Human osteoclasts derive from CD14-positive monocytes

British Journal of Haematology

Volumn 106, Issue 1, 1999, Pages 167-170

  Massey, H M ^a   Flanagan, Adrienne M ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

Bone resorption; Calcitonin receptor; CD14; Osteoclasts; Vitronectin receptor

Indexed keywords

CALCITONIN RECEPTOR; CD14 ANTIGEN; VITRONECTIN RECEPTOR;

ANIMAL CELL; ANTIGEN EXPRESSION; ARTICLE; CELL CULTURE; CELL LINEAGE; CELL SEPARATION; MONOCYTE; NONHUMAN; OSTEOCLAST; OSTEOLYSIS; PRIORITY JOURNAL; RAT; STEM CELL;

ANTIGENS, CD14; CELL DIFFERENTIATION; HUMANS; MONOCYTES; OSTEOCLASTS;

EID: 0032864471     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.1999.01491.x     Document Type: Article

References (12)

1. Anderson, D.M., Maraskovsky, E., Billingsley, W.L., Dougall, W.C., Tometsko, M.E., Roux, E.R., Teepe, M.C., DuBose, R.F., Cosman, D. & Galibert, L. (1997) A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function. Nature, 390, 175-179.
2. Athanasou, N.A. & Quinn, J. (1990) Immunophenotypic differences between osteoclasts and macrophage polykaryons: immunohistochemical distinction and implications for osteoclast ontogeny and function. Journal of Clinical Pathology, 43, 997-1003.
3. Chambers, T.J. (1992) Regulation of osteoclast development and function. Biology and Physiology of the Osteoclast (ed. by B. R. Rifkin and C. V. Gay), pp. 105-128. CRC Press, Boca Raton.
4. btsA 58 transgenic mouse. Proceedings of the National Academy of Sciences of the United States of America, 90, 5578-5582.
5. Fujikawa, Y., Quinn, J.M.W., Sabokbar, A., McGee, J.O.D. & Athanasou, N.A. (1996) The human osteoclast precursor circulates in the monocyte fraction. Endocrinology, 137, 4058-4060.
6. Grigoriadis, A.E., Wang, Z.-Q., Cecchini, M.G., Hofstetter, W., Felix, R., Fleisch, H.A. & Wagner, E.F. (1994) c-Fos: a key regulator of osteoclast-macrophage lineage determination and bone remodeling. Science, 266, 443-447.
7. Iotsova, V., Caamano, J., Loy, J., Yang, Y., Lewin, A. & Bravo, R. (1997) Osteopetrosis in mice lacking NF-kB1 and NF-kB2. Nature Medicine, 3, 1285-1289.
8. Lacey, D.L., Timms, E., Tan, H.-L., Kelley, M.J., Dunstan, C.R., Burgess, T., Elliott, R., Colombero, A., Elliot, G., Scully, S., Hsu, H., Sullivan. J., Hawkins, N., Davy, E., Capparelli, C., Eli, A., Qian, Y.-X., Kaufman, S., Sarosi, I., Shaloub, V., Senaldi, G., Guo, J., Delaney, J. & Boyle, W.J. (1998) Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation bind activation. Cell, 93, 165-176.
9. 2, interleukin 1α and tumor necrosis factor α increase human osteoclast formation and bone resorption in vitro. Endocrinology, 139, 3157-3164.
10. Morrison, M.S. & Arnett, T.R. (1998) pH effects on osteoclast formation and activation. Bone, 22, 305.
11. Wong, B.R., Rho, J., Arron, J., Robinson, E., Orlinick, J., Chao, M., Kalachikov, S., Cayani, E., Bartlett, F.S., Frankel, W.N., Lee, S.Y. & Choi, Y. (1997) TRANCE is a novel ligand of the tumor necrosis factor receptor family that activates c-Jun N-terminal kinase in T cells. Journal of Biological Chemistry, 272, 25190-25194.
12. Yasuda, H., Shima, N., Nakagawa, N., Yamaguchi, K., Kinosaki, M., Mochizuki, S.-I., Tomoyasu, A., Yano, K., Goto, M., Murakakami, A., Tsuda, E., Morinaga, T., Higahio, K., Udagawa, N., Takahashi, N. & Suda, T. (1998) Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factory and is identical to TRANCE/RANKL. Proceedings of the National Academy of Sciences of the United States of America, 95, 3597-3602.