The osteoclast and its unique cytoskeleton

Annals of the New York Academy of Sciences

Volumn 1240, Issue 1, 2011, Pages 14-17

  Teitelbaum, Steven L ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Actin ring; Cytoskeleton; Integrin; Osteoclast

Indexed keywords

ACTIN; COLONY STIMULATING FACTOR 1; PROTEIN KINASE SYK; RAC PROTEIN; SYNAPTOTAGMIN; SYNAPTOTAGMIN VII; UNCLASSIFIED DRUG; VITRONECTIN RECEPTOR;

ANIMAL CELL; CELL MEMBRANE; CELL ORGANELLE; CELL STRUCTURE; CYTOSKELETON; EXOCYTOSIS; LYSOSOME; MICROENVIRONMENT; NONHUMAN; NOTE; ONCOGENE SRC; OSTEOCLAST; OSTEOLYSIS; POLARIZATION; SIGNAL TRANSDUCTION;

EID: 83755225707     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2011.06283.x     Document Type: Note

References (14)

1. McHugh, K.P., K. Hodivala-Dilke, M.H. Zheng, et al. 2000. Mice lacking β3 integrins are osteosclerotic because of dysfunctional osteoclasts. J. Clin. Invest. 105: 433-440.
2. Faccio, R., D.V. Novack, A. Zallone, et al. 2003. Dynamic changes in the osteoclast cytoskeleton in response to growth factors and cell attachment are controlled by β3 integrin. J. Cell Biol. 162: 499-509.
3. Zou, W., H. Kitaura, J. Reeve, et al. 2007. Syk, c-Src, the αvβ3 integrin, and ITAM immunoreceptors, in concert, regulate osteoclastic bone resorption. J. Cell Biol. 176: 877-888.
4. Zou, W., J.L. Reeve, H. Zhao, et al. 2009. Syk tyrosine 317 negatively regulates osteoclast function via the ubiquitin-protein isopeptide ligase activity of Cbl. J. Biol. Chem. 284: 18833-18839.
5. Reeve, J.L., W. Zou, Y. Liu, et al. 2009. SLP-76 couples Syk to the osteoclast cytoskeleton. J. Immunol. 183: 1804-1812.
6. Faccio, R., S.L. Teitelbaum, K. Fujikawa, et al. 2005. Vav3 regulates osteoclast function and bone mass. Nat. Med. 11: 284-290.
7. Ito, Y., S.L. Teitelbaum, W. Zou, et al. 2010. Cdc42 regulates bone modeling and remodeling in mice by modulating RANKL/M-CSF signaling and osteoclast polarization. J. Clin. Invest. 120: 1981-1993.
8. Faccio, R., S. Takeshita, A. Zallone, et al. 2003. c-Fms and the αvβ3 integrin collaborate during osteoclast differentiation. J. Clin. Invest. 111: 749-758.
9. Croke, M., F.P. Ross, M. Korhonen, et al. 2011. Rac deletion in osteoclasts causes severe osteopetrosis. J. Cell Sci. (In press).
10. Lacey, D.L., E. Timms, H.L. Tan, et al. 1998. Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell 93: 165-176.
11. Zou, W., J.L. Reeve, Y. Liu, et al. 2008. DAP12 couples c-Fms activation to the osteoclast cytoskeleton by recruitment of Syk. Mol. Cell 31: 422-431.
12. Faccio, R., M. Grano, S. Colucci, et al. 2002. Localization and possible role of two different αvβ3 integrin conformations in resting and resorbing osteoclasts. J. Cell Sci. 115: 2919-2929.
13. Zhao, H., Y. Ito, J. Chappel, et al. 2008. Synaptotagmin VII regulates bone remodeling by modulating osteoclast and osteoblast secretion. Dev. Cell 14: 914-925.
14. Baron, R., L. Neff, D. Louvard & P.J. Courtoy. 1985. Cell-mediated extracellular acidification and bone resorption: evidence for a low pH in resorbing lacunae and localization of a 100-kD lysosomal membrane protein at the osteoclast ruffled border. J. Cell Biol. 101: 2210-2222.