J.S. Weissman, and J.L. Brodsky. 2001. The action of molecular chaperones in the early secretory pathway. Annu. Rev. Genet. 35:149-191.
7. Hanks, S.K., and T. Hunter. 1995. Protein kinases 6. The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification. FASEB J. 9:576-596.
8. Harding, H., Y. Zhang, and D. Ron. 1999. Translation and protein folding are coupled by an endoplasmic reticulum resident kinase. Nature. 397:271-274.
9. Harding, H., I. Novoa, Y. Zhang, H. Zeng, R.C. Wek, M. Schapira, and D. Ron. 2000a. Regulated translation initiation controls stress-induced gene expression in mammalian cells. Mol. Cell. 6:1099-1108.
10. Harding, H., Y. Zhang, A. Bertolotti, H. Zeng, and D. Ron. 2000b. Perk is essential for translational regulation and cell survival during the unfolded protein response. Mol. Cell. 5:897-904.
11. Harding, H., H. Zeng, Y. Zhang, R. Jungreis, P. Chung, H. Plesken, D. Sabatini, and D. Ron. 2001. Diabetes Mellitus and excocrine pancreatic dysfunction in Perk-/- mice reveals a role for translational control in survival of secretory cells. Mol. Cell. 7:1153-1163.
12. Harding, H., Y. Zhang, H. Zeng, I. Novoa, P. Lu, M. Calfon, N. Sadri, C. Yun, B. Popko, R. Paules, et al. 2003. An integrated stress response regulates amino acid metabolism and resistance to oxidative stress. Mol. Cell. 11:619-633.
13. Hinnebusch, A.G. 2000. Mechanism and regulation of initiator methionyl-tRNA binding to ribosomes. In Translational Control of Gene Expression. N. Sonenberg, J.W.B. Hershey, and M.B. Mathews, editors. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY. 185-243.
14. Huse, M., and J. Kuriyan. 2002. The conformational plasticity of protein kinases. Cell. 109:275-282.
15. Ito, T., A. Marintchev, and G. Wagner. 2004. Solution structure of human initiation factor eIF2alpha reveals homology to the elongation factor eEF1B. Structure (Camb). 12:1693-1704.
16. Kaufman, R.J. 2002. Orchestrating the unfolded protein response in health and disease. J. Clin. Invest. 110:1389-1398.
17. Kazlauskas, A., and J.A. Cooper. 1989. Autophosphorylation of the PDGF receptor in the kinase insert region regulates interactions with cell proteins. Cell. 58:1121-1133.
18. Lu, P.D., H.P. Harding, and D. Ron. 2004a. Translation re-initiation at alternative open reading frames regulates gene expression in an integrated stress response. J. Cell Biol. 167:27-33.
19. Lu, P.D., C. Jousse, S.J. Marciniak, Y. Zhang, I. Novoa, D. Scheuner, R.J. Kaufman, D. Ron, and H.P. Harding. 2004b. Cytoprotection by pre-emptive conditional phosphorylation of translation initiation factor 2. EMBO J. 23:169-179.
20. Ma, Y., Y. Lu, H. Zeng, D. Ron, W. Mo, and T.A. Neubert. 2001. Characterization of phosphopeptides from protein digests using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and nanoelectrospray quadrupole time-of-flight mass spectrometry. Rapid Commun. Mass Spectrom. 15:1693-1700.
21. Mellor, H., and C.G. Proud. 1991. A synthetic peptide substrate for initiation factor-2 kinases. Biochem. Biophys. Res. Commun. 178:430-437.
22. Mori, K. 2000. Tripartite management of unfolded proteins in the endoplasmic reticulum. Cell. 101:451-454.
23. Padyana, A.K., H. Qiu, A. Roll-Mecak, A.G. Hinnebusch, and S.K. Burley. 2005. Structural basis for autoinhibition and mutational activation of eukaryotic initiation factor 2alpha protein kinase GCN2. J. Biol. Chem. 280:29289-29299.
24. Patil, C., and P. Walter. 2001. Intracellular signaling from the endoplasmic reticulum to the nucleus: the unfolded protein response in yeast and mammals. Curr. Opin. Cell Biol. 13:349-355.
25. Ron, D. 2002. Translational control in the endoplasmic reticulum stress response. J. Clin. Invest. 110:1383-1388.
26. Ron, D., and H. Harding. 2000. PERK and translational control by stress in the endoplasmic reticulum. In Translational Control of Gene Expression. N. Sonenberg, J.W.B. Hershey, and M.B. Mathews, editors. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY. 547-560.
27. Vattem, K.M., and R.C. Wek. 2004. Reinitiation involving upstream ORFs regulates ATF4 mRNA translation in mammalian cells. Proc. Natl. Acad. Sci. USA. 101:11269-11274.
28. Zhang, P., B. McGrath, S. Li, A. Frank, F. Zambito, J. Reinert, M. Gannon, K. Ma, K. McNaughton, and D.R. Cavener. 2002. The PERK eukaryotic initiation factor 2 alpha kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreas. Mol. Cell. Biol. 22:3864-3874.