메뉴 건너뛰기




Volumn 16, Issue 6, 2009, Pages 676-684

Anti-inflammatory effects of fibrates: An overview

Author keywords

Adhesion molecules; C reactive protein; Fibrates; Inflammation; Interleukin; Statins

Indexed keywords

ANTIHYPERTENSIVE AGENT; ANTITHROMBOCYTIC AGENT; ATORVASTATIN; BEZAFIBRATE; C REACTIVE PROTEIN; CIPROFIBRATE; CLOFIBRATE; COLESEVELAM; EZETIMIBE; FENOFIBRATE; FIBRIC ACID DERIVATIVE; FLUINDOSTATIN; GEMFIBROZIL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; MEVINOLIN; NICOTINIC ACID; OMEGA 3 FATTY ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PLACEBO; SIMVASTATIN;

EID: 65649118218     PISSN: 09298673     EISSN: None     Source Type: Journal    
DOI: 10.2174/092986709787458416     Document Type: Review
Times cited : (28)

References (134)
  • 1
    • 0033552883 scopus 로고    scopus 로고
    • Atherosclerosis - an inflammatory disease
    • Ross, R. Atherosclerosis - an inflammatory disease. N. Engl. J. Med., 1999, 340, 115-26.
    • (1999) N. Engl. J. Med , vol.340 , pp. 115-126
    • Ross, R.1
  • 3
    • 34248641015 scopus 로고    scopus 로고
    • C-reactive protein and the prediction of cardiovascular events among those at intermediate risk: Moving an inflammatory hypothesis toward consensus
    • Ridker, P. M. C-reactive protein and the prediction of cardiovascular events among those at intermediate risk: Moving an inflammatory hypothesis toward consensus. J. Am. Coll. Cardiol., 2007, 49, 2129-38.
    • (2007) J. Am. Coll. Cardiol , vol.49 , pp. 2129-2138
    • Ridker, P.M.1
  • 5
    • 38549148785 scopus 로고    scopus 로고
    • C-reactive protein (CRP): More than just an innocent bystander?
    • Paraskevas, K. I.; Mikhailidis, D. P. C-reactive protein (CRP): More than just an innocent bystander? Curr. Med. Res. Opin., 2008, 24, 75-8.
    • (2008) Curr. Med. Res. Opin , vol.24 , pp. 75-78
    • Paraskevas, K.I.1    Mikhailidis, D.P.2
  • 6
    • 49849106228 scopus 로고    scopus 로고
    • Do we need to consider inflammatory markers when we treat atherosclerotic disease?
    • Athyros, V. G.; Kakafika, A. I.; Karagiannis, A.; Mikhailidis, D. P. Do we need to consider inflammatory markers when we treat atherosclerotic disease? Atherosclerosis, 2008, 200, 1-12.
    • (2008) Atherosclerosis , vol.200 , pp. 1-12
    • Athyros, V.G.1    Kakafika, A.I.2    Karagiannis, A.3    Mikhailidis, D.P.4
  • 7
    • 33846856622 scopus 로고    scopus 로고
    • C-reactive protein (CRP)-lowering agents
    • Prasad, K. C-reactive protein (CRP)-lowering agents. Cardiovasc. Drug Rev., 2006, 24, 33-50.
    • (2006) Cardiovasc. Drug Rev , vol.24 , pp. 33-50
    • Prasad, K.1
  • 10
    • 34548645400 scopus 로고    scopus 로고
    • Fenofibrate: A novel formulation (Triglide) in the treatment of lipid disorders: A review
    • Tziomalos, K.; Athyros, V. G. Fenofibrate: A novel formulation (Triglide) in the treatment of lipid disorders: A review. Int. J. Nanomedicine., 2006, 1, 129-47.
    • (2006) Int. J. Nanomedicine , vol.1 , pp. 129-147
    • Tziomalos, K.1    Athyros, V.G.2
  • 11
    • 0023232216 scopus 로고
    • Helsinki Heart Study: Primary-prevention trial with gemfibrozil in middle-aged men with dyslipidemia. Safety of treatment, changes in risk factors, and incidence of coronary heart disease
    • Frick, M. H.; Elo, O.; Haapa, K.; Heinonen, O. P.; Heinsalmi, P.; Helo, P.; Huttunen, J. K.; Kaitaniemi, P.; Koskinen, P.; Manninen, V.; Helsinki Heart Study: Primary-prevention trial with gemfibrozil in middle-aged men with dyslipidemia. Safety of treatment, changes in risk factors, and incidence of coronary heart disease. N. Engl. J. Med., 1987, 317, 1237-45.
    • (1987) N. Engl. J. Med , vol.317 , pp. 1237-1245
    • Frick, M.H.1    Elo, O.2    Haapa, K.3    Heinonen, O.P.4    Heinsalmi, P.5    Helo, P.6    Huttunen, J.K.7    Kaitaniemi, P.8    Koskinen, P.9    Manninen, V.10
  • 12
    • 0033527030 scopus 로고    scopus 로고
    • Gemfibrozil for the secondary prevention of coronary heart disease in men with low levels of high-density lipoprotein cholesterol. Veterans Affairs High-Density Lipoprotein Cholesterol Intervention Trial Study Group
    • Rubins, H. B.; Robins, S. J.; Collins, D.; Fye, C. L.; Anderson, J. W.; Elam, M. B.; Faas, F. H.; Linares, E.; Schaefer, E. J.; Schectman, G.; Wilt, T. J.; Wittes, J. Gemfibrozil for the secondary prevention of coronary heart disease in men with low levels of high-density lipoprotein cholesterol. Veterans Affairs High-Density Lipoprotein Cholesterol Intervention Trial Study Group. N. Engl. J. Med., 1999, 341, 410-8.
    • (1999) N. Engl. J. Med , vol.341 , pp. 410-418
    • Rubins, H.B.1    Robins, S.J.2    Collins, D.3    Fye, C.L.4    Anderson, J.W.5    Elam, M.B.6    Faas, F.H.7    Linares, E.8    Schaefer, E.J.9    Schectman, G.10    Wilt, T.J.11    Wittes, J.12
  • 15
    • 33846623798 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors as transcriptional nodal points and therapeutic targets
    • Brown, J. D.; Plutzky, J. Peroxisome proliferator-activated receptors as transcriptional nodal points and therapeutic targets. Circulation, 2007, 115, 518-33.
    • (2007) Circulation , vol.115 , pp. 518-533
    • Brown, J.D.1    Plutzky, J.2
  • 16
    • 0030985318 scopus 로고    scopus 로고
    • Fatty acids, eicosanoids, and hypolipidemic agents identified as ligands of peroxisome proliferator-activated receptors by coactivator-dependent receptor ligand assay
    • Krey, G.; Braissant, O.; L'Horset, F.; Kalkhoven, E.; Perroud, M.; Parker, M. G.; Wahli, W. Fatty acids, eicosanoids, and hypolipidemic agents identified as ligands of peroxisome proliferator-activated receptors by coactivator-dependent receptor ligand assay. Mol Endocrinol., 1997, 11, 779-91.
    • (1997) Mol Endocrinol , vol.11 , pp. 779-791
    • Krey, G.1    Braissant, O.2    L'Horset, F.3    Kalkhoven, E.4    Perroud, M.5    Parker, M.G.6    Wahli, W.7
  • 17
    • 27444437661 scopus 로고    scopus 로고
    • Beneficial vascular and metabolic effects of peroxisome proliferator-activated receptor-alpha activators
    • Han, S. H.; Quon, M. J.; Koh, K. K. Beneficial vascular and metabolic effects of peroxisome proliferator-activated receptor-alpha activators. Hypertension, 2005, 46, 1086-92.
    • (2005) Hypertension , vol.46 , pp. 1086-1092
    • Han, S.H.1    Quon, M.J.2    Koh, K.K.3
  • 18
    • 53149090164 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors in the modulation of the immune/inflammatory response in atherosclerosis
    • Fernandez, A. Z. Peroxisome proliferator-activated receptors in the modulation of the immune/inflammatory response in atherosclerosis. PPAR. Res., 2008, 2008, 285842.
    • (2008) PPAR. Res , vol.2008 , pp. 285842
    • Fernandez, A.Z.1
  • 20
    • 0034711185 scopus 로고    scopus 로고
    • Induction of IkappaBalpha expression as a mechanism contributing to the anti-inflammatory activities of peroxisome proliferator-activated receptor-alpha activators
    • Delerive, P.; Gervois, P.; Fruchart, J. C.; Staels, B. Induction of IkappaBalpha expression as a mechanism contributing to the anti-inflammatory activities of peroxisome proliferator-activated receptor-alpha activators. J. Biol. Chem., 2000, 275, 36703-7.
    • (2000) J. Biol. Chem , vol.275 , pp. 36703-36707
    • Delerive, P.1    Gervois, P.2    Fruchart, J.C.3    Staels, B.4
  • 21
    • 0037438377 scopus 로고    scopus 로고
    • Fibrates down-regulate IL-1-stimulated C-reactive protein gene expression in hepatocytes by reducing nuclear p50-NFkappa B-C/EBP-beta complex formation
    • Kleemann, R.; Gervois, P. P.; Verschuren, L.; Staels, B.; Princen, H. M.; Kooistra, T. Fibrates down-regulate IL-1-stimulated C-reactive protein gene expression in hepatocytes by reducing nuclear p50-NFkappa B-C/EBP-beta complex formation. Blood, 2003, 101, 545-51.
    • (2003) Blood , vol.101 , pp. 545-551
    • Kleemann, R.1    Gervois, P.P.2    Verschuren, L.3    Staels, B.4    Princen, H.M.5    Kooistra, T.6
  • 22
    • 1942533537 scopus 로고    scopus 로고
    • Global suppression of IL-6-induced acute phase response gene expression after chronic in vivo treatment with the peroxisome proliferator-activated receptor-alpha activator fenofibrate
    • Gervois, P.; Kleemann, R.; Pilon, A.; Percevault, F.; Koenig, W.; Staels, B.; Kooistra, T. Global suppression of IL-6-induced acute phase response gene expression after chronic in vivo treatment with the peroxisome proliferator-activated receptor-alpha activator fenofibrate. J. Biol. Chem., 2004, 279, 16154-60.
    • (2004) J. Biol. Chem , vol.279 , pp. 16154-16160
    • Gervois, P.1    Kleemann, R.2    Pilon, A.3    Percevault, F.4    Koenig, W.5    Staels, B.6    Kooistra, T.7
  • 23
    • 0033594810 scopus 로고    scopus 로고
    • PPARalpha activators inhibit cytokine-induced vascular cell adhesion molecule-1 expression in human endothelial cells
    • Marx, N.; Sukhova, G. K.; Collins, T.; Libby, P.; Plutzky, J. PPARalpha activators inhibit cytokine-induced vascular cell adhesion molecule-1 expression in human endothelial cells. Circulation, 1999, 99, 3125-31.
    • (1999) Circulation , vol.99 , pp. 3125-3131
    • Marx, N.1    Sukhova, G.K.2    Collins, T.3    Libby, P.4    Plutzky, J.5
  • 24
    • 44249124486 scopus 로고    scopus 로고
    • Systemic and distal repercussions of liver-specific peroxisome proliferator-activated receptor-alpha control of the acute-phase response
    • Mansouri, R. M.; Bauge, E.; Staels, B.; Gervois, P. Systemic and distal repercussions of liver-specific peroxisome proliferator-activated receptor-alpha control of the acute-phase response. Endocrinology, 2008, 149, 3215-23.
    • (2008) Endocrinology , vol.149 , pp. 3215-3223
    • Mansouri, R.M.1    Bauge, E.2    Staels, B.3    Gervois, P.4
  • 27
    • 33750441154 scopus 로고    scopus 로고
    • Inhibitory effects of micronized fenofibrate on carotid atherosclerosis in patients with essential hypertension
    • Zhu, S.; Su, G.; Meng, Q. H. Inhibitory effects of micronized fenofibrate on carotid atherosclerosis in patients with essential hypertension. Clin. Chem., 2006, 52, 2036-42.
    • (2006) Clin. Chem , vol.52 , pp. 2036-2042
    • Zhu, S.1    Su, G.2    Meng, Q.H.3
  • 28
    • 0036228041 scopus 로고    scopus 로고
    • Differential effects of gemfibrozil on migration, proliferation and proteoglycan production in human vascular smooth muscle cells
    • Nigro, J.; Dilley, R. J.; Little, P. J. Differential effects of gemfibrozil on migration, proliferation and proteoglycan production in human vascular smooth muscle cells. Atherosclerosis, 2002, 162, 119-29.
    • (2002) Atherosclerosis , vol.162 , pp. 119-129
    • Nigro, J.1    Dilley, R.J.2    Little, P.J.3
  • 29
    • 0032546485 scopus 로고    scopus 로고
    • Expression of peroxisome proliferator-activated receptor alpha (PPAR alpha) in primary cultures of human vascular endothelial cells
    • Inoue, I.; Shino, K.; Noji, S.; Awata, T.; Katayama, S. Expression of peroxisome proliferator-activated receptor alpha (PPAR alpha) in primary cultures of human vascular endothelial cells. Biochem Biophys. Res. Commun., 1998, 246, 370-4.
    • (1998) Biochem Biophys. Res. Commun , vol.246 , pp. 370-374
    • Inoue, I.1    Shino, K.2    Noji, S.3    Awata, T.4    Katayama, S.5
  • 32
    • 0344333464 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma activators inhibit gene expression and migration in human vascular smooth muscle cells
    • Marx, N.; Schonbeck, U.; Lazar, M. A.; Libby, P.; Plutzky, J. Peroxisome proliferator-activated receptor gamma activators inhibit gene expression and migration in human vascular smooth muscle cells. Circ. Res., 1998, 83, 1097-103.
    • (1998) Circ. Res , vol.83 , pp. 1097-1103
    • Marx, N.1    Schonbeck, U.2    Lazar, M.A.3    Libby, P.4    Plutzky, J.5
  • 33
    • 2442711384 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors and atherogenesis: Regulators of gene expression in vascular cells
    • Marx, N.; Duez, H.; Fruchart, J. C.; Staels, B. Peroxisome proliferator-activated receptors and atherogenesis: Regulators of gene expression in vascular cells. Circ. Res., 2004, 94, 1168-78.
    • (2004) Circ. Res , vol.94 , pp. 1168-1178
    • Marx, N.1    Duez, H.2    Fruchart, J.C.3    Staels, B.4
  • 34
    • 0032587328 scopus 로고    scopus 로고
    • PPARgamma activation in human endothelial cells increases plasminogen activator inhibitor type-1 expression: PPARgamma as a potential mediator in vascular disease
    • Marx, N.; Bourcier, T.; Sukhova, G. K.; Libby, P.; Plutzky, J. PPARgamma activation in human endothelial cells increases plasminogen activator inhibitor type-1 expression: PPARgamma as a potential mediator in vascular disease. Arterioscler. Thromb. Vasc. Biol., 1999, 19, 546-51.
    • (1999) Arterioscler. Thromb. Vasc. Biol , vol.19 , pp. 546-551
    • Marx, N.1    Bourcier, T.2    Sukhova, G.K.3    Libby, P.4    Plutzky, J.5
  • 35
    • 0031870652 scopus 로고    scopus 로고
    • Macrophages in human atheroma contain PPARgamma: Differentiation-dependent peroxisomal proliferator-activated receptor gamma(PPARgamma) expression and reduction of MMP-9 activity through PPARgamma activation in mononuclear phagocytes in vitro
    • Marx, N.; Sukhova, G.; Murphy, C.; Libby, P.; Plutzky, J. Macrophages in human atheroma contain PPARgamma: Differentiation-dependent peroxisomal proliferator-activated receptor gamma(PPARgamma) expression and reduction of MMP-9 activity through PPARgamma activation in mononuclear phagocytes in vitro. Am. J. Pathol., 1998, 153, 17-23.
    • (1998) Am. J. Pathol , vol.153 , pp. 17-23
    • Marx, N.1    Sukhova, G.2    Murphy, C.3    Libby, P.4    Plutzky, J.5
  • 38
    • 0028865357 scopus 로고
    • High-density lipoproteins inhibit cytokine-induced expression of endothelial cell adhesion molecules
    • Cockerill, G. W.; Rye, K. A.; Gamble, J. R.; Vadas, M. A.; Barter, P. J. High-density lipoproteins inhibit cytokine-induced expression of endothelial cell adhesion molecules. Arterioscler. Thromb. Vasc. Biol., 1995, 15, 1987-94.
    • (1995) Arterioscler. Thromb. Vasc. Biol , vol.15 , pp. 1987-1994
    • Cockerill, G.W.1    Rye, K.A.2    Gamble, J.R.3    Vadas, M.A.4    Barter, P.J.5
  • 41
  • 43
    • 16644380225 scopus 로고    scopus 로고
    • Fenofibrate effectively reduces remnants, and small dense LDL, and increases HDL particle number in hypertriglyceridemic men - a nuclear magnetic resonance study
    • Ikewaki, K.; Tohyama, J.; Nakata, Y.; Wakikawa, T.; Kido, T.; Mochizuki, S. Fenofibrate effectively reduces remnants, and small dense LDL, and increases HDL particle number in hypertriglyceridemic men - a nuclear magnetic resonance study. J. Atheroscler. Thromb., 2004, 11, 278-85.
    • (2004) J. Atheroscler. Thromb , vol.11 , pp. 278-285
    • Ikewaki, K.1    Tohyama, J.2    Nakata, Y.3    Wakikawa, T.4    Kido, T.5    Mochizuki, S.6
  • 44
    • 20344364136 scopus 로고    scopus 로고
    • Effects of fenofibrate on inflammatory cytokines and blood pressure in patients with hypertriglyceridemia
    • Ye, P.; Li, J. J.; Su, G.; Zhang, C. Effects of fenofibrate on inflammatory cytokines and blood pressure in patients with hypertriglyceridemia. Clin. Chim. Acta, 2005, 356, 229-32.
    • (2005) Clin. Chim. Acta , vol.356 , pp. 229-232
    • Ye, P.1    Li, J.J.2    Su, G.3    Zhang, C.4
  • 45
    • 19944379835 scopus 로고    scopus 로고
    • Beneficial effects of fenofibrate to improve endothelial dysfunction and raise adiponectin levels in patients with primary hypertriglyceridemia
    • Koh, K. K.; Han, S. H.; Quon, M. J.; Yeal, A. J.; Shin, E. K. Beneficial effects of fenofibrate to improve endothelial dysfunction and raise adiponectin levels in patients with primary hypertriglyceridemia. Diabetes Care, 2005, 28, 1419-24.
    • (2005) Diabetes Care , vol.28 , pp. 1419-1424
    • Koh, K.K.1    Han, S.H.2    Quon, M.J.3    Yeal, A.J.4    Shin, E.K.5
  • 46
    • 31644446113 scopus 로고    scopus 로고
    • Interleukin-6-174 G/C promoter polymorphism and effects of fenofibrate and simvastatin on inflammatory markers in hypercholesterolemic patients
    • Potaczek, D. P.; Undas, A.; Celinska-Lowenhoff, M.; Szczeklik, A. Interleukin-6-174 G/C promoter polymorphism and effects of fenofibrate and simvastatin on inflammatory markers in hypercholesterolemic patients. Blood Coagul. Fibrinolysis, 2006, 17, 35-8.
    • (2006) Blood Coagul. Fibrinolysis , vol.17 , pp. 35-38
    • Potaczek, D.P.1    Undas, A.2    Celinska-Lowenhoff, M.3    Szczeklik, A.4
  • 47
    • 33746218022 scopus 로고    scopus 로고
    • The I allele of the angiotensin-converting enzyme gene polymorphism may determine an increase in homocysteine levels in fibrate-treated subjects
    • Potaczek, D. P.; Undas, A.; Celinska-Lowenhoff, M.; Szczeklik, A. The I allele of the angiotensin-converting enzyme gene polymorphism may determine an increase in homocysteine levels in fibrate-treated subjects. Cardiovasc. Drugs Ther., 2006, 20, 229-32.
    • (2006) Cardiovasc. Drugs Ther , vol.20 , pp. 229-232
    • Potaczek, D.P.1    Undas, A.2    Celinska-Lowenhoff, M.3    Szczeklik, A.4
  • 48
    • 22144434443 scopus 로고    scopus 로고
    • Early antithrombotic and anti-inflammatory effects of simvastatin versus fenofibrate in patients with hypercholesterolemia
    • Undas, A.; Celinska-Lowenhoff, M.; Domagala, T. B.; Iwaniec, T.; Dropinski, J.; Lowenhoff, T.; Szczeklik, A. Early antithrombotic and anti-inflammatory effects of simvastatin versus fenofibrate in patients with hypercholesterolemia. Thromb. Haemost., 2005, 94, 193-9.
    • (2005) Thromb. Haemost , vol.94 , pp. 193-199
    • Undas, A.1    Celinska-Lowenhoff, M.2    Domagala, T.B.3    Iwaniec, T.4    Dropinski, J.5    Lowenhoff, T.6    Szczeklik, A.7
  • 50
    • 9144232352 scopus 로고    scopus 로고
    • Statin and fibrate treatment of combined hyperlipidemia: The effects on some novel risk factors
    • Sebestjen, M.; Keber, I.; Zegura, B.; Simcic, S.; Bozic, M.; Fressart, M. M.; Stegnar, M. Statin and fibrate treatment of combined hyperlipidemia: The effects on some novel risk factors. Thromb. Haemost., 2004, 92, 1129-35.
    • (2004) Thromb. Haemost , vol.92 , pp. 1129-1135
    • Sebestjen, M.1    Keber, I.2    Zegura, B.3    Simcic, S.4    Bozic, M.5    Fressart, M.M.6    Stegnar, M.7
  • 51
    • 0242661386 scopus 로고    scopus 로고
    • Efficacy of fenofibrate and simvastatin on endothelial function and inflammatory markers in patients with combined hyperlipidemia: Relations with baseline lipid profiles
    • Wang, T. D.; Chen, W. J.; Lin, J. W.; Cheng, C. C.; Chen, M. F.; Lee, Y. T. Efficacy of fenofibrate and simvastatin on endothelial function and inflammatory markers in patients with combined hyperlipidemia: Relations with baseline lipid profiles. Atherosclerosis, 2003, 170, 315-23.
    • (2003) Atherosclerosis , vol.170 , pp. 315-323
    • Wang, T.D.1    Chen, W.J.2    Lin, J.W.3    Cheng, C.C.4    Chen, M.F.5    Lee, Y.T.6
  • 52
    • 0034782457 scopus 로고    scopus 로고
    • Both fenofibrate and atorvastatin improve vascular reactivity in combined hyperlipidaemia (fenofibrate versus atorvastatin trial - FAT)
    • Malik, J.; Melenovsky, V.; Wichterle, D.; Haas, T.; Simek, J.; Ceska, R.; Hradec, J. Both fenofibrate and atorvastatin improve vascular reactivity in combined hyperlipidaemia (fenofibrate versus atorvastatin trial - FAT). Cardiovasc. Res., 2001, 52, 290-8.
    • (2001) Cardiovasc. Res , vol.52 , pp. 290-298
    • Malik, J.1    Melenovsky, V.2    Wichterle, D.3    Haas, T.4    Simek, J.5    Ceska, R.6    Hradec, J.7
  • 53
    • 17444438664 scopus 로고    scopus 로고
    • Comparison of the effects of atorvastatin or fenofibrate on nonlipid biochemical risk factors and the LDL particle size in subjects with combined hyperlipidemia
    • Melenovsky, V.; Malik, J.; Wichterle, D.; Simek, J.; Pisarikova, A.; Skrha, J.; Poledne, R.; Stavek, P.; Ceska, R. Comparison of the effects of atorvastatin or fenofibrate on nonlipid biochemical risk factors and the LDL particle size in subjects with combined hyperlipidemia. Am. Heart J., 2002, 144, E6.
    • (2002) Am. Heart J , vol.144
    • Melenovsky, V.1    Malik, J.2    Wichterle, D.3    Simek, J.4    Pisarikova, A.5    Skrha, J.6    Poledne, R.7    Stavek, P.8    Ceska, R.9
  • 54
    • 24344489423 scopus 로고    scopus 로고
    • Monocyte release of tumor necrosis factor-alpha and interleukin-1beta in primary type IIa and IIb dyslipidemic patients treated with statins or fibrates
    • Okopien, B.; Krysiak, R.; Kowalski, J.; Madej, A.; Belowski, D.; Zielinski, M.; Herman, Z. S. Monocyte release of tumor necrosis factor-alpha and interleukin-1beta in primary type IIa and IIb dyslipidemic patients treated with statins or fibrates. J. Cardiovasc. Pharmacol., 2005, 46, 377-86.
    • (2005) J. Cardiovasc. Pharmacol , vol.46 , pp. 377-386
    • Okopien, B.1    Krysiak, R.2    Kowalski, J.3    Madej, A.4    Belowski, D.5    Zielinski, M.6    Herman, Z.S.7
  • 55
    • 16344383482 scopus 로고    scopus 로고
    • The effect of fenofibrate on the levels of high sensitivity C-reactive protein in dyslipidaemic hypertensive patients
    • Coban, E.; Ozdogan, M.; Yazicioglu, G.; Sari, R. The effect of fenofibrate on the levels of high sensitivity C-reactive protein in dyslipidaemic hypertensive patients. Int. J. Clin. Pract., 2005, 59, 415-8.
    • (2005) Int. J. Clin. Pract , vol.59 , pp. 415-418
    • Coban, E.1    Ozdogan, M.2    Yazicioglu, G.3    Sari, R.4
  • 56
    • 33646393509 scopus 로고    scopus 로고
    • Effects of short-term fenofibrate treatment on circulating markers of inflammation and hemostasis in patients with impaired glucose tolerance
    • Okopien, B.; Krysiak, R.; Herman, Z. S. Effects of short-term fenofibrate treatment on circulating markers of inflammation and hemostasis in patients with impaired glucose tolerance. J. Clin. Endocrinol. Metab, 2006, 91, 1770-8.
    • (2006) J. Clin. Endocrinol. Metab , vol.91 , pp. 1770-1778
    • Okopien, B.1    Krysiak, R.2    Herman, Z.S.3
  • 57
    • 43949097868 scopus 로고    scopus 로고
    • Fenofibrate reduces fasting and postprandial inflammatory responses among hypertriglyceridemia patients with the metabolic syndrome
    • Rosenson, R. S.; Huskin, A. L.; Wolff, D. A.; Helenowski, I. B.; Rademaker, A. W. Fenofibrate reduces fasting and postprandial inflammatory responses among hypertriglyceridemia patients with the metabolic syndrome. Atherosclerosis, 2008, 198, 381-8.
    • (2008) Atherosclerosis , vol.198 , pp. 381-388
    • Rosenson, R.S.1    Huskin, A.L.2    Wolff, D.A.3    Helenowski, I.B.4    Rademaker, A.W.5
  • 58
    • 34248187694 scopus 로고    scopus 로고
    • Decrease in inflammatory cardiovascular risk markers in hyperlipidemic diabetic patients treated with fenofibrate
    • Wu, T. J.; Ou, H. Y.; Chou, C. W.; Hsiao, S. H.; Lin, C. Y.; Kao, P. C. Decrease in inflammatory cardiovascular risk markers in hyperlipidemic diabetic patients treated with fenofibrate. Ann. Clin. Lab Sci., 2007, 37, 158-66.
    • (2007) Ann. Clin. Lab Sci , vol.37 , pp. 158-166
    • Wu, T.J.1    Ou, H.Y.2    Chou, C.W.3    Hsiao, S.H.4    Lin, C.Y.5    Kao, P.C.6
  • 59
    • 33646371983 scopus 로고    scopus 로고
    • Additive beneficial effects of fenofibrate combined with candesartan in the treatment of hyper-triglyceridemic hypertensive patients
    • Koh, K. K.; Quon, M. J.; Han, S. H.; Chung, W. J.; Ahn, J. Y.; Kim, J. A.; Lee, Y.; Shin, E. K. Additive beneficial effects of fenofibrate combined with candesartan in the treatment of hyper-triglyceridemic hypertensive patients. Diabetes Care, 2006, 29, 195-201.
    • (2006) Diabetes Care , vol.29 , pp. 195-201
    • Koh, K.K.1    Quon, M.J.2    Han, S.H.3    Chung, W.J.4    Ahn, J.Y.5    Kim, J.A.6    Lee, Y.7    Shin, E.K.8
  • 60
    • 2342485967 scopus 로고    scopus 로고
    • Effects of fenofibrate on lipoproteins, vasomotor function, and serological markers of inflammation, plaque stabilization, and hemostasis
    • Kon, K. K.; Yeal, A. J.; Hwan, H. S.; Kyu, J. D.; Sik, K. H.; Cheon, L. K.; Kyun, S. E.; Sakuma, I. Effects of fenofibrate on lipoproteins, vasomotor function, and serological markers of inflammation, plaque stabilization, and hemostasis. Atherosclerosis, 2004, 174, 379-83.
    • (2004) Atherosclerosis , vol.174 , pp. 379-383
    • Kon, K.K.1    Yeal, A.J.2    Hwan, H.S.3    Kyu, J.D.4    Sik, K.H.5    Cheon, L.K.6    Kyun, S.E.7    Sakuma, I.8
  • 61
    • 30044446335 scopus 로고    scopus 로고
    • Microvascular endothelial function in subjects with Type 2 diabetes and the effect of lipid-lowering therapy
    • Fegan, P. G.; Shore, A. C.; Mawson, D.; Tooke, J. E.; MacLeod, K. M. Microvascular endothelial function in subjects with Type 2 diabetes and the effect of lipid-lowering therapy. Diabet. Med., 2005, 22, 1670-6.
    • (2005) Diabet. Med , vol.22 , pp. 1670-1676
    • Fegan, P.G.1    Shore, A.C.2    Mawson, D.3    Tooke, J.E.4    MacLeod, K.M.5
  • 62
    • 38749088004 scopus 로고    scopus 로고
    • Differential effect of atorvastatin and fenofibrate on plasma oxidized low-density lipoprotein, inflammation markers, and cell adhesion molecules in patients with type 2 diabetes mellitus
    • Hogue, J. C.; Lamarche, B.; Tremblay, A. J.; Bergeron, J.; Gagne, C.; Couture, P. Differential effect of atorvastatin and fenofibrate on plasma oxidized low-density lipoprotein, inflammation markers, and cell adhesion molecules in patients with type 2 diabetes mellitus. Metabolism, 2008, 57, 380-6.
    • (2008) Metabolism , vol.57 , pp. 380-386
    • Hogue, J.C.1    Lamarche, B.2    Tremblay, A.J.3    Bergeron, J.4    Gagne, C.5    Couture, P.6
  • 63
    • 33748100547 scopus 로고    scopus 로고
    • Effects of fenofibrate on C-reactive protein levels in hypertriglyceridemic patients
    • Kim, C. J. Effects of fenofibrate on C-reactive protein levels in hypertriglyceridemic patients. J. Cardiovasc. Pharmacol., 2006, 47, 758-63.
    • (2006) J. Cardiovasc. Pharmacol , vol.47 , pp. 758-763
    • Kim, C.J.1
  • 65
    • 0036090215 scopus 로고    scopus 로고
    • Effect of ciprofibrate on C-reactive protein and fibrinogen levels
    • Rizos, E.; Kostoula, A.; Elisaf, M.; Mikhailidis, D. P. Effect of ciprofibrate on C-reactive protein and fibrinogen levels. Angiology, 2002, 53, 273-7.
    • (2002) Angiology , vol.53 , pp. 273-277
    • Rizos, E.1    Kostoula, A.2    Elisaf, M.3    Mikhailidis, D.P.4
  • 67
    • 0036121471 scopus 로고    scopus 로고
    • Jonkers, I. J.; Mohrschladt, M. F.; Westendorp, R. G.; van der, L. A.; Smelt, A. H. Severe hypertriglyceridemia with insulin resistance is associated with systemic inflammation: Reversal with bezafibrate therapy in a randomized controlled trial. Am. J. Med., 2002, 112, 275-80.
    • Jonkers, I. J.; Mohrschladt, M. F.; Westendorp, R. G.; van der, L. A.; Smelt, A. H. Severe hypertriglyceridemia with insulin resistance is associated with systemic inflammation: Reversal with bezafibrate therapy in a randomized controlled trial. Am. J. Med., 2002, 112, 275-80.
  • 69
    • 44149105864 scopus 로고    scopus 로고
    • Fluvastatin improves arterial stiffness in patients with coronary artery disease and hyperlipidemia: A 5-year follow-up study
    • Hongo, M.; Tsutsui, H.; Mawatari, E.; Hidaka, H.; Kumazaki, S.; Yazaki, Y.; Takahashi, M.; Kinoshita, O.; Ikeda, U. Fluvastatin improves arterial stiffness in patients with coronary artery disease and hyperlipidemia: A 5-year follow-up study. Circ. J., 2008, 72, 722-8.
    • (2008) Circ. J , vol.72 , pp. 722-728
    • Hongo, M.1    Tsutsui, H.2    Mawatari, E.3    Hidaka, H.4    Kumazaki, S.5    Yazaki, Y.6    Takahashi, M.7    Kinoshita, O.8    Ikeda, U.9
  • 70
    • 19344366802 scopus 로고    scopus 로고
    • Effects of bezafibrate on lipoprotein subclasses and inflammatory markers in patients with hypertriglyceridemia - a nuclear magnetic resonance study
    • Ikewaki, K.; Noma, K.; Tohyama, J.; Kido, T.; Mochizuki, S. Effects of bezafibrate on lipoprotein subclasses and inflammatory markers in patients with hypertriglyceridemia - a nuclear magnetic resonance study. Int. J. Cardiol., 2005, 101, 441-7.
    • (2005) Int. J. Cardiol , vol.101 , pp. 441-447
    • Ikewaki, K.1    Noma, K.2    Tohyama, J.3    Kido, T.4    Mochizuki, S.5
  • 71
    • 0345305421 scopus 로고    scopus 로고
    • Effects of bezafibrate and simvastatin on endothelial activation and lipid peroxidation in hypercholesterolemia: Evidence of different vascular protection by different lipid-lowering treatments
    • Desideri, G.; Croce, G.; Tucci, M.; Passacquale, G.; Broccoletti, S.; Valeri, L.; Santucci, A.; Ferri, C. Effects of bezafibrate and simvastatin on endothelial activation and lipid peroxidation in hypercholesterolemia: Evidence of different vascular protection by different lipid-lowering treatments. J. Clin. Endocrinol. Metab, 2003, 88, 5341-7.
    • (2003) J. Clin. Endocrinol. Metab , vol.88 , pp. 5341-5347
    • Desideri, G.1    Croce, G.2    Tucci, M.3    Passacquale, G.4    Broccoletti, S.5    Valeri, L.6    Santucci, A.7    Ferri, C.8
  • 72
    • 0034035848 scopus 로고    scopus 로고
    • Effects of fluvastatin and bezafibrate combination on plasma fibrinogen, t-plasminogen activator inhibitor and C reactive protein levels in coronary artery disease patients with mixed hyperlipidaemia (FACT study). Fluvastatin Alone and in Combination Treatment
    • Cortellaro, M.; Cofrancesco, E.; Boschetti, C.; Cortellaro, F.; Mancini, M.; Mariani, M.; Paoletti, R. Effects of fluvastatin and bezafibrate combination on plasma fibrinogen, t-plasminogen activator inhibitor and C reactive protein levels in coronary artery disease patients with mixed hyperlipidaemia (FACT study). Fluvastatin Alone and in Combination Treatment. Thromb. Haemost., 2000, 83, 549-53.
    • (2000) Thromb. Haemost , vol.83 , pp. 549-553
    • Cortellaro, M.1    Cofrancesco, E.2    Boschetti, C.3    Cortellaro, F.4    Mancini, M.5    Mariani, M.6    Paoletti, R.7
  • 74
    • 0034681920 scopus 로고    scopus 로고
    • Plasma concentration of interleukin-6 and the risk of future myocardial infarction among apparently healthy men
    • Ridker, P. M.; Rifai, N.; Stampfer, M. J.; Hennekens, C. H. Plasma concentration of interleukin-6 and the risk of future myocardial infarction among apparently healthy men. Circulation, 2000, 101, 1767-72.
    • (2000) Circulation , vol.101 , pp. 1767-1772
    • Ridker, P.M.1    Rifai, N.2    Stampfer, M.J.3    Hennekens, C.H.4
  • 75
    • 0037190065 scopus 로고    scopus 로고
    • Inflammatory biomarkers, hormone replacement therapy, and incident coronary heart disease: Prospective analysis from the Women's Health Initiative observational study
    • Pradhan, A. D.; Manson, J. E.; Rossouw, J. E.; Siscovick, D. S.; Mouton, C. P.; Rifai, N.; Wallace, R. B.; Jackson, R. D.; Pettinger, M. B.; Ridker, P. M. Inflammatory biomarkers, hormone replacement therapy, and incident coronary heart disease: Prospective analysis from the Women's Health Initiative observational study. JAMA, 2002, 288, 980-7.
    • (2002) JAMA , vol.288 , pp. 980-987
    • Pradhan, A.D.1    Manson, J.E.2    Rossouw, J.E.3    Siscovick, D.S.4    Mouton, C.P.5    Rifai, N.6    Wallace, R.B.7    Jackson, R.D.8    Pettinger, M.B.9    Ridker, P.M.10
  • 76
    • 34548624338 scopus 로고    scopus 로고
    • Fenofibrate and pioglitazone improve endothelial function and reduce arterial stiffness in obese glucose tolerant men
    • Ryan, K. E.; McCance, D. R.; Powell, L.; McMahon, R.; Trimble, E. R. Fenofibrate and pioglitazone improve endothelial function and reduce arterial stiffness in obese glucose tolerant men. Atherosclerosis, 2007, 194, e123-e130.
    • (2007) Atherosclerosis , vol.194
    • Ryan, K.E.1    McCance, D.R.2    Powell, L.3    McMahon, R.4    Trimble, E.R.5
  • 77
    • 0034625079 scopus 로고    scopus 로고
    • Elevation of tumor necrosis factor-alpha and increased risk of recurrent coronary events after myocardial infarction
    • Ridker, P. M.; Rifai, N.; Pfeffer, M.; Sacks, F.; Lepage, S.; Braunwald, E. Elevation of tumor necrosis factor-alpha and increased risk of recurrent coronary events after myocardial infarction. Circulation, 2000, 101, 2149-53.
    • (2000) Circulation , vol.101 , pp. 2149-2153
    • Ridker, P.M.1    Rifai, N.2    Pfeffer, M.3    Sacks, F.4    Lepage, S.5    Braunwald, E.6
  • 78
    • 4644227838 scopus 로고    scopus 로고
    • Comparative effects of statin and fibrate on nitric oxide bioactivity and matrix metalloproteinase in hyperlipidemia
    • Koh, K. K.; Ahn, J. Y.; Jin, D. K.; Han, S. H.; Kim, H. S.; Choi, I. S.; Ahn, T. H.; Shin, E. K.; Jeong, E. M. Comparative effects of statin and fibrate on nitric oxide bioactivity and matrix metalloproteinase in hyperlipidemia. Int. J. Cardiol., 2004, 97, 239-44.
    • (2004) Int. J. Cardiol , vol.97 , pp. 239-244
    • Koh, K.K.1    Ahn, J.Y.2    Jin, D.K.3    Han, S.H.4    Kim, H.S.5    Choi, I.S.6    Ahn, T.H.7    Shin, E.K.8    Jeong, E.M.9
  • 79
    • 33947716172 scopus 로고    scopus 로고
    • Endothelial function and dysfunction: Testing and clinical relevance
    • Deanfield, J. E.; Halcox, J. P.; Rabelink, T. J. Endothelial function and dysfunction: Testing and clinical relevance. Circulation, 2007, 115, 1285-95.
    • (2007) Circulation , vol.115 , pp. 1285-1295
    • Deanfield, J.E.1    Halcox, J.P.2    Rabelink, T.J.3
  • 80
    • 0031438497 scopus 로고    scopus 로고
    • Circulating adhesion molecules VCAM-1, ICAM-1, and E-selectin in carotid atherosclerosis and incident coronary heart disease cases: The Atherosclerosis Risk In Communities (ARIC) study
    • Hwang, S. J.; Ballantyne, C. M.; Sharrett, A. R.; Smith, L. C.; Davis, C. E.; Gotto, A. M., Jr.; Boerwinkle, E. Circulating adhesion molecules VCAM-1, ICAM-1, and E-selectin in carotid atherosclerosis and incident coronary heart disease cases: The Atherosclerosis Risk In Communities (ARIC) study. Circulation, 1997, 96, 4219-25.
    • (1997) Circulation , vol.96 , pp. 4219-4225
    • Hwang, S.J.1    Ballantyne, C.M.2    Sharrett, A.R.3    Smith, L.C.4    Davis, C.E.5    Gotto Jr., A.M.6    Boerwinkle, E.7
  • 82
    • 0032501738 scopus 로고    scopus 로고
    • Plasma concentration of soluble intercellular adhesion molecule 1 and risks of future myocardial infarction in apparently healthy men
    • Ridker, P. M.; Hennekens, C. H.; Roitman-Johnson, B.; Stampfer, M. J.; Allen, J. Plasma concentration of soluble intercellular adhesion molecule 1 and risks of future myocardial infarction in apparently healthy men. Lancet, 1998, 351, 88-92.
    • (1998) Lancet , vol.351 , pp. 88-92
    • Ridker, P.M.1    Hennekens, C.H.2    Roitman-Johnson, B.3    Stampfer, M.J.4    Allen, J.5
  • 83
  • 84
    • 0034089237 scopus 로고    scopus 로고
    • Increased levels of soluble vascular cell adhesion molecule 1 are associated with risk of cardiovascular mortality in type 2 diabetes: The Hoorn study
    • Jager, A.; van Hinsbergh, V. W.; Kostense, P. J.; Emeis, J. J.; Nijpels, G.; Dekker, J. M.; Heine, R. J.; Bouter, L. M.; Stehouwer, C. D. Increased levels of soluble vascular cell adhesion molecule 1 are associated with risk of cardiovascular mortality in type 2 diabetes: The Hoorn study. Diabetes, 2000, 49, 485-91.
    • (2000) Diabetes , vol.49 , pp. 485-491
    • Jager, A.1    van Hinsbergh, V.W.2    Kostense, P.J.3    Emeis, J.J.4    Nijpels, G.5    Dekker, J.M.6    Heine, R.J.7    Bouter, L.M.8    Stehouwer, C.D.9
  • 86
    • 34547687824 scopus 로고    scopus 로고
    • Fenofibrate therapy ameliorates fasting and postprandial lipoproteinemia, oxidative stress, and the inflammatory response in subjects with hypertriglyceridemia and the metabolic syndrome
    • Rosenson, R. S.; Wolff, D. A.; Huskin, A. L.; Helenowski, I. B.; Rademaker, A. W. Fenofibrate therapy ameliorates fasting and postprandial lipoproteinemia, oxidative stress, and the inflammatory response in subjects with hypertriglyceridemia and the metabolic syndrome. Diabetes Care, 2007, 30, 1945-51.
    • (2007) Diabetes Care , vol.30 , pp. 1945-1951
    • Rosenson, R.S.1    Wolff, D.A.2    Huskin, A.L.3    Helenowski, I.B.4    Rademaker, A.W.5
  • 87
  • 88
    • 2942515106 scopus 로고    scopus 로고
    • Differential effects of fenofibrate versus atorvastatin on the concentrations of E-selectin and vascular cellular adhesion molecule-1 in patients with type 2 diabetes mellitus and mixed hyperlipoproteinemia: A randomized cross-over trial
    • Empen, K.; Frost, R. J.; Geiss, H. C.; Otto, C.; Parhofer, K. G. Differential effects of fenofibrate versus atorvastatin on the concentrations of E-selectin and vascular cellular adhesion molecule-1 in patients with type 2 diabetes mellitus and mixed hyperlipoproteinemia: A randomized cross-over trial. Cardiovasc. Diabetol., 2003, 2, 17.
    • (2003) Cardiovasc. Diabetol , vol.2 , pp. 17
    • Empen, K.1    Frost, R.J.2    Geiss, H.C.3    Otto, C.4    Parhofer, K.G.5
  • 89
    • 27744452548 scopus 로고    scopus 로고
    • The effect of ciprofibrate on flow-mediated dilation and inflammatory markers in patients with combined hyperlipidemia
    • Kovacs, I.; Toldy, E.; Abel, T.; Tarjan, J.; Csaszar, A. The effect of ciprofibrate on flow-mediated dilation and inflammatory markers in patients with combined hyperlipidemia. Endothelium, 2005, 12, 179-83.
    • (2005) Endothelium , vol.12 , pp. 179-183
    • Kovacs, I.1    Toldy, E.2    Abel, T.3    Tarjan, J.4    Csaszar, A.5
  • 90
    • 9244235035 scopus 로고    scopus 로고
    • The levels of soluble adhesion molecules in diabetic and nondiabetic patients with combined hyperlipoproteinemia and the effect of ciprofibrate therapy
    • Okapcova, J.; Gabor, D. The levels of soluble adhesion molecules in diabetic and nondiabetic patients with combined hyperlipoproteinemia and the effect of ciprofibrate therapy. Angiology, 2004, 55, 629-39.
    • (2004) Angiology , vol.55 , pp. 629-639
    • Okapcova, J.1    Gabor, D.2
  • 91
    • 0037353329 scopus 로고    scopus 로고
    • Effects of hypolipidemic treatment on serum markers of vascular inflammation in dyslipidemic men
    • Hernandez, C.; Lecube, A.; Barbera, G.; Chacon, P.; Lima, J.; Simo, R. Effects of hypolipidemic treatment on serum markers of vascular inflammation in dyslipidemic men. Med. Sci. Monit., 2003, 9, CR114-CR119.
    • (2003) Med. Sci. Monit , vol.9
    • Hernandez, C.1    Lecube, A.2    Barbera, G.3    Chacon, P.4    Lima, J.5    Simo, R.6
  • 92
    • 85136357216 scopus 로고    scopus 로고
    • Danesh, J, Lewington, S, Thompson, S. G, Lowe, G. D, Collins, R, Kostis, J. B, Wilson, A. C, Folsom, A. R, Wu, K, Benderly, M, Goldbourt, U, Willeit, J, Kiechl, S, Yarnell, J. W, Sweetnam, P. M, Elwood, P. C, Cushman, M, Psaty, B. M, Tracy, R. P, Tybjaerg-Hansen, A, Haverkate, F, de Maat, M. P, Fowkes, F. G, Lee, A. J, Smith, F. B, Salomaa, V, Harald, K, Rasi, R, Vahtera, E, Jousilahti, P, Pekkanen, J, D'Agostino, R, Kannel, W. B, Wilson, P. W, Tofler, G, Arocha-Pinango, C. L, Rodriguez-Larralde, A, Nagy, E, Mijares, M, Espinosa, R, Rodriquez-Roa, E, Ryder, E, Diez-Ewald, M. P, Campos, G, Fernandez, V, Torres, E, Marchioli, R, Valagussa, F, Rosengren, A, Wilhelmsen, L, Lappas, G, Eriksson, H, Cremer, P, Nagel, D, Curb, J. D, Rodriguez, B, Yano, K, Salonen, J. T, Nyyssonen, K, Tuomainen, T. P, Hedblad, B, Lind, P, Loewel, H, Koenig, W, Meade, T. W, Cooper, J. A, De Stavola, B, Anti-Inflammatory Effects of Fibrates Curren
    • Danesh, J.; Lewington, S.; Thompson, S. G.; Lowe, G. D.; Collins, R.; Kostis, J. B.; Wilson, A. C.; Folsom, A. R.; Wu, K.; Benderly, M.; Goldbourt, U.; Willeit, J.; Kiechl, S.; Yarnell, J. W.; Sweetnam, P. M.; Elwood, P. C.; Cushman, M.; Psaty, B. M.; Tracy, R. P.; Tybjaerg-Hansen, A.; Haverkate, F.; de Maat, M. P.; Fowkes, F. G.; Lee, A. J.; Smith, F. B.; Salomaa, V.; Harald, K.; Rasi, R.; Vahtera, E.; Jousilahti, P.; Pekkanen, J.; D'Agostino, R.; Kannel, W. B.; Wilson, P. W.; Tofler, G.; Arocha-Pinango, C. L.; Rodriguez-Larralde, A.; Nagy, E.; Mijares, M.; Espinosa, R.; Rodriquez-Roa, E.; Ryder, E.; Diez-Ewald, M. P.; Campos, G.; Fernandez, V.; Torres, E.; Marchioli, R.; Valagussa, F.; Rosengren, A.; Wilhelmsen, L.; Lappas, G.; Eriksson, H.; Cremer, P.; Nagel, D.; Curb, J. D.; Rodriguez, B.; Yano, K.; Salonen, J. T.; Nyyssonen, K.; Tuomainen, T. P.; Hedblad, B.; Lind, P.; Loewel, H.; Koenig, W.; Meade, T. W.; Cooper, J. A.; De Stavola, B.; Anti-Inflammatory Effects of Fibrates Current Medicinal Chemistry, 2009 Vol. 16, No. 6 683 Knottenbelt, C.; Miller, G. J.; Cooper, J. A.; Bauer, K. A.; Rosenberg, R. D.; Sato, S.; Kitamura, A.; Naito, Y.; Palosuo, T.; Ducimetiere, P.; Amouyel, P.; Arveiler, D.; Evans, A. E.; Ferrieres, J.; Juhan-Vague, I.; Bingham, A.; Schulte, H.; Assmann, G.; Cantin, B.; Lamarche, B.; Despres, J. P.; Dagenais, G. R.; Tunstall-Pedoe, H.; Woodward, M.; Ben Shlomo, Y.; Davey, S. G.; Palmieri, V.; Yeh, J. L.; Rudnicka, A.; Ridker, P.; Rodeghiero, F.; Tosetto, A.; et al. Plasma fibrinogen level and the risk of major cardiovascular diseases and nonvascular mortality: an individual participant meta-analysis. JAMA, 2005, 294, 1799-809.
  • 93
    • 65649116805 scopus 로고    scopus 로고
    • Elevated fibrinogen levels and subsequent subclinical atherosclerosis: The CARDIA Study
    • Jul 2 [Epub ahead of print
    • Green, D.; Foiles, N.; Chan, C.; Schreiner, P. J.; Liu, K. Elevated fibrinogen levels and subsequent subclinical atherosclerosis: The CARDIA Study. Atherosclerosis, 2008 Jul 2 [Epub ahead of print].
    • (2008) Atherosclerosis
    • Green, D.1    Foiles, N.2    Chan, C.3    Schreiner, P.J.4    Liu, K.5
  • 95
    • 0027282665 scopus 로고
    • Effect of three fibrate derivatives and of two HMG-CoA reductase inhibitors on plasma fibrinogen level in patients with primary hypercholesterolemia
    • Branchi, A.; Rovellini, A.; Sommariva, D.; Gugliandolo, A. G.; Fasoli, A. Effect of three fibrate derivatives and of two HMG-CoA reductase inhibitors on plasma fibrinogen level in patients with primary hypercholesterolemia. Thromb. Haemost., 1993, 70, 241-3.
    • (1993) Thromb. Haemost , vol.70 , pp. 241-243
    • Branchi, A.1    Rovellini, A.2    Sommariva, D.3    Gugliandolo, A.G.4    Fasoli, A.5
  • 96
    • 0029982038 scopus 로고    scopus 로고
    • Angiographic assessment of effects of bezafibrate on progression of coronary artery disease in young male postinfarction patients
    • Ericsson, C. G.; Hamsten, A.; Nilsson, J.; Grip, L.; Svane, B.; de Faire, U. Angiographic assessment of effects of bezafibrate on progression of coronary artery disease in young male postinfarction patients. Lancet, 1996, 347, 849-53.
    • (1996) Lancet , vol.347 , pp. 849-853
    • Ericsson, C.G.1    Hamsten, A.2    Nilsson, J.3    Grip, L.4    Svane, B.5    de Faire, U.6
  • 97
    • 0025449707 scopus 로고
    • The effect of a slow release formulation of bezafibrate on lipids, glucose homeostasis, platelets and fibrinogen in type II diabetics: A pilot study
    • Mathur, S.; Barradas, M. A.; Mikhailidis, D. P.; Dandona, P. The effect of a slow release formulation of bezafibrate on lipids, glucose homeostasis, platelets and fibrinogen in type II diabetics: A pilot study. Diabetes Res., 1990, 14, 133-8.
    • (1990) Diabetes Res , vol.14 , pp. 133-138
    • Mathur, S.1    Barradas, M.A.2    Mikhailidis, D.P.3    Dandona, P.4
  • 98
    • 0033153214 scopus 로고    scopus 로고
    • Statin + fibrate combination therapy fluvastatin with bezafibrate or ciprofibrate in high risk patients with vascular disease
    • Papadakis, J. A.; Ganotakis, E. S.; Jagroop, I. A.; Winder, A. F.; Mikhailidis, D. P. Statin + fibrate combination therapy fluvastatin with bezafibrate or ciprofibrate in high risk patients with vascular disease. Int. J. Cardiol., 1999, 69, 237-44.
    • (1999) Int. J. Cardiol , vol.69 , pp. 237-244
    • Papadakis, J.A.1    Ganotakis, E.S.2    Jagroop, I.A.3    Winder, A.F.4    Mikhailidis, D.P.5
  • 99
    • 0036636769 scopus 로고    scopus 로고
    • Atorvastatin and micronized fenofibrate alone and in combination in type 2 diabetes with combined hyperlipidemia
    • Athyros, V. G.; Papageorgiou, A. A.; Athyrou, V. V.; Demitriadis, D. S.; Kontopoulos, A. G. Atorvastatin and micronized fenofibrate alone and in combination in type 2 diabetes with combined hyperlipidemia. Diabetes Care, 2002, 25, 1198-202.
    • (2002) Diabetes Care , vol.25 , pp. 1198-1202
    • Athyros, V.G.1    Papageorgiou, A.A.2    Athyrou, V.V.3    Demitriadis, D.S.4    Kontopoulos, A.G.5
  • 100
    • 0032988037 scopus 로고    scopus 로고
    • Effect of micronized fenofibrate and losartan combination on uric acid metabolism in hypertensive patients with hyperuricemia
    • Elisaf, M.; Tsimichodimos, V.; Bairaktari, E.; Siamopoulos, K. C. Effect of micronized fenofibrate and losartan combination on uric acid metabolism in hypertensive patients with hyperuricemia. J. Cardiovasc. Pharmacol., 1999, 34, 60-3.
    • (1999) J. Cardiovasc. Pharmacol , vol.34 , pp. 60-63
    • Elisaf, M.1    Tsimichodimos, V.2    Bairaktari, E.3    Siamopoulos, K.C.4
  • 101
    • 18744365508 scopus 로고    scopus 로고
    • Efficacy and safety of the coadministration of ezetimibe with fenofibrate in patients with mixed hyperlipidaemia
    • Farnier, M.; Freeman, M. W.; Macdonell, G.; Perevozskaya, I.; Davies, M. J.; Mitchel, Y. B.; Gumbiner, B. Efficacy and safety of the coadministration of ezetimibe with fenofibrate in patients with mixed hyperlipidaemia. Eur. Heart J., 2005, 26, 897-905.
    • (2005) Eur. Heart J , vol.26 , pp. 897-905
    • Farnier, M.1    Freeman, M.W.2    Macdonell, G.3    Perevozskaya, I.4    Davies, M.J.5    Mitchel, Y.B.6    Gumbiner, B.7
  • 102
    • 0030463802 scopus 로고    scopus 로고
    • Effects of simvastatin and ciprofibrate alone and in combination on lipid profile, plasma fibrinogen and low density lipoprotein particle structure and distribution in patients with familial combined hyperlipidaemia and coronary artery disease
    • Kontopoulos, A. G.; Athyros, V. G.; Papageorgiou, A. A.; Hatzikonstandinou, H. A.; Mayroudi, M. C.; Boudoulas, H. Effects of simvastatin and ciprofibrate alone and in combination on lipid profile, plasma fibrinogen and low density lipoprotein particle structure and distribution in patients with familial combined hyperlipidaemia and coronary artery disease. Coron. Artery Dis., 1996, 7, 843-50.
    • (1996) Coron. Artery Dis , vol.7 , pp. 843-850
    • Kontopoulos, A.G.1    Athyros, V.G.2    Papageorgiou, A.A.3    Hatzikonstandinou, H.A.4    Mayroudi, M.C.5    Boudoulas, H.6
  • 103
    • 0032467957 scopus 로고    scopus 로고
    • Prothrombotic and lipoprotein variables in patients attending a cardiovascular risk management clinic: Response to ciprofibrate or lifestyle advice
    • Mikhailidis, D. P.; Ganotakis, E. S.; Spyropoulos, K. A.; Jagroop, I. A.; Byrne, D. J.; Winder, A. F. Prothrombotic and lipoprotein variables in patients attending a cardiovascular risk management clinic: Response to ciprofibrate or lifestyle advice. Int. Angiol., 1998, 17, 225-33.
    • (1998) Int. Angiol , vol.17 , pp. 225-233
    • Mikhailidis, D.P.1    Ganotakis, E.S.2    Spyropoulos, K.A.3    Jagroop, I.A.4    Byrne, D.J.5    Winder, A.F.6
  • 104
    • 0032076207 scopus 로고    scopus 로고
    • Effects of two different fibric acid derivatives on lipoproteins, cholesteryl ester transfer, fibrinogen, plasminogen activator inhibitor and paraoxonase activity in type IIb hyperlipoproteinaemia
    • Durrington, P. N.; Mackness, M. I.; Bhatnagar, D.; Julier, K.; Prais, H.; Arrol, S.; Morgan, J.; Wood, G. N. Effects of two different fibric acid derivatives on lipoproteins, cholesteryl ester transfer, fibrinogen, plasminogen activator inhibitor and paraoxonase activity in type IIb hyperlipoproteinaemia. Atherosclerosis, 1998, 138, 217-25.
    • (1998) Atherosclerosis , vol.138 , pp. 217-225
    • Durrington, P.N.1    Mackness, M.I.2    Bhatnagar, D.3    Julier, K.4    Prais, H.5    Arrol, S.6    Morgan, J.7    Wood, G.N.8
  • 105
    • 0030695967 scopus 로고    scopus 로고
    • Effects of gemfibrozil and ciprofibrate on plasma levels of tissue-type plasminogen activator, plasminogen activator inhibitor-1 and fibrinogen in hyperlipidaemic patients
    • Kockx, M.; de Maat, M. P.; Knipscheer, H. C.; Kastelein, J. J.; Kluft, C.; Princen, H. M.; Kooistra, T. Effects of gemfibrozil and ciprofibrate on plasma levels of tissue-type plasminogen activator, plasminogen activator inhibitor-1 and fibrinogen in hyperlipidaemic patients. Thromb. Haemost., 1997, 78, 1167-72.
    • (1997) Thromb. Haemost , vol.78 , pp. 1167-1172
    • Kockx, M.1    de Maat, M.P.2    Knipscheer, H.C.3    Kastelein, J.J.4    Kluft, C.5    Princen, H.M.6    Kooistra, T.7
  • 108
    • 33847612773 scopus 로고    scopus 로고
    • Biomarkers of atherosclerotic plaque instability and rupture
    • Koenig, W.; Khuseyinova, N. Biomarkers of atherosclerotic plaque instability and rupture. Arterioscler. Thromb. Vasc. Biol., 2007, 27, 15-26.
    • (2007) Arterioscler. Thromb. Vasc. Biol , vol.27 , pp. 15-26
    • Koenig, W.1    Khuseyinova, N.2
  • 109
    • 0037432168 scopus 로고    scopus 로고
    • Association between plasma levels of monocyte chemoattractant protein-1 and long-term clinical outcomes in patients with acute coronary syndromes
    • de Lemos, J. A.; Morrow, D. A.; Sabatine, M. S.; Murphy, S. A.; Gibson, C. M.; Antman, E. M.; McCabe, C. H.; Cannon, C. P.; Braunwald, E. Association between plasma levels of monocyte chemoattractant protein-1 and long-term clinical outcomes in patients with acute coronary syndromes. Circulation, 2003, 107, 690-5.
    • (2003) Circulation , vol.107 , pp. 690-695
    • de Lemos, J.A.1    Morrow, D.A.2    Sabatine, M.S.3    Murphy, S.A.4    Gibson, C.M.5    Antman, E.M.6    McCabe, C.H.7    Cannon, C.P.8    Braunwald, E.9
  • 110
    • 33645517268 scopus 로고    scopus 로고
    • Inflammatory biomarkers in Mcute coronary syndromes: Part IV: matrix metalloproteinases and biomarkers of platelet activation
    • Armstrong, E. J.; Morrow, D. A.; Sabatine, M. S. Inflammatory biomarkers in Mcute coronary syndromes: Part IV: matrix metalloproteinases and biomarkers of platelet activation. Circulation, 2006, 113, e382-e385.
    • (2006) Circulation , vol.113
    • Armstrong, E.J.1    Morrow, D.A.2    Sabatine, M.S.3
  • 112
    • 33846658406 scopus 로고    scopus 로고
    • Association between lipoprotein-associated phospholipase A2 and cardiovascular disease: A systematic review
    • Garza, C. A.; Montori, V. M.; McConnell, J. P.; Somers, V. K.; Kullo, I. J.; Lopez-Jimenez, F. Association between lipoprotein-associated phospholipase A2 and cardiovascular disease: A systematic review. Mayo Clin. Proc., 2007, 82, 159-65.
    • (2007) Mayo Clin. Proc , vol.82 , pp. 159-165
    • Garza, C.A.1    Montori, V.M.2    McConnell, J.P.3    Somers, V.K.4    Kullo, I.J.5    Lopez-Jimenez, F.6
  • 113
    • 35148848559 scopus 로고    scopus 로고
    • New insights into the role of lipoprotein(a)-associated lipoprotein-associated phospholipase A2 in atherosclerosis and cardiovascular disease
    • Tsimikas, S.; Tsironis, L. D.; Tselepis, A. D. New insights into the role of lipoprotein(a)-associated lipoprotein-associated phospholipase A2 in atherosclerosis and cardiovascular disease. Arterioscler. Thromb. Vasc. Biol., 2007, 27, 2094-9.
    • (2007) Arterioscler. Thromb. Vasc. Biol , vol.27 , pp. 2094-2099
    • Tsimikas, S.1    Tsironis, L.D.2    Tselepis, A.D.3
  • 114
    • 34447314752 scopus 로고    scopus 로고
    • The effect of orlistat and fenofibrate, alone or in combination, on small dense LDL and lipoprotein-associated phospholipase A2 in obese patients with metabolic syndrome
    • Filippatos, T. D.; Gazi, I. F.; Liberopoulos, E. N.; Athyros, V. G.; Elisaf, M. S.; Tselepis, A. D.; Kiortsis, D. N. The effect of orlistat and fenofibrate, alone or in combination, on small dense LDL and lipoprotein-associated phospholipase A2 in obese patients with metabolic syndrome. Atherosclerosis, 2007, 193, 428-37.
    • (2007) Atherosclerosis , vol.193 , pp. 428-437
    • Filippatos, T.D.1    Gazi, I.F.2    Liberopoulos, E.N.3    Athyros, V.G.4    Elisaf, M.S.5    Tselepis, A.D.6    Kiortsis, D.N.7
  • 115
    • 34248342266 scopus 로고    scopus 로고
    • Low-density lipoprotein-dependent and -independent effects of cholesterol-lowering therapies on C-reactive protein: A meta-analysis
    • Kinlay, S. Low-density lipoprotein-dependent and -independent effects of cholesterol-lowering therapies on C-reactive protein: A meta-analysis. J. Am. Coll. Cardiol., 2007, 49, 2003-9.
    • (2007) J. Am. Coll. Cardiol , vol.49 , pp. 2003-2009
    • Kinlay, S.1
  • 116
    • 33745685394 scopus 로고    scopus 로고
    • The reduction of inflammatory biomarkers by statin, fibrate, and combination therapy among diabetic patients with mixed dyslipidemia: The DIACOR (Diabetes and Combined Lipid Therapy Regimen) study
    • Muhlestein, J. B.; May, H. T.; Jensen, J. R.; Horne, B. D.; Lanman, R. B.; Lavasani, F.; Wolfert, R. L.; Pearson, R. R.; Yannicelli, H. D.; Anderson, J. L. The reduction of inflammatory biomarkers by statin, fibrate, and combination therapy among diabetic patients with mixed dyslipidemia: The DIACOR (Diabetes and Combined Lipid Therapy Regimen) study. J. Am. Coll. Cardiol., 2006, 48, 396-401.
    • (2006) J. Am. Coll. Cardiol , vol.48 , pp. 396-401
    • Muhlestein, J.B.1    May, H.T.2    Jensen, J.R.3    Horne, B.D.4    Lanman, R.B.5    Lavasani, F.6    Wolfert, R.L.7    Pearson, R.R.8    Yannicelli, H.D.9    Anderson, J.L.10
  • 118
    • 13844272245 scopus 로고    scopus 로고
    • Effectiveness and tolerability of simvastatin plus fenofibrate for combined hyperlipidemia (the SAFARI trial)
    • Grundy, S. M.; Vega, G. L.; Yuan, Z.; Battisti, W. P.; Brady, W. E.; Palmisano, J. Effectiveness and tolerability of simvastatin plus fenofibrate for combined hyperlipidemia (the SAFARI trial). Am. J. Cardiol., 2005, 95, 462-8.
    • (2005) Am. J. Cardiol , vol.95 , pp. 462-468
    • Grundy, S.M.1    Vega, G.L.2    Yuan, Z.3    Battisti, W.P.4    Brady, W.E.5    Palmisano, J.6
  • 122
    • 33751423668 scopus 로고    scopus 로고
    • Non-low-density lipoprotein cholesterol-associated actions of ezetimibe: An overview
    • Gazi, I. F.; Mikhailidis, D. P. Non-low-density lipoprotein cholesterol-associated actions of ezetimibe: An overview. Expert. Opin. Ther. Targets., 2006, 10, 851-66.
    • (2006) Expert. Opin. Ther. Targets , vol.10 , pp. 851-866
    • Gazi, I.F.1    Mikhailidis, D.P.2
  • 125
    • 47949116865 scopus 로고    scopus 로고
    • The effect of orlistat and ezetimibe, alone or in combination, on serum LDL and small dense LDL cholesterol levels in overweight and obese patients with hypercholesterolaemia
    • Nakou, E. S.; Filippatos, T. D.; Georgoula, M.; Kiortsis, D. N.; Tselepis, A. D.; Mikhailidis, D. P.; Elisaf, M. S. The effect of orlistat and ezetimibe, alone or in combination, on serum LDL and small dense LDL cholesterol levels in overweight and obese patients with hypercholesterolaemia. Curr. Med. Res. Opin., 2008, 24, 1919-29.
    • (2008) Curr. Med. Res. Opin , vol.24 , pp. 1919-1929
    • Nakou, E.S.1    Filippatos, T.D.2    Georgoula, M.3    Kiortsis, D.N.4    Tselepis, A.D.5    Mikhailidis, D.P.6    Elisaf, M.S.7
  • 126
    • 35648972148 scopus 로고    scopus 로고
    • The use of colesevelam hydrochloride in the treatment of dyslipidemia: A review
    • Davidson, M. H. The use of colesevelam hydrochloride in the treatment of dyslipidemia: A review. Expert. Opin. Pharmacother., 2007, 8, 2569-78.
    • (2007) Expert. Opin. Pharmacother , vol.8 , pp. 2569-2578
    • Davidson, M.H.1
  • 127
    • 42549095738 scopus 로고    scopus 로고
    • Colesevelam hydrochloride in clinical practice: A new approach in the treatment of hypercholesterolaemia
    • Florentin, M.; Liberopoulos, E. N.; Mikhailidis, D. P.; Elisaf, M. S. Colesevelam hydrochloride in clinical practice: A new approach in the treatment of hypercholesterolaemia. Curr. Med. Res. Opin., 2008, 24, 995-1009.
    • (2008) Curr. Med. Res. Opin , vol.24 , pp. 995-1009
    • Florentin, M.1    Liberopoulos, E.N.2    Mikhailidis, D.P.3    Elisaf, M.S.4
  • 129
    • 33748038025 scopus 로고    scopus 로고
    • Effects of extended-release niacin on lipoprotein particle size, distribution, and inflammatory markers in patients with coronary artery disease
    • Kuvin, J. T.; Dave, D. M.; Sliney, K. A.; Mooney, P.; Patel, A. R.; Kimmelstiel, C. D.; Karas, R. H. Effects of extended-release niacin on lipoprotein particle size, distribution, and inflammatory markers in patients with coronary artery disease. Am. J. Cardiol., 2006, 98, 743-5.
    • (2006) Am. J. Cardiol , vol.98 , pp. 743-745
    • Kuvin, J.T.1    Dave, D.M.2    Sliney, K.A.3    Mooney, P.4    Patel, A.R.5    Kimmelstiel, C.D.6    Karas, R.H.7
  • 130
    • 33749154105 scopus 로고    scopus 로고
    • Effects of omega-3 fatty acids on serum markers of cardiovascular disease risk: A systematic review
    • Balk, E. M.; Lichtenstein, A. H.; Chung, M.; Kupelnick, B.; Chew, P.; Lau, J. Effects of omega-3 fatty acids on serum markers of cardiovascular disease risk: A systematic review. Atherosclerosis, 2006, 189, 19-30.
    • (2006) Atherosclerosis , vol.189 , pp. 19-30
    • Balk, E.M.1    Lichtenstein, A.H.2    Chung, M.3    Kupelnick, B.4    Chew, P.5    Lau, J.6
  • 132
    • 35548963388 scopus 로고    scopus 로고
    • Fish oils and vascular disease prevention: An update
    • Tziomalos, K.; Athyros, V. G.; Mikhailidis, D. P. Fish oils and vascular disease prevention: An update. Curr. Med. Chem., 2007, 14, 2622-8.
    • (2007) Curr. Med. Chem , vol.14 , pp. 2622-2628
    • Tziomalos, K.1    Athyros, V.G.2    Mikhailidis, D.P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.