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Volumn 524, Issue 2, 2013, Pages 152-155

Two novel and functional DNA sequence variants within an upstream enhancer of the human NKX2-5 gene in ventricular septal defects

Author keywords

Congenital heart disease; DNA sequence variants; Enhancer; NKX2 5; Ventricular septal defects

Indexed keywords

TRANSCRIPTION FACTOR NKX2.5;

EID: 84878635839     PISSN: 03781119     EISSN: 18790038     Source Type: Journal    
DOI: 10.1016/j.gene.2013.04.043     Document Type: Article
Times cited : (14)

References (60)
  • 1
    • 0033430230 scopus 로고    scopus 로고
    • Mutations in the cardiac transcription factor NKX2.5 affect diverse cardiac developmental pathways
    • Benson D.W., et al. Mutations in the cardiac transcription factor NKX2.5 affect diverse cardiac developmental pathways. J. Clin. Invest. 1999, 104:1567-1573.
    • (1999) J. Clin. Invest. , vol.104 , pp. 1567-1573
    • Benson, D.W.1
  • 2
    • 0034634279 scopus 로고    scopus 로고
    • Cardiac septal and valvular dysmorphogenesis in mice heterozygous for mutations in the homeobox gene Nkx2-5
    • Biben C. Cardiac septal and valvular dysmorphogenesis in mice heterozygous for mutations in the homeobox gene Nkx2-5. Circ. Res. 2000, 87:888-895.
    • (2000) Circ. Res. , vol.87 , pp. 888-895
    • Biben, C.1
  • 3
    • 39749191367 scopus 로고    scopus 로고
    • The developmental genetics of congenital heart disease
    • Bruneau B.G. The developmental genetics of congenital heart disease. Nature 2008, 451:943-948.
    • (2008) Nature , vol.451 , pp. 943-948
    • Bruneau, B.G.1
  • 4
    • 84863149111 scopus 로고    scopus 로고
    • Epigenetics and cardiovascular development
    • Chang C.P., Bruneau B.G. Epigenetics and cardiovascular development. Annu. Rev. Physiol. 2012, 74:41-68.
    • (2012) Annu. Rev. Physiol. , vol.74 , pp. 41-68
    • Chang, C.P.1    Bruneau, B.G.2
  • 5
    • 33847297490 scopus 로고    scopus 로고
    • Combinatorial signaling in the heart orchestrates cardiac induction, lineage specification and chamber formation
    • Dunwoodie S.L. Combinatorial signaling in the heart orchestrates cardiac induction, lineage specification and chamber formation. Semin. Cell Dev. Biol. 2007, 18:54-66.
    • (2007) Semin. Cell Dev. Biol. , vol.18 , pp. 54-66
    • Dunwoodie, S.L.1
  • 6
    • 17844407425 scopus 로고    scopus 로고
    • Dysregulation of connexins and inactivation of NFATc1 in the cardiovascular system of Nkx2-5 null mutants
    • Dupays L., et al. Dysregulation of connexins and inactivation of NFATc1 in the cardiovascular system of Nkx2-5 null mutants. J. Mol. Cell. Cardiol. 2005, 38:787-798.
    • (2005) J. Mol. Cell. Cardiol. , vol.38 , pp. 787-798
    • Dupays, L.1
  • 7
    • 0029779002 scopus 로고    scopus 로고
    • The atrial natriuretic factor promoter is a downstream target for Nkx-2.5 in the myocardium
    • Durocher D., Chen C.Y., Ardati A., Schwartz R.J., Nemer M. The atrial natriuretic factor promoter is a downstream target for Nkx-2.5 in the myocardium. Mol. Cell Biol. 1996, 16:4648-4655.
    • (1996) Mol. Cell Biol. , vol.16 , pp. 4648-4655
    • Durocher, D.1    Chen, C.Y.2    Ardati, A.3    Schwartz, R.J.4    Nemer, M.5
  • 8
    • 0030799792 scopus 로고    scopus 로고
    • The cardiac transcription factors Nkx2-5 and GATA-4 are mutual cofactors
    • Durocher D., Charron F., Warren R., Schwartz R.J., Nemer M. The cardiac transcription factors Nkx2-5 and GATA-4 are mutual cofactors. EMBO J. 1997, 16:5687-5696.
    • (1997) EMBO J. , vol.16 , pp. 5687-5696
    • Durocher, D.1    Charron, F.2    Warren, R.3    Schwartz, R.J.4    Nemer, M.5
  • 9
    • 0037975739 scopus 로고    scopus 로고
    • Cardiac homeobox gene NKX2-5 mutations and congenital heart disease: associations with atrial septal defect and hypoplastic left heart syndrome
    • Elliott D.A., et al. Cardiac homeobox gene NKX2-5 mutations and congenital heart disease: associations with atrial septal defect and hypoplastic left heart syndrome. J. Am. Coll. Cardiol. 2003, 41:2072-2076.
    • (2003) J. Am. Coll. Cardiol. , vol.41 , pp. 2072-2076
    • Elliott, D.A.1
  • 11
    • 84872091789 scopus 로고    scopus 로고
    • Heart Disease and Stroke Statistics-2013 Update: a report from the American Heart Association
    • Go A.S., et al. Heart Disease and Stroke Statistics-2013 Update: a report from the American Heart Association. Circulation 2013, 127:e6-e245.
    • (2013) Circulation , vol.127
    • Go, A.S.1
  • 12
    • 0037093383 scopus 로고    scopus 로고
    • Cooperative action of Tbx2 and Nkx2.5 inhibits ANF expression in the atrioventricular canal: implications for cardiac chamber formation
    • Habets P.E., et al. Cooperative action of Tbx2 and Nkx2.5 inhibits ANF expression in the atrioventricular canal: implications for cardiac chamber formation. Genes Dev. 2002, 16:1234-1246.
    • (2002) Genes Dev. , vol.16 , pp. 1234-1246
    • Habets, P.E.1
  • 13
    • 0034931034 scopus 로고    scopus 로고
    • Tbx5 associates with Nkx2-5 and synergistically promotes cardiomyocyte differentiation
    • Hiroi Y., et al. Tbx5 associates with Nkx2-5 and synergistically promotes cardiomyocyte differentiation. Nat. Genet. 2001, 28:276-280.
    • (2001) Nat. Genet. , vol.28 , pp. 276-280
    • Hiroi, Y.1
  • 15
    • 11144355678 scopus 로고    scopus 로고
    • Nkx2-5 mutation causes anatomic hypoplasia of the cardiac conduction system
    • Jay P.Y., et al. Nkx2-5 mutation causes anatomic hypoplasia of the cardiac conduction system. J. Clin. Invest. 2004, 113:1130-1137.
    • (2004) J. Clin. Invest. , vol.113 , pp. 1130-1137
    • Jay, P.Y.1
  • 16
    • 0034947445 scopus 로고    scopus 로고
    • Progressive atrioventricular conduction defects and heart failure in mice expressing a mutant Csx/Nkx2.5 homeoprotein
    • Kasahara H., et al. Progressive atrioventricular conduction defects and heart failure in mice expressing a mutant Csx/Nkx2.5 homeoprotein. J. Clin. Invest. 2001, 108:189-201.
    • (2001) J. Clin. Invest. , vol.108 , pp. 189-201
    • Kasahara, H.1
  • 17
    • 0037350193 scopus 로고    scopus 로고
    • Nkx2.5 homeoprotein regulates expression of gap junction protein connexin 43 and sarcomere organization in postnatal cardiomyocytes
    • Kasahara H., et al. Nkx2.5 homeoprotein regulates expression of gap junction protein connexin 43 and sarcomere organization in postnatal cardiomyocytes. J. Mol. Cell. Cardiol. 2003, 35:243-256.
    • (2003) J. Mol. Cell. Cardiol. , vol.35 , pp. 243-256
    • Kasahara, H.1
  • 18
    • 0037091085 scopus 로고    scopus 로고
    • Nkx-2.5 gene induction in mice is mediated by a Smad consensus regulatory region
    • Liberatore C.M., Searcy-Schrick R.D., Vincent E.B., Yutzey K.E. Nkx-2.5 gene induction in mice is mediated by a Smad consensus regulatory region. Dev. Biol. 2002, 244:243-256.
    • (2002) Dev. Biol. , vol.244 , pp. 243-256
    • Liberatore, C.M.1    Searcy-Schrick, R.D.2    Vincent, E.B.3    Yutzey, K.E.4
  • 19
    • 0032937224 scopus 로고    scopus 로고
    • Control of early cardiac-specific transcription of Nkx2-5 by a GATA-dependent enhancer
    • Lien C.L., Wu C., Mercer B., Webb R., Richardson J.A., Olson E.N. Control of early cardiac-specific transcription of Nkx2-5 by a GATA-dependent enhancer. Development 1999, 126:75-84.
    • (1999) Development , vol.126 , pp. 75-84
    • Lien, C.L.1    Wu, C.2    Mercer, B.3    Webb, R.4    Richardson, J.A.5    Olson, E.N.6
  • 20
    • 0037090906 scopus 로고    scopus 로고
    • Cardiac-specific activity of an Nkx2-5 enhancer requires an evolutionarily conserved Smad binding site
    • Lien C.L., McAnally J., Richardson J.A., Olson E.N. Cardiac-specific activity of an Nkx2-5 enhancer requires an evolutionarily conserved Smad binding site. Dev. Biol. 2002, 244:257-266.
    • (2002) Dev. Biol. , vol.244 , pp. 257-266
    • Lien, C.L.1    McAnally, J.2    Richardson, J.A.3    Olson, E.N.4
  • 21
    • 77951919333 scopus 로고    scopus 로고
    • MicroRNA regulatory networks in cardiovascular development
    • Liu N., Olson E.N. MicroRNA regulatory networks in cardiovascular development. Dev. Cell 2010, 18:510-525.
    • (2010) Dev. Cell , vol.18 , pp. 510-525
    • Liu, N.1    Olson, E.N.2
  • 22
    • 0029090829 scopus 로고
    • Myogenic and morphogenetic defects in the heart tubes of murine embryos lacking the homeo box gene Nkx2-5
    • Lyons I., et al. Myogenic and morphogenetic defects in the heart tubes of murine embryos lacking the homeo box gene Nkx2-5. Genes Dev. 1995, 9:1654-1666.
    • (1995) Genes Dev. , vol.9 , pp. 1654-1666
    • Lyons, I.1
  • 23
    • 84858770543 scopus 로고    scopus 로고
    • Transcription factor pathways and congenital heart disease
    • McCulley D.J., Black B.L. Transcription factor pathways and congenital heart disease. Curr. Top. Dev. Biol. 2012, 100:253-277.
    • (2012) Curr. Top. Dev. Biol. , vol.100 , pp. 253-277
    • McCulley, D.J.1    Black, B.L.2
  • 25
    • 33847656148 scopus 로고    scopus 로고
    • Nkx2.5 cell-autonomous gene function is required for the postnatal formation of the peripheral ventricular conduction system
    • Meysen S. Nkx2.5 cell-autonomous gene function is required for the postnatal formation of the peripheral ventricular conduction system. Dev. Biol. 2007, 303:740-753.
    • (2007) Dev. Biol. , vol.303 , pp. 740-753
    • Meysen, S.1
  • 26
    • 33748489726 scopus 로고    scopus 로고
    • Tbx5-dependent rheostatic control of cardiac gene expression and morphogenesis
    • Mori A.D., et al. Tbx5-dependent rheostatic control of cardiac gene expression and morphogenesis. Dev. Biol. 2006, 297:566-586.
    • (2006) Dev. Biol. , vol.297 , pp. 566-586
    • Mori, A.D.1
  • 27
    • 34250754981 scopus 로고    scopus 로고
    • A molecular pathway including Id2, Tbx5, and Nkx2-5 required for cardiac conduction system development
    • Moskowitz I.P., et al. A molecular pathway including Id2, Tbx5, and Nkx2-5 required for cardiac conduction system development. Cell 2007, 129:1365-1376.
    • (2007) Cell , vol.129 , pp. 1365-1376
    • Moskowitz, I.P.1
  • 28
    • 33749361499 scopus 로고    scopus 로고
    • Gene regulatory networks in the evolution and development of the heart
    • Olson E.N. Gene regulatory networks in the evolution and development of the heart. Science 2006, 313:1922-1927.
    • (2006) Science , vol.313 , pp. 1922-1927
    • Olson, E.N.1
  • 29
    • 84878259638 scopus 로고    scopus 로고
    • Genetic and functional analysis of the NKX2-5 gene promoter in patients with ventricular septal defects
    • Pang S., et al. Genetic and functional analysis of the NKX2-5 gene promoter in patients with ventricular septal defects. Pediatr. Cardiol. 2012, 33:1355-1361.
    • (2012) Pediatr. Cardiol. , vol.33 , pp. 1355-1361
    • Pang, S.1
  • 30
    • 11144357335 scopus 로고    scopus 로고
    • Nkx2-5 pathways and congenital heart disease; loss of ventricular myocyte lineage specification leads to progressive cardiomyopathy and complete heart block
    • Pashmforoush M., et al. Nkx2-5 pathways and congenital heart disease; loss of ventricular myocyte lineage specification leads to progressive cardiomyopathy and complete heart block. Cell 2004, 117:373-386.
    • (2004) Cell , vol.117 , pp. 373-386
    • Pashmforoush, M.1
  • 31
    • 33847344204 scopus 로고    scopus 로고
    • An Nkx2-5/Bmp2/Smad1 negative feedback loop controls heart progenitor specification and proliferation
    • Prall O.W., et al. An Nkx2-5/Bmp2/Smad1 negative feedback loop controls heart progenitor specification and proliferation. Cell 2007, 128:947-959.
    • (2007) Cell , vol.128 , pp. 947-959
    • Prall, O.W.1
  • 32
    • 4644358238 scopus 로고    scopus 로고
    • GATA4 is a dosage-sensitive regulator of cardiac morphogenesis
    • Pu W.T., Ishiwata T., Juraszek A.L., Ma Q., Izumo S. GATA4 is a dosage-sensitive regulator of cardiac morphogenesis. Dev. Biol. 2004, 275:235-244.
    • (2004) Dev. Biol. , vol.275 , pp. 235-244
    • Pu, W.T.1    Ishiwata, T.2    Juraszek, A.L.3    Ma, Q.4    Izumo, S.5
  • 33
    • 84860338564 scopus 로고    scopus 로고
    • Genetic analysis of the TBX20 gene promoter region in patients with ventricular septal defects
    • Qiao Y., et al. Genetic analysis of the TBX20 gene promoter region in patients with ventricular septal defects. Gene 2012, 500:28-31.
    • (2012) Gene , vol.500 , pp. 28-31
    • Qiao, Y.1
  • 34
    • 84865569856 scopus 로고    scopus 로고
    • Genetic analysis of an enhancer of the NKX2-5 gene in ventricular septal defects
    • Qin X., et al. Genetic analysis of an enhancer of the NKX2-5 gene in ventricular septal defects. Gene 2012, 508:106-109.
    • (2012) Gene , vol.508 , pp. 106-109
    • Qin, X.1
  • 35
    • 77953689537 scopus 로고    scopus 로고
    • Comprehensive genotype-phenotype analysis in 230 patients with tetralogy of Fallot
    • Rauch R., et al. Comprehensive genotype-phenotype analysis in 230 patients with tetralogy of Fallot. J. Med. Genet. 2010, 47:321-331.
    • (2010) J. Med. Genet. , vol.47 , pp. 321-331
    • Rauch, R.1
  • 36
    • 78049442656 scopus 로고    scopus 로고
    • NKX2-5: an update on this hypermutable homeodomain protein and its role in human congenital heart disease (CHD)
    • Reamon-Buettner S.M., Borlak J. NKX2-5: an update on this hypermutable homeodomain protein and its role in human congenital heart disease (CHD). Hum. Mutat. 2010, 31:1185-1194.
    • (2010) Hum. Mutat. , vol.31 , pp. 1185-1194
    • Reamon-Buettner, S.M.1    Borlak, J.2
  • 37
    • 0033013018 scopus 로고    scopus 로고
    • Identification of upstream regulatory regions in the heart-expressed homeobox gene Nkx2-5
    • Reecy J.M., et al. Identification of upstream regulatory regions in the heart-expressed homeobox gene Nkx2-5. Development 1999, 126:839-849.
    • (1999) Development , vol.126 , pp. 839-849
    • Reecy, J.M.1
  • 38
    • 0032479573 scopus 로고    scopus 로고
    • Congenital heart disease caused by mutations in the transcription factor NKX2-5
    • Schott J.J., et al. Congenital heart disease caused by mutations in the transcription factor NKX2-5. Science 1998, 281:108-111.
    • (1998) Science , vol.281 , pp. 108-111
    • Schott, J.J.1
  • 39
    • 0032727374 scopus 로고    scopus 로고
    • Building the heart piece by piece: modularity of cis-elements regulating Nkx2-5 transcription
    • Schwartz R.J., Olson E.N. Building the heart piece by piece: modularity of cis-elements regulating Nkx2-5 transcription. Development 1999, 126:4187-4192.
    • (1999) Development , vol.126 , pp. 4187-4192
    • Schwartz, R.J.1    Olson, E.N.2
  • 40
    • 0031647382 scopus 로고    scopus 로고
    • A GATA-dependent nkx-2.5 regulatory element activates early cardiac gene expression in transgenic mice
    • Searcy R.D., Vincent E.B., Liberatore C.M., Yutzey K.E. A GATA-dependent nkx-2.5 regulatory element activates early cardiac gene expression in transgenic mice. Development 1998, 125:4461-4470.
    • (1998) Development , vol.125 , pp. 4461-4470
    • Searcy, R.D.1    Vincent, E.B.2    Liberatore, C.M.3    Yutzey, K.E.4
  • 41
    • 0037067697 scopus 로고    scopus 로고
    • Combinatorial expression of GATA4, Nkx2-5, and serum response factor directs early cardiac gene activity
    • Sepulveda J.L., Vlahopoulos S., Iyer D., Belaguli N., Schwartz R.J. Combinatorial expression of GATA4, Nkx2-5, and serum response factor directs early cardiac gene activity. J. Biol. Chem. 2002, 277:25775-25782.
    • (2002) J. Biol. Chem. , vol.277 , pp. 25775-25782
    • Sepulveda, J.L.1    Vlahopoulos, S.2    Iyer, D.3    Belaguli, N.4    Schwartz, R.J.5
  • 42
    • 84865790759 scopus 로고    scopus 로고
    • Functional analysis of the novel sequence variants within TBX5 gene promoter in patients with ventricular septal defects
    • Shan J., et al. Functional analysis of the novel sequence variants within TBX5 gene promoter in patients with ventricular septal defects. Transl. Res. 2012, 160:237-238.
    • (2012) Transl. Res. , vol.160 , pp. 237-238
    • Shan, J.1
  • 44
    • 0029972345 scopus 로고    scopus 로고
    • Molecular cloning and characterization of human cardiac homeobox gene CSX1
    • Shiojima I., et al. Molecular cloning and characterization of human cardiac homeobox gene CSX1. Circ. Res. 1996, 79:920-929.
    • (1996) Circ. Res. , vol.79 , pp. 920-929
    • Shiojima, I.1
  • 46
    • 78149237904 scopus 로고    scopus 로고
    • Mutational spectrum in the cardiac transcription factor gene NKX2.5 (CSX) associated with congenital heart disease
    • Stallmeyer B., Fenge H., Nowak-Göttl U., Schulze-Bahr E. Mutational spectrum in the cardiac transcription factor gene NKX2.5 (CSX) associated with congenital heart disease. Clin. Genet. 2010, 78:533-540.
    • (2010) Clin. Genet. , vol.78 , pp. 533-540
    • Stallmeyer, B.1    Fenge, H.2    Nowak-Göttl, U.3    Schulze-Bahr, E.4
  • 47
    • 0036362978 scopus 로고    scopus 로고
    • Efficient Cre-mediated deletion in cardiac progenitor cells conferred by a 3'UTR-ires-Cre allele of the homeobox gene Nkx2-5
    • Stanley E.G., et al. Efficient Cre-mediated deletion in cardiac progenitor cells conferred by a 3'UTR-ires-Cre allele of the homeobox gene Nkx2-5. Int. J. Dev. Biol. 2002, 46:431-439.
    • (2002) Int. J. Dev. Biol. , vol.46 , pp. 431-439
    • Stanley, E.G.1
  • 48
    • 0141615095 scopus 로고    scopus 로고
    • Cardiac T-box factor Tbx20 directly interacts with Nkx2-5, GATA4, and GATA5 in regulation of gene expression in the developing heart
    • Stennard F.A., et al. Cardiac T-box factor Tbx20 directly interacts with Nkx2-5, GATA4, and GATA5 in regulation of gene expression in the developing heart. Dev. Biol. 2003, 262:206-224.
    • (2003) Dev. Biol. , vol.262 , pp. 206-224
    • Stennard, F.A.1
  • 49
    • 84880317634 scopus 로고    scopus 로고
    • Chromatin remodelling complex dosage modulates transcription factor function in heart development
    • Takeuchi J.K., et al. Chromatin remodelling complex dosage modulates transcription factor function in heart development. Nat. Commun. 2011, 2:187.
    • (2011) Nat. Commun. , vol.2 , pp. 187
    • Takeuchi, J.K.1
  • 50
    • 0032907924 scopus 로고    scopus 로고
    • The cardiac homeobox gene Csx/Nkx2.5 lies genetically upstream of multiple genes essential for heart development
    • Tanaka M., Chen Z., Bartunkova S., Yamasaki N., Izumo S. The cardiac homeobox gene Csx/Nkx2.5 lies genetically upstream of multiple genes essential for heart development. Development 1999, 126:1269-1280.
    • (1999) Development , vol.126 , pp. 1269-1280
    • Tanaka, M.1    Chen, Z.2    Bartunkova, S.3    Yamasaki, N.4    Izumo, S.5
  • 51
    • 0344428124 scopus 로고    scopus 로고
    • Complex modular cis-acting elements regulate expression of the cardiac specifying homeobox gene Csx/Nkx2.5
    • Tanaka M., Wechsler S.B., Lee I.W., Yamasaki N., Lawitts J.A., Izumo S. Complex modular cis-acting elements regulate expression of the cardiac specifying homeobox gene Csx/Nkx2.5. Development 1999, 126:1439-1450.
    • (1999) Development , vol.126 , pp. 1439-1450
    • Tanaka, M.1    Wechsler, S.B.2    Lee, I.W.3    Yamasaki, N.4    Lawitts, J.A.5    Izumo, S.6
  • 52
    • 79959962188 scopus 로고    scopus 로고
    • Ablation of Nkx2-5 at mid-embryonic stage results in premature lethality and cardiac malformation
    • Terada R., Warren S., Lu J.T., Chien K.R., Wessels A., Kasahara H. Ablation of Nkx2-5 at mid-embryonic stage results in premature lethality and cardiac malformation. Cardiovasc. Res. 2011, 91:289-299.
    • (2011) Cardiovasc. Res. , vol.91 , pp. 289-299
    • Terada, R.1    Warren, S.2    Lu, J.T.3    Chien, K.R.4    Wessels, A.5    Kasahara, H.6
  • 53
    • 0037025368 scopus 로고    scopus 로고
    • Csx/Nkx2-5 is required for homeostasis and survival of cardiac myocytes in the adult heart
    • Toko H., et al. Csx/Nkx2-5 is required for homeostasis and survival of cardiac myocytes in the adult heart. J. Biol. Chem. 2002, 277:24735-24743.
    • (2002) J. Biol. Chem. , vol.277 , pp. 24735-24743
    • Toko, H.1
  • 54
    • 0029669183 scopus 로고    scopus 로고
    • Molecular cloning, chromosomal mapping, and characterization of the human cardiac-specific homeobox gene hCsx
    • Turbay D., Wechsler S.B., Blanchard K.M., Izumo S. Molecular cloning, chromosomal mapping, and characterization of the human cardiac-specific homeobox gene hCsx. Mol. Med. 1996, 2:86-96.
    • (1996) Mol. Med. , vol.2 , pp. 86-96
    • Turbay, D.1    Wechsler, S.B.2    Blanchard, K.M.3    Izumo, S.4
  • 56
    • 77952367604 scopus 로고    scopus 로고
    • Mortality in adult congenital heart disease
    • Verheugt C.L., et al. Mortality in adult congenital heart disease. Eur. Heart J. 2010, 31:1220-1229.
    • (2010) Eur. Heart J. , vol.31 , pp. 1220-1229
    • Verheugt, C.L.1
  • 57
    • 57149103137 scopus 로고    scopus 로고
    • Cooperative interaction of Nkx2.5 and Mef2c transcription factors during heart development
    • Vincentz J.W., Barnes R.M., Firulli B.A., Conway S.J., Firulli A.B. Cooperative interaction of Nkx2.5 and Mef2c transcription factors during heart development. Dev. Dyn. 2008, 237:3809-3819.
    • (2008) Dev. Dyn. , vol.237 , pp. 3809-3819
    • Vincentz, J.W.1    Barnes, R.M.2    Firulli, B.A.3    Conway, S.J.4    Firulli, A.B.5
  • 58
    • 84867314852 scopus 로고    scopus 로고
    • Genetic analysis of the TBX1 gene promoter in ventricular septal defects
    • Wang H., et al. Genetic analysis of the TBX1 gene promoter in ventricular septal defects. Mol. Cell. Biochem. 2012, 370:53-58.
    • (2012) Mol. Cell. Biochem. , vol.370 , pp. 53-58
    • Wang, H.1
  • 59
    • 77957601615 scopus 로고    scopus 로고
    • Genetic factors in non-syndromic congenital heart malformations
    • Wessels M.W., Willems P.J. Genetic factors in non-syndromic congenital heart malformations. Clin. Genet. 2010, 78:103-123.
    • (2010) Clin. Genet. , vol.78 , pp. 103-123
    • Wessels, M.W.1    Willems, P.J.2
  • 60
    • 84859726679 scopus 로고    scopus 로고
    • Genetic analysis of the promoter region of the GATA4 gene in patients with ventricular septal defects
    • Wu G., Shan J., Pang S., Wei X., Zhang H., Yan B. Genetic analysis of the promoter region of the GATA4 gene in patients with ventricular septal defects. Transl. Res. 2012, 159:376-382.
    • (2012) Transl. Res. , vol.159 , pp. 376-382
    • Wu, G.1    Shan, J.2    Pang, S.3    Wei, X.4    Zhang, H.5    Yan, B.6


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