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Volumn 220, Issue 2, 2012, Pages 537-544

Significant differential effects of omega-3 fatty acids and fenofibrate in patients with hypertriglyceridemia

Author keywords

Fenofibrate; Hypertriglyceridemia; Insulin resistance; Omega 3 fatty acids

Indexed keywords

ADIPONECTIN; C REACTIVE PROTEIN; FENOFIBRATE; FIBRINOGEN; GLYCOSYLATED HEMOGLOBIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; OMEGA 3 FATTY ACID; PLACEBO; TRIACYLGLYCEROL;

EID: 84855950126     PISSN: 00219150     EISSN: 18791484     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2011.11.018     Document Type: Article
Times cited : (52)

References (50)
  • 1
    • 77952708442 scopus 로고    scopus 로고
    • Effects of fibrates on cardiovascular outcomes: a systematic review and meta-analysis
    • Jun M., Foote C., Lv J., et al. Effects of fibrates on cardiovascular outcomes: a systematic review and meta-analysis. Lancet 2010, 375:1875-1884.
    • (2010) Lancet , vol.375 , pp. 1875-1884
    • Jun, M.1    Foote, C.2    Lv, J.3
  • 2
    • 38649136909 scopus 로고    scopus 로고
    • Vascular and metabolic effects of treatment of combined hyperlipidemia: focus on statins and fibrates
    • Koh K.K., Quon M.J., Rosenson R.S., Chung W.-J., Han S.H. Vascular and metabolic effects of treatment of combined hyperlipidemia: focus on statins and fibrates. Int J Cardiol 2008, 124:149-159.
    • (2008) Int J Cardiol , vol.124 , pp. 149-159
    • Koh, K.K.1    Quon, M.J.2    Rosenson, R.S.3    Chung, W.-J.4    Han, S.H.5
  • 3
    • 0345109256 scopus 로고    scopus 로고
    • Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-prevenzione trial: gruppo Italiano per lo studio della sopravvivenza nell'infarto miocardico
    • Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-prevenzione trial: gruppo Italiano per lo studio della sopravvivenza nell'infarto miocardico. Lancet 1999, 354:447-455.
    • (1999) Lancet , vol.354 , pp. 447-455
  • 4
    • 0037161373 scopus 로고    scopus 로고
    • Early protection against sudden death by n-3 polyunsaturated fatty acids after myocardial infarction: time-course analysis of the results of the gruppo Italiano per lo studio della sopravvivenza nell'infarto miocardico (GISSI)-prevenzione
    • Marchioli R., Barzi F., Bomba E., et al. Early protection against sudden death by n-3 polyunsaturated fatty acids after myocardial infarction: time-course analysis of the results of the gruppo Italiano per lo studio della sopravvivenza nell'infarto miocardico (GISSI)-prevenzione. Circulation 2002, 105:1897-1903.
    • (2002) Circulation , vol.105 , pp. 1897-1903
    • Marchioli, R.1    Barzi, F.2    Bomba, E.3
  • 5
    • 49749139672 scopus 로고    scopus 로고
    • Long-term fish consumption and n-3 fatty acid intake in relation to (sudden) coronary heart disease death: the Zutphen study
    • Streppel M.T., Ocke M.C., Boshuizen H.C., Kok F.J., Kromhout D. Long-term fish consumption and n-3 fatty acid intake in relation to (sudden) coronary heart disease death: the Zutphen study. Eur Heart J 2008, 29:2024-2030.
    • (2008) Eur Heart J , vol.29 , pp. 2024-2030
    • Streppel, M.T.1    Ocke, M.C.2    Boshuizen, H.C.3    Kok, F.J.4    Kromhout, D.5
  • 6
    • 41449110020 scopus 로고    scopus 로고
    • Prescription omega-3 fatty acids and their lipid effects: physiologic mechanisms of action and clinical implications
    • Bays H.E., Tighe A.P., Sadovsky R., Davidson M.H. Prescription omega-3 fatty acids and their lipid effects: physiologic mechanisms of action and clinical implications. Expert Rev Cardiovasc Ther 2008, 6:391-409.
    • (2008) Expert Rev Cardiovasc Ther , vol.6 , pp. 391-409
    • Bays, H.E.1    Tighe, A.P.2    Sadovsky, R.3    Davidson, M.H.4
  • 7
    • 0034641662 scopus 로고    scopus 로고
    • Differential effects of eicosapentaenoic acid and docosahexaenoic acid on vascular reactivity of the forearm microcirculation in hyperlipidemic, overweight men
    • Mori T.A., Watts G.F., Burke V., Hilme E., Puddey I.B., Beilin L.J. Differential effects of eicosapentaenoic acid and docosahexaenoic acid on vascular reactivity of the forearm microcirculation in hyperlipidemic, overweight men. Circulation 2000, 102:1264-1269.
    • (2000) Circulation , vol.102 , pp. 1264-1269
    • Mori, T.A.1    Watts, G.F.2    Burke, V.3    Hilme, E.4    Puddey, I.B.5    Beilin, L.J.6
  • 8
    • 77749264445 scopus 로고    scopus 로고
    • Effects of n-3 fatty acids on macro- and microvascular function in subjects with type 2 diabetes mellitus
    • Stirban A., Nandrean S., Gotting C., et al. Effects of n-3 fatty acids on macro- and microvascular function in subjects with type 2 diabetes mellitus. Am J Clin Nutr 2010, 91:808-813.
    • (2010) Am J Clin Nutr , vol.91 , pp. 808-813
    • Stirban, A.1    Nandrean, S.2    Gotting, C.3
  • 9
    • 0001539238 scopus 로고    scopus 로고
    • Effects of statins on vascular wall: vasomotor function, inflammation, and plaque stability
    • Koh K.K. Effects of statins on vascular wall: vasomotor function, inflammation, and plaque stability. Cardiovasc Res 2000, 47:648-657.
    • (2000) Cardiovasc Res , vol.47 , pp. 648-657
    • Koh, K.K.1
  • 10
    • 33646178955 scopus 로고    scopus 로고
    • Reciprocal relationships between insulin resistance and endothelial dysfunction: molecular and pathophysiological mechanisms
    • Kim J., Montagnani M., Koh K.K., Quon M.J. Reciprocal relationships between insulin resistance and endothelial dysfunction: molecular and pathophysiological mechanisms. Circulation 2006, 113:1888-1904.
    • (2006) Circulation , vol.113 , pp. 1888-1904
    • Kim, J.1    Montagnani, M.2    Koh, K.K.3    Quon, M.J.4
  • 11
    • 33846154584 scopus 로고    scopus 로고
    • Reciprocal relationships between abnormal metabolic parameters and endothelial dysfunction
    • Han S.H., Quon M.J., Koh K.K. Reciprocal relationships between abnormal metabolic parameters and endothelial dysfunction. Curr Opin Lipidol 2007, 18:58-65.
    • (2007) Curr Opin Lipidol , vol.18 , pp. 58-65
    • Han, S.H.1    Quon, M.J.2    Koh, K.K.3
  • 12
    • 77949368037 scopus 로고    scopus 로고
    • Diabetes, insulin resistance and atherosclerosis surrogates in patients with coronary atherosclerosis
    • Park H.-W., Kwon T.G., Kim K.-Y., Bae J.-H. Diabetes, insulin resistance and atherosclerosis surrogates in patients with coronary atherosclerosis. Korean Circ J 2010, 40:62-67.
    • (2010) Korean Circ J , vol.40 , pp. 62-67
    • Park, H.-W.1    Kwon, T.G.2    Kim, K.-Y.3    Bae, J.-H.4
  • 13
    • 79955702903 scopus 로고    scopus 로고
    • Prevention of atherosclerosis in overweight/obese patients: in need of novel multi-targeted approaches
    • Lim S., Despres J.-P., Koh K.K. Prevention of atherosclerosis in overweight/obese patients: in need of novel multi-targeted approaches. Circ J 2011, 75:1019-1027.
    • (2011) Circ J , vol.75 , pp. 1019-1027
    • Lim, S.1    Despres, J.-P.2    Koh, K.K.3
  • 14
    • 33846618661 scopus 로고    scopus 로고
    • Adiponectin and cardiovascular disease: response to therapeutic interventions
    • Han S.H., Quon M.J., Kim J.A., Koh K.K. Adiponectin and cardiovascular disease: response to therapeutic interventions. J Am Coll Cardiol 2007, 49:531-538.
    • (2007) J Am Coll Cardiol , vol.49 , pp. 531-538
    • Han, S.H.1    Quon, M.J.2    Kim, J.A.3    Koh, K.K.4
  • 15
    • 51649124024 scopus 로고    scopus 로고
    • Leptin and cardiovascular disease: response to therapeutic interventions
    • Koh K.K., Park S.M., Quon M.J. Leptin and cardiovascular disease: response to therapeutic interventions. Circulation 2008, 117:3238-3249.
    • (2008) Circulation , vol.117 , pp. 3238-3249
    • Koh, K.K.1    Park, S.M.2    Quon, M.J.3
  • 16
    • 67650169799 scopus 로고    scopus 로고
    • Adiponectin levels and risk of type 2 diabetes: a systematic review and meta-analysis
    • Li S., Shin H.J., Ding E.L., van Dam R.M. Adiponectin levels and risk of type 2 diabetes: a systematic review and meta-analysis. JAMA 2009, 302:179-188.
    • (2009) JAMA , vol.302 , pp. 179-188
    • Li, S.1    Shin, H.J.2    Ding, E.L.3    van Dam, R.M.4
  • 17
    • 33748778726 scopus 로고    scopus 로고
    • Effects of simvastatin alone or combined with ramipril on nitric oxide bioactivity and inflammation markers in hypercholesterolemic patients
    • Son J.W., Koh K.K., You S.M., et al. Effects of simvastatin alone or combined with ramipril on nitric oxide bioactivity and inflammation markers in hypercholesterolemic patients. Korean Circ J 2003, 33:1053-1059.
    • (2003) Korean Circ J , vol.33 , pp. 1053-1059
    • Son, J.W.1    Koh, K.K.2    You, S.M.3
  • 18
    • 20844456215 scopus 로고    scopus 로고
    • Additive beneficial effects of losartan combined with simvastatin in the treatment of hypercholesterolemic, hypertensive patients
    • Koh K.K., Quon M.J., Han S.H., et al. Additive beneficial effects of losartan combined with simvastatin in the treatment of hypercholesterolemic, hypertensive patients. Circulation 2004, 110:3687-3692.
    • (2004) Circulation , vol.110 , pp. 3687-3692
    • Koh, K.K.1    Quon, M.J.2    Han, S.H.3
  • 19
    • 19944379835 scopus 로고    scopus 로고
    • Beneficial effects of fenofibrate to improve endothelial dysfunction and raise adiponectin levels in patients with primary hypertriglyceridemia
    • Koh K.K., Han S.H., Quon M.J., Ahn J.Y., Shin E.K. Beneficial effects of fenofibrate to improve endothelial dysfunction and raise adiponectin levels in patients with primary hypertriglyceridemia. Diabetes Care 2005, 28:1419-1424.
    • (2005) Diabetes Care , vol.28 , pp. 1419-1424
    • Koh, K.K.1    Han, S.H.2    Quon, M.J.3    Ahn, J.Y.4    Shin, E.K.5
  • 20
    • 33644653151 scopus 로고    scopus 로고
    • Anti-inflammatory and metabolic effects of candesartan in hypertensive patients
    • Koh K.K., Quon M.J., Han S.H., Chung W.-J., Lee Y., Shin E.K. Anti-inflammatory and metabolic effects of candesartan in hypertensive patients. Int J Cardiol 2006, 108:96-100.
    • (2006) Int J Cardiol , vol.108 , pp. 96-100
    • Koh, K.K.1    Quon, M.J.2    Han, S.H.3    Chung, W.-J.4    Lee, Y.5    Shin, E.K.6
  • 21
    • 61449088554 scopus 로고    scopus 로고
    • Amlodipine improves endothelial function and metabolic parameters in patients with hypertension
    • Koh K.K., Han S.H., Ahn J.Y., Chung W.-J., Lee Y., Shin E.K. Amlodipine improves endothelial function and metabolic parameters in patients with hypertension. Int J Cardiol 2009, 133:23-31.
    • (2009) Int J Cardiol , vol.133 , pp. 23-31
    • Koh, K.K.1    Han, S.H.2    Ahn, J.Y.3    Chung, W.-J.4    Lee, Y.5    Shin, E.K.6
  • 22
    • 77949300393 scopus 로고    scopus 로고
    • Atorvastatin causes insulin resistance and increases ambient glycemia in hypercholesterolemic patients
    • Koh K.K., Quon M.J., Han S.H., Lee Y., Kim S.J., Shin E.K. Atorvastatin causes insulin resistance and increases ambient glycemia in hypercholesterolemic patients. J Am Coll Cardiol 2010, 55:1209-1216.
    • (2010) J Am Coll Cardiol , vol.55 , pp. 1209-1216
    • Koh, K.K.1    Quon, M.J.2    Han, S.H.3    Lee, Y.4    Kim, S.J.5    Shin, E.K.6
  • 23
    • 0034456568 scopus 로고    scopus 로고
    • Quantitative insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans
    • Katz A., Nambi S.S., Mather K., et al. Quantitative insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans. J Clin Endocrinol Metab 2000, 85:2402-2410.
    • (2000) J Clin Endocrinol Metab , vol.85 , pp. 2402-2410
    • Katz, A.1    Nambi, S.S.2    Mather, K.3
  • 24
    • 38349006256 scopus 로고    scopus 로고
    • Current approaches for assessing insulin sensitivity and resistance in vivo: advantages, limitations, and appropriate usage
    • Muniyappa R., Lee S., Chen H., Quon M.J. Current approaches for assessing insulin sensitivity and resistance in vivo: advantages, limitations, and appropriate usage. Am J Physiol Endocrinol Metab 2008, 294:e15-e26.
    • (2008) Am J Physiol Endocrinol Metab , vol.294
    • Muniyappa, R.1    Lee, S.2    Chen, H.3    Quon, M.J.4
  • 25
    • 0037432152 scopus 로고    scopus 로고
    • Reciprocal association of C-reactive protein with adiponectin in blood stream and adipose tissue
    • Ouchi N., Kihara S., Funahashi T., et al. Reciprocal association of C-reactive protein with adiponectin in blood stream and adipose tissue. Circulation 2003, 107:671-674.
    • (2003) Circulation , vol.107 , pp. 671-674
    • Ouchi, N.1    Kihara, S.2    Funahashi, T.3
  • 26
    • 18944381282 scopus 로고    scopus 로고
    • Additive beneficial effects of fenofibrate combined with atorvastatin in the treatment of patients with combined hyperlipidemia
    • Koh K.K., Quon M.J., Han S.H., et al. Additive beneficial effects of fenofibrate combined with atorvastatin in the treatment of patients with combined hyperlipidemia. J Am Coll Cardiol 2005, 45:1649-1653.
    • (2005) J Am Coll Cardiol , vol.45 , pp. 1649-1653
    • Koh, K.K.1    Quon, M.J.2    Han, S.H.3
  • 27
    • 33646371983 scopus 로고    scopus 로고
    • Additive beneficial effects of fenofibrate combined with candesartan in the treatment of hypertriglyceridemic, hypertensive patients
    • Koh K.K., Quon M.J., Han S.H., et al. Additive beneficial effects of fenofibrate combined with candesartan in the treatment of hypertriglyceridemic, hypertensive patients. Diabetes Care 2006, 29:195-201.
    • (2006) Diabetes Care , vol.29 , pp. 195-201
    • Koh, K.K.1    Quon, M.J.2    Han, S.H.3
  • 28
    • 33644664433 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor (PPAR)alpha activation increases adiponectin receptors and reduces obesity-related inflammation in adipose tissue: comparison of activation of PPARalpha, PPARgamma, and their combination
    • Tsuchida A., Yamauchi T., Takekawa S., et al. Peroxisome proliferator-activated receptor (PPAR)alpha activation increases adiponectin receptors and reduces obesity-related inflammation in adipose tissue: comparison of activation of PPARalpha, PPARgamma, and their combination. Diabetes 2005, 54:3358-3370.
    • (2005) Diabetes , vol.54 , pp. 3358-3370
    • Tsuchida, A.1    Yamauchi, T.2    Takekawa, S.3
  • 29
    • 25144517287 scopus 로고    scopus 로고
    • Effect of PPAR-alpha and -gamma agonist on the expression of visfatin, adiponectin, and TNF-alpha in visceral fat of OLETF rats
    • Choi K.C., Ryu O.H., Lee K.W., et al. Effect of PPAR-alpha and -gamma agonist on the expression of visfatin, adiponectin, and TNF-alpha in visceral fat of OLETF rats. Biochem Biophys Res Commun 2005, 336:747-753.
    • (2005) Biochem Biophys Res Commun , vol.336 , pp. 747-753
    • Choi, K.C.1    Ryu, O.H.2    Lee, K.W.3
  • 30
    • 34547687824 scopus 로고    scopus 로고
    • Fenofibrate therapy ameliorates fasting and postprandial lipoproteinemia, oxidative stress, and the inflammatory response in subjects with hypertriglyceridemia and the metabolic syndrome
    • Rosenson R.S., Wolff D.A., Huskin A.L., Helenowski I.B., Rademaker A.W. Fenofibrate therapy ameliorates fasting and postprandial lipoproteinemia, oxidative stress, and the inflammatory response in subjects with hypertriglyceridemia and the metabolic syndrome. Diabetes Care 2007, 30:1945-1951.
    • (2007) Diabetes Care , vol.30 , pp. 1945-1951
    • Rosenson, R.S.1    Wolff, D.A.2    Huskin, A.L.3    Helenowski, I.B.4    Rademaker, A.W.5
  • 31
    • 60849116123 scopus 로고    scopus 로고
    • Effect of fenofibrate on adiponectin and inflammatory biomarkers in metabolic syndrome patients
    • Rosenson R.S. Effect of fenofibrate on adiponectin and inflammatory biomarkers in metabolic syndrome patients. Obesity (Silver Spring) 2009, 17:504-509.
    • (2009) Obesity (Silver Spring) , vol.17 , pp. 504-509
    • Rosenson, R.S.1
  • 32
    • 69349102944 scopus 로고    scopus 로고
    • Antiatherosclerotic and anti-insulin resistance effects of adiponectin: basic and clinical studies
    • Han S.H., Sakuma I., Shin E.K., Koh K.K. Antiatherosclerotic and anti-insulin resistance effects of adiponectin: basic and clinical studies. Prog Cardiovasc Dis 2009, 52:126-140.
    • (2009) Prog Cardiovasc Dis , vol.52 , pp. 126-140
    • Han, S.H.1    Sakuma, I.2    Shin, E.K.3    Koh, K.K.4
  • 33
    • 0242581695 scopus 로고    scopus 로고
    • Adiponectin stimulates production of nitric oxide in vascular endothelial cells
    • Chen H., Montagnani M., Funahashi T., Shimomura I., Quon M.J. Adiponectin stimulates production of nitric oxide in vascular endothelial cells. J Biol Chem 2003, 278:45021-45026.
    • (2003) J Biol Chem , vol.278 , pp. 45021-45026
    • Chen, H.1    Montagnani, M.2    Funahashi, T.3    Shimomura, I.4    Quon, M.J.5
  • 34
    • 0034595980 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor alpha activators improve insulin sensitivity and reduce adiposity
    • Guerre-Millo M., Gervois P., Raspe E., et al. Peroxisome proliferator-activated receptor alpha activators improve insulin sensitivity and reduce adiposity. J Biol Chem 2000, 275:16638-16642.
    • (2000) J Biol Chem , vol.275 , pp. 16638-16642
    • Guerre-Millo, M.1    Gervois, P.2    Raspe, E.3
  • 35
    • 77951704587 scopus 로고    scopus 로고
    • Effects of combination lipid therapy in type 2 diabetes mellitus
    • Ginsberg H.N., Elam M.B., Lovato L.C., et al. Effects of combination lipid therapy in type 2 diabetes mellitus. N Eng J Med 2010, 362:1563-1574.
    • (2010) N Eng J Med , vol.362 , pp. 1563-1574
    • Ginsberg, H.N.1    Elam, M.B.2    Lovato, L.C.3
  • 36
    • 77954654472 scopus 로고    scopus 로고
    • Effects of medical therapies on retinopathy progression in type 2 diabetes
    • Chew E.Y., Ambrosius W.T., Davis M.D., et al. Effects of medical therapies on retinopathy progression in type 2 diabetes. N Engl J Med 2010, 363:233-244.
    • (2010) N Engl J Med , vol.363 , pp. 233-244
    • Chew, E.Y.1    Ambrosius, W.T.2    Davis, M.D.3
  • 37
    • 78650175916 scopus 로고    scopus 로고
    • The fish oil story remains fish
    • Eckel R.H. The fish oil story remains fish. Circulation 2010, 122:2110-2112.
    • (2010) Circulation , vol.122 , pp. 2110-2112
    • Eckel, R.H.1
  • 38
    • 0842263178 scopus 로고    scopus 로고
    • Acute omega-3 fatty acid enrichment selectively reverses high-saturated fat feeding-induced insulin hypersecretion but does not improve peripheral insulin resistance
    • Holness M.J., Smith N.D., Greenwood G.K., Sugden M.C. Acute omega-3 fatty acid enrichment selectively reverses high-saturated fat feeding-induced insulin hypersecretion but does not improve peripheral insulin resistance. Diabetes 2004, 53(Suppl.):S166-S171.
    • (2004) Diabetes , vol.53 , Issue.SUPPL.
    • Holness, M.J.1    Smith, N.D.2    Greenwood, G.K.3    Sugden, M.C.4
  • 39
    • 33748794808 scopus 로고    scopus 로고
    • A model of insulin resistance and nonalcoholic steatohepatitis in rats: role of peroxisome proliferator-activated receptor alpha and n-3 polyunsaturated fatty acid treatment on liver injury
    • Svegliati-Baroni G., Candelaresi C., Saccomanno S., et al. A model of insulin resistance and nonalcoholic steatohepatitis in rats: role of peroxisome proliferator-activated receptor alpha and n-3 polyunsaturated fatty acid treatment on liver injury. Am J Pathol 2006, 169:846-860.
    • (2006) Am J Pathol , vol.169 , pp. 846-860
    • Svegliati-Baroni, G.1    Candelaresi, C.2    Saccomanno, S.3
  • 40
    • 4444304524 scopus 로고    scopus 로고
    • Oxidized omega-3 fatty acids inhibit NF-kappaB activation via a PPARalpha-dependent pathway
    • Mishra A., Chaudhary A., Sethi S. Oxidized omega-3 fatty acids inhibit NF-kappaB activation via a PPARalpha-dependent pathway. Arterioscler Thromb Vasc Biol 2004, 24:1621-1627.
    • (2004) Arterioscler Thromb Vasc Biol , vol.24 , pp. 1621-1627
    • Mishra, A.1    Chaudhary, A.2    Sethi, S.3
  • 41
    • 33845700309 scopus 로고    scopus 로고
    • Omega-3 may indirectly reduce hepatocyte triglycerides through modulation of hyperinsulinemia, cytokines and adipocytokines
    • Shapiro H., Bruck R. Omega-3 may indirectly reduce hepatocyte triglycerides through modulation of hyperinsulinemia, cytokines and adipocytokines. Am J Cardiol 2007, 99:146.
    • (2007) Am J Cardiol , vol.99 , pp. 146
    • Shapiro, H.1    Bruck, R.2
  • 42
    • 0028960421 scopus 로고
    • Improvement of serum lipids and blood pressure during intervention with n-3 fatty acids was not associated with changes in insulin levels in subjects with combined hyperlipidaemia
    • Grundt H., Nilsen D.W., Hetland O., et al. Improvement of serum lipids and blood pressure during intervention with n-3 fatty acids was not associated with changes in insulin levels in subjects with combined hyperlipidaemia. J Intern Med 1995, 237:249-259.
    • (1995) J Intern Med , vol.237 , pp. 249-259
    • Grundt, H.1    Nilsen, D.W.2    Hetland, O.3
  • 43
    • 0034762548 scopus 로고    scopus 로고
    • An omega-3 polyunsaturated fatty acid concentrate administered for one year decreased triglycerides in simvastatin treated patients with coronary heart disease and persisting hypertriglyceridaemia
    • Durrington P.N., Bhatnagar D., Mackness M.I., et al. An omega-3 polyunsaturated fatty acid concentrate administered for one year decreased triglycerides in simvastatin treated patients with coronary heart disease and persisting hypertriglyceridaemia. Heart 2001, 85:544-548.
    • (2001) Heart , vol.85 , pp. 544-548
    • Durrington, P.N.1    Bhatnagar, D.2    Mackness, M.I.3
  • 44
    • 33947583493 scopus 로고    scopus 로고
    • Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): a randomised open-label, blinded endpoint analysis
    • Yokoyama M., Origasa H., Matsuzaki M., et al. Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): a randomised open-label, blinded endpoint analysis. Lancet 2007, 369:1090-1098.
    • (2007) Lancet , vol.369 , pp. 1090-1098
    • Yokoyama, M.1    Origasa, H.2    Matsuzaki, M.3
  • 45
    • 53049110571 scopus 로고    scopus 로고
    • Effect of n-3 polyunsaturated fatty acids in patients with chronic heart failure (the GISSI-HF trial): a randomised, double-blind, placebo-controlled trial
    • Gissi-HF Investigators
    • Tavazzi L., Maggioni A.P., Marchioli R., et al. Effect of n-3 polyunsaturated fatty acids in patients with chronic heart failure (the GISSI-HF trial): a randomised, double-blind, placebo-controlled trial. Lancet 2008, 372:1223-1230. Gissi-HF Investigators.
    • (2008) Lancet , vol.372 , pp. 1223-1230
    • Tavazzi, L.1    Maggioni, A.P.2    Marchioli, R.3
  • 46
    • 78650169331 scopus 로고    scopus 로고
    • OMEGA, a randomized, placebo-controlled trial to test the effect of highly purified omega-3 fatty acids on top of modern guideline adjusted therapy after myocardial infarction
    • Rauch B., Schiele R., Schneider S., et al. OMEGA, a randomized, placebo-controlled trial to test the effect of highly purified omega-3 fatty acids on top of modern guideline adjusted therapy after myocardial infarction. Circulation 2010, 122:2152-2159.
    • (2010) Circulation , vol.122 , pp. 2152-2159
    • Rauch, B.1    Schiele, R.2    Schneider, S.3
  • 47
    • 78549233384 scopus 로고    scopus 로고
    • N-3 Fatty acids and cardiovascular events after myocardial infarction
    • Alpha Omega Trial Group
    • Kromhout D., Giltay E., Geleijnse J.M. N-3 Fatty acids and cardiovascular events after myocardial infarction. N Engl J Med 2010, 363:2015-2026. Alpha Omega Trial Group.
    • (2010) N Engl J Med , vol.363 , pp. 2015-2026
    • Kromhout, D.1    Giltay, E.2    Geleijnse, J.M.3
  • 48
    • 0035182026 scopus 로고    scopus 로고
    • Repeatability characteristics of simple indices of insulin resistance: implications for research applications
    • Mather K.J., Hunt A.E., Steinberg H.O., et al. Repeatability characteristics of simple indices of insulin resistance: implications for research applications. J Clin Endocrinol Metab 2001, 86:5457-5464.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 5457-5464
    • Mather, K.J.1    Hunt, A.E.2    Steinberg, H.O.3
  • 49
    • 18444370558 scopus 로고    scopus 로고
    • QUICKI is useful for following improvements in insulin sensitivity after therapy in patients with type 2 diabetes mellitus
    • Katsuki A., Sumida Y., Gabazza E.C., et al. QUICKI is useful for following improvements in insulin sensitivity after therapy in patients with type 2 diabetes mellitus. J Clin Endocrinol Metab 2002, 87:2906-2908.
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 2906-2908
    • Katsuki, A.1    Sumida, Y.2    Gabazza, E.C.3
  • 50
    • 0037315294 scopus 로고    scopus 로고
    • Prediction of type 2 diabetes using simple measures of insulin resistance: combined results from the San Antonio heart study, the Mexico City diabetes study, and the insulin resistance atherosclerosis study
    • Hanley A.J., Williams K., Gonzalez C., et al. Prediction of type 2 diabetes using simple measures of insulin resistance: combined results from the San Antonio heart study, the Mexico City diabetes study, and the insulin resistance atherosclerosis study. Diabetes 2003, 52:463-469.
    • (2003) Diabetes , vol.52 , pp. 463-469
    • Hanley, A.J.1    Williams, K.2    Gonzalez, C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.