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Volumn 97, Issue 2, 2013, Pages 165-174

Gene mutations of acute myeloid leukemia in the genome era

Author keywords

Acute myeloid leukemia; Chromosome translocation; Epigenetics; Gene mutation; Genome sequencing; Prognosis

Indexed keywords

ASXL1 PROTEIN; BCOR PROTEIN; COHESIN; DNA METHYLTRANSFERASE 3A; ISOCITRATE DEHYDROGENASE 1; ISOCITRATE DEHYDROGENASE 2; REGULATOR PROTEIN; REPRESSOR PROTEIN; TET1 PROTEIN; TET2 PROTEIN; TET3 PROTEIN; TRANSCRIPTION FACTOR EZH2; UNCLASSIFIED DRUG; CELL CYCLE PROTEIN; COREPRESSOR PROTEIN; NONHISTONE PROTEIN;

EID: 84878730351     PISSN: 09255710     EISSN: 18653774     Source Type: Journal    
DOI: 10.1007/s12185-013-1257-4     Document Type: Article
Times cited : (56)

References (95)
  • 1
    • 27244452986 scopus 로고    scopus 로고
    • Genetics of myeloid malignancies: Pathogenetic and clinical implications
    • Frohling S, Scholl C, Gilliland DG, Levine RL. Genetics of myeloid malignancies: pathogenetic and clinical implications. J Clin Oncol. 2005;23:6285-95.
    • (2005) J Clin Oncol , vol.23 , pp. 6285-6295
    • Frohling, S.1    Scholl, C.2    Gilliland, D.G.3    Levine, R.L.4
  • 2
    • 33751267902 scopus 로고    scopus 로고
    • Acute myeloid leukaemia
    • Estey E, Dohner H. Acute myeloid leukaemia. Lancet. 2006;368: 1894-907.
    • (2006) Lancet , vol.368 , pp. 1894-1907
    • Estey, E.1    Dohner, H.2
  • 3
    • 80052384568 scopus 로고    scopus 로고
    • Deregulated transcription factors in leukemia
    • Shima Y, Kitabayashi I. Deregulated transcription factors in leukemia. Int J Hematol. 2011;94:134-41.
    • (2011) Int J Hematol , vol.94 , pp. 134-141
    • Shima, Y.1    Kitabayashi, I.2
  • 4
    • 2942516037 scopus 로고    scopus 로고
    • The 8;21 translocation in leukemogenesis
    • Peterson LF, Zhang DE. The 8;21 translocation in leukemogenesis. Oncogene. 2004;23:4255-62.
    • (2004) Oncogene , vol.23 , pp. 4255-4262
    • Peterson, L.F.1    Zhang, D.E.2
  • 5
    • 19944431253 scopus 로고    scopus 로고
    • AML1-ETO and C-KIT mutation/overexpression in t(8;21) leukemia: Implication in stepwise leukemogenesis and response to Gleevec
    • Wang YY, Zhou GB, Yin T, Chen B, Shi JY, Liang WX, et al. AML1-ETO and C-KIT mutation/overexpression in t(8;21) leukemia: implication in stepwise leukemogenesis and response to Gleevec. Proc Natl Acad Sci USA. 2005;102:1104-9.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 1104-1109
    • Wang, Y.Y.1    Zhou, G.B.2    Yin, T.3    Chen, B.4    Shi, J.Y.5    Liang, W.X.6
  • 7
    • 0036636857 scopus 로고    scopus 로고
    • Core-binding factors in haematopoiesis and leukaemia
    • Speck NA, Gilliland DG. Core-binding factors in haematopoiesis and leukaemia. Nat Rev Cancer. 2002;2:502-13.
    • (2002) Nat Rev Cancer , vol.2 , pp. 502-513
    • Speck, N.A.1    Gilliland, D.G.2
  • 8
    • 73949090504 scopus 로고    scopus 로고
    • AML1/RUNX1 mutations in 470 adult patients with de novo acute myeloid leukemia: Prognostic implication and interaction with other gene alterations
    • Tang JL, Hou HA, Chen CY, Liu CY, Chou WC, Tseng MH, et al. AML1/RUNX1 mutations in 470 adult patients with de novo acute myeloid leukemia: prognostic implication and interaction with other gene alterations. Blood. 2009;114:5352-61.
    • (2009) Blood , vol.114 , pp. 5352-5361
    • Tang, J.L.1    Hou, H.A.2    Chen, C.Y.3    Liu, C.Y.4    Chou, W.C.5    Tseng, M.H.6
  • 9
    • 63849241865 scopus 로고    scopus 로고
    • Double CEBPA mutations, but not single CEBPA mutations, define a subgroup of acute myeloid leukemia with a distinctive gene expression profile that is uniquely associated with a favorable outcome
    • Wouters BJ, Lowenberg B, Erpelinck-Verschueren CA, van Putten WL, Valk PJ, Delwel R. Double CEBPA mutations, but not single CEBPA mutations, define a subgroup of acute myeloid leukemia with a distinctive gene expression profile that is uniquely associated with a favorable outcome. Blood. 2009;113:3088-91.
    • (2009) Blood , vol.113 , pp. 3088-3091
    • Wouters, B.J.1    Lowenberg, B.2    Erpelinck-Verschueren, C.A.3    Van, P.W.L.4    Valk, P.J.5    Delwel, R.6
  • 10
    • 59149096563 scopus 로고    scopus 로고
    • Dysregulation of the C/EBPalpha differentiation pathway in human cancer
    • Koschmieder S, Halmos B, Levantini E, Tenen DG. Dysregulation of the C/EBPalpha differentiation pathway in human cancer. J Clin Oncol. 2009;27:619-28.
    • (2009) J Clin Oncol , vol.27 , pp. 619-628
    • Koschmieder, S.1    Halmos, B.2    Levantini, E.3    Tenen, D.G.4
  • 11
    • 79952092487 scopus 로고    scopus 로고
    • Molecular genetics of adult acute myeloid leukemia: Prognostic and therapeutic implications
    • Marcucci G, Haferlach T, Dohner H. Molecular genetics of adult acute myeloid leukemia: prognostic and therapeutic implications. J Clin Oncol. 2011;29:475-86.
    • (2011) J Clin Oncol , vol.29 , pp. 475-486
    • Marcucci, G.1    Haferlach, T.2    Dohner, H.3
  • 12
    • 0024990090 scopus 로고
    • N-ras mutations in adult de novo acute myelogenous leukemia: Prevalence and clinical significance
    • Radich JP, Kopecky KJ, Willman CL, Weick J, Head D, Appelbaum F, et al. N-ras mutations in adult de novo acute myelogenous leukemia: prevalence and clinical significance. Blood. 1990;76:801-7.
    • (1990) Blood , vol.76 , pp. 801-807
    • Radich, J.P.1    Kopecky, K.J.2    Willman, C.L.3    Weick, J.4    Head, D.5    Appelbaum, F.6
  • 13
    • 0028214608 scopus 로고
    • Prognostic importance of mutations in the ras proto-oncogenes in de novo acute myeloid leukemia
    • Neubauer A, Dodge RK, George SL, Davey FR, Silver RT, Schiffer CA, et al. Prognostic importance of mutations in the ras proto-oncogenes in de novo acute myeloid leukemia. Blood. 1994;83:1603-11.
    • (1994) Blood , vol.83 , pp. 1603-1611
    • Neubauer, A.1    Dodge, R.K.2    George, S.L.3    Davey, F.R.4    Silver, R.T.5    Schiffer, C.A.6
  • 14
    • 0030451722 scopus 로고    scopus 로고
    • Internal tandem duplication of the FLT3 gene found in acute myeloid leukemia
    • Nakao M, Yokota S, Iwai T, Kaneko H, Horiike S, Kashima K, et al. Internal tandem duplication of the FLT3 gene found in acute myeloid leukemia. Leukemia. 1996;10:1911-8.
    • (1996) Leukemia , vol.10 , pp. 1911-1918
    • Nakao, M.1    Yokota, S.2    Iwai, T.3    Kaneko, H.4    Horiike, S.5    Kashima, K.6
  • 15
    • 0033134792 scopus 로고    scopus 로고
    • Prognostic implication of FLT3 and N-RAS gene mutations in acute myeloid leukemia
    • Kiyoi H, Naoe T, Nakano Y, Yokota S, Minami S, Miyawaki S, et al. Prognostic implication of FLT3 and N-RAS gene mutations in acute myeloid leukemia. Blood. 1999;93:3074-80.
    • (1999) Blood , vol.93 , pp. 3074-3080
    • Kiyoi, H.1    Naoe, T.2    Nakano, Y.3    Yokota, S.4    Minami, S.5    Miyawaki, S.6
  • 16
    • 0035871889 scopus 로고    scopus 로고
    • Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies
    • Yamamoto Y, Kiyoi H, Nakano Y, Suzuki R, Kodera Y, Miyawaki S, et al. Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies. Blood. 2001;97:2434-9.
    • (2001) Blood , vol.97 , pp. 2434-2439
    • Yamamoto, Y.1    Kiyoi, H.2    Nakano, Y.3    Suzuki, R.4    Kodera, Y.5    Miyawaki, S.6
  • 17
    • 48749121814 scopus 로고    scopus 로고
    • Core binding factor acute myeloid leukemia
    • Paschka P. Core binding factor acute myeloid leukemia. Semin Oncol. 2008;35:410-7.
    • (2008) Semin Oncol , vol.35 , pp. 410-417
    • Paschka, P.1
  • 20
    • 33646432204 scopus 로고    scopus 로고
    • Prognostic impact of c-KIT mutations in core binding factor leukemias: An Italian retrospective study
    • Cairoli R, Beghini A, Grillo G, Nadali G, Elice F, Ripamonti CB, et al. Prognostic impact of c-KIT mutations in core binding factor leukemias: An Italian retrospective study. Blood. 2006;107: 3463-8.
    • (2006) Blood , vol.107 , pp. 3463-3468
    • Cairoli, R.1    Beghini, A.2    Grillo, G.3    Nadali, G.4    Elice, F.5    Ripamonti, C.B.6
  • 21
    • 0036093475 scopus 로고    scopus 로고
    • FLT3 internal tandem duplication mutations associated with human acute myeloid leukemias induce myeloproliferative disease in a murine bone marrow transplant model
    • Kelly LM, Liu Q, Kutok JL, Williams IR, Boulton CL, Gilliland DG. FLT3 internal tandem duplication mutations associated with human acute myeloid leukemias induce myeloproliferative disease in a murine bone marrow transplant model. Blood. 2002;99:310-8.
    • (2002) Blood , vol.99 , pp. 310-318
    • Kelly, L.M.1    Liu, Q.2    Kutok, J.L.3    Williams, I.R.4    Boulton, C.L.5    Gilliland, D.G.6
  • 22
    • 0033043084 scopus 로고    scopus 로고
    • Molecular evolution of acute myeloid leukaemia in relapse: Unstable N-ras and FLT3 genes compared with p53 gene
    • Nakano Y, Kiyoi H, Miyawaki S, Asou N, Ohno R, Saito H, et al. Molecular evolution of acute myeloid leukaemia in relapse: unstable N-ras and FLT3 genes compared with p53 gene. Br J Haematol. 1999;104:659-64.
    • (1999) Br J Haematol , vol.104 , pp. 659-664
    • Nakano, Y.1    Kiyoi, H.2    Miyawaki, S.3    Asou, N.4    Ohno, R.5    Saito, H.6
  • 23
    • 77957810002 scopus 로고    scopus 로고
    • High-frequency type I/II mutational shifts between diagnosis and relapse are associated with outcome in pediatric AML: Implications for personalized medicine
    • Bachas C, Schuurhuis GJ, Hollink IH, Kwidama ZJ, Goemans BF, Zwaan CM, et al. High-frequency type I/II mutational shifts between diagnosis and relapse are associated with outcome in pediatric AML: implications for personalized medicine. Blood. 2010;116:2752-8.
    • (2010) Blood , vol.116 , pp. 2752-2758
    • Bachas, C.1    Schuurhuis, G.J.2    Hollink, I.H.3    Kwidama, Z.J.4    Goemans, B.F.5    Zwaan, C.M.6
  • 24
    • 33745198953 scopus 로고    scopus 로고
    • Stability and prognostic influence of FLT3 mutations in paired initial and relapsed AML samples
    • Cloos J, Goemans BF, Hess CJ, van Oostveen JW, Waisfisz Q, Corthals S, et al. Stability and prognostic influence of FLT3 mutations in paired initial and relapsed AML samples. Leukemia. 2006;20:1217-20.
    • (2006) Leukemia , vol.20 , pp. 1217-1220
    • Cloos, J.1    Goemans, B.F.2    Hess, C.J.3    Van, O.J.W.4    Waisfisz, Q.5    Corthals, S.6
  • 26
  • 27
    • 24144494881 scopus 로고    scopus 로고
    • Clinical characteristics and prognostic implications of NPM1 mutations in acute myeloid leukemia
    • Suzuki T, Kiyoi H, Ozeki K, Tomita A, Yamaji S, Suzuki R, et al. Clinical characteristics and prognostic implications of NPM1 mutations in acute myeloid leukemia. Blood. 2005;106:2854-61.
    • (2005) Blood , vol.106 , pp. 2854-2861
    • Suzuki, T.1    Kiyoi, H.2    Ozeki, K.3    Tomita, A.4    Yamaji, S.5    Suzuki, R.6
  • 28
    • 0141465061 scopus 로고    scopus 로고
    • The role of FLT3 in haematopoietic malignancies
    • Stirewalt DL, Radich JP. The role of FLT3 in haematopoietic malignancies. Nat Rev Cancer. 2003;3:650-65.
    • (2003) Nat Rev Cancer , vol.3 , pp. 650-665
    • Stirewalt, D.L.1    Radich, J.P.2
  • 29
    • 33744455709 scopus 로고    scopus 로고
    • Biology, clinical relevance, and molecularly targeted therapy in acute leukemia with FLT3 mutation
    • Kiyoi H, Naoe T. Biology, clinical relevance, and molecularly targeted therapy in acute leukemia with FLT3 mutation. Int J Hematol. 2006;83:301-8.
    • (2006) Int J Hematol , vol.83 , pp. 301-308
    • Kiyoi, H.1    Naoe, T.2
  • 30
    • 0036020954 scopus 로고    scopus 로고
    • FLT3 in human hematologic malignancies
    • Kiyoi H, Naoe T. FLT3 in human hematologic malignancies. Leuk Lymphoma. 2002;43:1541-7.
    • (2002) Leuk Lymphoma , vol.43 , pp. 1541-1547
    • Kiyoi, H.1    Naoe, T.2
  • 36
    • 84866378702 scopus 로고    scopus 로고
    • The role of mutations in epigenetic regulators in myeloid malignancies
    • Shih AH, Abdel-Wahab O, Patel JP, Levine RL. The role of mutations in epigenetic regulators in myeloid malignancies. Nat Rev Cancer. 2012;12:599-612.
    • (2012) Nat Rev Cancer , vol.12 , pp. 599-612
    • Shih, A.H.1    Abdel-Wahab, O.2    Patel, J.P.3    Levine, R.L.4
  • 37
    • 78549279199 scopus 로고    scopus 로고
    • Distinct clinical and biological features of de novo acute myeloid leukemia with additional sex comb-like 1 (ASXL1) mutations
    • Chou WC, Huang HH, Hou HA, Chen CY, Tang JL, Yao M, et al. Distinct clinical and biological features of de novo acute myeloid leukemia with additional sex comb-like 1 (ASXL1) mutations. Blood. 2010;116:4086-94.
    • (2010) Blood , vol.116 , pp. 4086-4094
    • Chou, W.C.1    Huang, H.H.2    Hou, H.A.3    Chen, C.Y.4    Tang, J.L.5    Yao, M.6
  • 38
    • 83055161507 scopus 로고    scopus 로고
    • Whole-exome sequencing identifies somatic mutations of BCOR in acute myeloid leukemia with normal karyotype
    • Grossmann V, Tiacci E, Holmes AB, Kohlmann A, Martelli MP, Kern W, et al. Whole-exome sequencing identifies somatic mutations of BCOR in acute myeloid leukemia with normal karyotype. Blood. 2011;118:6153-63.
    • (2011) Blood , vol.118 , pp. 6153-6163
    • Grossmann, V.1    Tiacci, E.2    Holmes, A.B.3    Kohlmann, A.4    Martelli, M.P.5    Kern, W.6
  • 39
    • 82155183257 scopus 로고    scopus 로고
    • Somatic mutations in the transcriptional corepressor gene BCORL1 in adult acute myelogenous leukemia
    • Li M, Collins R, Jiao Y, Ouillette P, Bixby D, Erba H, et al. Somatic mutations in the transcriptional corepressor gene BCORL1 in adult acute myelogenous leukemia. Blood. 2011; 118:5914-7.
    • (2011) Blood , vol.118 , pp. 5914-5917
    • Li, M.1    Collins, R.2    Jiao, Y.3    Ouillette, P.4    Bixby, D.5    Erba, H.6
  • 41
    • 84868148842 scopus 로고    scopus 로고
    • Splicing factor mutations in myelodysplasia
    • Ogawa S. Splicing factor mutations in myelodysplasia. Int J Hematol. 2012;96:438-42.
    • (2012) Int J Hematol , vol.96 , pp. 438-442
    • Ogawa, S.1
  • 42
    • 84868091622 scopus 로고    scopus 로고
    • SF3B1 haploinsufficiency leads to formation of ring sideroblasts in myelodysplastic syndromes
    • Visconte V, Rogers HJ, Singh J, Barnard J, Bupathi M, Traina F, et al. SF3B1 haploinsufficiency leads to formation of ring sideroblasts in myelodysplastic syndromes. Blood. 2012;120: 3173-86.
    • (2012) Blood , vol.120 , pp. 3173-3186
    • Visconte, V.1    Rogers, H.J.2    Singh, J.3    Barnard, J.4    Bupathi, M.5    Traina, F.6
  • 43
    • 79955538247 scopus 로고    scopus 로고
    • Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain
    • Guo JU, Su Y, Zhong C, Ming GL, Song H. Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain. Cell. 2011;145:423-34.
    • (2011) Cell , vol.145 , pp. 423-434
    • Guo, J.U.1    Su, Y.2    Zhong, C.3    Ming, G.L.4    Song, H.5
  • 44
    • 66149146320 scopus 로고    scopus 로고
    • Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1
    • Tahiliani M, Koh KP, Shen Y, Pastor WA, Bandukwala H, Brudno Y, et al. Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1. Science. 2009;324:930-5.
    • (2009) Science , vol.324 , pp. 930-935
    • Tahiliani, M.1    Koh, K.P.2    Shen, Y.3    Pastor, W.A.4    Bandukwala, H.5    Brudno, Y.6
  • 45
    • 78650175023 scopus 로고    scopus 로고
    • Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2
    • Ko M, Huang Y, Jankowska AM, Pape UJ, Tahiliani M, Bandukwala HS, et al. Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2. Nature. 2010;468:839-43.
    • (2010) Nature , vol.468 , pp. 839-843
    • Ko, M.1    Huang, Y.2    Jankowska, A.M.3    Pape, U.J.4    Tahiliani, M.5    Bandukwala, H.S.6
  • 46
    • 67651065502 scopus 로고    scopus 로고
    • Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies
    • Abdel-Wahab O, Mullally A, Hedvat C, Garcia-Manero G, Patel J, Wadleigh M, et al. Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies. Blood. 2009;114: 144-7.
    • (2009) Blood , vol.114 , pp. 144-147
    • Abdel-Wahab, O.1    Mullally, A.2    Hedvat, C.3    Garcia-Manero, G.4    Patel, J.5    Wadleigh, M.6
  • 47
    • 79954428737 scopus 로고    scopus 로고
    • TET2 mutations improve the new European Leukemia Net risk classification of acute myeloid leukemia: A Cancer and Leukemia Group B study
    • Metzeler KH, Maharry K, Radmacher MD, Mrozek K, Margeson D, Becker H, et al. TET2 mutations improve the new European Leukemia Net risk classification of acute myeloid leukemia: A Cancer and Leukemia Group B study. J Clin Oncol. 2011;29: 1373-81.
    • (2011) J Clin Oncol , vol.29 , pp. 1373-1381
    • Metzeler, K.H.1    Maharry, K.2    Radmacher, M.D.3    Mrozek, K.4    Margeson, D.5    Becker, H.6
  • 48
    • 84862266735 scopus 로고    scopus 로고
    • TET2 mutations in acute myeloid leukemia (AML): Results from a comprehensive genetic and clinical analysis of the AML study group
    • Gaidzik VI, Paschka P, Spath D, Habdank M, Kohne CH, Germing U, et al. TET2 mutations in acute myeloid leukemia (AML): results from a comprehensive genetic and clinical analysis of the AML study group. J Clin Oncol. 2012;30:1350-7.
    • (2012) J Clin Oncol , vol.30 , pp. 1350-1357
    • Gaidzik, V.I.1    Paschka, P.2    Spath, D.3    Habdank, M.4    Kohne, C.H.5    Germing, U.6
  • 49
    • 80053620171 scopus 로고    scopus 로고
    • TET2 mutation is an unfavorable prognostic factor in acute myeloid leukemia patients with intermediate-risk cytogenetics
    • Chou WC, Chou SC, Liu CY, Chen CY, Hou HA, Kuo YY, et al. TET2 mutation is an unfavorable prognostic factor in acute myeloid leukemia patients with intermediate-risk cytogenetics. Blood. 2011;118:3803-10.
    • (2011) Blood , vol.118 , pp. 3803-3810
    • Chou, W.C.1    Chou, S.C.2    Liu, C.Y.3    Chen, C.Y.4    Hou, H.A.5    Kuo, Y.Y.6
  • 50
  • 51
    • 80052495940 scopus 로고    scopus 로고
    • Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA
    • He YF, Li BZ, Li Z, Liu P, Wang Y, Tang Q, et al. Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA. Science. 2011;333:1303-7.
    • (2011) Science , vol.333 , pp. 1303-1307
    • He, Y.F.1    Li, B.Z.2    Li, Z.3    Liu, P.4    Wang, Y.5    Tang, Q.6
  • 52
    • 79954457998 scopus 로고    scopus 로고
    • Genome-wide analysis of 5-hydroxymethylcytosine distribution reveals its dual function in transcriptional regulation in mouse embryonic stem cells
    • Wu H, D'Alessio AC, Ito S, Wang Z, Cui K, Zhao K, et al. Genome-wide analysis of 5-hydroxymethylcytosine distribution reveals its dual function in transcriptional regulation in mouse embryonic stem cells. Genes Dev. 2011;25:679-84.
    • (2011) Genes Dev , vol.25 , pp. 679-684
    • Wu, H.1    D'Alessio, A.C.2    Ito, S.3    Wang, Z.4    Cui, K.5    Zhao, K.6
  • 53
    • 79956323623 scopus 로고    scopus 로고
    • Dynamic regulation of 5-hydroxymethylcytosine in mouse ES cells and during differentiation
    • Ficz G, Branco MR, Seisenberger S, Santos F, Krueger F, Hore TA, et al. Dynamic regulation of 5-hydroxymethylcytosine in mouse ES cells and during differentiation. Nature. 2011;473: 398-402.
    • (2011) Nature , vol.473 , pp. 398-402
    • Ficz, G.1    Branco, M.R.2    Seisenberger, S.3    Santos, F.4    Krueger, F.5    Hore, T.A.6
  • 54
    • 79960064353 scopus 로고    scopus 로고
    • Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation
    • Moran-Crusio K, Reavie L, Shih A, Abdel-Wahab O, Ndiaye- Lobry D, Lobry C, et al. Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation. Cancer Cell. 2011;20:11-24.
    • (2011) Cancer Cell , vol.20 , pp. 11-24
    • Moran-Crusio, K.1    Reavie, L.2    Shih, A.3    Abdel-Wahab, O.4    Ndiaye-Lobry, D.5    Lobry, C.6
  • 55
    • 79955059411 scopus 로고    scopus 로고
    • The DNMT3 family of mammalian de novo DNA methyltransferases
    • Chedin F. The DNMT3 family of mammalian de novo DNA methyltransferases. Prog Mol Biol Transl Sci. 2011;101:255-85.
    • (2011) Prog Mol Biol Transl Sci , vol.101 , pp. 255-285
    • Chedin, F.1
  • 56
    • 79960735923 scopus 로고    scopus 로고
    • Incidence and prognostic influence of DNMT3A mutations in acute myeloid leukemia
    • Thol F, Damm F, Ludeking A, Winschel C, Wagner K, Morgan M, et al. Incidence and prognostic influence of DNMT3A mutations in acute myeloid leukemia. J Clin Oncol. 2011;29:2889-96.
    • (2011) J Clin Oncol , vol.29 , pp. 2889-2896
    • Thol, F.1    Damm, F.2    Ludeking, A.3    Winschel, C.4    Wagner, K.5    Morgan, M.6
  • 57
    • 79953176952 scopus 로고    scopus 로고
    • Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia
    • Yan XJ, Xu J, Gu ZH, Pan CM, Lu G, Shen Y, et al. Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia. Nat Genet. 2011;43:309-15.
    • (2011) Nat Genet , vol.43 , pp. 309-315
    • Yan, X.J.1    Xu, J.2    Gu, Z.H.3    Pan, C.M.4    Lu, G.5    Shen, Y.6
  • 58
    • 84856477048 scopus 로고    scopus 로고
    • Frequency, onset and clinical impact of somatic DNMT3A mutations in therapy-related and secondary acute myeloid leukemia
    • Fried I, Bodner C, Pichler MM, Lind K, Beham-Schmid C, Quehenberger F, et al. Frequency, onset and clinical impact of somatic DNMT3A mutations in therapy-related and secondary acute myeloid leukemia. Haematologica. 2012;97:246-50.
    • (2012) Haematologica , vol.97 , pp. 246-250
    • Fried, I.1    Bodner, C.2    Pichler, M.M.3    Lind, K.4    Beham-Schmid, C.5    Quehenberger, F.6
  • 59
    • 34547725157 scopus 로고    scopus 로고
    • DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA
    • Ooi SK, Qiu C, Bernstein E, Li K, Jia D, Yang Z, et al. DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA. Nature. 2007;448:714-7.
    • (2007) Nature , vol.448 , pp. 714-717
    • Ooi, S.K.1    Qiu, C.2    Bernstein, E.3    Li, K.4    Jia, D.5    Yang, Z.6
  • 60
    • 34247337999 scopus 로고    scopus 로고
    • De novo DNA methyltransferase is essential for self-renewal, but not for differentiation, in hematopoietic stem cells
    • Tadokoro Y, Ema H, Okano M, Li E, Nakauchi H. De novo DNA methyltransferase is essential for self-renewal, but not for differentiation, in hematopoietic stem cells. J Exp Med. 2007;204:715-22.
    • (2007) J Exp Med , vol.204 , pp. 715-722
    • Tadokoro, Y.1    Ema, H.2    Okano, M.3    Li, E.4    Nakauchi, H.5
  • 61
  • 62
    • 78751662908 scopus 로고    scopus 로고
    • The Polycomb complex PRC2 and its mark in life
    • Margueron R, Reinberg D. The Polycomb complex PRC2 and its mark in life. Nature. 2011;469:343-9.
    • (2011) Nature , vol.469 , pp. 343-349
    • Margueron, R.1    Reinberg, D.2
  • 63
    • 0033569427 scopus 로고    scopus 로고
    • Functional antagonism of the Polycomb- Group genes eed and Bmi1 in hemopoietic cell proliferation
    • Lessard J, Schumacher A, Thorsteinsdottir U, van Lohuizen M, Magnuson T, Sauvageau G. Functional antagonism of the Polycomb- Group genes eed and Bmi1 in hemopoietic cell proliferation. Genes Dev. 1999;13:2691-703.
    • (1999) Genes Dev , vol.13 , pp. 2691-2703
    • Lessard, J.1    Schumacher, A.2    Thorsteinsdottir, U.3    Van, L.M.4    Magnuson, T.5    Sauvageau, G.6
  • 65
    • 75749124332 scopus 로고    scopus 로고
    • Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin
    • Morin RD, Johnson NA, Severson TM, Mungall AJ, An J, Goya R, et al. Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin. Nat Genet. 2010;42:181-5.
    • (2010) Nat Genet , vol.42 , pp. 181-185
    • Morin, R.D.1    Johnson, N.A.2    Severson, T.M.3    Mungall, A.J.4    An, J.5    Goya, R.6
  • 66
    • 84864567410 scopus 로고    scopus 로고
    • Ezh2 augments leukemogenicity by reinforcing differentiation blockage in acute myeloid leukemia
    • Tanaka S, Miyagi S, Sashida G, Chiba T, Yuan J, Mochizuki- Kashio M, et al. Ezh2 augments leukemogenicity by reinforcing differentiation blockage in acute myeloid leukemia. Blood. 2012;120:1107-17.
    • (2012) Blood , vol.120 , pp. 1107-1117
    • Tanaka, S.1    Miyagi, S.2    Sashida, G.3    Chiba, T.4    Yuan, J.5    Mochizuki-Kashio, M.6
  • 67
    • 77955085750 scopus 로고    scopus 로고
    • Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders
    • Ernst T, Chase AJ, Score J, Hidalgo-Curtis CE, Bryant C, Jones AV, et al. Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders. Nat Genet. 2010;42:722-6.
    • (2010) Nat Genet , vol.42 , pp. 722-726
    • Ernst, T.1    Chase, A.J.2    Score, J.3    Hidalgo-Curtis, C.E.4    Bryant, C.5    Jones, A.V.6
  • 68
    • 79960227474 scopus 로고    scopus 로고
    • Concomitant analysis of EZH2 and ASXL1 mutations in myelofibrosis, chronic myelomonocytic leukemia and blast-phase myeloproliferative neoplasms
    • Abdel-Wahab O, Pardanani A, Patel J, Wadleigh M, Lasho T, Heguy A, et al. Concomitant analysis of EZH2 and ASXL1 mutations in myelofibrosis, chronic myelomonocytic leukemia and blast-phase myeloproliferative neoplasms. Leukemia. 2011; 25:1200-2.
    • (2011) Leukemia , vol.25 , pp. 1200-1202
    • Abdel-Wahab, O.1    Pardanani, A.2    Patel, J.3    Wadleigh, M.4    Lasho, T.5    Heguy, A.6
  • 70
    • 77956265489 scopus 로고    scopus 로고
    • IDH mutations in glioma and acute myeloid leukemia
    • Dang L, Jin S, Su SM. IDH mutations in glioma and acute myeloid leukemia. Trends Mol Med. 2010;16:387-97.
    • (2010) Trends Mol Med , vol.16 , pp. 387-397
    • Dang, L.1    Jin, S.2    Su, S.M.3
  • 71
    • 77952536841 scopus 로고    scopus 로고
    • IDH1 and IDH2 gene mutations identify novel molecular subsets within de novo cytogenetically normal acute myeloid leukemia: A Cancer and Leukemia Group B study
    • Marcucci G, Maharry K, Wu YZ, Radmacher MD, Mrozek K, Margeson D, et al. IDH1 and IDH2 gene mutations identify novel molecular subsets within de novo cytogenetically normal acute myeloid leukemia: A Cancer and Leukemia Group B study. J Clin Oncol. 2010;28:2348-55.
    • (2010) J Clin Oncol , vol.28 , pp. 2348-2355
    • Marcucci, G.1    Maharry, K.2    Wu, Y.Z.3    Radmacher, M.D.4    Mrozek, K.5    Margeson, D.6
  • 72
    • 77955907891 scopus 로고    scopus 로고
    • IDH1 and IDH2 mutations are frequent genetic alterations in acute myeloid leukemia and confer adverse prognosis in cytogenetically normal acute myeloid leukemia with NPM1 mutation without FLT3 internal tandem duplication
    • Paschka P, Schlenk RF, Gaidzik VI, Habdank M, Kronke J, Bullinger L, et al. IDH1 and IDH2 mutations are frequent genetic alterations in acute myeloid leukemia and confer adverse prognosis in cytogenetically normal acute myeloid leukemia with NPM1 mutation without FLT3 internal tandem duplication. J Clin Oncol. 2010;28:3636-43.
    • (2010) J Clin Oncol , vol.28 , pp. 3636-3643
    • Paschka, P.1    Schlenk, R.F.2    Gaidzik, V.I.3    Habdank, M.4    Kronke, J.5    Bullinger, L.6
  • 73
    • 77956050251 scopus 로고    scopus 로고
    • Prognostic impact of IDH2 mutations in cytogenetically normal acute myeloid leukemia
    • Thol F, Damm F, Wagner K, Gohring G, Schlegelberger B, Hoelzer D, et al. Prognostic impact of IDH2 mutations in cytogenetically normal acute myeloid leukemia. Blood. 2010;116: 614-6.
    • (2010) Blood , vol.116 , pp. 614-616
    • Thol, F.1    Damm, F.2    Wagner, K.3    Gohring, G.4    Schlegelberger, B.5    Hoelzer, D.6
  • 74
    • 77952481300 scopus 로고    scopus 로고
    • Impact of IDH1 R132 mutations and an IDH1 single nucleotide polymorphism in cytogenetically normal acute myeloid leukemia: SNP rs11554137 is an adverse prognostic factor
    • Wagner K, Damm F, Gohring G, Gorlich K, Heuser M, Schafer I, et al. Impact of IDH1 R132 mutations and an IDH1 single nucleotide polymorphism in cytogenetically normal acute myeloid leukemia: SNP rs11554137 is an adverse prognostic factor. J Clin Oncol. 2010;28:2356-64.
    • (2010) J Clin Oncol , vol.28 , pp. 2356-2364
    • Wagner, K.1    Damm, F.2    Gohring, G.3    Gorlich, K.4    Heuser, M.5    Schafer, I.6
  • 75
    • 77649305610 scopus 로고    scopus 로고
    • The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate
    • Ward PS, Patel J, Wise DR, Abdel-Wahab O, Bennett BD, Coller HA, et al. The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate. Cancer Cell. 2010;17: 225-34.
    • (2010) Cancer Cell , vol.17 , pp. 225-234
    • Ward, P.S.1    Patel, J.2    Wise, D.R.3    Abdel-Wahab, O.4    Bennett, B.D.5    Coller, H.A.6
  • 77
    • 64849098267 scopus 로고    scopus 로고
    • Gliomaderived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha
    • Zhao S, Lin Y, Xu W, Jiang W, Zha Z, Wang P, et al. Gliomaderived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha. Science. 2009;324:261-5.
    • (2009) Science , vol.324 , pp. 261-265
    • Zhao, S.1    Lin, Y.2    Xu, W.3    Jiang, W.4    Zha, Z.5    Wang, P.6
  • 79
    • 80053963323 scopus 로고    scopus 로고
    • CTCF, cohesin, and histone variants: Connecting the genome
    • Millau JF, Gaudreau L. CTCF, cohesin, and histone variants: connecting the genome. Biochem Cell Biol. 2011;89:505-13.
    • (2011) Biochem Cell Biol , vol.89 , pp. 505-513
    • Millau, J.F.1    Gaudreau, L.2
  • 80
    • 84868554484 scopus 로고    scopus 로고
    • Commonly altered genomic regions in acute myeloid leukemia are enriched for somatic mutations involved in chromatin-remodeling and splicing
    • Dolnik A, Engelmann JC, Scharfenberger-Schmeer M, Mauch J, Kelkenberg-Schade S, Haldemann B, et al. Commonly altered genomic regions in acute myeloid leukemia are enriched for somatic mutations involved in chromatin-remodeling and splicing. Blood. 2012;120:e83-e92.
    • (2012) Blood , vol.120
    • Dolnik, A.1    Engelmann, J.C.2    Scharfenberger-Schmeer, M.3    Mauch, J.4    Kelkenberg-Schade, S.5    Haldemann, B.6
  • 82
    • 34447538496 scopus 로고    scopus 로고
    • A novel corepressor, BCoR-L1, represses transcription through an interaction with CtBP
    • Pagan JK, Arnold J, Hanchard KJ, Kumar R, Bruno T, Jones MJ, et al. A novel corepressor, BCoR-L1, represses transcription through an interaction with CtBP. J Biol Chem. 2007;282: 15248-57.
    • (2007) J Biol Chem , vol.282 , pp. 15248-15257
    • Pagan, J.K.1    Arnold, J.2    Hanchard, K.J.3    Kumar, R.4    Bruno, T.5    Jones, M.J.6
  • 83
    • 74949143986 scopus 로고    scopus 로고
    • Loss-of-function Additional sex combs like 1 mutations disrupt hematopoiesis but do not cause severe myelodysplasia or leukemia
    • Fisher CL, Pineault N, Brookes C, Helgason CD, Ohta H, Bodner C, et al. Loss-of-function Additional sex combs like 1 mutations disrupt hematopoiesis but do not cause severe myelodysplasia or leukemia. Blood. 2010;115:38-46.
    • (2010) Blood , vol.115 , pp. 38-46
    • Fisher, C.L.1    Pineault, N.2    Brookes, C.3    Helgason, C.D.4    Ohta, H.5    Bodner, C.6
  • 84
    • 0031946630 scopus 로고    scopus 로고
    • The Additional sex combs gene of drosophila encodes a chromatin protein that binds to shared and unique Polycomb group sites on polytene chromosomes
    • Sinclair DA, Milne TA, Hodgson JW, Shellard J, Salinas CA, Kyba M, et al. The Additional sex combs gene of Drosophila encodes a chromatin protein that binds to shared and unique Polycomb group sites on polytene chromosomes. Development. 1998;125:1207-16.
    • (1998) Development , vol.125 , pp. 1207-1216
    • Sinclair, D.A.1    Milne, T.A.2    Hodgson, J.W.3    Shellard, J.4    Salinas, C.A.5    Kyba, M.6
  • 85
    • 84865152223 scopus 로고    scopus 로고
    • ASXL1 mutations promote myeloid transformation through loss of PRC2-mediated gene repression
    • Abdel-Wahab O, Adli M, Lafave LM, Gao J, Hricik T, Shih AH, et al. ASXL1 mutations promote myeloid transformation through loss of PRC2-mediated gene repression. Cancer Cell. 2012;22: 180-93.
    • (2012) Cancer Cell , vol.22 , pp. 180-193
    • Abdel-Wahab, O.1    Adli, M.2    Lafave, L.M.3    Gao, J.4    Hricik, T.5    Shih, A.H.6
  • 87
    • 84255176496 scopus 로고    scopus 로고
    • ASXL1 mutations identify a high-risk subgroup of older patients with primary cytogenetically normal AML within the ELN favorable genetic category
    • Metzeler KH, Becker H, Maharry K, Radmacher MD, Kohlschmidt J, Mrozek K, et al. ASXL1 mutations identify a high-risk subgroup of older patients with primary cytogenetically normal AML within the ELN favorable genetic category. Blood. 2011; 118:6920-9.
    • (2011) Blood , vol.118 , pp. 6920-6929
    • Metzeler, K.H.1    Becker, H.2    Maharry, K.3    Radmacher, M.D.4    Kohlschmidt, J.5    Mrozek, K.6
  • 88
    • 84867806184 scopus 로고    scopus 로고
    • A novel hierarchical prognostic model of AML solely based on molecular mutations
    • Grossmann V, Schnittger S, Kohlmann A, Eder C, Roller A, Dicker F, et al. A novel hierarchical prognostic model of AML solely based on molecular mutations. Blood. 2012;120:2963-72.
    • (2012) Blood , vol.120 , pp. 2963-2972
    • Grossmann, V.1    Schnittger, S.2    Kohlmann, A.3    Eder, C.4    Roller, A.5    Dicker, F.6
  • 89
    • 80053629571 scopus 로고    scopus 로고
    • Disruption of the ASXL1 gene is frequent in primary, post-essential thrombocytosis and post-polycythemia vera myelofibrosis, but not essential thrombocytosis or polycythemia vera: Analysis of molecular genetics and clinical phenotypes
    • Stein BL, Williams DM, O'Keefe C, Rogers O, Ingersoll RG, Spivak JL, et al. Disruption of the ASXL1 gene is frequent in primary, post-essential thrombocytosis and post-polycythemia vera myelofibrosis, but not essential thrombocytosis or polycythemia vera: Analysis of molecular genetics and clinical phenotypes. Haematologica. 2011;96:1462-9.
    • (2011) Haematologica , vol.96 , pp. 1462-1469
    • Stein, B.L.1    Williams, D.M.2    O'Keefe, C.3    Rogers, O.4    Ingersoll, R.G.5    Spivak, J.L.6
  • 90
    • 84859595800 scopus 로고    scopus 로고
    • Mutations affecting mRNA splicing define distinct clinical phenotypes and correlate with patient outcome in myelodysplastic syndromes
    • Damm F, Kosmider O, Gelsi-Boyer V, Renneville A, Carbuccia N, Hidalgo-Curtis C, et al. Mutations affecting mRNA splicing define distinct clinical phenotypes and correlate with patient outcome in myelodysplastic syndromes. Blood. 2012;119:3211-8.
    • (2012) Blood , vol.119 , pp. 3211-3218
    • Damm, F.1    Kosmider, O.2    Gelsi-Boyer, V.3    Renneville, A.4    Carbuccia, N.5    Hidalgo-Curtis, C.6
  • 92
    • 84862012956 scopus 로고    scopus 로고
    • The role of minor subpopulations within the leukemic blast compartment of AML patients at initial diagnosis in the development of relapse
    • Bachas C, Schuurhuis GJ, Assaraf YG, Kwidama ZJ, Kelder A, Wouters F, et al. The role of minor subpopulations within the leukemic blast compartment of AML patients at initial diagnosis in the development of relapse. Leukemia. 2012;26:1313-20.
    • (2012) Leukemia , vol.26 , pp. 1313-1320
    • Bachas, C.1    Schuurhuis, G.J.2    Assaraf, Y.G.3    Kwidama, Z.J.4    Kelder, A.5    Wouters, F.6
  • 93
    • 84862776906 scopus 로고    scopus 로고
    • Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing
    • Ding L, Ley TJ, Larson DE, Miller CA, Koboldt DC, Welch JS, et al. Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing. Nature. 2012;481:506-10.
    • (2012) Nature , vol.481 , pp. 506-510
    • Ding, L.1    Ley, T.J.2    Larson, D.E.3    Miller, C.A.4    Koboldt, D.C.5    Welch, J.S.6
  • 94
    • 77955914238 scopus 로고    scopus 로고
    • Refinement of cytogenetic classification in acute myeloid leukemia: Determination of prognostic significance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the United Kingdom medical research council trials
    • Grimwade D, Hills RK, Moorman AV, Walker H, Chatters S, Goldstone AH, et al. Refinement of cytogenetic classification in acute myeloid leukemia: determination of prognostic significance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the United Kingdom Medical Research Council trials. Blood. 2010;116:354-65.
    • (2010) Blood , vol.116 , pp. 354-365
    • Grimwade, D.1    Hills, R.K.2    Moorman, A.V.3    Walker, H.4    Chatters, S.5    Goldstone, A.H.6
  • 95
    • 77449159028 scopus 로고    scopus 로고
    • Diagnosis and management of acute myeloid leukemia in adults: Recommendations from an international expert panel, on behalf of the European leukemia net
    • Dohner H, Estey EH, Amadori S, Appelbaum FR, Buchner T, Burnett AK, et al. Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European Leukemia Net. Blood. 2010;115:453-74.
    • (2010) Blood , vol.115 , pp. 453-474
    • Dohner, H.1    Estey, E.H.2    Amadori, S.3    Appelbaum, F.R.4    Buchner, T.5    Burnett, A.K.6


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