Postmenopausal osteoporosis: The role of immune system cells

Clinical and Developmental Immunology

Volumn 2013, Issue , 2013, Pages

  Faienza, Maria Felicia ^a   Ventura, Annamaria ^a   Marzano, Flaviana ^b   Cavallo, Luciano ^a  

^a UNIVERSITY OF BARI   (Italy)

^b CNR   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ALENDRONIC ACID; CALCITONIN RECEPTOR; CATHEPSIN K; COLONY STIMULATING FACTOR 1; DENOSUMAB; ESTROGEN RECEPTOR ALPHA; ETIDRONIC ACID; GELATINASE B; INTERLEUKIN 1; INTERLEUKIN 6; OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOPROTEGERIN; PARATHYROID HORMONE[1-34]; RALOXIFENE; RISEDRONIC ACID; SALCATONIN; SELECTIVE ESTROGEN RECEPTOR MODULATOR; TUMOR NECROSIS FACTOR ALPHA; VITRONECTIN RECEPTOR; ZOLEDRONIC ACID; BONE DENSITY CONSERVATION AGENT; ESTROGEN; FOLLITROPIN;

ALCOHOL CONSUMPTION; BODY MASS; BONE FRAGILITY; BONE MASS; BONE MATRIX; BONE REMODELING; BONE STRENGTH; CALCIUM INTAKE; CELL DIFFERENTIATION; CELL FUNCTION; CELL LINEAGE; CYTOKINE PRODUCTION; DRUG HALF LIFE; ESOPHAGUS CANCER; FRACTURE; HEART ATRIUM FIBRILLATION; HUMAN; IMMUNOCOMPETENT CELL; JAW OSTEONECROSIS; MUSCULOSKELETAL PAIN; NONHUMAN; OSSIFICATION; OSTEOBLAST; OSTEOCLASTOGENESIS; OSTEOLYSIS; PHYSICAL ACTIVITY; POSTMENOPAUSE OSTEOPOROSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; RHEUMATOID ARTHRITIS; SMOKING; BIOSYNTHESIS; BONE; BONE DENSITY; DEFICIENCY; DRUG EFFECTS; FEMALE; FRACTURES, BONE; IMMUNE SYSTEM; IMMUNOLOGY; OSTEOCLAST; OSTEOPOROSIS, POSTMENOPAUSAL; PATHOLOGY; POSTMENOPAUSE; PREVENTION AND CONTROL; DRUG EFFECT;

BONE AND BONES; BONE DENSITY; BONE DENSITY CONSERVATION AGENTS; BONE RESORPTION; ESTROGENS; FEMALE; FOLLICLE STIMULATING HORMONE; FRACTURES, BONE; HUMANS; IMMUNE SYSTEM; OSTEOCLASTS; OSTEOPOROSIS, POSTMENOPAUSAL; POSTMENOPAUSE;

EID: 84878625469     PISSN: 17402522     EISSN: 17402530     Source Type: Journal    
DOI: 10.1155/2013/575936     Document Type: Review

References (80)

1. Clowes J. A., Riggs B. L., Khosla S., The role of the immune system in the pathophysiology of osteoporosis. Immunological Reviews 2005 208 207 227 2-s2.0-28544439444 10.1111/j.0105-2896.2005.00334.x (Pubitemid 41746395)
2. Ginaldi L., Di Benedetto M. C., De Martinis M., Osteoporosis, inflammation and ageing. Immunity and Ageing 2005 2, article 14 2-s2.0-33749354009 10.1186/1742-4933-2-14 (Pubitemid 44848797)
3. Arron J. R., Choi Y., Bone versus immune system. Nature 2000 408 6812 535 536 2-s2.0-0034735792 10.1038/35046196
4. Kotake S., Udagawa N., Hakoda M., Activated human T cells directly induce osteoclastogenesis from human monocytes: possible role of T cells in bone destruction in rheumatoid arthritis patients. Arthritis & Rheumatism 2001 44 1003 1012 (Pubitemid 32433604)
5. Roato I., Grano M., Brunetti G., Colucci S., Mussa A., Bertetto O., Ferracini R., Mechanisms of spontaneous osteoclastogenesis in cancer with bone involvement. FASEB Journal 2005 19 2 228 230 2-s2.0-13244273716 10.1096/fj.04-1823fje (Pubitemid 40189264)
6. Roato I., Brunetti G., Gorassini E., Grano M., Colucci S., Bonello L., Buffoni L., Manfredi R., Ruffini E., Ottaviani D., Ciuffreda L., Mussa A., Ferracini R., IL-7 up-regulates TNF- α -dependent osteoclastogenesis in patients affected by solid tumor. PLoS ONE 2006 1 1, article e124 2-s2.0-35448982256 10.1371/journal.pone.0000124
7. Brunetti G., Colucci S., Pignataro P., Coricciati M., Mori G., Cirulli N., Zallone A., Grassi F. R., Grano M., T cells support osteoclastogenesis in an in vitro model derived from human periodontitis patients. Journal of Periodontology 2005 76 10 1675 1680 2-s2.0-27844548531 10.1902/jop.2005.76.10. 1675 (Pubitemid 41645576)
8. Colucci S., Brunetti G., Cantatore F. P., Oranger A., Mori G., Quarta L., Cirulli N., Mancini L., Corrado A., Grassi F. R., Grano M., Lymphocytes and synovial fluid fibroblasts support osteoclastogenesis through RANKL, TNF α and IL-7 in an in vitro model derived from human psoriatic arthritis. Journal of Pathology 2007 212 1 47 55 2-s2.0-34248582794 10.1002/path.2153 (Pubitemid 46746289)
9. Faienza M. F., Brunetti G., Colucci S., Piacente L., Ciccarelli M., Giordani L., Del Vecchio G. C., D'Amore M., Albanese L., Cavallo L., Grano M., Osteoclastogenesis in children with 21-hydroxylase deficiency on long-term glucocorticoid therapy: the role of receptor activator of nuclear factor- B ligand/osteoprotegerin imbalance. Journal of Clinical Endocrinology and Metabolism 2009 94 7 2269 2276 2-s2.0-67650221408 10.1210/jc.2008-2446
10. Brunetti G., Faienza M. F., Picente L., High dickkopf-1 levels in sera and leukocytes from children with 21-hydroxylase deficiency on chronic glucocorticoid treatment. American Journal of Physiology 2013 304 546 554
11. Ventura A., Brunetti G., Colucci S., Oranger A., Ladisa F., Cavallo L., Grano M., Faienza M. F., Glucocorticoid-induced osteoporosis in children with 21-hydroxylase deficiency. BioMed Research International 2013 2013 8 250462 10.1155/2013/250462
12. D'Amelio P., Grimaldi A., Di Bella S., Brianza S. Z. M., Cristofaro M. A., Tamone C., Giribaldi G., Ulliers D., Pescarmona G. P., Isaia G., Estrogen deficiency increases osteoclastogenesis up-regulating T cells activity: a key mechanism in osteoporosis. Bone 2008 43 1 92 100 2-s2.0-44949083462 10.1016/j.bone.2008.02.017
13. McNamara L. M., Perspective on post-menopausal osteoporosis: establishing an interdisciplinary understanding of the sequence of events from the molecular level to whole bone fractures. Journal of the Royal Society Interface 2010 7 44 353 372 2-s2.0-75949164155 10.1098/rsif.2009.0282
14. Lerner U. H., Bone remodeling in post-menopausal osteoporosis. Journal of Dental Research 2006 85 7 584 595 2-s2.0-33746128874 (Pubitemid 44085947)
15. Raisz L. G., Pathogenesis of osteoporosis: concepts, conflicts, and prospects. The Journal of Clinical Investigation 2005 115 12 3318 3325 2-s2.0-31044432767 10.1172/JCI27071 (Pubitemid 43121814)
16. Massey H. M., Flanagan A. M., Human osteoclasts derive from CD14-positive monocytes. British Journal of Haematology 1999 106 1 167 170 2-s2.0-0032864471 10.1046/j.1365-2141.1999.01491.x (Pubitemid 29343545)
17. Boyle W. J., Simonet W. S., Lacey D. L., Osteoclast differentiation and activation. Nature 2003 423 6937 337 342 2-s2.0-0037673945 10.1038/nature01658 (Pubitemid 40852708)
18. Helfrich M. H., Thesingh C. W., Mieremet R. H. P., van Iperen-van Gent A. S., Osteoclast generation from human fetal bone marrow in cocultures with murine fetal long bones. A model for in vitro study of human osteoclast formation and function. Cell and Tissue Research 1987 249 1 125 136 2-s2.0-0023233953 (Pubitemid 17120689)
19. Takahashi N., Akatsu T., Udagawa N., Sasaki T., Yamaguchi A., Moseley J. M., Martin T. J., Suda T., Osteoblastic cells are involved in osteoclast formation. Endocrinology 1988 123 5 2600 2602 2-s2.0-0023790708
20. Inaoka T., Bilbe G., Ishibashi O., Tezuka K. I., Kumegawa M., Kokubo T., Molecular cloning of human cDNA for cathepsin K: novel cysteine proteinase predominantly expressed in bone. Biochemical and Biophysical Research Communications 1995 206 1 89 96 2-s2.0-0028831635 10.1006/bbrc.1995.1013
21. Boyce B. F., Yoneda T., Lowe C., Soriano P., Mundy G. R., Requirement of pp60(c-src) expression for osteoclasts to form ruffled borders and resorb bone in mice. The Journal of Clinical Investigation 1992 90 4 1622 1627 2-s2.0-0026612467
22. Hentunen T. A., Jackson S. H., Chung H., Reddy S. V., Lorenzo J., Choi S. J., David Roodman G., Characterization of immortalized osteoclast precursors developed from mice transgenic for both bcl-X(L) and simian virus 40 large T antigen. Endocrinology 1999 140 7 2954 2961 2-s2.0-0033305156 (Pubitemid 30650608)
23. Clover J., Dodds R. A., Gowen M., Integrin subunit expression by human osteoblasts and osteoclasts in situ and in culture. Journal of Cell Science 1992 103 1 267 271 2-s2.0-0026786361
24. Teitelbaum S. L., The osteoclast and its unique cytoskeleton. Annals of the New York Academy of Sciences 2011 1240 14 17
25. NIH Consensus Development Panel on Osteoporosis Prevention, Diagnosis, and Therapy, Osteoporosis prevention, diagnosis, and therapy. Journal of the American Medical Association 2001 285 6 785 795 2-s2.0-0035857351
26. Britton C., Walsh J., Paget disease of bone-an update. Australian Family Physician 2012 41 100 103
27. Kanis J. A., Pathophysiology and Treatment of Paget's Disease of Bone 1998 London, UK Martin Dunitz
28. Brunetti G., Marzano F., Colucci S., Ventura A., Cavallo L., Grano M., Faienza M. F., Genotype-phenotype correlation in juvenile Paget disease: role of molecular alterations of the TNFRSF11B gene. Endocrine 2012 42 266 271
29. Watts N. B., Bilezikian J. P., Camacho P. M., AACE Osteoporosis Task Force, American Association of Clinical Endocrinologists Medical Guidelines for Clinical Practice for the diagnosis and treatment of postmenopausal osteoporosis. Endocrine Practice 2010 16 supplement 3 1 37
30. Riggs B. L., Khosla S., Melton L. J. III, Sex steroids and the construction and conservation of the adult skeleton. Endocrine Reviews 2002 23 3 279 302 2-s2.0-0035985305 10.1210/er.23.3.279 (Pubitemid 34651948)
31. Mohamed E. I., Tarantino U., Promenzio L., De Lorenzo A., Predicting bone mineral density of postmenopausal healthy and cirrhotic Italian women using age and body mass index. Acta Diabetologica 2003 40 supplement 1 S23 S28 2-s2.0-0142240247 10.1007/s00592-003-0021-2 (Pubitemid 37322712)
32. Kanis J. A., Johnell O., Requirements for DXA for the management of osteoporosis in Europe. Osteoporosis International 2005 16 3 229 238 2-s2.0-15044344862 10.1007/s00198-004-1811-2 (Pubitemid 40379422)
33. Kanis J. A., Johansson H., Oden A., Johnell O., De Laet C., Eisman J. A., McCloskey E. V., Mellstrom D., Melton L. J., Pols H. A. P., Reeve J., Silman A. J., Tenenhouse A., A family history of fracture and fracture risk: a meta-analysis. Bone 2004 35 5 1029 1037 2-s2.0-8444247855 10.1016/j.bone.2004. 06.017 (Pubitemid 39487348)
34. Shea B., Wells G., Cranney A., Zytaruk N., Robinson V., Griffith L., Hamel C., Ortiz Z., Peterson J., Adachi J., Tugwell P., Guyatt G., WITHDRAWN: calcium supplementation on bone loss in postmenopausal women. Cochrane Database of Systematic Reviews 2007 3 CD004526 2-s2.0-35348880846
35. Tussing L., Chapman-Novakofski K., Osteoporosis prevention education: behavior theories and calcium intake. Journal of the American Dietetic Association 2005 105 1 92 97 2-s2.0-11344264637 10.1016/j.jada.2004.10.025 (Pubitemid 40075498)
36. Prentice A., Diet, nutrition and the prevention of osteoporosis. Public Health Nutrition 2004 7 1 227 243 2-s2.0-1542320651 10.1079/PHN2003590 (Pubitemid 38294519)
37. Knoke J. D., Barrett-Connor E., Weight loss: a determinant of hip bone loss in older men and women: The Rancho Bernardo Study. American Journal of Epidemiology 2003 158 12 1132 1138 2-s2.0-0348010432 10.1093/aje/kwg265 (Pubitemid 37548782)
38. Broussard D. L., Magnus J. H., Risk assessment and screening for low bone mineral density in a multi-ethnic population of women and men: does one approach fit all? Osteoporosis International 2004 15 5 349 360 2-s2.0-2442449229 10.1007/s00198-003-1549-2 (Pubitemid 38639329)
39. Liu X., Kohyama T., Kobayashi T., Abe S., Kim H. J., Reed E. C., Rennard S. I., Cigarette smoke extract inhibits chemotaxis and collagen gel contraction mediated by human bone marrow osteoprogenitor cells and osteoblast-like cells. Osteoporosis International 2003 14 3 235 242 2-s2.0-0346845133 10.1007/s00198-002-1350-7 (Pubitemid 40826237)
40. Lee L. L., Lee J. S. C., Waldman S. D., Casper R. F., Grynpas M. D., Polycyclic aromatic hydrocarbons present in cigarette smoke cause bone loss in an ovariectomized rat model. Bone 2002 30 6 917 923 2-s2.0-0036273242 10.1016/S8756-3282(02)00726-3 (Pubitemid 34616023)
41. Ford M. A., Bass M. A., Turner L. W., Mauromoustakos A., Graves B. S., Past and recent physical activity and bone mineral density in college-aged women. Journal of Strength and Conditioning Research 2004 18 3 405 409 2-s2.0-4444282157 10.1519/13343.1 (Pubitemid 39207749)
42. Asikainen T. M., Kukkonen-Harjula K., Miilunpalo S., Exercise for health for early postmenopausal women: a systematic review of randomised controlled trials. Sports Medicine 2004 34 11 753 778 2-s2.0-6044258975 10.2165/00007256-200434110-00004 (Pubitemid 39382183)
43. Kim M. J., Shim M. S., Kim M. K., Lee Y., Shin Y. G., Chung C. H., Kwon S. O., Effect of chronic alcohol ingestion on bone mineral density in males without liver cirrhosis. The Korean Journal of Internal Medicine 2003 18 3 174 180 2-s2.0-0642277744
44. Oursler M. J., Osdoby P., Pyfferoen J., Riggs B. L., Spelsberg T. C., Avian osteoclasts as estrogen target cells. Proceedings of the National Academy of Sciences of the United States of America 1991 88 15 6613 6617 2-s2.0-0026000340 10.1073/pnas.88.15.6613 (Pubitemid 21914998)
45. Srivastava S., Toraldo G., Weitzmann M. N., Cenci S., Ross F. P., Pacifici R., Estrogen decreases osteoclast formation by down-regulating receptor activator of NF-kappa B ligand (RANKL)-induced JNK activation. The Journal of Biological Chemistry 2001 276 12 8836 8840 2-s2.0-0035937747 10.1074/jbc.M010764200
46. Robinson L. J., Yaroslavskiy B. B., Griswold R. D., Zadorozny E. V., Guo L., Tourkova I. L., Blair H. C., Estrogen inhibits RANKL-stimulated osteoclastic differentiation of human monocytes through estrogen and RANKL-regulated interaction of estrogen receptor- α with BCAR1 and Traf6. Experimental Cell Research 2009 315 7 1287 1301 2-s2.0-63049085423 10.1016/j.yexcr.2009.01. 014
47. Eghbali-Fatourechi G., Khosla S., Sanyal A., Boyle W. J., Lacey D. L., Riggs B. L., Role of RANK ligand in mediating increased bone resorption in early postmenopausal women. The Journal of Clinical Investigation 2003 111 8 1221 1230 2-s2.0-0037398261 10.1172/JCI200317215 (Pubitemid 36519939)
48. Hofbauer L. C., Khosla S., Dunstan C. R., Lacey D. L., Spelsberg T. C., Riggs B. L., Estrogen stimulates gene expression and protein production of osteoprotegerin in human osteoblastic cells. Endocrinology 1999 140 9 4367 4370 2-s2.0-0033304632 (Pubitemid 30647136)
49. Manolagas S. C., Jilka R. L., Mechanisms of disease: bone marrow, cytokines, and bone remodeling-emerging insights into the pathophysiology of osteoporosis. The New England Journal of Medicine 1995 332 5 305 311 2-s2.0-0028925088 10.1056/NEJM199502023320506
50. Tanaka S., Takahashi N., Udagawa N., Tamura T., Akatsu T., Stanley E. R., Kurokawa T., Suda T., Macrophage colony-stimulating factor is indispensable for both proliferation and differentiation of osteoclast progenitors. The Journal of Clinical Investigation 1993 91 1 257 263 2-s2.0-0027473329 (Pubitemid 23037280)
51. Kimble R. B., Vannice J. L., Bloedow D. C., Thompson R. C., Hopfer W., Kung V. T., Brownfield C., Pacifici R., Interleukin-1 receptor antagonist decreases bone loss and bone resorption in ovariectomized rats. The Journal of Clinical Investigation 1994 93 5 1959 1967 2-s2.0-0028206914 (Pubitemid 24143073)
52. Ammann P., Rizzoli R., Bonjour J. P., Bourrin S., Meyer J. M., Vassalli P., Garcia I., Transgenic mice expressing soluble tumor necrosis factor-receptor are protected against bone loss caused by estrogen deficiency. The Journal of Clinical Investigation 1997 99 7 1699 1703 2-s2.0-0030950131 (Pubitemid 27163821)
53. Kimble R. B., Srivastava S., Ross F. P., Matayoshi A., Pacifici R., Estrogen deficiency increases the ability of stromal cells to support murine osteoclastogenesis via an interleukin-1-and tumor necrosis factor- mediated stimulation of macrophage colony-stimulating factor production. The Journal of Biological Chemistry 1996 271 46 28890 28897 2-s2.0-0029802660 10.1074/jbc.271.46.28890 (Pubitemid 26382589)
54. Breuil V., Ticchioni M., Testa J., Roux C. H., Ferrari P., Breittmayer J. P., Albert-Sabonnadière C., Durant J., De Perreti F., Bernard A., Euller-Ziegler L., Carle G. F., Immune changes in post-menopausal osteoporosis: The Immunos Study. Osteoporosis International 2010 21 5 805 814 2-s2.0-77951254310 10.1007/s00198-009-1018-7
55. Kousteni S., Bellido T., Plotkin L. I., O'Brien C. A., Bodenner D. L., Han L., Han K., DiGregorio G. B., Katzenellenbogen J. A., Katzenellenbogen B. S., Roberson P. K., Weinstein R. S., Jilka R. L., Manolagas S. C., Nongenotropic, sex-nonspecific signaling through the estrogen or androgen receptors: dissociation from transcriptional activity. Cell 2001 104 5 719 730 2-s2.0-0035831020 (Pubitemid 32241022)
56. Rosen C. J., Pathogenesis of osteoporosis. Baillière's Best Practice & Research 2000 14 181 193
57. Jilka R. L., Passeri G., Girasole G., Cooper S., Abrams J., Broxmeyer H., Manolagas S. C., Estrogen loss upregulates hematopoiesis in the mouse: a mediating role of IL-6. Experimental Hematology 1995 23 6 500 506 2-s2.0-0029013885
58. Jilka R. L., Hangoc G., Girasole G., Passeri G., Williams D. C., Abrams J. S., Boyce B., Broxmeyer H., Manolagas S. C., Increased osteoclast development after estrogen loss: mediation by interleukin-6. Science 1992 257 5066 88 91 2-s2.0-0026777433
59. Di Gregorio G. B., Yamamoto M., Ali A. A., Abe E., Roberson P., Manolagas S. C., Jilka R. L., Attenuation of the self-renewal of transit-amplifying osteoblast progenitors in the murine bone marrow by 17 β -estradiol. The Journal of Clinical Investigation 2001 107 7 803 812 2-s2.0-0035057030 (Pubitemid 32274033)
60. Jilka R. L., Takahashi K., Munshi M., Williams D. C., Roberson P. K., Manolagas S. C., Loss of estrogen upregulates osteoblastogenesis in the murine bone marrow evidence for autonomy from factors released during bone resorption. The Journal of Clinical Investigation 1998 101 9 1942 1950 2-s2.0-0032080656 (Pubitemid 28226114)
61. Kousteni S., Han L., Chen J. R., Almeida M., Plotkin L. I., Bellido T., Manolagas S. C., Kinase-mediated regulation of common transcription factors accounts for the bone-protective effects of sex steroids. The Journal of Clinical Investigation 2003 111 11 1651 1664 2-s2.0-0038819062 (Pubitemid 38057747)
62. Bord S., Beavan S., Ireland D., Horner A., Compston J. E., Mechanisms by which high-dose estrogen therapy produces anabolic skeletal effects in postmenopausal women: role of locally produced growth factors. Bone 2001 29 3 216 222 2-s2.0-0034840054 10.1016/S8756-3282(01)00501-4 (Pubitemid 32823563)
63. Weitzmann M. N., Pacifici R., T cells: unexpected players in the bone loss induced by estrogen deficiency and in basal bone homeostasis. Annals of the New York Academy of Sciences 2007 1116 360 375 2-s2.0-37249045914 10.1196/annals.1402.068 (Pubitemid 350274346)
64. Straub R. H., The complex role of estrogens in inflammation. Endocrine Reviews 2007 28 5 521 574 2-s2.0-34547792318 10.1210/er.2007-0001 (Pubitemid 47236336)
65. Onal M., Xiong J., Chen X., Thostenson J. D., Almeida M., Manolagas S. C., O'Brien C. A., Receptor activator of nuclear factor B ligand (RANKL) protein expression by B lymphocytes contributes to ovariectomy-induced bone loss. The Journal of Biological Chemistry 2012 287 29851 29860
66. Mirza F. S., Padhi I. D., Raisz L. G., Lorenzo J. A., Serum sclerostin levels negatively correlate with parathyroid hormone levels and free estrogen index in postmenopausal women. Journal of Clinical Endocrinology and Metabolism 2010 95 4 1991 1997 2-s2.0-77951644377 10.1210/jc.2009-2283
67. Kim B. J., Bae S. J., Lee S. Y., Lee Y. S., Baek J. E., Park S. Y., Lee S. H., Koh J. M., Kim G. S., TNF- α mediates the stimulation of sclerostin expression in an estrogen-deficient condition. Biochemical and Biophysical Research Communications 2012 424 170 175
68. Tyagi A. M., Srivastava K., Mansoori M. N., Trivedi R., Chattopadhyay N., Singh D., Estrogen deficiency induces the differentiation of IL-17 secreting Th17 cells: a new candidate in the pathogenesis of osteoporosis. PLoS One 2012 7 9 e44552
69. Boyce B. F., Xing L., Bruton and Tec: new links in osteoimmunology. Cell Metabolism 2008 7 4 283 285 2-s2.0-41449105195 10.1016/j.cmet.2008.03.013 (Pubitemid 351455223)
70. Takayanagi H., Sato K., Takaoka A., Taniguchi T., Interplay between interferon and other cytokine systems in bone metabolism. Immunological Reviews 2005 208 181 193 2-s2.0-28544442029 (Pubitemid 41746393)
71. Brandão C. M., Machado G. P., Acurcio Fde A., Pharmacoeconomic analysis of strategies to treat postmenopausal osteoporosis: a systematic review. Revista Brasileira de Reumatologia 2012 52 924 937
72. MacLean C., Newberry S., Maglione M., McMahon M., Ranganath V., Suttorp M., Mojica W., Timmer M., Alexander A., McNamara M., Desai S. B., Zhou A., Chen S., Carter J., Tringale C., Valentine D., Johnsen B., Grossman J., Systematic review: comparative effectiveness of treatments to prevent fractures in men and women with low bone density or osteoporosis. Annals of Internal Medicine 2008 148 3 197 213 2-s2.0-39349086278 (Pubitemid 351665507)
73. Papaioannou A., Morin S., Cheung A. M., Atkinson S., Brown J. P., Feldman S., Hanley D. A., Hodsman A., Jamal S. A., Kaiser S. M., Kvern B., Siminoski K., Leslie W. D., 2010 clinical practice guidelines for the diagnosis and management of osteoporosis in Canada: summary. Canadian Medical Association Journal 2010 182 17 1864 1873 2-s2.0-78649680817 10.1503/cmaj.100771
74. Rosen C. J., Bilezikian J. P., Clinical review 123: hot topic-anabolic therapy for osteoporosis. Journal of Clinical Endocrinology and Metabolism 2001 86 3 957 964 2-s2.0-0035047954 10.1210/jc.86.3.957 (Pubitemid 32322965)
75. Belavic J. M., Denosumab, (Prolia): a new option in the treatment of osteoporosis. Nurse Practitioner 2011 36 11 12
76. Favus M. J., Bisphosphonates for osteoporosis. The New England Journal of Medicine 2010 363 21 2027 2035 2-s2.0-78549264482 10.1056/NEJMct1004903
77. Watts N. B., Diab D. L., Long-term use of bisphosphonates in osteoporosis. Journal of Clinical Endocrinology and Metabolism 2010 95 4 1555 1565 2-s2.0-77951634320 10.1210/jc.2009-1947
78. Miller P. D., A review of the efficacy and safety of denosumab in postmenopausal women with osteoporosis. Therapeutic Advances in Musculoskeletal Disease 2011 3 271 282
79. Moen M. D., Keam S. J., Denosumab: a review of its use in the treatment of postmenopausal osteoporosis. Drugs and Aging 2011 28 1 63 82 2-s2.0-78650651667 10.2165/11203300-000000000-00000
80. Baron R., Ferrari S., Russell R. G. G., Denosumab and bisphosphonates: different mechanisms of action and effects. Bone 2011 48 4 677 692 2-s2.0-79952698455 10.1016/j.bone.2010.11.020